CY1106930T1 - Παραγωγα κυκλοπεντυλο-ομαδας - Google Patents
Παραγωγα κυκλοπεντυλο-ομαδαςInfo
- Publication number
- CY1106930T1 CY1106930T1 CY20071101314T CY071101314T CY1106930T1 CY 1106930 T1 CY1106930 T1 CY 1106930T1 CY 20071101314 T CY20071101314 T CY 20071101314T CY 071101314 T CY071101314 T CY 071101314T CY 1106930 T1 CY1106930 T1 CY 1106930T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- trifluoromethyl
- hydroxy
- optionally substituted
- independently hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Photoreceptors In Electrophotography (AREA)
- Lubricants (AREA)
Abstract
Η παρούσα εφεύρεση αφορά καινούρια παράγωγα κυκλοπεντυλο-ομάδας του παρακάτω γενικού χημικού τύπου (Ι), όπου το Χ είναι μεθυλενο-ομάδα, ομάδα οξυγόνου, θειο-ομάδα ή ομάδα ΝR7, το R1 είναι ευθεία ή διακλαδισμένη αλυσίδα αλκυλο-ομάδων C1-C8 ή αλκενυλενο-ομάδων C3-C8 ή αλκυνυλενο-ομάδων C3-C8, προαιρετικά υποκατεστημένη με CF3, φαινυλο-ομάδα, φαινοξυ-ομάδα ή ναφθυλο-ομάδα ενώ οι αρωματικοί δακτύλιοι προαιρετικά υποκαθίστανται με μία ή περισσότερες αλκυλο-ομάδες C1-C4, αλογονο-ομάδες, τριφθορομεθυλο-ομάδες, υδροξυ-ομάδες ή αλκοξυ-ομάδες C1-C4, τα R2 και R3 είναι ανεξαρτήτως υδρογονο-ομάδα, αλυσίδα αλκυλο-ομάδων C1-C3, αλογονο-ομάδα, τριφθορομεθυλο-ομάδα, υδροξυ-ομάδα ή αλκοξυ-ομάδα C1-C4 και τα R4, R5, R6 και R7 είναι ανεξάρτητα υδρογονο-ομάδα ή αλκυλο-ομάδα C1-C6, και τα φαρμακευτικά αποδεκτά άλατα αυτών, που δρουν ως διαμορφωτές καναλιών νατρίου ή/και ασβεστίου και επομένως μπορούν να χρησιμοποιηθούν στην αποτροπή, ανακούφιση και θεραπεία μιας μεγάλης γκάμας παθολογιών, περιλαμβανομένων, αλλά όχι περιοριστικά, νευρολογικών, ψυχιατρικών, καρδιαγγειακών, φλεγμονωδών, οφθαλμολογικών, ουρολογικών, μεταβολικών και γαστρεντερικών παθήσεων, όπου έχει περιγραφτεί ότι οι παραπάνω μηχανισμοί παίζουν παθολογικό ρόλο.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03027050A EP1533295A1 (en) | 2003-11-24 | 2003-11-24 | Cyclopentyl Derivatives |
| EP04819587A EP1687259B1 (en) | 2003-11-24 | 2004-11-12 | Cyclopentyl derivates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106930T1 true CY1106930T1 (el) | 2012-09-26 |
Family
ID=34429431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071101314T CY1106930T1 (el) | 2003-11-24 | 2007-10-11 | Παραγωγα κυκλοπεντυλο-ομαδας |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7265244B2 (el) |
| EP (2) | EP1533295A1 (el) |
| JP (1) | JP4769194B2 (el) |
| KR (1) | KR101142074B1 (el) |
| CN (1) | CN100391935C (el) |
| AT (1) | ATE369331T1 (el) |
| AU (1) | AU2004295043B2 (el) |
| BR (1) | BRPI0416842B8 (el) |
| CA (1) | CA2546962C (el) |
| CY (1) | CY1106930T1 (el) |
| DE (1) | DE602004008103T2 (el) |
| DK (1) | DK1687259T3 (el) |
| ES (1) | ES2291982T3 (el) |
| HK (1) | HK1097512A1 (el) |
| IL (1) | IL175847A (el) |
| NO (1) | NO335826B1 (el) |
| NZ (1) | NZ547393A (el) |
| PL (1) | PL1687259T3 (el) |
| PT (1) | PT1687259E (el) |
| RU (1) | RU2372325C2 (el) |
| SI (1) | SI1687259T1 (el) |
| WO (1) | WO2005054178A1 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2027083B1 (en) * | 2006-05-18 | 2012-07-11 | Boehringer Ingelheim International GmbH | Method of preparing chiral cyclic beta-aminocarboxamides |
| EA019529B1 (ru) * | 2007-12-19 | 2014-04-30 | Ньюрон Фармасьютикалс С.П.А. | Альфа-аминоамидные производные, применяемые в лечении психиатрических расстройств |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177576B (en) * | 1975-06-02 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 2-amino-cyclohexane carboxylic acid,its amides and similar compounds |
| US5532254A (en) * | 1995-06-07 | 1996-07-02 | Eli Lilly And Company | Modulation of calcium channels using benzothiophenes |
| JP4160136B2 (ja) * | 1996-08-29 | 2008-10-01 | 武田薬品工業株式会社 | 縮合環状エーテル類、その製造法および剤 |
| GB9727523D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| TWI283577B (en) * | 1999-10-11 | 2007-07-11 | Sod Conseils Rech Applic | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
| WO2003057219A1 (en) * | 2001-12-27 | 2003-07-17 | Ortho-Mcneil Pharmaceutical Inc. | Aroyl pyrrole heteroeryl and methanols useful for treating a central nervous system disorder |
-
2003
- 2003-11-24 EP EP03027050A patent/EP1533295A1/en not_active Withdrawn
-
2004
- 2004-11-12 JP JP2006540265A patent/JP4769194B2/ja not_active Expired - Fee Related
- 2004-11-12 PT PT04819587T patent/PT1687259E/pt unknown
- 2004-11-12 DK DK04819587T patent/DK1687259T3/da active
- 2004-11-12 PL PL04819587T patent/PL1687259T3/pl unknown
- 2004-11-12 EP EP04819587A patent/EP1687259B1/en active Active
- 2004-11-12 DE DE602004008103T patent/DE602004008103T2/de active Active
- 2004-11-12 NZ NZ547393A patent/NZ547393A/en not_active IP Right Cessation
- 2004-11-12 BR BRPI0416842A patent/BRPI0416842B8/pt not_active IP Right Cessation
- 2004-11-12 AU AU2004295043A patent/AU2004295043B2/en not_active Ceased
- 2004-11-12 KR KR1020067010038A patent/KR101142074B1/ko active IP Right Grant
- 2004-11-12 ES ES04819587T patent/ES2291982T3/es active Active
- 2004-11-12 RU RU2006117774/04A patent/RU2372325C2/ru active
- 2004-11-12 SI SI200430429T patent/SI1687259T1/sl unknown
- 2004-11-12 CN CNB2004800346593A patent/CN100391935C/zh not_active Expired - Fee Related
- 2004-11-12 CA CA2546962A patent/CA2546962C/en not_active Expired - Fee Related
- 2004-11-12 WO PCT/EP2004/012835 patent/WO2005054178A1/en active IP Right Grant
- 2004-11-12 AT AT04819587T patent/ATE369331T1/de active
- 2004-11-12 US US10/580,366 patent/US7265244B2/en active Active
-
2006
- 2006-05-23 NO NO20062352A patent/NO335826B1/no not_active IP Right Cessation
- 2006-05-23 IL IL175847A patent/IL175847A/en active IP Right Grant
-
2007
- 2007-03-09 HK HK07102611A patent/HK1097512A1/xx not_active IP Right Cessation
- 2007-10-11 CY CY20071101314T patent/CY1106930T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0956855T3 (da) | Immunhæmmende effekter af 8-substituerede xanthin-derivater | |
| IN266803B (el) | ||
| MX2009013119A (es) | Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio. | |
| IL175848A0 (en) | N - acyl - n' - benzyl - alkylendiamino derivatives | |
| CY1118033T1 (el) | Φθοριωμενα παραγωγα αρυλαλκυλαμινοκαρβοξαμιδιου | |
| CY1106930T1 (el) | Παραγωγα κυκλοπεντυλο-ομαδας | |
| ATE453610T1 (de) | Antimikrobiell wirksame 4-methyl-4-aryl-2- pentanole, deren herstellung und verwendung | |
| CY1108359T1 (el) | Παραγωγα 3-αμινοπυρρολιδονης | |
| ATE553099T1 (de) | Substituierte benzylaminoalkylenheterocyclen | |
| SE0400440D0 (sv) | Novel Cinnamic Amides | |
| FI914219A0 (fi) | 3-(1h-indazol-3-yl)-4-pyridinaminer, foerfarande och mellanprodukter foer deras framstaellning och deras anvaendning som laekemedel. | |
| FR2903698B1 (fr) | Nouveaux derives de 5-thioxylopyranose. | |
| WO2005110406A3 (en) | Phenyl derivatives for the treatment of abnormal cell growth |