CY1112126T1 - Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνων - Google Patents
Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνωνInfo
- Publication number
- CY1112126T1 CY1112126T1 CY20111101176T CY111101176T CY1112126T1 CY 1112126 T1 CY1112126 T1 CY 1112126T1 CY 20111101176 T CY20111101176 T CY 20111101176T CY 111101176 T CY111101176 T CY 111101176T CY 1112126 T1 CY1112126 T1 CY 1112126T1
- Authority
- CY
- Cyprus
- Prior art keywords
- vegf
- bonds
- treatment
- neural disorders
- use toy
- Prior art date
Links
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 title 1
- 102000058223 human VEGFA Human genes 0.000 title 1
- 230000001537 neural effect Effects 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 abstract 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με την νευρολογική και φυσιολογική δυσλειτουργία που συσχετίζεται με τις διαταραχές των νευρώνων. Ειδικότερα, η εφεύρεση συσχετίζεται με την εμπλοκή του αγγειακού ενδοθηλιακού αυξητικού παράγοντα (VEGF) και των ομολόγων στην αιτιολογία των διαταραχών των κινητικών νευρώνων. Η εφεύρεση αφορά περαιτέρω έναν καινοφανή, μεταλλαγμένο διαγονιδιακό ποντικό (VEGFm/m) με μια ομόζυγη απαλοιφή στο αποκριτικό στην υποξία στοιχείο (HRE) του προαγωγού του VEGF η οποία αλλοιώνει την υποξική ανοδική ρύθμιση του VEGF. Αυτά τα ποντίκια υποφέρουν από δριμεία μυϊκή αδυναμία έναρξης ενηλίκων λόγω της προοδευτικής εκφύλισης των νωτιαίων κινητικών νευρώνων η οποία θυμίζει την αμυοτροφική πλευρική σκλήρυνση (ALS) - μια μοιραία διαταραχή με άγνωστη αιτιολογία. Προσέτι, η νευροπάθεια αυτών των ποντικών δεν προκαλείται από αγγειακά ελλείμματα, αλλά οφείλεται στα ελαττωματικά μεσολαβούμενα από τον VEGF σήματα επιβίωσης στους κινητικούς νευρώνες. Η παρούσα εφεύρεση συσχετίζεται ειδικότερα με την ισομορφή VEGF165 η οποία διεγείρει την επιβίωση των κινητικών νευρώνων μέσω της δέσμευσης στην νευροφιλίνη-1, έναν υποδοχέα γνωστό ότι δεσμεύει την σεμαφορίνη-3Α η οποία εμπλέκεται στην επανάταξη των αξόνων και τον νευρωνικό θάνατο, και τον Υποδοχέα-2 του VEGF. Η παρούσα εφεύρεση σχετίζεται τοιουτοτρόπως με την χρήση του VEGF, ειδικότερα του VEGF165, για την αγωγή των διαταραχών των νευρώνων και σχετίζεται, επιπλέον, με την χρήση των πολυμορφισμών στον προαγωγό του VEGF για την διάγνωση των τελευταίων διαταραχών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00201325 | 2000-04-12 | ||
EP00203382 | 2000-09-29 | ||
EP01947222A EP1272208B1 (en) | 2000-04-12 | 2001-04-12 | Use of vegf 165 and homologues to treat neuron disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112126T1 true CY1112126T1 (el) | 2015-11-04 |
Family
ID=26072122
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111101176T CY1112126T1 (el) | 2000-04-12 | 2011-11-30 | Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνων |
CY20151100131T CY1116296T1 (el) | 2000-04-12 | 2015-02-10 | Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων |
CY20151101015T CY1116933T1 (el) | 2000-04-12 | 2015-11-11 | Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100131T CY1116296T1 (el) | 2000-04-12 | 2015-02-10 | Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων |
CY20151101015T CY1116933T1 (el) | 2000-04-12 | 2015-11-11 | Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων |
Country Status (10)
Country | Link |
---|---|
US (5) | US7226908B2 (el) |
EP (3) | EP1272208B1 (el) |
AT (1) | ATE526981T1 (el) |
AU (2) | AU6896801A (el) |
CA (3) | CA2404616C (el) |
CY (3) | CY1112126T1 (el) |
DK (3) | DK1272208T3 (el) |
ES (3) | ES2372809T3 (el) |
PT (3) | PT2277528E (el) |
WO (1) | WO2001076620A2 (el) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1272208B1 (en) * | 2000-04-12 | 2011-10-05 | VIB vzw | Use of vegf 165 and homologues to treat neuron disorders |
JP2005526482A (ja) * | 2001-08-10 | 2005-09-08 | イムクローン システムズ インコーポレイティド | Vegfr−1を発現する幹細胞の単離および動員 |
US7981863B2 (en) | 2001-09-19 | 2011-07-19 | Neuronova Ab | Treatment of Parkinson's disease with PDGF |
US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
EP1663293A2 (en) * | 2003-09-23 | 2006-06-07 | Ludwig Institute For Cancer Research | Vege-cor vege-d materials and methods for stimulation of neural stem cells |
CA2568158A1 (en) * | 2004-05-27 | 2005-12-15 | D. Collen Research Foundation Vzw | Treatment of amyotrophic lateral sclerosis |
US20070021421A1 (en) * | 2005-07-25 | 2007-01-25 | Hampton Thomas G | Measurement of gait dynamics and use of beta-blockers to detect, prognose, prevent and treat amyotrophic lateral sclerosis |
WO2007023479A2 (en) * | 2005-08-23 | 2007-03-01 | Royal College Of Surgeons In Ireland | Treatment of central nervous system injury |
CN101534865A (zh) * | 2005-10-19 | 2009-09-16 | Ibc药品公司 | 生物活性装配体的制备方法及其用途 |
GB0803912D0 (en) * | 2008-02-29 | 2008-05-07 | Univ Bristol | Novel Uses of VEGFxxxb |
ES2376930B1 (es) * | 2009-02-05 | 2013-01-24 | Universidad Del Pais Vasco | Método para el tratamiento de enfermedades neurodegenerativas. |
EP2456784B1 (en) | 2009-07-24 | 2017-01-11 | Advanced Accelerator Applications S.A. | Compounds modulators of vegf activity and uses thereof |
WO2014035433A1 (en) * | 2012-08-31 | 2014-03-06 | Jan Nolta | Genetically modified msc and therapeutic methods |
US20140065110A1 (en) | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
US9663564B2 (en) | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
RU2639175C1 (ru) * | 2016-11-14 | 2017-12-20 | Общество с ограниченной ответственностью "НекстГен" | Способ индукции регенерации периферического нерва |
EP3773677A1 (en) * | 2018-04-12 | 2021-02-17 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Anti-aging compositions and methods of use |
CN113057142B (zh) * | 2021-03-30 | 2022-12-09 | 四川大学华西医院 | 一种视网膜内和/或视网膜下纤维化动物模型的构建方法 |
WO2023214189A1 (en) * | 2022-05-05 | 2023-11-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and composition for treating neurodegenerative disorder |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US3013780A (en) | 1957-12-09 | 1961-12-19 | Shell Oil Co | Gas-liquid contacting apparatus with shutter trays |
NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
DE69434538T2 (de) | 1994-03-08 | 2006-08-10 | Human Genome Sciences, Inc. | Vaskulärer endothelialer Wachstumsfaktor 2 |
CN1229498C (zh) | 1996-02-21 | 2005-11-30 | 美国国有卫生与人类服务部 | 重组的核糖核酸酶蛋白质 |
US6013780A (en) | 1996-09-06 | 2000-01-11 | Technion Research & Development Co. Ltd. | VEGF145 expression vectors |
US5965363A (en) | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
CA2277869A1 (en) | 1997-01-17 | 1998-07-23 | Institut National De La Sante Et De La Recherche Medicale | Adenoviral-vector-mediated gene transfer into medullary motor neurons |
NZ314594A (en) | 1997-04-14 | 1998-06-26 | Patchett Ag Air Ltd | A spray boom including outlet nozzle clearing means and actuators therefor |
JP2002505873A (ja) * | 1998-03-13 | 2002-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
DK1064382T3 (da) * | 1998-03-17 | 2008-12-08 | Genentech Inc | Homologe polypeptider til VEGF og BMP1 |
DE69940318D1 (de) | 1998-09-23 | 2009-03-05 | Oxford Biomedica Ltd | Polynucleotidkonstrukte und ihre verwendungen |
DE60021360T2 (de) | 1999-04-15 | 2006-05-24 | Caritas St. Elizabeth's Medical Center of Boston, Inc., Boston | Vegf angiogenische wachstumsfaktoren zur behandlung von peripherer neuropathie |
US7125856B1 (en) * | 1999-04-15 | 2006-10-24 | St. Elizabeth's Medical Center Of Boston, Inc. | Angiogenic growth factors for treatment of peripheral neuropathy |
AU6733400A (en) * | 1999-08-30 | 2001-03-26 | Sumitomo Pharmaceuticals Company, Limited | Novel uses of semaphorin and vegf |
US6930089B2 (en) | 2000-02-04 | 2005-08-16 | D. Collen Research Foundation Vzw | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic disease or stroke |
EP1272208B1 (en) * | 2000-04-12 | 2011-10-05 | VIB vzw | Use of vegf 165 and homologues to treat neuron disorders |
NZ529915A (en) | 2001-06-20 | 2007-07-27 | Ludwig Inst Cancer Res | Stimulation of vascularization of ischemic tissue by angiogenesis with VEGF-B186 |
JP2006517586A (ja) | 2003-02-04 | 2006-07-27 | ラドウィグ インスティテュート フォー キャンサー リサーチ | 幹細胞のvegf−b及びpdgf調節 |
CA2568158A1 (en) | 2004-05-27 | 2005-12-15 | D. Collen Research Foundation Vzw | Treatment of amyotrophic lateral sclerosis |
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2001
- 2001-04-12 EP EP01947222A patent/EP1272208B1/en not_active Expired - Lifetime
- 2001-04-12 ES ES01947222T patent/ES2372809T3/es not_active Expired - Lifetime
- 2001-04-12 PT PT101788537T patent/PT2277528E/pt unknown
- 2001-04-12 PT PT101788107T patent/PT2295070E/pt unknown
- 2001-04-12 DK DK01947222.4T patent/DK1272208T3/da active
- 2001-04-12 PT PT01947222T patent/PT1272208E/pt unknown
- 2001-04-12 US US10/257,423 patent/US7226908B2/en not_active Expired - Fee Related
- 2001-04-12 CA CA002404616A patent/CA2404616C/en not_active Expired - Fee Related
- 2001-04-12 CA CA002659656A patent/CA2659656A1/en not_active Abandoned
- 2001-04-12 DK DK10178853.7T patent/DK2277528T3/en active
- 2001-04-12 EP EP10178810.7A patent/EP2295070B1/en not_active Expired - Lifetime
- 2001-04-12 DK DK10178810.7T patent/DK2295070T3/en active
- 2001-04-12 AU AU6896801A patent/AU6896801A/xx active Pending
- 2001-04-12 AT AT01947222T patent/ATE526981T1/de active
- 2001-04-12 ES ES10178810.7T patent/ES2551160T3/es not_active Expired - Lifetime
- 2001-04-12 WO PCT/EP2001/004293 patent/WO2001076620A2/en active Application Filing
- 2001-04-12 AU AU2001268968A patent/AU2001268968B2/en not_active Ceased
- 2001-04-12 CA CA2654413A patent/CA2654413C/en not_active Expired - Fee Related
- 2001-04-12 ES ES10178853.7T patent/ES2528217T3/es not_active Expired - Lifetime
- 2001-04-12 EP EP10178853.7A patent/EP2277528B1/en not_active Expired - Lifetime
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2007
- 2007-04-25 US US11/789,703 patent/US20080032314A1/en not_active Abandoned
- 2007-06-04 US US11/810,017 patent/US7592314B2/en not_active Expired - Fee Related
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2008
- 2008-11-19 US US12/313,338 patent/US7888322B2/en not_active Expired - Fee Related
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2010
- 2010-12-03 US US12/928,131 patent/US20110288020A1/en not_active Abandoned
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2011
- 2011-11-30 CY CY20111101176T patent/CY1112126T1/el unknown
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2015
- 2015-02-10 CY CY20151100131T patent/CY1116296T1/el unknown
- 2015-11-11 CY CY20151101015T patent/CY1116933T1/el unknown
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