CY1105966T1 - Ρυθμιση ντοπαμινικων υποδοχεων ανθρωπου συζευγμενων με πρωτεϊνη g - Google Patents

Ρυθμιση ντοπαμινικων υποδοχεων ανθρωπου συζευγμενων με πρωτεϊνη g

Info

Publication number
CY1105966T1
CY1105966T1 CY20071100122T CY071100122T CY1105966T1 CY 1105966 T1 CY1105966 T1 CY 1105966T1 CY 20071100122 T CY20071100122 T CY 20071100122T CY 071100122 T CY071100122 T CY 071100122T CY 1105966 T1 CY1105966 T1 CY 1105966T1
Authority
CY
Cyprus
Prior art keywords
protein
human
regulation
reagents
dopamine receptors
Prior art date
Application number
CY20071100122T
Other languages
English (en)
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of CY1105966T1 publication Critical patent/CY1105966T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Αντιδραστήρια τα οποία ρυθμίζουν τον ντοπαμινοειδή υποδοχέα του ανθρώπου ο οποίος υποδοχέας είναι συζευγμένος με πρωτεΐνη G (GPCR τύπου DA) καθώς και αντιδραστήρια τα οποία δεσμεύονται στα προϊόντα των γονιδίων του GPCR τύπου DA μπορούν να διαδραματίσουν σημαντικό ρόλο στην αποτροπή, βελτίωση, ή διόρθωση δυσλειτουργιών ή ασθενειών όπως, μεταξύ άλλων, η παχυσαρκία και σχετιζόμενες ασθένειες, ο καρκίνος, ο διαβήτης, η οστεοπόρωση, το άγχος, η κατάθλιψη, η υπέρταση, η ημικρανία, οι καταναγκαστικές διαταραχές, η σχιζοφρένεια, ο αυτισμός, οι νευροεκφυλιστικές διαταραχές, όπως η ασθένεια Alzheimer, ο Παρκινσονισμός, και η χορεία Huntington, καθώς και η επαγόμενη από χημειοθεραπεία έμεση.
CY20071100122T 2000-05-18 2007-01-29 Ρυθμιση ντοπαμινικων υποδοχεων ανθρωπου συζευγμενων με πρωτεϊνη g CY1105966T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20519500P 2000-05-18 2000-05-18
PCT/EP2001/005559 WO2001087929A2 (en) 2000-05-18 2001-05-16 Regulation of human dopamine-like g protein-coupled receptor

Publications (1)

Publication Number Publication Date
CY1105966T1 true CY1105966T1 (el) 2011-04-06

Family

ID=22761200

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100122T CY1105966T1 (el) 2000-05-18 2007-01-29 Ρυθμιση ντοπαμινικων υποδοχεων ανθρωπου συζευγμενων με πρωτεϊνη g

Country Status (9)

Country Link
EP (1) EP1287133B1 (el)
AT (1) ATE348162T1 (el)
AU (1) AU6744501A (el)
CY (1) CY1105966T1 (el)
DE (1) DE60125169T2 (el)
DK (1) DK1287133T3 (el)
ES (1) ES2278755T3 (el)
PT (1) PT1287133E (el)
WO (1) WO2001087929A2 (el)

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US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
EP1770159A1 (en) 2000-12-01 2007-04-04 Astellas Pharma Inc. Process for manufacturing a pharmaceutical composition for treating diabetes
BRPI0406761A (pt) 2003-01-14 2005-12-20 Arena Pharm Inc Derivados de arila e heteroarila 1,2,3-trissubstituìdos como moduladores do metabolismo e a profilaxia e tratamento de distúrbios relacionados a estes tais como diabetes e hiper-glicemia
US7083933B1 (en) 2003-05-09 2006-08-01 Prosidion Limited Methods for identification of modulators of OSGPR116 activity
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
RS20060018A (en) 2003-07-14 2007-12-31 Arena Pharmaceuticals Inc., Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
DOP2006000008A (es) * 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
ES2354390T3 (es) * 2006-04-11 2011-03-14 Arena Pharmaceuticals, Inc. Procedimientos de uso del receptor gpr119 para identificar compuestos útiles para aumentar la masa ósea en un individuo.
PE20071221A1 (es) * 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
WO2009038974A1 (en) 2007-09-20 2009-03-26 Irm Llc Compounds and compositions as modulators of gpr119 activity
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
AU2011305525B2 (en) 2010-09-22 2016-08-18 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
IL285890B (en) 2015-06-22 2022-07-01 Arena Pharm Inc Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
ATE366815T1 (de) * 1998-11-20 2007-08-15 Arena Pharm Inc Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand
US6221660B1 (en) * 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
GB9923177D0 (en) * 1999-09-30 1999-12-01 Pfizer Ltd Novel polypeptide
EP1226250A2 (en) * 1999-11-03 2002-07-31 MERCK PATENT GmbH Gpcr-kd5 polypeptides and dna sequences thereof
AU784543B2 (en) * 1999-11-16 2006-04-27 Pharmacia & Upjohn Company Novel G protein-coupled receptors
CA2392961A1 (en) * 1999-12-10 2001-06-14 Incyte Genomics, Inc. G-protein coupled receptors

Also Published As

Publication number Publication date
AU6744501A (en) 2001-11-26
WO2001087929A3 (en) 2002-05-30
DE60125169D1 (de) 2007-01-25
PT1287133E (pt) 2007-03-30
EP1287133A2 (en) 2003-03-05
DK1287133T3 (da) 2007-03-26
WO2001087929A2 (en) 2001-11-22
ES2278755T3 (es) 2007-08-16
DE60125169T2 (de) 2007-11-22
ATE348162T1 (de) 2007-01-15
EP1287133B1 (en) 2006-12-13

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