CY1111711T1 - Αντι-ιικα πυριμιδινικα νουκλεοζιτικα παραγωγα - Google Patents

Αντι-ιικα πυριμιδινικα νουκλεοζιτικα παραγωγα

Info

Publication number
CY1111711T1
CY1111711T1 CY20111100693T CY111100693T CY1111711T1 CY 1111711 T1 CY1111711 T1 CY 1111711T1 CY 20111100693 T CY20111100693 T CY 20111100693T CY 111100693 T CY111100693 T CY 111100693T CY 1111711 T1 CY1111711 T1 CY 1111711T1
Authority
CY
Cyprus
Prior art keywords
alkyl
pyrimidine nucleoside
nucleoside derivatives
neutral
amino acid
Prior art date
Application number
CY20111100693T
Other languages
Greek (el)
English (en)
Inventor
Christopher Mcguigan
Jan Balzarini
Marco Migliore
Original Assignee
University College Cardiff Consultants Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cardiff Consultants Limited filed Critical University College Cardiff Consultants Limited
Publication of CY1111711T1 publication Critical patent/CY1111711T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY20111100693T 2006-05-09 2011-07-15 Αντι-ιικα πυριμιδινικα νουκλεοζιτικα παραγωγα CY1111711T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0609178.9A GB0609178D0 (en) 2006-05-09 2006-05-09 Novel compounds
EP07732706A EP2016081B1 (en) 2006-05-09 2007-05-09 Anti-viral pyrimidine nucleoside derivatives

Publications (1)

Publication Number Publication Date
CY1111711T1 true CY1111711T1 (el) 2015-10-07

Family

ID=36637171

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100693T CY1111711T1 (el) 2006-05-09 2011-07-15 Αντι-ιικα πυριμιδινικα νουκλεοζιτικα παραγωγα

Country Status (22)

Country Link
US (3) US8329664B2 (https=)
EP (1) EP2016081B1 (https=)
JP (1) JP5261374B2 (https=)
KR (1) KR101447522B1 (https=)
CN (1) CN101443332B (https=)
AT (1) ATE506367T1 (https=)
AU (1) AU2007246814B2 (https=)
BR (1) BRPI0711354A2 (https=)
CA (1) CA2656780C (https=)
CY (1) CY1111711T1 (https=)
DE (1) DE602007014030D1 (https=)
DK (1) DK2016081T3 (https=)
EA (1) EA015178B1 (https=)
ES (1) ES2365057T3 (https=)
GB (1) GB0609178D0 (https=)
IL (1) IL194806A (https=)
NZ (1) NZ573377A (https=)
PL (1) PL2016081T3 (https=)
PT (1) PT2016081E (https=)
SI (1) SI2016081T1 (https=)
TW (1) TWI385172B (https=)
WO (1) WO2007129083A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0009486D0 (en) * 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
GB2452556A (en) * 2007-09-07 2009-03-11 Univ Leuven Kath Nucleoside analogues esterified at 3 and/or 5 positions by neutral non-polar amino acid, or oligopeptide thereof, for combating Varicella Zoster virus
US9260469B2 (en) * 2010-10-09 2016-02-16 Contravir Pharmaceuticals, Inc. Method of preparation of antiviral compounds and useful intermediates thereof
CN102443032B (zh) * 2010-10-09 2015-07-22 英希比泰克斯公司 制备抗病毒组合物的方法及其中间体的应用
MD4110C1 (ro) * 2010-10-21 2011-12-31 Валериу РУДИК Preparat antiherpetiс
KR101875997B1 (ko) * 2015-05-04 2018-07-06 엔 앤드 엔 파마세우티칼스 인크. 엔-메탄노카르바티미딘을 이용한 대상포진의 치료방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62255499A (ja) 1986-04-28 1987-11-07 Teijin Ltd 螢光性ヌクレオシド又はヌクレオチド
EP0346108A3 (en) 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
YU43193A (sh) 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
GB9505025D0 (en) 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6022876A (en) 1996-11-15 2000-02-08 Yale University L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections
GB9708611D0 (en) 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
GB9716231D0 (en) 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues
HK1053126A1 (zh) 1999-07-22 2003-10-10 新生物生物公司 酶催化的治疗活化
BR0012676A (pt) 1999-07-22 2003-07-01 Newbiotics Inc Métodos para tratamento de tumores resistentes a terapia
MXPA02000761A (es) 1999-07-22 2002-08-12 Newbiotics Inc Agentes terapeuticos anti-infecciosos catalizados por enzima.
GB0009486D0 (en) * 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
GB0011203D0 (en) * 2000-05-09 2000-06-28 Univ Cardiff Chemical compounds
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
MY141594A (en) * 2000-06-15 2010-05-14 Novirio Pharmaceuticals Ltd 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
TW200500375A (en) * 2002-06-28 2005-01-01 Idenix Cayman Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
WO2004084453A2 (en) 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
US20050137141A1 (en) 2003-10-24 2005-06-23 John Hilfinger Prodrug composition
CA2566541C (en) 2004-06-07 2012-10-09 Anadys Pharmaceuticals, Inc. 3-.beta.-d-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof

Also Published As

Publication number Publication date
KR101447522B1 (ko) 2014-10-06
US20100222295A1 (en) 2010-09-02
EA200870505A1 (ru) 2009-04-28
PL2016081T3 (pl) 2011-12-30
KR20090042204A (ko) 2009-04-29
EP2016081A1 (en) 2009-01-21
JP5261374B2 (ja) 2013-08-14
ATE506367T1 (de) 2011-05-15
CN101443332B (zh) 2011-11-09
ES2365057T3 (es) 2011-09-21
DK2016081T3 (da) 2011-06-20
IL194806A (en) 2015-08-31
EP2016081B1 (en) 2011-04-20
CA2656780C (en) 2015-04-28
NZ573377A (en) 2011-03-31
US20130096079A1 (en) 2013-04-18
US8859512B2 (en) 2014-10-14
GB0609178D0 (en) 2006-06-21
US8329664B2 (en) 2012-12-11
CN101443332A (zh) 2009-05-27
WO2007129083A1 (en) 2007-11-15
AU2007246814B2 (en) 2012-07-19
US20150072948A1 (en) 2015-03-12
CA2656780A1 (en) 2007-11-15
JP2009536188A (ja) 2009-10-08
BRPI0711354A2 (pt) 2011-09-27
TWI385172B (zh) 2013-02-11
AU2007246814A1 (en) 2007-11-15
TW200813066A (en) 2008-03-16
SI2016081T1 (sl) 2011-09-30
US9427447B2 (en) 2016-08-30
DE602007014030D1 (de) 2011-06-01
IL194806A0 (en) 2009-09-22
EA015178B1 (ru) 2011-06-30
PT2016081E (pt) 2011-06-28

Similar Documents

Publication Publication Date Title
CY1111711T1 (el) Αντι-ιικα πυριμιδινικα νουκλεοζιτικα παραγωγα
JO3067B1 (ar) بيرميدينات بيرازولو امينو كمثبطات ل fak
NO2018033I1 (no) Varicella Zoster Virus (VZV) glykoproteinE (gE) - krav 1 i NO 341841
NZ597544A (en) Modified 4'-nucleosides as antiviral agents
EA201070164A1 (ru) Твердый препарат, включающий алоглиптин и гидрохлорид метформина
EA201170456A1 (ru) Синергические комбинации макроциклического ингибитора вируса гепатита с и нуклеозида
EA200801287A1 (ru) Пиримидиновые производные для лечения аномального клеточного роста
MY145856A (en) Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis c virus
PE20080179A1 (es) FORMAS CRISTALINAS DE LA SAL MALEATO DE 5-AMINO-3-(2',3'-DI-O-ACETIL-BETA-D-RIBOFURANOSIL)-3H-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA
ATE435223T1 (de) Pyrimidin-, chinazolin-, pteridin- und triazinderivate
WO2006027628A3 (en) Naphthalimide derivatives as antiviral agents
MX2009011579A (es) Pirimidinonas como moduladores de caseina cinasa ii (ck2).
EA201000848A1 (ru) Ингибиторы протеинкиназы и их применение
EA201270275A1 (ru) Кристаллическое соединение пиридазина
EA200970041A1 (ru) Ингибиторы акт (протеинкиназы в)
WO2006116733A3 (en) Protein kinase inhibitors
TR200402534T4 (tr) Viral enfeksiyonların tedavisinde yararlı oksazinokuinolonlar.
BR0215016A (pt) Piridoquinoxalinas antivirìcas
PE20061378A1 (es) INHIBIDORES DE LA ACTIVIDAD DE Akt
SI2850054T1 (en) A process for the production of amino acid compounds
JP2009536188A5 (https=)
EA200702637A1 (ru) Производные пурина
DE602007012436D1 (de) Pseudoprolindipeptide
WO2004037166A3 (en) Therapeutic guanidines
GB0717526D0 (en) Improvements in or relating to compositions for the treatment or prophylaxis of viral infections