CY1105687T1 - Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir) - Google Patents

Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir)

Info

Publication number
CY1105687T1
CY1105687T1 CY20061100345T CY061100345T CY1105687T1 CY 1105687 T1 CY1105687 T1 CY 1105687T1 CY 20061100345 T CY20061100345 T CY 20061100345T CY 061100345 T CY061100345 T CY 061100345T CY 1105687 T1 CY1105687 T1 CY 1105687T1
Authority
CY
Cyprus
Prior art keywords
lir
family
polypeptides
immunosepherin
members
Prior art date
Application number
CY20061100345T
Other languages
English (en)
Inventor
David J. Cosman
Dirk M. Anderson
Luis G. Borges
Original Assignee
Immunex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation filed Critical Immunex Corporation
Publication of CY1105687T1 publication Critical patent/CY1105687T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Περιγράφεται οικογένεια μορίων πολυπεπτιδίων ανοσοϋποδοχέων της υπεροικογένειας ανοσοσφαιρίνων (LIR). Αποκαλύπτονται αλληλουχίες του κωδικοποιούν μέλη της οικογένειας LIR και οι συμπεραινόμενες αλληλουχίες αμινοξέων, πολυπεπτίδια που κωδικοποιούνται από DNA που υβριδοποιείται με καθορισμένες αλληλουχίες νουκλεοτιδίων, διαδικασίες για παραγωγή πολυπεπτιδίων της οικογένειας LIR, και ειδικά αντισώματα που στρέφονται εναντίον πολυπεπτιδίων LIR. Τα μέλη της οικογένειας LIR μπορούν να χρησιμοποιηθούν για θεραπευτική αγωγή αυτοάνοσων νοσημάτων και ασθενειών που σχετίζονται με κατεσταλμένη ανοσολειτουργία.
CY20061100345T 1999-05-12 2006-03-13 Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir) CY1105687T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/310,463 US6384203B1 (en) 1999-05-12 1999-05-12 Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
PCT/US2000/013228 WO2000068383A2 (en) 1999-05-12 2000-05-12 Family of immunoregulators designated leukocyte immunoglobulin-like receptors (lir)

Publications (1)

Publication Number Publication Date
CY1105687T1 true CY1105687T1 (el) 2010-12-22

Family

ID=23202628

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100345T CY1105687T1 (el) 1999-05-12 2006-03-13 Οικογενεια ανοσορυθμιστων που οριζονται ως υποδοχεις λευκοκυτταρων παρομοιοι με ανοσοσφαιρινες (lir)

Country Status (11)

Country Link
US (4) US6384203B1 (el)
EP (3) EP1772515A1 (el)
JP (1) JP2002543787A (el)
AT (1) ATE312917T1 (el)
AU (1) AU4713700A (el)
CA (1) CA2371193A1 (el)
CY (1) CY1105687T1 (el)
DE (1) DE60024808T2 (el)
DK (1) DK1177292T3 (el)
ES (1) ES2254173T3 (el)
WO (1) WO2000068383A2 (el)

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US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20050238643A1 (en) * 2001-11-14 2005-10-27 Arm Jonathan P Modulation of lir function to treat rheumatoid arthritis
AU2002361728A1 (en) * 2001-12-14 2003-06-30 President And Fellows Of Harvard College Immunocellular receptors related to neurological disorders
WO2005070964A1 (ja) * 2004-01-27 2005-08-04 Medical And Biological Laboratories Co., Ltd. 単球の単離方法
US8299016B2 (en) 2004-09-03 2012-10-30 The Trustees Of Columbia University In The City Of New York ILT3 polypeptides and uses thereof
EP1799840A4 (en) * 2004-09-03 2009-02-18 Univ Columbia ILT3-POLYPEPTIDES AND USES THEREOF
US20070037186A1 (en) 2005-05-20 2007-02-15 Yuqiu Jiang Thyroid fine needle aspiration molecular assay
GB0510627D0 (en) * 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
JP5372500B2 (ja) * 2005-06-17 2013-12-18 トレラクス リクイデーティング トラスト Ｉｌｔ３結合分子およびその使用
EP1912675B1 (en) 2005-07-25 2014-02-12 Emergent Product Development Seattle, LLC B-cell reduction using cd37-specific and cd20-specific binding molecules
US8409577B2 (en) 2006-06-12 2013-04-02 Emergent Product Development Seattle, Llc Single chain multivalent binding proteins with effector function
WO2008094176A2 (en) * 2006-06-19 2008-08-07 Tolerx, Inc. Ilt3 binding molecules and uses therefor
GB0623539D0 (en) * 2006-11-24 2007-01-03 Avidex Ltd Polypeptides
US20090148447A1 (en) * 2007-07-06 2009-06-11 Trubion Pharmaceuticals, Inc. Binding Peptides Having a C-terminally Disposed Specific Binding Domain
WO2009060159A1 (en) * 2007-11-08 2009-05-14 Medigene Limited Mutated ilt molecules
JP6013733B2 (ja) * 2008-04-11 2016-10-25 エマージェント プロダクト デベロップメント シアトル， エルエルシー Ｃｄ３７免疫治療薬および二機能性化学療法薬とのその組合せ
EP2525822B1 (en) 2010-01-20 2017-05-10 Merck Sharp & Dohme Corp. Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
EP2525813B1 (en) 2010-01-20 2017-01-04 Merck Sharp & Dohme Corp. Anti-ilt5 antibodies and ilt5-binding antibody fragments
WO2013033734A1 (en) 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
WO2016065329A1 (en) * 2014-10-24 2016-04-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
US10765742B2 (en) 2015-07-17 2020-09-08 The Trustees Of Columbia University In The City Of New York Methods of treating CD166-expressing cancer
KR20180053322A (ko) 2015-09-21 2018-05-21 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Cd3 결합 폴리펩타이드
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IL297748A (en) 2020-05-01 2022-12-01 Ngm Biopharmaceuticals Inc ilt binding agents and methods of using them

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Also Published As

Publication number Publication date
WO2000068383A3 (en) 2001-01-18
EP1199362A3 (en) 2002-07-17
JP2002543787A (ja) 2002-12-24
US20030060614A1 (en) 2003-03-27
WO2000068383A2 (en) 2000-11-16
CA2371193A1 (en) 2000-11-16
EP1199362A2 (en) 2002-04-24
ATE312917T1 (de) 2005-12-15
US6384203B1 (en) 2002-05-07
AU4713700A (en) 2000-11-21
EP1177292B8 (en) 2006-05-17
DE60024808D1 (de) 2006-01-19
EP1772515A1 (en) 2007-04-11
EP1177292B1 (en) 2005-12-14
ES2254173T3 (es) 2006-06-16
US7875703B2 (en) 2011-01-25
US20030027358A1 (en) 2003-02-06
EP1177292A2 (en) 2002-02-06
DK1177292T3 (da) 2006-05-01
US20100080801A1 (en) 2010-04-01
DE60024808T2 (de) 2006-10-05

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