CY1105687T1 - Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir) - Google Patents

Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir)

Info

Publication number
CY1105687T1
CY1105687T1 CY20061100345T CY061100345T CY1105687T1 CY 1105687 T1 CY1105687 T1 CY 1105687T1 CY 20061100345 T CY20061100345 T CY 20061100345T CY 061100345 T CY061100345 T CY 061100345T CY 1105687 T1 CY1105687 T1 CY 1105687T1
Authority
CY
Cyprus
Prior art keywords
lir
family
polypeptides
immunosepherin
members
Prior art date
Application number
CY20061100345T
Other languages
English (en)
Inventor
David J. Cosman
Dirk M. Anderson
Luis G. Borges
Original Assignee
Immunex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation filed Critical Immunex Corporation
Publication of CY1105687T1 publication Critical patent/CY1105687T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Περιγράφεται οικογένεια μορίων πολυπεπτιδίων ανοσοϋποδοχέων της υπεροικογένειας ανοσοσφαιρίνων (LIR). Αποκαλύπτονται αλληλουχίες του κωδικοποιούν μέλη της οικογένειας LIR και οι συμπεραινόμενες αλληλουχίες αμινοξέων, πολυπεπτίδια που κωδικοποιούνται από DNA που υβριδοποιείται με καθορισμένες αλληλουχίες νουκλεοτιδίων, διαδικασίες για παραγωγή πολυπεπτιδίων της οικογένειας LIR, και ειδικά αντισώματα που στρέφονται εναντίον πολυπεπτιδίων LIR. Τα μέλη της οικογένειας LIR μπορούν να χρησιμοποιηθούν για θεραπευτική αγωγή αυτοάνοσων νοσημάτων και ασθενειών που σχετίζονται με κατεσταλμένη ανοσολειτουργία.
CY20061100345T 1999-05-12 2006-03-13 Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir) CY1105687T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/310,463 US6384203B1 (en) 1999-05-12 1999-05-12 Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
PCT/US2000/013228 WO2000068383A2 (en) 1999-05-12 2000-05-12 Family of immunoregulators designated leukocyte immunoglobulin-like receptors (lir)

Publications (1)

Publication Number Publication Date
CY1105687T1 true CY1105687T1 (el) 2010-12-22

Family

ID=23202628

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100345T CY1105687T1 (el) 1999-05-12 2006-03-13 Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir)

Country Status (11)

Country Link
US (4) US6384203B1 (el)
EP (3) EP1199362A3 (el)
JP (1) JP2002543787A (el)
AT (1) ATE312917T1 (el)
AU (1) AU4713700A (el)
CA (1) CA2371193A1 (el)
CY (1) CY1105687T1 (el)
DE (1) DE60024808T2 (el)
DK (1) DK1177292T3 (el)
ES (1) ES2254173T3 (el)
WO (1) WO2000068383A2 (el)

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US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
WO2003041650A2 (en) * 2001-11-14 2003-05-22 Immunex Corporation Modulation of lir function to treat rheumatoid arthritis
AU2002357267A1 (en) * 2001-12-14 2003-06-30 President And Fellows Of Harvard College Immune related neuronal receptors and therapeutic uses thereof
JPWO2005070964A1 (ja) * 2004-01-27 2008-01-17 株式会社医学生物学研究所 単球の単離方法
US8299016B2 (en) 2004-09-03 2012-10-30 The Trustees Of Columbia University In The City Of New York ILT3 polypeptides and uses thereof
WO2006033811A2 (en) * 2004-09-03 2006-03-30 The Trustees Of Columbia University In The City Of New York Ilt3 polypeptides and uses thereof
US20070037186A1 (en) 2005-05-20 2007-02-15 Yuqiu Jiang Thyroid fine needle aspiration molecular assay
GB0510627D0 (en) * 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
US8901281B2 (en) * 2005-06-17 2014-12-02 Merck Sharp & Dohme Corp. ILT3 binding molecules and uses therefor
SI1912675T1 (sl) 2005-07-25 2014-07-31 Emergent Product Development Seattle, Llc zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20
CA2654317A1 (en) 2006-06-12 2007-12-21 Trubion Pharmaceuticals, Inc. Single-chain multivalent binding proteins with effector function
EP2041180B8 (en) * 2006-06-19 2014-03-05 Liquidating Trust Ilt3 binding molecules and uses therefor
GB0623539D0 (en) * 2006-11-24 2007-01-03 Avidex Ltd Polypeptides
AU2008287195A1 (en) * 2007-07-06 2009-02-19 Emergent Product Development Seattle, Llc Binding peptides having a C-terminally disposed specific binding domain
WO2009060159A1 (en) * 2007-11-08 2009-05-14 Medigene Limited Mutated ilt molecules
PT2132228E (pt) * 2008-04-11 2011-10-11 Emergent Product Dev Seattle Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
WO2011091181A1 (en) 2010-01-20 2011-07-28 Tolerx, Inc. Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
WO2011091177A1 (en) 2010-01-20 2011-07-28 Tolerx, Inc. Anti-ilt5 antibodies and ilt5-binding antibody fragments
US9696312B2 (en) 2011-09-02 2017-07-04 The Trustees Of Columbia University In The City Of New York Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
US10316094B2 (en) 2014-10-24 2019-06-11 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inducing phagocytosis of MHC class I positive cells and countering anti-CD47/SIRPA resistance
EP3325006A4 (en) 2015-07-17 2019-03-06 The Trustees of Columbia University in the City of New York METHOD FOR TREATING CD166-EXPRESSIVE CANCER
EP3352760A4 (en) 2015-09-21 2019-03-06 Aptevo Research and Development LLC CD3 BINDING POLYPEPTIDES
KR20200103706A (ko) 2017-12-22 2020-09-02 조운스 테라퓨틱스, 인크. Lilrb2에 대한 항체
TW202428604A (zh) 2018-07-09 2024-07-16 美商戊瑞治療有限公司 結合至ilt4的抗體
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Also Published As

Publication number Publication date
DE60024808D1 (de) 2006-01-19
DE60024808T2 (de) 2006-10-05
US6384203B1 (en) 2002-05-07
US20100080801A1 (en) 2010-04-01
EP1177292B8 (en) 2006-05-17
US20030060614A1 (en) 2003-03-27
WO2000068383A2 (en) 2000-11-16
EP1772515A1 (en) 2007-04-11
DK1177292T3 (da) 2006-05-01
JP2002543787A (ja) 2002-12-24
ES2254173T3 (es) 2006-06-16
US7875703B2 (en) 2011-01-25
EP1199362A2 (en) 2002-04-24
EP1177292A2 (en) 2002-02-06
US20030027358A1 (en) 2003-02-06
EP1177292B1 (en) 2005-12-14
AU4713700A (en) 2000-11-21
CA2371193A1 (en) 2000-11-16
ATE312917T1 (de) 2005-12-15
WO2000068383A3 (en) 2001-01-18
EP1199362A3 (en) 2002-07-17

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