BR0112920A - Derivados de variolina b - Google Patents
Derivados de variolina bInfo
- Publication number
- BR0112920A BR0112920A BR0112920-1A BR0112920A BR0112920A BR 0112920 A BR0112920 A BR 0112920A BR 0112920 A BR0112920 A BR 0112920A BR 0112920 A BR0112920 A BR 0112920A
- Authority
- BR
- Brazil
- Prior art keywords
- sup
- dotted line
- substituent
- absent
- bond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"DERIVADOS DE VARIOLINA B". A invenção fornece compostos anti-tumor de fórmula (I), onde R^ 1^ é um substituinte aromático; R^ 2^ é hidrogênio ou um substituinte quando a linha pontilhada está ausente, ou R^ 2^ está ausente quando a linha pontilhada representa uma ligação para produzir uma ligação dupla entre o nitrogênio que transporta R^ 2^ e o carbono que transporta R^ 3^; R^ 3^ é um grupo oxo = O quando a linha pontilhada está ausente ou é um substituinte quando a linha pontilhada representa uma ligação para produzir uma ligação dupla entre o nitrogênio transportando R^ 2^ e o carbono transportando R^ 3^; R^ 4^ é hidrogênio ou um substituinte; e sais farmaceuticamente aceitáveis destes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0019117.1A GB0019117D0 (en) | 2000-08-03 | 2000-08-03 | Derivatives of variolin B |
| PCT/GB2001/003517 WO2002012240A1 (en) | 2000-08-03 | 2001-08-03 | Derivatives of variolin b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0112920A true BR0112920A (pt) | 2003-07-01 |
Family
ID=9896947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0112920-1A BR0112920A (pt) | 2000-08-03 | 2001-08-03 | Derivados de variolina b |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7329666B2 (pt) |
| EP (1) | EP1307454B1 (pt) |
| JP (1) | JP2004505976A (pt) |
| KR (1) | KR100937606B1 (pt) |
| CN (1) | CN1275965C (pt) |
| AT (1) | ATE432932T1 (pt) |
| AU (2) | AU2001276510B2 (pt) |
| BR (1) | BR0112920A (pt) |
| CA (1) | CA2417629C (pt) |
| CY (1) | CY1109337T1 (pt) |
| DE (1) | DE60138889D1 (pt) |
| DK (1) | DK1307454T3 (pt) |
| ES (1) | ES2328013T3 (pt) |
| GB (1) | GB0019117D0 (pt) |
| IL (2) | IL154155A0 (pt) |
| MX (1) | MXPA03001047A (pt) |
| NZ (1) | NZ523864A (pt) |
| PT (1) | PT1307454E (pt) |
| RU (1) | RU2293737C2 (pt) |
| SI (1) | SI1307454T1 (pt) |
| UA (1) | UA77400C2 (pt) |
| WO (1) | WO2002012240A1 (pt) |
| ZA (1) | ZA200300797B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2799757B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DK1299388T3 (da) * | 2000-07-11 | 2009-08-31 | Pharma Mar Sa | Variolin-derivater som anti-cancermidler |
| GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
| EP2313102A2 (en) | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| CN106674132B (zh) * | 2016-11-22 | 2019-04-26 | 上海书亚医药科技有限公司 | 一种嘧啶类除草剂的制备方法与应用 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1299388T3 (da) * | 2000-07-11 | 2009-08-31 | Pharma Mar Sa | Variolin-derivater som anti-cancermidler |
| GB0116966D0 (en) * | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
-
2000
- 2000-08-03 GB GBGB0019117.1A patent/GB0019117D0/en not_active Ceased
-
2001
- 2001-03-08 UA UA2003021828A patent/UA77400C2/uk unknown
- 2001-08-03 BR BR0112920-1A patent/BR0112920A/pt not_active IP Right Cessation
- 2001-08-03 PT PT01954163T patent/PT1307454E/pt unknown
- 2001-08-03 AU AU2001276510A patent/AU2001276510B2/en not_active Ceased
- 2001-08-03 RU RU2003105824/04A patent/RU2293737C2/ru not_active IP Right Cessation
- 2001-08-03 CN CNB018166652A patent/CN1275965C/zh not_active Expired - Fee Related
- 2001-08-03 DE DE60138889T patent/DE60138889D1/de not_active Expired - Lifetime
- 2001-08-03 SI SI200130929T patent/SI1307454T1/sl unknown
- 2001-08-03 NZ NZ523864A patent/NZ523864A/en unknown
- 2001-08-03 WO PCT/GB2001/003517 patent/WO2002012240A1/en active IP Right Grant
- 2001-08-03 CA CA2417629A patent/CA2417629C/en not_active Expired - Fee Related
- 2001-08-03 DK DK01954163T patent/DK1307454T3/da active
- 2001-08-03 AT AT01954163T patent/ATE432932T1/de active
- 2001-08-03 MX MXPA03001047A patent/MXPA03001047A/es active IP Right Grant
- 2001-08-03 ES ES01954163T patent/ES2328013T3/es not_active Expired - Lifetime
- 2001-08-03 AU AU7651001A patent/AU7651001A/xx active Pending
- 2001-08-03 JP JP2002518215A patent/JP2004505976A/ja active Pending
- 2001-08-03 US US10/343,391 patent/US7329666B2/en not_active Expired - Fee Related
- 2001-08-03 IL IL15415501A patent/IL154155A0/xx unknown
- 2001-08-03 EP EP01954163A patent/EP1307454B1/en not_active Expired - Lifetime
- 2001-08-03 KR KR1020037001574A patent/KR100937606B1/ko not_active IP Right Cessation
-
2003
- 2003-01-27 IL IL154155A patent/IL154155A/en not_active IP Right Cessation
- 2003-01-29 ZA ZA200300797A patent/ZA200300797B/en unknown
-
2007
- 2007-07-27 US US11/829,379 patent/US20080033001A1/en not_active Abandoned
-
2009
- 2009-09-01 CY CY20091100914T patent/CY1109337T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2293737C2 (ru) | 2007-02-20 |
| DK1307454T3 (da) | 2009-09-14 |
| ES2328013T3 (es) | 2009-11-06 |
| KR100937606B1 (ko) | 2010-01-20 |
| US7329666B2 (en) | 2008-02-12 |
| CN1468240A (zh) | 2004-01-14 |
| CN1275965C (zh) | 2006-09-20 |
| AU2001276510B2 (en) | 2007-01-25 |
| CY1109337T1 (el) | 2014-07-02 |
| DE60138889D1 (de) | 2009-07-16 |
| SI1307454T1 (sl) | 2009-12-31 |
| AU7651001A (en) | 2002-02-18 |
| IL154155A0 (en) | 2003-07-31 |
| MXPA03001047A (es) | 2004-02-26 |
| US20080033001A1 (en) | 2008-02-07 |
| CA2417629C (en) | 2010-10-19 |
| ZA200300797B (en) | 2004-04-29 |
| WO2002012240A1 (en) | 2002-02-14 |
| EP1307454A1 (en) | 2003-05-07 |
| IL154155A (en) | 2010-05-31 |
| EP1307454B1 (en) | 2009-06-03 |
| JP2004505976A (ja) | 2004-02-26 |
| US20040058939A1 (en) | 2004-03-25 |
| PT1307454E (pt) | 2009-09-03 |
| UA77400C2 (en) | 2006-12-15 |
| GB0019117D0 (en) | 2000-09-27 |
| ATE432932T1 (de) | 2009-06-15 |
| KR20030038684A (ko) | 2003-05-16 |
| NZ523864A (en) | 2004-09-24 |
| CA2417629A1 (en) | 2002-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: PHARMA MAR S.A. SOCIEDAD UNIPERSONAL (ES) Free format text: TRANSFERIDO DE: UNIVERSIDAD DE BARCELONA |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012. |