CS239595B1

CS239595B1 - Disinfectant and / or disinfectant component

Info

Publication number: CS239595B1
Application number: CS841454A
Authority: CS
Inventors: Vendelin Macho; Milan Polievka; Rudolf Kosalko; Jan Sipos; Richard Macho; Ludovit Jurecek
Original assignee: Vendelin Macho; Milan Polievka; Rudolf Kosalko; Jan Sipos; Richard Macho; Ludovit Jurecek
Priority date: 1984-03-01
Filing date: 1984-03-01
Publication date: 1986-01-16
Also published as: CS145484A1

Abstract

Dezinfekčný prostriedok- a/alebo dezinfekčný komponent dezinfekčných prostriedkov, detergentov, konzervačných prostriedkov a nátěrových látok je na báze derivátov fenolu alebo derivátov fenolátov, připadne za přítomnosti pomocných látok (tenzidy, resp. emulgátory, dispergátory, farbivá, vonné látky, riozpúšťadlá), pričom účinnú látku tvoří aspoň jeden monoalkylfenol až tetraalkylfenol s alkylom C6 až Cie, najma vo formě alkylfenolátu a/alebo aspoň jeden arylalkylfenol s molovou hmotnosťou nad 276 g . mól-1 obecného vzorca RR‘(C6HzR“)OX v ktorom X = H, Na, K alebo NHí, R a R‘ = Η, benzyl, benzylmetyl, R“ = H, alkyl C4 až Cis. Uplatnenie má v chemickom priemysle (využívajú sa medziprodukty a vedlajšie produkty, aplikujú sa v nátěrových látkách, vo výrobě detergentov), v zdravotníctve, vo veterinárstve a podobné.The disinfectant and/or disinfectant component of disinfectants, detergents, preservatives and coatings is based on phenol derivatives or phenolate derivatives, optionally in the presence of auxiliary substances (surfactants, or emulsifiers, dispersants, dyes, fragrances, solvents), the active substance being at least one monoalkylphenol to tetraalkylphenol with alkyl C6 to C16, especially in the form of alkyl phenolate and/or at least one arylalkylphenol with a molar mass above 276 g mol-1 of the general formula RR'(C6HzR")OX in which X = H, Na, K or NHí, R and R' = Η, benzyl, benzylmethyl, R" = H, alkyl C4 to C16. It has applications in the chemical industry (intermediate products and by-products are used, they are applied in coatings, in the production of detergents), in healthcare, in veterinary medicine and the like.

Description

239595 3

BACKGROUND OF THE INVENTION The present invention relates to a practically odorless, yet petrochemical composition, of a readily available, effective disinfectant or disintegrant component of disinfectants, detergents, preservatives, impregnating agents, paints, and the like, mainly with significant bactericidal, fungicidal, respectively. antimycotic effects.

Especially effective and harmless odorless disinfection is particularly useful for preventing infectious disease threats and for eradicating infections. It is also important in public and private sanitary facilities, in the use of xylogen, especially on synthetic fibers that cannot be sterilized at high temperatures. under pressure and even as cotton fabrics. Furthermore, for the disinfection of the Department of Hospitals, disinfection of medical equipment and, last but not least, veterinary medicine and livestock production with massive livestock breeding where there is a danger of various epidemics. In addition, for the protection of wood against wood-blocking fungi, odorless, side-effect-free and effective fungicidal agents or impregnating coatings, coatings and the like are suitable.

For this purpose, a number of phenols are used as disinfectants, such as cresols, chlorophenols, tetrachlorophenol and pentachlorophenol, 2-hydroxydiphenyl, benzylphenols, cyclohexylphenols [Spaulding EM: J. Hosp. 9, 5 (1972); Ehrhart G., Rusching H.:Arzneimittel - Entwicklung - Wirkung —— Darstellung, 4 vol, 25-30 Verlag Cheie (1972); čs. patents 150, 889, 152, 180 and 183, 478; Lindner K .: Tenside - Textilhilf-smittel Waschrohstoffe WissenschaftlicheVerlagsgesselschaft MBH - Stuttgart (1971)]. Their disadvantage is either unpleasant odors, side-effects, but their production is necessary for relatively large-scale degrees. A technically relatively easy to obtain, yet effective and practically odorless, and without side-effect is a disinfectant or disinfectant component according to the invention.

SUMMARY OF THE INVENTION The present invention is directed to a disinfectant and / or disinfectant, detergent, preservative, and coating component comprising a phenol derivative and / or an alkali metal phenolate derivative and / or a phenolate ammonium derivative, optionally together with excipients. by activating at least one monoalkylphenol to tetraalkylphenol with alkyls having a carbon number of 6 to 18, preferably in the form of monoalkylphenolate to tetraalkylphenate and / or at least one aryl alkylphenol having a molecular weight of over 276g. mol-1 of the general formula

RR '(C 6 H 2 R ") OX wherein X = H, Na, K, or NH 1; R and R '= H, benzyl, benzylmethyl; R '= H, C4 to C18 alkyl. The advantage of the disintegrating agent and / or the disinfectant component is the relatively high disinfection efficiency, in particular the bacterial and antimycotic activity, and the fact that other products of phenol alkylation and aryl-alkylation of phenol, for which there is a lack of technical properties, can also be used. -economic evaluation. A further advantage is the possibility of simultaneously producing hydrophobic components for non-ionic or anionic surfactants or intermediates for antioxidants, as well as active substances of the disintegrant or disintegration component on one device.

On the one hand, these compounds can be intentionally produced and isolated as by-products from the alkylation of phenol by higher olefins, higher alcohols, alkyl halides or alkyl-tert-butyl ethers, further from arylalkylation of phenol with styrene or methyl phenylcarboline or methylcyclohexylcarbinol. In addition, it can be produced by alkylation of benzylphenol and / or benzylmethylphenol with alkali, alkyl-tert-butyl ethers, alcohols, alkyl chlorides with C1 -C18 alkyls. Particularly suitable for this purpose are octylphenol, nonylphenol, dodecylphenol, tetradecylphenol, hexadecylphenol, octadecylphenol and their dialkyl to tri-alkylphenols. Tetraalkylphenol-containing monoalkylphenols are an important starting material for the production of non-ionic surfactants for the production of alkyl salicylates and also other additives in mineral oils and the like, but may be similar to the by-products dialkylphenols to tetra-alkylphenols, respectively. mono- to tetraalkylphenates with a disinfectant or disinfectant component of disinfectants, detergents, impregnating agents, fungicides, paints. Excipients include ionic and non-ionic surfactants, especially protective colloids, respectively. emulsifiers and dispersants, solvents, fragrances, binders, fillers, thixotropic substances, dyes and pigments.

Disinfectants according to the invention are applied as such or diluted in organic solvents, in particular ethanol, optionally dispersed in water under the action of emulsifiers or dispersants. In the case of the preparation of aqueous solutions, their application is preferably in the form of an alkyl- and / or an- alkaline arylalkylphenates. Such solutions or emulsions, or dispersions, typically have an effective concentration of 0.5 to 5%, but can reach up to tens of percent. While the solubility of the molecules decreases, the solubility of the emulsifiers and / or dispersants makes it possible to prepare the endowed emulsions or effervescent agents even in water. Thus, the active substances are often applied as a component, whether disinfectants, detergents, impregnating oils, impregnating agents, for example against wood-destroying fungi, as a component of paints, for example for timber-building and other timber industry products. -l, during restoration works etc. The disinfectant compositions as well as the disinfectant components of the present invention can also be combined with known other disinfectants or disinfectants.

Their effects as well as other advantages are clear from the examples. Example 1 Commercial nonylphenol is treated with an aqueous solution of sodium hydroxide at a concentration of 10% by weight. with co-activity of 0.2 wt. lauryl polyglycol is prepared in an aqueous solution of sodium nonylphenolate. The concentration of the active ingredient in the aqueous solution is adjusted to 15% by weight. sodium nonylphenolate.

Similarly, an aqueous solution of mixtures of sodium dibenzylmethylphenol, sodium tricresolate and sodium cumylphenate is prepared.

Minimum Inhibitory Concentration (MIC) Values in pg. cm-3 media, are determined by dilution method. The 0-8 active substance is diluted in a series of tubes in 10% DMSO, microorganisms are added (10 9 cells in 1 cm 3 of solution). Disinfectants are allowed to act for 30, 60 and 120 minutes. Then transfer the inoculum (50 μΐ in volume) to tubes with 2 cm3 of test medium. These tubes were cultured for 24 hours in the case of bacteria and 48 hours in the case of yeasts and molds at 37 ° C and then the effect was evaluated. In tubes where growth of microorganisms, color is changed from red to rye. The MIC value is in the tube that remains last unchanged. The results obtained are summarized in Table 1. Example 2

The primary effect of disinfectants, namely tricresol, cumylphenol, nonylphenol with an admixture of 3.5 wt. dinolinylphenols, benzylmethylphenol and mixtures of isomers. dibenzylmethylphenol with an admixture of 1.5 percent by weight tribenzylmethylphenol (all in the form of phenolates in aqueous solution, respectively in emulsion) in a model trial of the growth curves of a sensitive strain of Candida albicans (fungicidal activity, expressed in MIC). So in the case of the MIC 2 50Q. cm-3; in the case of cumylphenol 150; nonylphenol 180; of benzylmethylphenol 125 and a mixture of isomers of dibenzyl methylphenols 125 µg. cm-3. 239595

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Alkylation of phenol at 140 +1 ° C with a catalytic bleaching action of aluminum by treating the fraction predominantly (above 90 ° C) of 1-alkene of 140-169 ° C, yielding di-alkylphenol (with Ca 3 alkyl) of 347 g . mole-1 (theoretically 346.58 gmole -1) determined by cryoscopy, as well as mono-alkylated with the same fraction of alkenes 4-benzylmethylphenol (alkylation, however, 80 ° C) with a molar mass of 329 g. In addition, the monoalkylphenol, alkylated with a mixture of mainly internal n-alkenes C max to C 6, of a molecular weight of 314 g. mole "1" is tested. the effect is shown in Table 2.

Claims

EXAMPLE 1 The isomers of dialkylphenols to tetra-alkylphenols with C9 alkyls having a molar mass of 574.1 gmol-1 (trinonylphenol has a molar mass of 472.8 g, mol-1 and tetranonyl-3, 10 phenol 599, As well as the mixture of isomers of di- (benzylmethyl) -phenols with a molar mass of 300.5 g / mole, 04 g of mole-1 are tested in a similar manner to that described in Example 1. The results of the bactericidal effects of Table 3 are as follows. Table 3 MIC values of effective disinfectants in fig.cm-3 medium after 30, 60 and 90 min Strain time (min) Mixture of isomers of dinonylphenol to tetranonylphenols, respectively dinonyl to tetranonylphenol Mixture of isomers of di- (benzylmethylphenols) , respectively, di- (benzyl-30 'sodium) 60' 90 'methyl sodium phenolates 30 60' 90 'Proteus vulgaris 160 80 80 160 20 10 Sarcina lutea 320 160 160 80 40 40 Eascherichia coli 320 320 320 80 40 40 Bacillus subtilis 320 320 320 80 80 80 Bacillus pumilis 320 320 320 40 80 80 Staphylococus aureus 80 10 10 20 2.5 1.0 Candida albicans 160 160 80 40 40 40 Candida pseudot 40 20 5 40 20 20 Sacharomyces cerevisiae 80 80 40 10 10 10 Aspergillus niger 160 80 80 160 160 160 SUBSTANCE Disinfectant and / or disinfectant, detergent- of preservatives and paints based on phenol and / or alkali metal phenol and / or ammonium phenol derivatives, optionally with auxiliaries, characterized in that the active ingredient is at least one mcoolkylphenol to tetraalkylphenol with alkyls having carbon numbers of 6 to 18, preferably in the form of monoalkylphenolate to tetraalkylphenate and / or at least one arylalkylphenol having a molar mass above 276g. mole-1 of the general formula RR '(C6H2R') OX wherein X is hydrogen H, sodium Na, potassium K, or NH 4 group, R and R '= H, benzyl, benzylmethyl, R 8 = H, alkyl C 1 -C 18.