CY1112568T1 - Χρηση των πυριμιδυλαμινοβενζαμιδων για τη θεραπεια των νοσων που ανταποκρινονται στην ρυθμιση της δρασης της τιε-2 κινασης - Google Patents

Χρηση των πυριμιδυλαμινοβενζαμιδων για τη θεραπεια των νοσων που ανταποκρινονται στην ρυθμιση της δρασης της τιε-2 κινασης

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Publication number
CY1112568T1
CY1112568T1 CY20111101146T CY111101146T CY1112568T1 CY 1112568 T1 CY1112568 T1 CY 1112568T1 CY 20111101146 T CY20111101146 T CY 20111101146T CY 111101146 T CY111101146 T CY 111101146T CY 1112568 T1 CY1112568 T1 CY 1112568T1
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CY
Cyprus
Prior art keywords
treatment
kinase
pyrimidylaminobenzamide
regulation
diseases
Prior art date
Application number
CY20111101146T
Other languages
English (en)
Inventor
Paul W Manley
Georg Martiny-Baron
Juergen Mestan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1112568T1 publication Critical patent/CY1112568T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται στη χρήση των ενώσεων πυριμιδυλαμινοβενζαμίδης για την παρασκευή ενός φαρμάκου για τη θεραπεία των νόσων που ανταποκρίνονται στη ρύθμιση της δράσης κινάσης, συγκεκριμένα της κινάσης tie-2, συγκεκριμένα για την θεραπευτική και/ή προφυλακτική αντιμετώπιση της λευχαιμίας, των μυελοδυσπλαστικών συνδρόμων ή της πνευμονικής υπέρτασης και σε μια μέθοδο θεραπείας των νόσων που ανταποκρίνονται στην ρύθμιση της δράσης της κινάσης, συγκεκριμένα της δράσης της κινάσης tie-2.
CY20111101146T 2005-01-28 2011-11-24 Χρηση των πυριμιδυλαμινοβενζαμιδων για τη θεραπεια των νοσων που ανταποκρινονται στην ρυθμιση της δρασης της τιε-2 κινασης CY1112568T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64789505P 2005-01-28 2005-01-28
US66240405P 2005-03-16 2005-03-16
EP06706432A EP1843771B1 (en) 2005-01-28 2006-01-26 Use of pyrimidylaminobenzamides for the treatment of diseases that respond to modulation of tie-2 kinase activity

Publications (1)

Publication Number Publication Date
CY1112568T1 true CY1112568T1 (el) 2016-02-10

Family

ID=36273382

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101146T CY1112568T1 (el) 2005-01-28 2011-11-24 Χρηση των πυριμιδυλαμινοβενζαμιδων για τη θεραπεια των νοσων που ανταποκρινονται στην ρυθμιση της δρασης της τιε-2 κινασης

Country Status (17)

Country Link
US (1) US20080114001A1 (el)
EP (1) EP1843771B1 (el)
JP (2) JP5373288B2 (el)
KR (2) KR101325424B1 (el)
CN (1) CN101203224B (el)
AT (1) ATE525073T1 (el)
AU (1) AU2006208638B2 (el)
BR (1) BRPI0606872A2 (el)
CA (1) CA2594687C (el)
CY (1) CY1112568T1 (el)
DK (1) DK1843771T3 (el)
ES (1) ES2373912T3 (el)
MX (1) MX2007009135A (el)
PL (1) PL1843771T3 (el)
PT (1) PT1843771E (el)
RU (1) RU2404776C2 (el)
WO (1) WO2006079539A2 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2629132C (en) * 2005-12-06 2014-05-27 Novartis Ag Pyrimidylaminobenzamide derivatives for the treatment of neurofibromatosis
WO2007137981A1 (en) * 2006-05-25 2007-12-06 Novartis Ag Inhibitors of tyrosine kinases
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
US8242271B2 (en) 2007-06-04 2012-08-14 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
RU2011109078A (ru) * 2008-08-13 2012-09-20 Новартис АГ (CH) Лечение легочной артериальной гипертензии
US9207782B2 (en) 2010-12-16 2015-12-08 Lg Electronics Inc. Remote controller, remote controlling method and display system having the same
WO2020214851A1 (en) * 2019-04-18 2020-10-22 Aerpio Pharmaceuticals, Inc. Methods of treating hypertension with activators of tie-2

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL179417B1 (en) * 1993-10-01 2000-09-29 Novartis Ag Pharmacologically active derivatives of pyridine and methods of obtaining them
TW533205B (en) * 1996-06-25 2003-05-21 Novartis Ag Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition
WO2000075139A2 (en) * 1999-06-03 2000-12-14 Basf Aktiengesellschaft Benzothiazinone and benzoxazinone compounds
US20030199525A1 (en) * 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
AU2003272007A1 (en) * 2002-10-25 2004-05-13 The Administrators Of The Tulane Educational Fund Use of n-5-4-(4-methylpiperaziomethyl)-benzoylamido!-2-methylphenyl!-4-(3-pyridyl)2-pyridine-amine for the treatment of pulmonary hypertension
EP1611123B8 (en) * 2003-04-09 2013-11-13 Exelixis, Inc. Tie-2 modulators and methods of use
JP4810427B2 (ja) * 2003-05-22 2011-11-09 アボット・ラボラトリーズ インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤
EP1633710A1 (en) * 2003-06-02 2006-03-15 Abbott Laboratories Isoindolin-1-one compounds as kinase inhibitors
AR045037A1 (es) * 2003-07-10 2005-10-12 Aventis Pharma Sa Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
GB0325031D0 (en) * 2003-10-27 2003-12-03 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
BRPI0606872A2 (pt) 2009-07-21
EP1843771A2 (en) 2007-10-17
KR20070104567A (ko) 2007-10-26
CN101203224B (zh) 2010-11-03
CA2594687A1 (en) 2006-08-03
EP1843771B1 (en) 2011-09-21
WO2006079539A2 (en) 2006-08-03
RU2007132255A (ru) 2009-03-10
RU2404776C2 (ru) 2010-11-27
KR20130100371A (ko) 2013-09-10
JP2008528531A (ja) 2008-07-31
MX2007009135A (es) 2007-09-06
ATE525073T1 (de) 2011-10-15
DK1843771T3 (da) 2012-01-16
AU2006208638A1 (en) 2006-08-03
US20080114001A1 (en) 2008-05-15
JP2013213042A (ja) 2013-10-17
CN101203224A (zh) 2008-06-18
CA2594687C (en) 2013-10-29
WO2006079539A3 (en) 2007-11-29
PT1843771E (pt) 2011-12-02
KR101325424B1 (ko) 2013-11-04
JP5373288B2 (ja) 2013-12-18
PL1843771T3 (pl) 2012-02-29
AU2006208638B2 (en) 2010-03-04
ES2373912T3 (es) 2012-02-10

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