CS252927B1 - Cosmetic agent for hair and head's epidermis care - Google Patents

Abstract

Cosmetic solution in the form of a solution suitable for its long-term irritability use contains tincture of myrrh witch hazel, 3-carboxy-4- acid -hydroxybenzene sulfonic, alkoxymacrogolsulfonane sodium, macrogol sulfosuccinate sodium, macrogol 9000 glycerololojan, macrogol 4,000 lanolin, securing agents stability of the preparation, anti-microbial resistance and pleasant fragrance of the product. The product is used for cosmetic purposes for regular hair and skin care head like shampoo especially before use recommended hair product / by MS. AO 244 38 7].

Description

The invention relates to a new cosmetic composition for the regular treatment of hair and scalp. The preparation is in the form of a clear solution of surfactants and contains active substances from witch hazel, myrrhea, 3-carboxy-4-hydroxybenzenesulfonic acid, as well as auxiliaries reducing excessive degreasing of hair and scalp - macrogol 4000 lanolin and macrogol 9000 glycerylolojan. Preparation pleasantly smells. M. Kaplan: Selecting Fragrances for Hair Preparations, Cosmet. Toilet., 94, 33-35 (1979) and does not sensitize the skin.

Hair loss, hair growth, scalp and hair dandruff, hair dandruff and hair cosmetics are covered in a number of work, including:

OUTSIDE. Robinson: A Study of Damaged Hair - J. Soc. Cosmet. Chem., 27, 155-161 (1976); F.A.O. Thiele: Clinical Aspects of Hair Loss and Its Cosmicological Importance - Brit.

Dermatol., 92, 355-358 (1975); F. 0. Ebling: Hair - 0.

252 927

Invest. Dermatol., 67, 98-105 (1976); U.-F. Haustein: Seborrhoe, Koptschuppung, Haarausfall - Med. Welt,

340-341 (19); H. Zaun: Diagnostics and Therapy bei Totalen Haarausfall - Dtsch. Copper. Wochenschr., 103: 997-998 (1978); V.H. Price: Testosterone Metabolism In The Skin - Arch. Dermatol., 111, 1496-1502 (1975); M.L. Garcia,

J. Diaz: Comprehensive Measurements on Human Hair - J. Soc. Cosmet. Chem., 27, 379-378 (1976); R. Kubba, Rook: Congenital triangular alopecia - Brit. 3. Dermatol *,

95, 657-659 (1979); G. Frentez: Topical Treatment of Extended Alopecia-Dermatologica, 155, 147-154 (1977);

R.Z. Shah, 3.K. Sugden: Some Aspects of the Role of Pityrosporum Oval in Dandruff - Pharm. Acta Helv., 51, 209-211 (1986).

3e a large number of inventions and patent applications are known which disclose the composition and / or the method of preparation of compositions for the treatment of hair and scalp / Czechoslovakia. author's certificate 211 937, Czechoslovak. 213 265, U.S. Pat. U.S. Patent 4,033,895 to B.R.D. Offenlegungsschrift 1,904,159, U.S. Pat. U.S. Patent 3,236,733; U.S. Patent 3,313,734; U.S. Patent 3,816,616; U.S. Patent 3,156,656; Patent

No. 697,655, U.S. Pat. U.S. Patent 3,671,634; U.S. Patent 3,809,329; Patent 3,808,311, Eur. Pat. Appl. 0108517, U.S. Pat. U.S. Patent 3,055,836; U.S. Patent 3,947,382; Patent

No. 048,338, U.S. Pat. U.S. Patent 3,950,417, B.R.D. Offenlegungsschrift 2,244,830, B.R.D. Offenlegungsschrift 1,901,029, Canad. No. 905,299, Canad. No. 909,774, but use substances which are highly racist and therefore not suitable for regular and frequent use to provide antimicrobial activity against dermatophytes. Active substance

D of Captan / N-trichloromethylthio-3,6,7,8-tetrahydrophthal p

imide (and selenium disulfide (Selsun)) are highly toxic

252 927 or allergic and there is a wide range of justified reservations, the same is true of parabens in higher concentrations, similar to sorbic acid. Also, the use of quaternary ammonium compounds that are cationic and in conjunction with anionic or amphoteric surfactants is not a suitable solution. In the long-term use, the vehicle of the cosmetic product becomes more important, where the targeted effect can be achieved by suitable selection of excipients and their optimal combination.

The aforementioned drawbacks and problems are overcome by the fact that the agents of the invention are used with substances strictly used in pharmacy and that they are based on their well-defined properties, which makes it possible to predict with certainty the resulting effect of the formulation. Each substance has been carefully tested and tested before use.

The preparation contains a combination of myrrh tincture in an amount of 0.1 to 5% by weight, a witch hazel extract in an amount of 0.1 to 5% by weight, 3-carboxy-4-hydroxybenzene sulfonic acid in an amount of 0.1 to 2% by weight, alkoxymacrogolsulfonan sodium in an amount of 10 to 75% by weight, macrogol of sodium sulfosuccinate in an amount of 10 to 75% by weight, macrogol of 9,000 glycerololojane in an amount of 1 to 10% by weight, macrogol of 4000 lanolin in an amount of 0.5 to 5% by weight, agents providing stability of the preparation, antimicrobial resistance, pleasant odor and propylene glycol.

This composition achieves the following advantages in particular: a robust and reliable action against dermatophytes is ensured, a mild anti-inflammatory effect is assured, a surfactant mixture has a suitable size WAS 22.5 data (Waschaktive Stoffe)

252 927 and greasy additives do not allow rapid degreasing of the scalp and hair and thus do not break the hair or reflect the effect of increased sebum secretion on the head.

Perfume is stabilized against decomposition and thus the usual penetrating increase of irritation or sensitization by the food antioxidant - butylhydroxytoluene. Stability is also favorably influenced by the ethylenediaminetetraacetic acid sodium salt. It provides an antimicrobial preservative effect

2-bromo-2-nitro-1,3-propanediol. The pleasant coloring of the preparation comes from dyes of natural origin from witch hazel extract and myrrh tincture and therefore no synthetic irritating dyes from the series of aniline dyes are necessary. The preparation is indicated for seborrhoea oleosa in combination with another hair activator preparation according to CS AO 244 387, which contains a combination of myrrh tincture in an amount of 0.1 to 5.0% by weight, witch hazel extract 0.1 to 5.0% by weight. camomile extract 0.2 to 5.0 wt.%, panthenol 0.1 to 2.0 wt.%, corn oil extract with unsaponifiable matter 0.1 to 1.0 wt.%. substances providing mild irritation of the scalp and providing a pleasant smell of the preparation: This composition achieves the following advantages: anti-inflammatory effect, disinfectant effect, hair follicles provide sufficient supply of necessary panthenol and vitamin E, which combines anti-inflammatory effect and nutritional effect for hair follicle . The vehicle is slightly irritating to provide blood circulation to the scalp without the need for substantially more toxic substances to irritate and blood supply to the scalp, such as nicotinates. The oily components of the vehicle do not allow rapid defatting of the scalp by the presence of ethyl alcohol. Perfume is against decomposition and thus the usual

AND

252 927 stabilized by the food antioxidant - butylhydroxytoluol. A suitable combination of propylene glycol, water and ethanol allows the formulation to be manufactured without the need to provide microbial attack with chemical preservatives. Pleasant coloring of the product is ensured by natural dye from witch hazel extract and myrrh tincture and therefore it is not necessary to choose synthetic irritating dyes from the range of aniline dyes.

Furthermore, the invention is illustrated by two examples without being limited thereto.

Example 1

Willow extract 0.25 % wt. Myrrh tincture 1,25 % wt. 3-Carboxy-4-hydroxybenzene sulfonic acid 1.20 % wt Sodium alkoxymacrogolsufonate / 28% solution / 50.00 % wt Sodium sulfosuccinate macrogol / 30% solution/ 25,00 % wt Macrogol 9 000 glycerylolojane (70% solution) 5.20 % wt Macrogol 4000 lanolin / 50% solution / 4.00 % wt 2-bromo-2-nitro-1,3-propanediol 0.02 % wt Disodium salt of etalenediaminetetraacetic acid 0.03 % wt Quebracho perfume 0.70 % wt 1,2-propanediol to 100.00 % wt

Example 1 - Preparation Method

Into a homogenizer equipped with a stirrer,

252, 927, sodium alkoxymacrogolsulfonate, sodium macrogol sulfosuccinate, macrogol 9,000 glyceryl lineage, macrogol 4000 lanolin, sodium ethylenediaminetetraacetic acid and sodium 3-carboxy-4-hydroxybenzene sulphonic acid are heated to 50 ° C. The mixture was stirred until a homogeneous solution was formed, then cooled to room temperature. Myrrh tincture, witch extract, 2-bromo-2-nitro-1,3-propanediol are added, dissolved in triplicate

1,2-propanol, the remaining 1,2-propanediol and perfume are added. After homogenization, the preparation is filled. Store at 15 - 25 C (CsL 3) in the dark.

Example 2

The composition of Example 1, 60 wt.

% Fluorochlorohydrocarbon F -12 40% w / w

Example 2 - Preparation Method

The mixture according to Example 1 and prepared according to the method of preparation ad 1 is filled into pressure vessels, which after filling with a continuous valve are filled with propellant gas (F-12) to the required weight. The product is stored at 15 - 25 ° C and under conditions of storage of pressure packs.

Tinctura myrrhae / CSL 1 /

It is formed by dissolving the myrrhea resins in ethanol and filtering. The resin is obtained from myrrh (Commiphora abyssinica, Engl.) of the Bursetaceae family. The resin contains essential oil (about 10%), bitumen (about 30-40%), and silica (92-92%) (50-60%). The effect is given by the content of substances, mainly terpenic hydrocarbons -ponene, and d, l-limonenene. Furthermore, eugenol, cresol, cuminaldehyde cinnamic aldehyde, myrhol, myrholic acid and aliphatic hydrocarbons, especially m-nonacosan. Drugs and tincture ra smells cinnamon aldehyde. Tincture has mainly astringent, disinfectant and deodorant effect. The antimicrobial effect has already been used in the past in the form of smoke (combustion of the resin) in smoking.

Extractum hamamelidis fluidum / CSL 2 /

It is prepared by percolation of witch hazel leaves with 50% alcohol. The leaf provides Hamamelis virginiana L. from the family Hamamelidaceae. The extract contains tannins, especially -hamamelitanin, flavonic glycosides, gallic acid and saponins /P.H. List, L. Horammer: Hagers Handbuch der PHARMAZEUTISCHEN PRAXIS, A. Ausg., Springer-Verlag Berlin, Heidelberg, New York 1980 /. The effect is astringent and anti-inflammatory / B. Head, F. Stary, F. Pospisil: Plants in Cosmetics, Nature - Bratislava 1982; H. Gabler: Arzneipflanzen in Medizin und Pharmazie, Verlag Muller + Steinicke, Munchen 1982 /. Due to decades of use in pharmacy and cosmetics, the extract was not subjected to any extra tests.

5-Carboxy-4-hydroxybenzene sulfonic acid (USP XXI) RS,

3. AB-DDR / RE /

Previously, in the form of the sodium salt, this acid was used as an antirheumatic agent (orally). In combination with samria

252 927 is used as a local anti-inflammatory drug. For excellent antifungal eiect, it is suitable for anti-dermatophytes. It does not irritate or allergy the skin.

The pharmaceutical compositions of the present invention

Determination of acute toxicity - experiments were carried out on mice of both sexes with an average weight of 25 g. conditions and fed animals with standard food and water ad libitum. LD? G was determined after oral administration by the Litchfield-Wilcoxon method with at least a five-dose procedure. The result in female mice was 15.0 / 12.0 to 18.75 / ml / kg. Furthermore, local irritation was determined on the mucosa of the mouth of the golden hamsters kept under standard conditions. Each animal in the appropriate group was dosed by oral gavage with 0.2 ml twice daily. The application was always performed on one side only, the other side served as a comparative control. At the same time, distilled water was applied to the control group. Neomucoseptonex nasal drops were applied in the same test series, which served as a second control. The product was tested after one day of administration, when animals were sacrificed and samples were taken for histological examination, and after five days of application under the same conditions, as well as sampling for histological examination. In addition, all samples were assessed macroscopically, the color of the mucosa, its blood flow and its integrity (erosion) were monitored. There were five animals in each group. The study concludes that the product does not irritate the mucosa.

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Clinical experience with the formulation of the invention

The product has been tested in a controlled clinical trial. It was tested in three ways: epicutaneous tests, external application and microscopic examination of epilated hair. A total of 100 patients were tested.

Epicutaneous tests - in undiluted state, samples were tested with standard Testoplast on the skin of the back in 100 patients. The results were evaluated 0.5 hours after removal of the patch (after 48 hours of sticking) and checked for another 24 hours. None of the 100 patients tested had a toxic reaction and no allergy. All outbreak tests were negative.

External application - monitoring of foaming, burning or itching of the skin after application, washing and degreasing ability, hair combability, perfuming and consumption of the preparation.

These results have been achieved - foaming very good, burning or itching of the skin did not occur during or after washing, in case of excessively oily hair it is necessary to use two shampoo baths. For more frequent hair washing (about 4 days) one bath is sufficient. Hair combability is very good. Perfume rated excellent.

Microscopic evaluation of epilated hair - loss of number of telogen hair not normal finding (30%) that occurs during and after washing hair. The preparation is indicated for seborrhoea olesa, where the use of another preparation - hair activator according to AO 244 387 leads to an increase in effect as has also been shown.

Determination of biological activity of sample preparation

Overview of effective dilution of the preparation of the invention

252 927 for selected microorganisms:

Microorganism

Effective dilution

Staphylococcus aureus 771 480 Staphylococcus epidermidis kk 120 Streptococcus pyogenes A kk 2 000 Streptococcus faecium kk 40 Escherichia coli 185/59 60 Proteus mirabilis Mi 60 Pseudomonas aeruginosa kk 40 Bacillus cereus kk 100 Candida albicans Ca 1 128 catarrhalis 1 1 000 Branhamella catarrhalis 2 2 000 Klebsiella pneumoniae kk 40 / kk - strains isolated from clinical materials /

Microorganism Dilution preparation at titre Fungistatic Fungicidal action action / 1: / / 1: / Trichophyton tonsurans 80 6 Trichophyton violaceum 3 840 640 Trichophyton megnii 480 40 Trichophyton floccosum 240 16 Trichophyton schoenleinii 2 560 480 Microsporon gypseum 30 4 Mentagrophytes interdigitale 40 2 Trichophytes interdigitale 80 10 Microsporon 480 480 Microsporon audouini 20 May 2

Claims (1)

SUBJECT OF THE INVENTION 252 927 Cosmetic preparation for the treatment of hair and scalp in the form of a solution, emulsion, suspension, gel or spray, containing a combination of myrrh tincture in an amount of 0,1 to 5% by weight, witch hazel extract 0,1 to 5% by weight, sodium alkoxymacrogoisulfonate in an amount 10 to 75% by weight of sodium sulfosuccinate macrogol in an amount of 10 to 75% by weight of macrogol 9000 glycerollojane in an amount of 1 to 10% by weight, macrogol 4000 lanolin in an amount of 0.5 to 5% by weight, agents providing stability of the preparation, antimicrobial resistance, pleasant odor of the preparation and propylene glycol, characterized in that it contains 3-carboxy-4-hydroxybenzene sulfonic acid in 0.1 to 2% by weight.