CY1109876T1 - Μεθοδοι για εκλεκτικη στοχευση - Google Patents

Μεθοδοι για εκλεκτικη στοχευση

Info

Publication number
CY1109876T1
CY1109876T1 CY20101100233T CY101100233T CY1109876T1 CY 1109876 T1 CY1109876 T1 CY 1109876T1 CY 20101100233 T CY20101100233 T CY 20101100233T CY 101100233 T CY101100233 T CY 101100233T CY 1109876 T1 CY1109876 T1 CY 1109876T1
Authority
CY
Cyprus
Prior art keywords
target
ligands
bound
bind
ligand complex
Prior art date
Application number
CY20101100233T
Other languages
English (en)
Inventor
David A Estell
Christopher J Murray
Pilar Tijerina
Yiyou Chen
Original Assignee
Genencor International, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor International, Inc. filed Critical Genencor International, Inc.
Publication of CY1109876T1 publication Critical patent/CY1109876T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)

Abstract

Μια μέθοδος εκλεκτικής στόχευσης γνωστοποιείται η οποία περιλαμβάνει την επαφή μιας βιβλιοθήκης συνδετών, ειδικότερα μιας πεπτιδικής βιβλιοθήκης, με έναν αντι-στόχο για να καταστεί δυνατή η δέσμευση των συνδετών στον αντι-στόχο το διαχωρισμό των μη-δεσμευμένων συνδετών από τους δεσμευμένους στον αντι-στόχο συνδέτες, την επαφή των μη-δεσμευμένων σε αντι-στόχο συνδετών με έναν στόχο καθιστώντας δυνατή τη δέσμευση των μη-δεσμευμένων συνδετών με τον στόχο για σχηματισμό ενός συμπλόκου δεσμευμένου σε στόχο συνδέτη το διαχωρισμό του συμπλόκου δεσμευμένου σε στόχο συνδέτη από συνδέτες οι οποίοι δεν δεσμεύονται στον στόχο, και την ταυτοποίηση των δεσμευμένων σε στόχο συνδετών στο σύμπλοκο δεσμευμένου σε στόχο συνδέτη όπου οι δεσμευμένοι σε στόχο συνδέτες έχουν μια KD μέσα στο εύρος από περίπου 10-7 έως 10-10 Μ. Επιπροσθέτως αξιώνονται οι συνδέτες οι οποίοι ταυτοποιούνται σύμφωνα με τη μέθοδο.
CY20101100233T 2000-04-14 2010-03-10 Μεθοδοι για εκλεκτικη στοχευση CY1109876T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19725900P 2000-04-14 2000-04-14
EP01930480A EP1360500B1 (en) 2000-04-14 2001-04-11 Methods for selective targeting

Publications (1)

Publication Number Publication Date
CY1109876T1 true CY1109876T1 (el) 2014-09-10

Family

ID=22728668

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100233T CY1109876T1 (el) 2000-04-14 2010-03-10 Μεθοδοι για εκλεκτικη στοχευση

Country Status (12)

Country Link
US (5) US20020098524A1 (el)
EP (1) EP1360500B1 (el)
JP (2) JP4966470B2 (el)
AT (1) ATE455304T1 (el)
AU (1) AU2001257012A1 (el)
CA (1) CA2405715C (el)
CY (1) CY1109876T1 (el)
DE (1) DE60141088D1 (el)
DK (1) DK1360500T3 (el)
ES (1) ES2338097T3 (el)
PT (1) PT1360500E (el)
WO (1) WO2001079479A2 (el)

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Also Published As

Publication number Publication date
DE60141088D1 (de) 2010-03-04
AU2001257012A1 (en) 2001-10-30
PT1360500E (pt) 2010-04-19
CA2405715A1 (en) 2001-10-25
US8318640B2 (en) 2012-11-27
WO2001079479A2 (en) 2001-10-25
EP1360500A2 (en) 2003-11-12
ES2338097T3 (es) 2010-05-04
ATE455304T1 (de) 2010-01-15
EP1360500B1 (en) 2010-01-13
US20130102757A1 (en) 2013-04-25
US20090093393A1 (en) 2009-04-09
DK1360500T3 (da) 2010-05-25
US8779091B2 (en) 2014-07-15
JP5689764B2 (ja) 2015-03-25
WO2001079479A3 (en) 2003-08-21
US20020098524A1 (en) 2002-07-25
US20050112692A1 (en) 2005-05-26
JP2004518403A (ja) 2004-06-24
JP4966470B2 (ja) 2012-07-04
US20140342930A1 (en) 2014-11-20
JP2012002818A (ja) 2012-01-05
CA2405715C (en) 2011-11-15

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