CS269651B1 - A method for preparing a water-soluble oxtract from a drug-free liquor - Google Patents

Abstract

The procedure involves the preparation of water-soluble extracts from medicinal plants. After enzymatic treatment, lipophilic constituents are isolated from a medicinal plant or from a mixture of medicinal plants by steam distillation, hydrophilic constituents are extracted with water in the presence of citric acid, the sulfuric filtrate is concentrated, mixed with a porous, non-toxic, water-soluble substance and spray-dried. Lipophilic constituents are applied to the dry extract in the agglomeration or granulation process. Water-soluble extracts from medicinal plants find application in pharmacy and food industry.

Description

The invention relates to a process for the preparation of water-soluble extracts from medicinal plants suitable for the preparation of concentrated aqueous extracts or dry extracts.

Water-soluble extracts from medicinal plants are used to prepare two types of instant tea spray extract, prepared by spray drying or granular tea, which is prepared by spraying a liquid extract of the medicinal plant in an agglomeration or granulation process onto carriers (saoharose or other sugars) and then dried. Can water-soluble extracts be present? prepared from one or a mixture of medicinal plants.

Among the other features of the processes for the preparation of water-soluble powder extracts from medicinal plants is the preparation of an aqueous extract or the isolation of fractions of constituents (Switzerland Pat. No. 400,742, 343,77), but the active compounds are not isolated in possible amounts. The spray-dried extract is then spray-dried, or the aqueous extract is concentrated and sugar-added with additives. (Man. Pat. 133,485).

Podfa man. pat. 157 020, essential oils are extracted from the fresh or dry medicinal plant with a solvent, or the essential oil aa is separated by distillation and steam, the aqueous extract aa is concentrated and dried in a spray drier. Excipients, isolated essential oil are added to the base powder thus prepared and a granulate is prepared. seamstress. pat. U.S. Pat. No. 263,967 discloses the preparation of a powder extract for soluble teas from medicinal plants, citric acid being used in the water extraction step at both normal and elevated temperatures. Eur. pat. 067 351 for the preparation of powder extracts from 11-year-old plants is used in aqueous extraction! at normal temperature the addition of carboxylic acid, or a salt thereof, suitable for food use, with water alone being used at the second reaction at elevated temperature. Before the exiracoic drug, yeah isolated and isolated? essential oils e.g. distillation and steam. The liquid drug formulation is prepared according to U.S. Pat. HUT 024 247 by percolation of the medicinal matrix with a mixture of water and an organic solvent, after prior enzymatic treatment of the active substance in aqueous suspension. It is not possible to prepare from the liquid extract prepared in this way! a water-soluble powder extract because an organic solvent is used in the extraction step.

The disadvantage of the above-mentioned methods is the still low degree of isolation of the constituents from the medicinal plants, compared to the amount theoretically obtainable.

Unexpectedly, it has been found that by altering the sequence of known operations used in the preparation of powdered extracts and medicinal plants, it is possible to achieve an increase in the potency of the active ingredients from the medicinal plants and thus better utilization of the preferred raw material. The present invention therefore relates to a process for the preparation of water-soluble extracts from medicinal plants using enzymatic treatment of medicinal plants, distilling essential oils with steam distillation and extraction with water in the presence of citric acid, the essence of which is The essential oil is isolated by distillation with a science pen and the medicinal plants are extracted with water or water in a citric acid solution. The defective medicinal plant extract thus prepared is concentrated and dried in a spray drier alone or by the addition of non-hazardous auxiliaries. Isolated essential oils are applied to the powder extract in an agglomeration or granulation process.

Essential oil drying

Procedure I Procedure II Procedure III

3.15 S (100%) 3.307 S (105%) 3.235 ε (102.7%)

85.0 g (100%) 87.0 g (102.3%) £ 83.5 (98.2%)

Procedure Is A distillate with steam, water extraction

Procedure II »Enzymatic treatment, steam distillate, extraction with water

Procedure III: Enzymatic treatment, percolaia

Handle: Chamomile 108 g, Fennel 108 g, Honeydew 87 g, Mata pieporaá 69 g,

Thyme 30 g

CS 269 651 B1

If the cited known processes I (Swiss Pat. No. 400,742, 343,767, 263,967, Hungarian Pat. as well as 100 then process III, (KUT 024 247) the isolation of essential oils reaches 102.7%. 102.3%. It can be seen from the comparison that the inclusion of enzymatic treatment of plants prior to steam treatment is important especially for increased amounts of isolated essential oils, and that subsequent extraction with water in the presence of citric acid proceeds to a higher degree, so that the overall effect of this sequence use of a more favorable drug.

Example

398 grams of fennel, ruman, pispora, musculoskeletal and thyme drugs are mixed with 4,500 ml of distilled water, 3 grams of altranic acid and 0.3 grams of Ultrazym 100 G pectolyte enzyme (Novoferment, Switzerland) are added. The mixture was heated to 50 ° C and allowed to stand for 1 hour. After this time, a mixture of 4 ml of ethereal oil was isolated from the mixture with water vapor, and the polytolytic enzyme was denatured. After cooling the mixture to 50 DEG C., a solution of 20 g of oleic acid in 1000 ml of distilled water is added and the mixture is left to stand for 1 hour.

3 300 ml of extract with a dry matter content of 2.13 l by weight are prepared by filtering the mixture. The mixed drug on the filter is extracted with 3,000 ml of distilled water heated to 90 ° C. 3,400 ml of extract with a dry matter content of 0.92% by weight are prepared by filtration. The combined extracts are concentrated under reduced pressure to 532 grams of solution and a dry matter content of 21.73% by weight. The concentrated mixed extract is added to 308 grams of corn starch syrup containing 75 dry matter. Drying of the mixture in a spray drier at an inlet temperature of 133 DEG C. and an outlet temperature of 85 DEG C. gives 328 g of a light brown, fluffy powder with a dry matter content of 95% by weight.

Claims (2)

When applied in accordance with procedures I (U.S. Pat. Nos. 400,742, 3,443,767, 263,967, U.S. Pat. No. 157020, Eur. Pat. No. 067,351), the degree of isolation of the oil-based oils reaches 100 .mu.l and the amount of extracted oil. as well as 100 µl, then procedure III, (HUT024 247) achieves the isolation of the asteroid oils to 102.7 µl of the amount extracted from the leachate of 98.2% to 80 µl of the present invention. and the amount of l & f as extracted is 102.3. Comparison It is seen that the inclusion of enzymatic treatment of plants with a prior art with water vapor is particularly important for the increased amounts of isolated apricot oils, and that subsequent extraction with water in the presence of oitranic acid takes place at an excellent level, so that the overall effect of this usporladanlw sequence operaoll next to a better utilized drug. For example, 398 grams of drug fsnikl, rumanSeka, and math, atypical honey mash is mixed with 4,500 ml of deionized water, adding 3 grams of oltaric acid and 0.3 grams of pectolytic enzyme Ultrasound 100O (Novoferment, Switzerland). The mixture is heated to 50 ° C and does not stand for 1 hour. After this time, a mixed aprotic oil of 4 ml was isolated from the de-ethanolic aqueous vapor mixture (pectolytocyclo-denaturing. After the mixture had been cooled to 50 ° C, a solution of 20 grams of nitric acid in 1000 ml of deionized water was added and no more stagnant). 3 300 ml of extract with a content of 2.13 liters of weight were added to the PUrated mixture and the mixture was extracted with 3000 ml of heated water heated to 90 ° C. The combined extracts are concentrated under reduced pressure to 532 grams of pitch t with a bed volume of 21.73% by weight. the temperature of 133 ° C * at a temperature of 85 ° C was dropped 328 grams of lump-free loose powder containing 95 µm of caking material PRBDMBT VTMXLBZU 1. A process for preparing water-soluble extracts from a plant with a herbicide of atherosclerosis with native paren, onymatlocate treatment of a plant with oxalic acid, water with water, in the presence of oitranic acid, susceptible to pressurization, or a mixture of presses. enzymatic treatment in aqueous suspension, after which they are isolated by water vapor deethanol and extracted with water in water in the presence of oltonic acid, the combined aqueous extracts are concentrated after filtration, and the alobo itself is dried in a mixture of non-toxic pumolants. rozpražovaooj sužlaml. 2. A process for preparing water soluble extracts from press plants according to claim 1, characterized in that the apertured oils isolated from the pressurized plants are deposited on the dried aqueous extract in the prooees aglomsráoo alsbo granulio.