CY1107295T1 - Σταθεροποιηση στερεων φορμουλων φαρμακων του θυρεοειδους - Google Patents
Σταθεροποιηση στερεων φορμουλων φαρμακων του θυρεοειδουςInfo
- Publication number
- CY1107295T1 CY1107295T1 CY20081100254T CY081100254T CY1107295T1 CY 1107295 T1 CY1107295 T1 CY 1107295T1 CY 20081100254 T CY20081100254 T CY 20081100254T CY 081100254 T CY081100254 T CY 081100254T CY 1107295 T1 CY1107295 T1 CY 1107295T1
- Authority
- CY
- Cyprus
- Prior art keywords
- thyroid
- formulon
- medications
- stabilization
- solid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Παρέχονται φαρμακευτικές φόρμουλες και μορφές δόσεων που έχουν βελτιωμένη σταθερότητα στην προκαλούμενη από την υγρασία αποικοδόμηση, όταν συγκρίνονται με συμβατικές μορφές δόσεων, ιδίως δισκία. Η ευρεσιτεχνία χαρακτηρίζεται από χαμηλής συμπιέσεως μορφές φαρμάκων του θυρεοειδούς μαζί με έκδοχα, κατά προτίμηση σε μορφές εντός κάψουλας. Σε άλλες υλοποιήσεις, σχετικώς μη-πτητικά έλαια μπορούν να αναμειχθούν με το φάρμακο και/ή τα έκδοχα για να σταθεροποιηθεί η φόρμουλα έναντι της προκαλούμενης από την υγρασία αποικοδόμησης. Υδρόφοβες κόνεις προστίθενται επίσης, προαιρετικώς, στις φόρμουλες.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23744200P | 2000-10-03 | 2000-10-03 | |
US09/690,973 US6855333B1 (en) | 2000-10-03 | 2000-10-18 | Stabilization of solid thyroid drug formulations |
EP01971348A EP1322294B1 (en) | 2000-10-03 | 2001-09-26 | Stabilization of solid thyroid drug formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107295T1 true CY1107295T1 (el) | 2012-11-21 |
Family
ID=26930677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100254T CY1107295T1 (el) | 2000-10-03 | 2008-03-05 | Σταθεροποιηση στερεων φορμουλων φαρμακων του θυρεοειδους |
Country Status (14)
Country | Link |
---|---|
US (1) | US6855333B1 (el) |
EP (1) | EP1322294B1 (el) |
CN (1) | CN1543341A (el) |
AT (1) | ATE380543T1 (el) |
AU (2) | AU9124401A (el) |
CA (4) | CA2641575C (el) |
CY (1) | CY1107295T1 (el) |
DE (1) | DE60131863T2 (el) |
ES (1) | ES2298262T3 (el) |
HK (1) | HK1055260A1 (el) |
MX (1) | MXPA03002809A (el) |
NZ (1) | NZ524567A (el) |
PT (1) | PT1322294E (el) |
WO (1) | WO2002028364A2 (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
EP1370244A1 (en) * | 2001-03-12 | 2003-12-17 | Novo Nordisk A/S | Novel tablets and capsules and a process for its preparation |
US20030099699A1 (en) * | 2001-11-13 | 2003-05-29 | Hanshew Dwight D. | Storage stable thyroxine active drug formulations and methods for their production |
US6645526B2 (en) | 2001-11-13 | 2003-11-11 | Mylan Pharmaceuticals, Inc. | Storage stable thyroxine active drug formulations and methods for their production |
ITMI20110713A1 (it) | 2011-04-29 | 2012-10-30 | Bracco Imaging Spa | Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina |
ITMI20022394A1 (it) | 2002-11-13 | 2004-05-14 | Bracco Spa | Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche. |
US10231931B1 (en) | 2018-03-23 | 2019-03-19 | Genus Lifesciences Inc. | Thyroid hormone oral dosage forms and methods of using the same |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4001211A (en) * | 1974-12-02 | 1977-01-04 | The Dow Chemical Company | Pharmaceutical capsules from improved thermogelling methyl cellulose ethers |
US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
EP0326618A1 (en) | 1987-03-04 | 1989-08-09 | Nippon Hypox Laboratories Incorporated | Medicinal composition containing albumin as carrier and process for its preparation |
US4983399A (en) * | 1989-10-18 | 1991-01-08 | Eastman Kodak Company | Direct compression carrier composition |
US5225204A (en) * | 1991-11-05 | 1993-07-06 | Chen Jivn Ren | Stable dosage of levothyroxine sodium and process of production |
DE4318577A1 (de) | 1993-06-04 | 1994-12-08 | Merck Patent Gmbh | Schmiermittelfreie, arzneimittelhaltige Tabletten |
US5688510A (en) | 1993-11-18 | 1997-11-18 | Nippon Shinyaku Co. Ltd. | Process for producing stable medicinal composition, and pharmaceutical preparation |
GB9401892D0 (en) | 1994-02-01 | 1994-03-30 | Boots Co Plc | Therapeutic agents |
IL115445A (en) | 1994-10-17 | 1999-08-17 | Akzo Nobel Nv | Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation |
US5756123A (en) * | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
DE19541128C2 (de) | 1995-10-27 | 1997-11-27 | Henning Berlin Gmbh & Co | Stabilisierte schilddrüsenhormonhaltige Arzneimittel |
US5635209A (en) | 1995-10-31 | 1997-06-03 | Vintage Pharmaceuticals, Inc. | Stabilized composition of levothyroxine sodium medication and method for its production |
US5955105A (en) * | 1995-11-14 | 1999-09-21 | Knoll Pharmaceutical Company | Stabilized thyroid hormone preparations and methods of making same |
CZ333698A3 (cs) | 1996-04-16 | 1999-01-13 | Bayer Ag | D-mannitol a způsob jeho přípravy |
US5800834A (en) | 1996-06-10 | 1998-09-01 | Spireas; Spiridon | Liquisolid systems and methods of preparing same |
US6399101B1 (en) | 2000-03-30 | 2002-06-04 | Mova Pharmaceutical Corp. | Stable thyroid hormone preparations and method of making same |
-
2000
- 2000-10-18 US US09/690,973 patent/US6855333B1/en not_active Expired - Lifetime
-
2001
- 2001-09-26 NZ NZ524567A patent/NZ524567A/xx not_active IP Right Cessation
- 2001-09-26 AU AU9124401A patent/AU9124401A/xx active Pending
- 2001-09-26 ES ES01971348T patent/ES2298262T3/es not_active Expired - Lifetime
- 2001-09-26 CA CA2641575A patent/CA2641575C/en not_active Expired - Lifetime
- 2001-09-26 EP EP01971348A patent/EP1322294B1/en not_active Expired - Lifetime
- 2001-09-26 WO PCT/US2001/029986 patent/WO2002028364A2/en active IP Right Grant
- 2001-09-26 MX MXPA03002809A patent/MXPA03002809A/es active IP Right Grant
- 2001-09-26 CA CA2641581A patent/CA2641581C/en not_active Expired - Lifetime
- 2001-09-26 CN CNA018165931A patent/CN1543341A/zh active Pending
- 2001-09-26 CA CA2641570A patent/CA2641570C/en not_active Expired - Lifetime
- 2001-09-26 PT PT01971348T patent/PT1322294E/pt unknown
- 2001-09-26 AT AT01971348T patent/ATE380543T1/de active
- 2001-09-26 AU AU2001291244A patent/AU2001291244B2/en not_active Ceased
- 2001-09-26 DE DE60131863T patent/DE60131863T2/de not_active Expired - Lifetime
- 2001-09-26 CA CA002423572A patent/CA2423572C/en not_active Expired - Lifetime
-
2003
- 2003-10-22 HK HK03107626A patent/HK1055260A1/xx not_active IP Right Cessation
-
2008
- 2008-03-05 CY CY20081100254T patent/CY1107295T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2641581A1 (en) | 2002-04-11 |
AU2001291244B2 (en) | 2006-09-21 |
CN1543341A (zh) | 2004-11-03 |
PT1322294E (pt) | 2008-02-28 |
CA2641581C (en) | 2011-11-29 |
AU9124401A (en) | 2002-04-15 |
EP1322294A2 (en) | 2003-07-02 |
CA2641575A1 (en) | 2002-04-11 |
WO2002028364A2 (en) | 2002-04-11 |
DE60131863D1 (de) | 2008-01-24 |
EP1322294B1 (en) | 2007-12-12 |
US6855333B1 (en) | 2005-02-15 |
DE60131863T2 (de) | 2008-12-11 |
HK1055260A1 (en) | 2004-01-02 |
CA2423572C (en) | 2009-01-06 |
CA2423572A1 (en) | 2002-04-11 |
NZ524567A (en) | 2004-12-24 |
ES2298262T3 (es) | 2008-05-16 |
CA2641570C (en) | 2014-04-22 |
WO2002028364A3 (en) | 2002-06-06 |
CA2641575C (en) | 2014-04-08 |
MXPA03002809A (es) | 2004-09-10 |
ATE380543T1 (de) | 2007-12-15 |
CA2641570A1 (en) | 2002-04-11 |
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