CY1109876T1 - Μεθοδοι για εκλεκτικη στοχευση - Google Patents
Μεθοδοι για εκλεκτικη στοχευσηInfo
- Publication number
- CY1109876T1 CY1109876T1 CY20101100233T CY101100233T CY1109876T1 CY 1109876 T1 CY1109876 T1 CY 1109876T1 CY 20101100233 T CY20101100233 T CY 20101100233T CY 101100233 T CY101100233 T CY 101100233T CY 1109876 T1 CY1109876 T1 CY 1109876T1
- Authority
- CY
- Cyprus
- Prior art keywords
- target
- ligands
- bound
- bind
- ligand complex
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
Abstract
Μια μέθοδος εκλεκτικής στόχευσης γνωστοποιείται η οποία περιλαμβάνει την επαφή μιας βιβλιοθήκης συνδετών, ειδικότερα μιας πεπτιδικής βιβλιοθήκης, με έναν αντι-στόχο για να καταστεί δυνατή η δέσμευση των συνδετών στον αντι-στόχο το διαχωρισμό των μη-δεσμευμένων συνδετών από τους δεσμευμένους στον αντι-στόχο συνδέτες, την επαφή των μη-δεσμευμένων σε αντι-στόχο συνδετών με έναν στόχο καθιστώντας δυνατή τη δέσμευση των μη-δεσμευμένων συνδετών με τον στόχο για σχηματισμό ενός συμπλόκου δεσμευμένου σε στόχο συνδέτη το διαχωρισμό του συμπλόκου δεσμευμένου σε στόχο συνδέτη από συνδέτες οι οποίοι δεν δεσμεύονται στον στόχο, και την ταυτοποίηση των δεσμευμένων σε στόχο συνδετών στο σύμπλοκο δεσμευμένου σε στόχο συνδέτη όπου οι δεσμευμένοι σε στόχο συνδέτες έχουν μια KD μέσα στο εύρος από περίπου 10-7 έως 10-10 Μ. Επιπροσθέτως αξιώνονται οι συνδέτες οι οποίοι ταυτοποιούνται σύμφωνα με τη μέθοδο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19725900P | 2000-04-14 | 2000-04-14 | |
EP01930480A EP1360500B1 (en) | 2000-04-14 | 2001-04-11 | Methods for selective targeting |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109876T1 true CY1109876T1 (el) | 2014-09-10 |
Family
ID=22728668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100233T CY1109876T1 (el) | 2000-04-14 | 2010-03-10 | Μεθοδοι για εκλεκτικη στοχευση |
Country Status (12)
Country | Link |
---|---|
US (5) | US20020098524A1 (el) |
EP (1) | EP1360500B1 (el) |
JP (2) | JP4966470B2 (el) |
AT (1) | ATE455304T1 (el) |
AU (1) | AU2001257012A1 (el) |
CA (1) | CA2405715C (el) |
CY (1) | CY1109876T1 (el) |
DE (1) | DE60141088D1 (el) |
DK (1) | DK1360500T3 (el) |
ES (1) | ES2338097T3 (el) |
PT (1) | PT1360500E (el) |
WO (1) | WO2001079479A2 (el) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7129326B2 (en) * | 2000-04-14 | 2006-10-31 | Genencor International, Inc. | Methods for selective targeting |
US20020098524A1 (en) | 2000-04-14 | 2002-07-25 | Murray Christopher J. | Methods for selective targeting |
WO2002048372A2 (en) * | 2000-12-14 | 2002-06-20 | Genencor International, Inc. | Target enzymes |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP1556067B1 (en) | 2002-10-08 | 2012-12-05 | Danisco US Inc. | Phenolic binding peptides |
EP1572723B1 (en) * | 2002-11-25 | 2013-02-27 | Danisco US Inc. | Skin binding peptides |
US7285264B2 (en) * | 2003-09-08 | 2007-10-23 | E.I. Du Pont De Nemours And Company | Peptide-based body surface coloring reagents |
BRPI0406215A (pt) | 2003-09-08 | 2005-08-09 | Du Pont | Peptìdeos, condicionadores, colorantes, composições para o cuidado do cabelo e pele, composições cosméticas, composição para o polimento da unha, método para a geração de um peptìdeo, métodos para a formação de uma camada protetora e métodos para a coloração dos cabelos, das unhas, da pele ou lábios e das sobrancelhas ou cìlios |
US20050054752A1 (en) * | 2003-09-08 | 2005-03-10 | O'brien John P. | Peptide-based diblock and triblock dispersants and diblock polymers |
US20050226839A1 (en) * | 2003-09-08 | 2005-10-13 | Xueying Huang | Pepetide-based body surface reagents for personal care |
US7585495B2 (en) | 2003-09-08 | 2009-09-08 | E. I. Du Pont De Nemours And Company | Method for identifying shampoo-resistant hair-binding peptides and hair benefit agents therefrom |
US7807141B2 (en) | 2003-09-08 | 2010-10-05 | E.I. Du Pont De Nemours And Company | Peptide-based oral care surface reagents for personal care |
US7220405B2 (en) | 2003-09-08 | 2007-05-22 | E. I. Du Pont De Nemours And Company | Peptide-based conditioners and colorants for hair, skin, and nails |
US20100311641A1 (en) * | 2003-09-08 | 2010-12-09 | E. I. Du Pont De Nemours And Company | Peptide-based body surface coloring reagents |
US20080113917A1 (en) * | 2003-11-06 | 2008-05-15 | Day Anthony G | Tgfbeta Supported and Binding Peptides |
AU2006246425B2 (en) * | 2003-11-06 | 2012-03-22 | Genencor International, Inc. | Personal care compositions and methods for their use |
US9062392B2 (en) * | 2003-12-30 | 2015-06-23 | Intel Corporation | Methods for isolating a peptide methods for identifying a peptide |
US20070196305A1 (en) * | 2005-03-01 | 2007-08-23 | Hong Wang | Method for identifying hair conditioner-resistant hair-binding peptides and hair benefit agents therefrom |
US20060286047A1 (en) * | 2005-06-21 | 2006-12-21 | Lowe David J | Methods for determining the sequence of a peptide motif having affinity for a substrate |
US20070065387A1 (en) * | 2005-09-16 | 2007-03-22 | Beck William A | Method for enhancing the effect of particulate benefit agents |
US7736633B2 (en) | 2005-09-28 | 2010-06-15 | E.I. Du Pont De Nemours And Company | Method for enhancing effects of colorants and conditioners |
US8318659B2 (en) | 2005-11-15 | 2012-11-27 | E I Du Pont De Nemours And Company | Peptide-based organic sunscreens |
US7632919B2 (en) | 2005-12-15 | 2009-12-15 | E.I. Du Pont De Nemours And Company | Polystyrene binding peptides and methods of use |
US7928076B2 (en) | 2005-12-15 | 2011-04-19 | E. I. Du Pont De Nemours And Company | Polypropylene binding peptides and methods of use |
US7709601B2 (en) | 2005-12-15 | 2010-05-04 | E. I. Du Pont De Nemours And Company | Nylon binding peptides and methods of use |
US7906617B2 (en) | 2005-12-15 | 2011-03-15 | E. I. Du Pont De Nemours And Company | Polyethylene binding peptides and methods of use |
US7700716B2 (en) | 2005-12-15 | 2010-04-20 | E. I. Du Pont De Nemours And Company | Polytetrafluoroethylene binding peptides and methods of use |
US7858581B2 (en) | 2005-12-15 | 2010-12-28 | E. I. Du Pont De Nemours And Company | PMMA binding peptides and methods of use |
WO2007109299A2 (en) * | 2006-03-21 | 2007-09-27 | Duke University | Peptide |
US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
DE102006030028A1 (de) * | 2006-06-29 | 2008-02-14 | Forschungszentrum Jülich GmbH | Verfahren zum Auffinden von spezifisch an einen Köder bindende Moleküle, sowie spezifisch an einen Köder bindende Moleküle und deren Verwendung |
US20080280810A1 (en) * | 2006-10-30 | 2008-11-13 | O'brien John P | Peptides having affinity for body surfaces |
US20080175798A1 (en) * | 2006-12-11 | 2008-07-24 | Beck William A | Peptide-based hair protectants |
US7951559B2 (en) | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
US7678883B2 (en) | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
US7754680B2 (en) | 2007-07-26 | 2010-07-13 | E. I. Du Pont De Nemours And Company | Peptides for binding calcium carbonates and methods of use |
US20090142283A1 (en) * | 2007-11-30 | 2009-06-04 | E. I. Du Pont De Nemours And Company | Peptide-based antidandruff reagents |
US7998702B2 (en) | 2008-09-17 | 2011-08-16 | E. I. Du Pont De Nemours And Company | Mutant arabinose promoter for inducible gene expression |
BRPI0823193A2 (pt) | 2008-10-15 | 2019-09-24 | Danisco Us Inc | inibidores de protease de bowman birk variantes modificados |
US7772181B2 (en) * | 2008-10-15 | 2010-08-10 | Danisco Us Inc. | Personal care compositions comprising modified variant Bowman Birk Protease Inhibitors |
US7803902B2 (en) | 2008-10-15 | 2010-09-28 | Danisco Us Inc. | Modified variant bowman birk protease inhibitors |
US8697654B2 (en) | 2008-12-18 | 2014-04-15 | E I Du Pont De Nemours And Company | Peptide linkers for effective multivalent peptide binding |
US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
US7915011B2 (en) * | 2009-03-05 | 2011-03-29 | E.I. Du Pont De Nemours And Company | Host cell modifications that improve peptide production and downstream processing |
CA2758049A1 (en) | 2009-03-30 | 2010-10-14 | E.I. Du Pont De Nemours And Company | Peptide-based systems for delivery of cosmetic agents |
WO2010114638A1 (en) | 2009-03-30 | 2010-10-07 | E. I. Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
US20100310495A1 (en) * | 2009-06-08 | 2010-12-09 | E. I. Du Pont De Nemours And Company | Peptides having affinity for poly (benzyl methacrylate-co-methacrylic acid) potassium salt copolymers and methods of use |
US20130224730A1 (en) * | 2009-11-18 | 2013-08-29 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Peptide ligands |
US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
ES2784495T3 (es) | 2010-12-20 | 2020-09-28 | Dupont Us Holding Llc | Generación enzimática de perácidos para su uso en productos para el cuidado bucodental |
US8652455B2 (en) | 2010-12-20 | 2014-02-18 | E I Du Pont De Nemours And Company | Targeted perhydrolases |
US9273336B2 (en) | 2011-02-21 | 2016-03-01 | E. I. Du Pont De Nemours And Company | Recombinant host cells having an increase in buoyant density |
US9062312B2 (en) | 2011-06-21 | 2015-06-23 | Danisco Us Inc. | Fusion peptides comprising multi-functional peptidic solubility tags for efficient production, processing and surface applications |
EP2991679A4 (en) | 2013-04-29 | 2016-12-07 | Adimab Llc | POLYSPECIFIC REAGENTS, PROCESS FOR THEIR PREPARATION AND USE |
BR112018013246A2 (pt) * | 2015-12-28 | 2018-12-04 | Idemitsu Kosan Co., Ltd. | rótulo de peptídeo e proteína rotulada incluindo o mesmo |
CN110453292B (zh) * | 2019-06-28 | 2021-06-29 | 浙江大学 | 一种利用噬菌体抗体库高效筛选纤维蛋白原的方法 |
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-
2001
- 2001-04-11 US US09/832,723 patent/US20020098524A1/en not_active Abandoned
- 2001-04-11 AT AT01930480T patent/ATE455304T1/de active
- 2001-04-11 AU AU2001257012A patent/AU2001257012A1/en not_active Abandoned
- 2001-04-11 PT PT01930480T patent/PT1360500E/pt unknown
- 2001-04-11 ES ES01930480T patent/ES2338097T3/es not_active Expired - Lifetime
- 2001-04-11 DE DE60141088T patent/DE60141088D1/de not_active Expired - Lifetime
- 2001-04-11 JP JP2001577462A patent/JP4966470B2/ja not_active Expired - Fee Related
- 2001-04-11 CA CA2405715A patent/CA2405715C/en not_active Expired - Fee Related
- 2001-04-11 DK DK01930480.7T patent/DK1360500T3/da active
- 2001-04-11 EP EP01930480A patent/EP1360500B1/en not_active Expired - Lifetime
- 2001-04-11 WO PCT/US2001/011811 patent/WO2001079479A2/en active Application Filing
-
2004
- 2004-10-19 US US10/968,732 patent/US20050112692A1/en not_active Abandoned
-
2008
- 2008-04-08 US US12/099,632 patent/US8318640B2/en not_active Expired - Lifetime
-
2010
- 2010-03-10 CY CY20101100233T patent/CY1109876T1/el unknown
-
2011
- 2011-07-27 JP JP2011164796A patent/JP5689764B2/ja not_active Expired - Fee Related
-
2012
- 2012-10-23 US US13/658,713 patent/US8779091B2/en not_active Expired - Fee Related
-
2014
- 2014-05-29 US US14/289,799 patent/US20140342930A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60141088D1 (de) | 2010-03-04 |
AU2001257012A1 (en) | 2001-10-30 |
PT1360500E (pt) | 2010-04-19 |
CA2405715A1 (en) | 2001-10-25 |
US8318640B2 (en) | 2012-11-27 |
WO2001079479A2 (en) | 2001-10-25 |
EP1360500A2 (en) | 2003-11-12 |
ES2338097T3 (es) | 2010-05-04 |
ATE455304T1 (de) | 2010-01-15 |
EP1360500B1 (en) | 2010-01-13 |
US20130102757A1 (en) | 2013-04-25 |
US20090093393A1 (en) | 2009-04-09 |
DK1360500T3 (da) | 2010-05-25 |
US8779091B2 (en) | 2014-07-15 |
JP5689764B2 (ja) | 2015-03-25 |
WO2001079479A3 (en) | 2003-08-21 |
US20020098524A1 (en) | 2002-07-25 |
US20050112692A1 (en) | 2005-05-26 |
JP2004518403A (ja) | 2004-06-24 |
JP4966470B2 (ja) | 2012-07-04 |
US20140342930A1 (en) | 2014-11-20 |
JP2012002818A (ja) | 2012-01-05 |
CA2405715C (en) | 2011-11-15 |
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