CS238753B1 - Insecticide agent for extirpation of lice and ektoparazit domestik aminals - Google Patents

Abstract

The invention addresses residual increases effects of fixation of effective insecticidal agents with macromolecular polymers with high nouns to hair and skin. Fixation of active substances is given on the one hand by the substantivity of polyvinylpyrrolidone or copolymers thereof, or derivatives thereof to the mid-peptides and secondly the ability of these polymers to form adducts with a number of organic compounds. Another the benefits of using these polymers are Their prosthetic effects.

Description

¹ The invention relates to insecticidal lotions rezlduálním with prolonged effect for use in human or veterinary field e.

Older, not completely safe insecticides, such as DDT e gamme HCH, were applied against the head lice mostly in the form of 1% water emulsion, which after a considerable exposure time (6 to 24 hours) had to be washed again with soap or shampoo. ).

Highly effective and fast acting pyrethroids have made it possible to produce insecticidal shampoos, which are often formulated as sprays. Their use is the most environmentally friendly in terms of hygiene and space. A prerequisite for their full and sustained successful use is a higher level of hygiene and prevention of reinfestation.

Both types of the above-mentioned anti-pediculosis preparations are characterized by very short efficacy residues, which generally limit to zero as a result of subsequent washing and flushing of the active ingredients before they bind to the hair or due to their rapid degradation in the case of poorly stable active ingredients. eg light-decaying types of pyrethroids).

Ectoparasites of domestic animals, in addition to spraying and bathing used in large-scale farms, also use pyrethroid shampoos without residual efficacy or semi-dry sprays with organophosphates.

It has now been found that the disadvantages of the present state, ie short residual effects, are eliminated by means of lice control of infant and ectoperasite pet animals based on insecticidally active substances (pyrethroids, organophosphates and chlorinated insecticides), monoglycols or polyglycols, lower alcohols. , perfume and water, containing according to the invention 0.1 to 5% of polymers or copolymers or derivatives of vinylpyrrolidone with an average molecular weight of 10,000 to 1,000,000.

An advantage of the inventive additions is that when using macromolecular polymers with high affinity for hair or fur (i.e., polypeptides) and good solubility, respectively. The ability to form adducts with a number of organic compounds will significantly prolong the residual effects. It is therefore particularly suitable to use polyvinylpyrrolidone with an average molecular weight of 10,000 to 1,000,000 or copolymers of polyvinylpyrrolidone, for example a copolymer of vinylimidazolium methochloride and vinylpyrrolidone. Substantivity to hair and skin due to the essentially peptide bond of pyrrolidone allows long-term fixation of these polymers to the hair or hair, as well as fixation of insecticidally active substances and thus conditional prolongation of biological activity. A further benefit of the use of polyvinylpyrrolidone and its copolymers is its protective effects, particularly desirable in view of the use of organic solvents and application to the skin, particularly in the pediatric population. If safe, active substances (especially pyrethroids) are used in such a formulation, there is no increased toxicological risk.

He did

Hair water containing 0.5 parts of permethrin, 1 part of polyvinylpyrrolidone PVP K 30, parts of monopropylene glycol, 78.5 parts of anhydrous ethyl alcohol was filled into an aerosol can and supplemented with dichlorodifluoromethane in a ratio of 7: 3.

The product was applied by a spray with a prolonged nozzle to the jails of the pupils of the special school by spraying for 0.5 to 1 s at 8 to 10 hairstyles. Immediately after application, the product was spread over the entire surface of the skin covered with hair. At the same time, the same formulation without polyvinylpyrrolidone was tested in the same way for other probants.

When using the formulation with polyvinylpyrrolidone, 50 days after application, a new lice incidence was found in less than 10% of children. Using a polyvinylpyrrolidone-free formulation, lice began to appear significantly earlier, after 10 days in 10% of children. In two cases larvae were found on day 10, indicating survival of nits.

Formulations · ' Number of % Attacked persons in days after application 1 , 0 20 30 50

without PVP 57 in 0 9.6 25.5 42 - 8 PVP 104 0 0 1 - 9.4

When investigating ovicidal effects in vitro, using a formulation with polyvinylpyrrolidone did not hatch a significant percentage of nits at all, and none of the larvae was able to completely enclose the egg shells. When applying the formulation without polyvinylpyrrolidone, a certain percentage of nits also died, but 7% of the larvae left the egg shells.

Example 2

Hair water containing 2 parts of trichlorphone, 1 part of polyvinylpyrrolidone, 20 parts of monopropylene glycol, 77 parts of anhydrous ethyl alcohol was filled into an aerosol container and supplemented with dichloromethane in a 7: 3 ratio.

The formulation was applied as in Example 1 and at the same time the formulation without polyvinylpyrrolidone was tested in the same way.

When using the polyvinylpyrrolidone formulation, 20% of children were rewound within 10 days after application, while nearly 90% of children were rewound within 10 days using the same formulation without polyvinylpyrrolidone.

Formulation Number of treated % Of persons attacked in 1 days after application 10 20 May without PVP 8 0 87 100 ALIGN! ε PVP 20 May 0 20 May 50

Example 3

Hair water containing 0.5 parts of permethrin, 1 part of a copolymer of vinylimidazolium methochloride and vinylpyrrolidone, 6 parts of polyethylene glycol 300, 67 parts of ethyl alcohol, parts of water and 0.5 parts of perfume was tested in vitro compared to the same formulation without the above polyvinylpyrrolidone copolymers. Simultaneously, both formulations according to Example 1 were tested, and were used without propellant (dichlodifluoromethane). The insecticidal efficacy was determined by determining the% mortality of female housefly, a susceptible strain of SRS / WHu in 24 hours after bathing in an aqueous solution of the following concentration:

Concentration % Mortality % of the preparation Example 1 Example 1 Example 3 Example 3 without PVP with PVP without Kop. PVP with kick. PVP

0.000 1 100 ALIGN! 100 ALIGN! 100 ALIGN! 100 ALIGN! 0.000 01 93 100 ALIGN! 100 ALIGN! 100 ALIGN! 0,000 001 86 100 ALIGN! 100 ALIGN! 100 ALIGN! 0.000 000 1 6 27 Mar: 47 86 0.000 000 01 6 6 33 80 0.000 000 001 0 0 0 6

A good insectieid efficacy of the composition of Example 3 against head lice also results from a comparison of the effects of the samples of Example 1β according to Example 3 on housefly. The above results also show a positive effect of polyvinylpyrrolidone (or copolymers thereof) on the immediate insecticidal efficacy, which in this case is better by binding the composition to the surface of the insect's body.

Example 4

Hair lotion containing 1 part molathion, 0.5 part quaternary derivative of PVP (poly (3-pyrrolidonyl-1- (N, N, N-trimethyl)) - 1-propylenylammonium chloride /), 5 parts nolvetlene ethylene in 300, 0.5 93 parts of perfume, 93 parts of isopropyl alcohol were filled into an aerosol container and supplemented with dichlorodifluoromethane 7: 3.

The formulation was applied as in Example 1 and the formulation without PVP derivative was again tested in the same manner.

When using a formulation without a PVP derivative, 27% of children were naïve 18 days after dosing, while there was no louse after 18 days when using the same formulation with a PVP derivative.

Formulation Number of treated 1 % Attacked people after days of application 8 18 bez der. PVP 41 0 14 27 Mar: s der. PVP 45 0 0 x / - o

x / in three cases, the dead dead were piled

Example 5

Hair water containing 1 part methoxychlor, 1 part polyvinylpyrrolidone, 6 parts polyethylene glycol 300, 92 parts isopropyl alcohol was tested in vitro as in case 3, and the formulation without polyvinylpyrrolidone was again tested in the same way. The mortality rate of the female housefly 24 hours after bathing in the aqueous suspension of the preparation was again significantly cleared for the formulation containing PVP:

Concentration% of preparation % Mortality with PVP without PVP 0.001 1 00 100 ALIGN! 0.000 1 100 ALIGN! 93 0,000 b, , 00 86 0,000 00, 86 47 0.000 000 1 6 0 0.000 000 01 0 0 In the examples 1 1 to 5 polymers were used with the following molecular weight:

Example 1 approx 40 000 Example 2 approx 40 000 Example 3 approx 150 000 Example 4 _ approx 000 000 Example 5 approx io 000

SUBJECT: THE INVENTION

Claims (1)

Insecticidal composition for the control of lice and ectoparasites of domestic animals based on insecticidally active substances from the group of pyrethroids, organophosphates, chlorinated insecticides, containing monoglycols or polyglycols, alcohols C8 to C5, perfume and water, characterized in that it contains 0.1 to 5% polymers or copolymers or vinylpyrrolidone derivatives having an average molecular weight of 10,000 to 1,000,000.