WO2002051419A3 - A pharmaceutical composition containing benzopyrano-oxopyrimidotetrahydrothiazine and its use in the treatment of hiv - Google Patents

A pharmaceutical composition containing benzopyrano-oxopyrimidotetrahydrothiazine and its use in the treatment of hiv Download PDF

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Publication number
WO2002051419A3
WO2002051419A3 PCT/EP2001/015145 EP0115145W WO02051419A3 WO 2002051419 A3 WO2002051419 A3 WO 2002051419A3 EP 0115145 W EP0115145 W EP 0115145W WO 02051419 A3 WO02051419 A3 WO 02051419A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxopyrimidotetrahydrothiazine
benzopyrano
treatment
hiv
pharmaceutical composition
Prior art date
Application number
PCT/EP2001/015145
Other languages
French (fr)
Other versions
WO2002051419A2 (en
Inventor
Clercq Erik De
Zeger Debyser
Willem Pluymers
Christophe Pannecouque
Myriam Witvrouw
Original Assignee
Leuven K U Res & Dev
Stichting Rega V Z W
Clercq Erik De
Zeger Debyser
Willem Pluymers
Christophe Pannecouque
Myriam Witvrouw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leuven K U Res & Dev, Stichting Rega V Z W, Clercq Erik De, Zeger Debyser, Willem Pluymers, Christophe Pannecouque, Myriam Witvrouw filed Critical Leuven K U Res & Dev
Priority to AU2002237251A priority Critical patent/AU2002237251A1/en
Publication of WO2002051419A2 publication Critical patent/WO2002051419A2/en
Publication of WO2002051419A3 publication Critical patent/WO2002051419A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Abstract

A benzopyrano-oxopyrimidotetrahydrothiazine or derivative thereof having formula (I) wherein: R1 is selected from hydrogen and halo, and R2 is selected from hydrogen, halo, hydroxy and methoxy, is useful as an inhibitor of a retroviral enzyme, namely HIV integrase, as an active ingredient for the treatment of retroviral infection in humans and mammals.
PCT/EP2001/015145 2000-12-22 2001-12-21 A pharmaceutical composition containing benzopyrano-oxopyrimidotetrahydrothiazine and its use in the treatment of hiv WO2002051419A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002237251A AU2002237251A1 (en) 2000-12-22 2001-12-21 A pharmaceutical composition containing benzopyrano-oxopyrimidotetrahydrothiazine and its use in the treatment of hiv

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25796100P 2000-12-22 2000-12-22
US60/257,961 2000-12-22

Publications (2)

Publication Number Publication Date
WO2002051419A2 WO2002051419A2 (en) 2002-07-04
WO2002051419A3 true WO2002051419A3 (en) 2002-11-14

Family

ID=22978515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/015145 WO2002051419A2 (en) 2000-12-22 2001-12-21 A pharmaceutical composition containing benzopyrano-oxopyrimidotetrahydrothiazine and its use in the treatment of hiv

Country Status (2)

Country Link
AU (1) AU2002237251A1 (en)
WO (1) WO2002051419A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5198055B2 (en) 2004-03-04 2013-05-15 カトリーケ・ウニフェルジテイト・ルーベン・カー・イュー・ルーベン・アール・アンド・ディ Phosphonic acid nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for producing them
BRPI0516219A (en) 2004-09-28 2008-08-26 Otsuka Pharma Co Ltd carbostyril compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06172365A (en) * 1992-12-11 1994-06-21 Yamasa Shoyu Co Ltd 10-thiaisoalloxazine derivative and its use
US6071905A (en) * 1997-04-02 2000-06-06 Natural Drug Sciences, Llc Biologically active substance on the basis of tetracyclic nitrogen heterocycles of pyrimidine row

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06172365A (en) * 1992-12-11 1994-06-21 Yamasa Shoyu Co Ltd 10-thiaisoalloxazine derivative and its use
US6071905A (en) * 1997-04-02 2000-06-06 Natural Drug Sciences, Llc Biologically active substance on the basis of tetracyclic nitrogen heterocycles of pyrimidine row

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEALE K K ET AL: "COMBINATIONS OF REVERSE TRANSCRIPTASE, PROTEASE, AND INTEGRASE INHIBITORS CAN BE SYNERGISTIC IN VITRO AGAINST DRUG-SENSITIVE AND RT INHIBITOR-RESISTANT MOLECULAR CLONES OF HIV-1", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 46, no. 3, June 2000 (2000-06-01), pages 223 - 232, XP001027294, ISSN: 0166-3542 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 511 (C - 1253) 27 September 1994 (1994-09-27) *

Also Published As

Publication number Publication date
AU2002237251A1 (en) 2002-07-08
WO2002051419A2 (en) 2002-07-04

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