CY1109337T1 - Παραγωγα βαριολινης β - Google Patents

Παραγωγα βαριολινης β

Info

Publication number
CY1109337T1
CY1109337T1 CY20091100914T CY091100914T CY1109337T1 CY 1109337 T1 CY1109337 T1 CY 1109337T1 CY 20091100914 T CY20091100914 T CY 20091100914T CY 091100914 T CY091100914 T CY 091100914T CY 1109337 T1 CY1109337 T1 CY 1109337T1
Authority
CY
Cyprus
Prior art keywords
sup
dotted line
substituent
absent
bond
Prior art date
Application number
CY20091100914T
Other languages
English (en)
Inventor
Mercedes Alvarez
David Fernandez Bleda
Jose Luis Fernandez Puentes
Original Assignee
Pharma Mar S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar S.A. filed Critical Pharma Mar S.A.
Publication of CY1109337T1 publication Critical patent/CY1109337T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση παρέχει αντινεοπλασιακές ενώσεις του τυπου (Ι), όπου R1 είναι αρωματικός υποκαταστάτης, R2 είναι υδρογόνο ή υποκαταστάτης όταν η διακεκομμένη γραμμή είναι απούσα, ή R2 είναι απούσα όταν η διακεκομμένη γραμμή αντιπρσωπεύει δεσμό για την παροχή διπλού δεσμού μεταξύ του αζώτου που φέρει την R2 και του άνθρακα που φέρει την R3· R3 είναι οξο ομάδα=Ο όταν η διακεκομμένη γραμμή είναι απούσα ή είναι υποκαταστάσης όταν διακεκομμένη γραμμή αντιπροσωπευεί δεσμό για την παροχή διπλού μεταξύ του αζώτου που φέρει την R2 και του άνθρακα που φέρει την R3 R4 είναι υδρογόνο ή υποκαταστάτης και φαρμακευτικώς αποδεκτά άλατα αυτών.
CY20091100914T 2000-08-03 2009-09-01 Παραγωγα βαριολινης β CY1109337T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0019117.1A GB0019117D0 (en) 2000-08-03 2000-08-03 Derivatives of variolin B
EP01954163A EP1307454B1 (en) 2000-08-03 2001-08-03 Derivatives of variolin b

Publications (1)

Publication Number Publication Date
CY1109337T1 true CY1109337T1 (el) 2014-07-02

Family

ID=9896947

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100914T CY1109337T1 (el) 2000-08-03 2009-09-01 Παραγωγα βαριολινης β

Country Status (23)

Country Link
US (2) US7329666B2 (el)
EP (1) EP1307454B1 (el)
JP (1) JP2004505976A (el)
KR (1) KR100937606B1 (el)
CN (1) CN1275965C (el)
AT (1) ATE432932T1 (el)
AU (2) AU2001276510B2 (el)
BR (1) BR0112920A (el)
CA (1) CA2417629C (el)
CY (1) CY1109337T1 (el)
DE (1) DE60138889D1 (el)
DK (1) DK1307454T3 (el)
ES (1) ES2328013T3 (el)
GB (1) GB0019117D0 (el)
IL (2) IL154155A0 (el)
MX (1) MXPA03001047A (el)
NZ (1) NZ523864A (el)
PT (1) PT1307454E (el)
RU (1) RU2293737C2 (el)
SI (1) SI1307454T1 (el)
UA (1) UA77400C2 (el)
WO (1) WO2002012240A1 (el)
ZA (1) ZA200300797B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002004447A1 (en) * 2000-07-11 2002-01-17 Pharma Mar, S.A. Variolin derivatives as anti-cancer agents
GB0116966D0 (en) * 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
WO2010002877A2 (en) 2008-07-03 2010-01-07 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
CN106674132B (zh) * 2016-11-22 2019-04-26 上海书亚医药科技有限公司 一种嘧啶类除草剂的制备方法与应用
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004447A1 (en) * 2000-07-11 2002-01-17 Pharma Mar, S.A. Variolin derivatives as anti-cancer agents
GB0116966D0 (en) * 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
AU2001276510B2 (en) 2007-01-25
CN1275965C (zh) 2006-09-20
CN1468240A (zh) 2004-01-14
ES2328013T3 (es) 2009-11-06
BR0112920A (pt) 2003-07-01
KR20030038684A (ko) 2003-05-16
EP1307454B1 (en) 2009-06-03
IL154155A (en) 2010-05-31
IL154155A0 (en) 2003-07-31
WO2002012240A1 (en) 2002-02-14
US20040058939A1 (en) 2004-03-25
KR100937606B1 (ko) 2010-01-20
RU2293737C2 (ru) 2007-02-20
AU7651001A (en) 2002-02-18
DK1307454T3 (da) 2009-09-14
DE60138889D1 (de) 2009-07-16
CA2417629A1 (en) 2002-02-14
GB0019117D0 (en) 2000-09-27
SI1307454T1 (sl) 2009-12-31
ZA200300797B (en) 2004-04-29
MXPA03001047A (es) 2004-02-26
JP2004505976A (ja) 2004-02-26
EP1307454A1 (en) 2003-05-07
ATE432932T1 (de) 2009-06-15
NZ523864A (en) 2004-09-24
US7329666B2 (en) 2008-02-12
US20080033001A1 (en) 2008-02-07
UA77400C2 (en) 2006-12-15
CA2417629C (en) 2010-10-19
PT1307454E (pt) 2009-09-03

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