CY1112126T1 - Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνων - Google Patents

Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνων

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Publication number
CY1112126T1
CY1112126T1 CY20111101176T CY111101176T CY1112126T1 CY 1112126 T1 CY1112126 T1 CY 1112126T1 CY 20111101176 T CY20111101176 T CY 20111101176T CY 111101176 T CY111101176 T CY 111101176T CY 1112126 T1 CY1112126 T1 CY 1112126T1
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CY
Cyprus
Prior art keywords
vegf
bonds
treatment
neural disorders
use toy
Prior art date
Application number
CY20111101176T
Other languages
English (en)
Inventor
Peter Carmeliet
Désiré Collen
Bert Oosthuyse
Original Assignee
Vib Vzw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vib Vzw filed Critical Vib Vzw
Publication of CY1112126T1 publication Critical patent/CY1112126T1/el

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Husbandry (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με την νευρολογική και φυσιολογική δυσλειτουργία που συσχετίζεται με τις διαταραχές των νευρώνων. Ειδικότερα, η εφεύρεση συσχετίζεται με την εμπλοκή του αγγειακού ενδοθηλιακού αυξητικού παράγοντα (VEGF) και των ομολόγων στην αιτιολογία των διαταραχών των κινητικών νευρώνων. Η εφεύρεση αφορά περαιτέρω έναν καινοφανή, μεταλλαγμένο διαγονιδιακό ποντικό (VEGFm/m) με μια ομόζυγη απαλοιφή στο αποκριτικό στην υποξία στοιχείο (HRE) του προαγωγού του VEGF η οποία αλλοιώνει την υποξική ανοδική ρύθμιση του VEGF. Αυτά τα ποντίκια υποφέρουν από δριμεία μυϊκή αδυναμία έναρξης ενηλίκων λόγω της προοδευτικής εκφύλισης των νωτιαίων κινητικών νευρώνων η οποία θυμίζει την αμυοτροφική πλευρική σκλήρυνση (ALS) - μια μοιραία διαταραχή με άγνωστη αιτιολογία. Προσέτι, η νευροπάθεια αυτών των ποντικών δεν προκαλείται από αγγειακά ελλείμματα, αλλά οφείλεται στα ελαττωματικά μεσολαβούμενα από τον VEGF σήματα επιβίωσης στους κινητικούς νευρώνες. Η παρούσα εφεύρεση συσχετίζεται ειδικότερα με την ισομορφή VEGF165 η οποία διεγείρει την επιβίωση των κινητικών νευρώνων μέσω της δέσμευσης στην νευροφιλίνη-1, έναν υποδοχέα γνωστό ότι δεσμεύει την σεμαφορίνη-3Α η οποία εμπλέκεται στην επανάταξη των αξόνων και τον νευρωνικό θάνατο, και τον Υποδοχέα-2 του VEGF. Η παρούσα εφεύρεση σχετίζεται τοιουτοτρόπως με την χρήση του VEGF, ειδικότερα του VEGF165, για την αγωγή των διαταραχών των νευρώνων και σχετίζεται, επιπλέον, με την χρήση των πολυμορφισμών στον προαγωγό του VEGF για την διάγνωση των τελευταίων διαταραχών.
CY20111101176T 2000-04-12 2011-11-30 Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνων CY1112126T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00201325 2000-04-12
EP00203382 2000-09-29
EP01947222A EP1272208B1 (en) 2000-04-12 2001-04-12 Use of vegf 165 and homologues to treat neuron disorders

Publications (1)

Publication Number Publication Date
CY1112126T1 true CY1112126T1 (el) 2015-11-04

Family

ID=26072122

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20111101176T CY1112126T1 (el) 2000-04-12 2011-11-30 Χρηση toy vegf 165 και των ομολογων για την αγωγη διαταραχων των νευρωνων
CY20151100131T CY1116296T1 (el) 2000-04-12 2015-02-10 Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων
CY20151101015T CY1116933T1 (el) 2000-04-12 2015-11-11 Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων

Family Applications After (2)

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CY20151100131T CY1116296T1 (el) 2000-04-12 2015-02-10 Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων
CY20151101015T CY1116933T1 (el) 2000-04-12 2015-11-11 Χρηση vegf και ομολογων στη θεραπευτικη αγωγη νευρωνικων διαταραχων

Country Status (10)

Country Link
US (5) US7226908B2 (el)
EP (3) EP2277528B1 (el)
AT (1) ATE526981T1 (el)
AU (2) AU6896801A (el)
CA (3) CA2659656A1 (el)
CY (3) CY1112126T1 (el)
DK (3) DK1272208T3 (el)
ES (3) ES2528217T3 (el)
PT (3) PT1272208E (el)
WO (1) WO2001076620A2 (el)

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WO2005030240A2 (en) * 2003-09-23 2005-04-07 Ludwig Institute For Cancer Research Vege-cor vege-d materials and methods for stimulation of neural stem cells
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Also Published As

Publication number Publication date
AU6896801A (en) 2001-10-23
EP2295070A1 (en) 2011-03-16
CY1116933T1 (el) 2017-04-05
EP1272208A2 (en) 2003-01-08
CA2404616C (en) 2009-08-18
DK2295070T3 (en) 2015-11-16
US20070249539A1 (en) 2007-10-25
US7226908B2 (en) 2007-06-05
DK1272208T3 (da) 2011-10-31
PT2295070E (pt) 2015-12-07
CA2654413A1 (en) 2001-10-18
DK2277528T3 (en) 2015-01-26
ATE526981T1 (de) 2011-10-15
WO2001076620A3 (en) 2001-12-20
EP2295070B1 (en) 2015-08-12
EP1272208B1 (en) 2011-10-05
PT2277528E (pt) 2015-02-05
CA2654413C (en) 2016-10-18
US7888322B2 (en) 2011-02-15
CA2404616A1 (en) 2001-10-18
US20080032314A1 (en) 2008-02-07
US20100041601A1 (en) 2010-02-18
ES2372809T3 (es) 2012-01-26
ES2528217T3 (es) 2015-02-05
US20110288020A1 (en) 2011-11-24
WO2001076620A2 (en) 2001-10-18
EP2277528B1 (en) 2014-11-12
EP2277528A2 (en) 2011-01-26
ES2551160T3 (es) 2015-11-16
CA2659656A1 (en) 2001-10-18
CY1116296T1 (el) 2017-02-08
AU2001268968B2 (en) 2006-10-19
EP2277528A3 (en) 2011-03-02
PT1272208E (pt) 2012-01-03
US7592314B2 (en) 2009-09-22
US20030105018A1 (en) 2003-06-05

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