CS224974B1 - The production of adsorbents of gall acids - Google Patents
The production of adsorbents of gall acids Download PDFInfo
- Publication number
- CS224974B1 CS224974B1 CS825566A CS556682A CS224974B1 CS 224974 B1 CS224974 B1 CS 224974B1 CS 825566 A CS825566 A CS 825566A CS 556682 A CS556682 A CS 556682A CS 224974 B1 CS224974 B1 CS 224974B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- adsorbents
- production
- lignin
- acid
- acids
- Prior art date
Links
- 239000003463 adsorbent Substances 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 239000002253 acid Substances 0.000 title description 5
- 150000007513 acids Chemical class 0.000 title 1
- 229920005610 lignin Polymers 0.000 claims description 9
- 239000003613 bile acid Substances 0.000 claims description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000218657 Picea Species 0.000 description 1
- 235000006732 Torreya nucifera Nutrition 0.000 description 1
- 244000111306 Torreya nucifera Species 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Compounds Of Unknown Constitution (AREA)
Description
Vynález sa týká sposobu přípravy adsorbentov žlčových kyselinoThe invention relates to a process for the preparation of bile acid adsorbents
Niektoré zložky rastlinných vláknin stimulujú pramenu cholesterolu na žlčové kyseliny v pečeni tým, že v zažívacom trakte viažu žlčové kyseliny, v dósledku čoho sa rovnováha reakcie cholesterol —> žlčové kyseliny posúva smerom doprava.Some plant fiber components stimulate the source of cholesterol to bile acids in the liver by binding bile acids in the gastrointestinal tract, causing the cholesterol -> bile acid balance to shift to the right.
Táto skutočnost má význam pri liečbe hypercholesterolémie.This is of importance in the treatment of hypercholesterolemia.
Z doteraz známých poznatkov vyplývá, že pri interakcii žlčových kyselin a zložiek vláknin ide pravděpodobně o fyzikálnu adsorpciu, pričom lignin sa uvažuje ako jedna z najpotencionálnejších polymérnych zložiek vláknin z hladiska jeho adsorpčnej kapacity na žlčové kyseliny, Štúdium reakčnej afinity izolovaných lignínových preparátov in vitro bolo predmetom práce Kaya a Waymana /i.K.Kay, S.Wayman: Dietary Pibers, Academie Press, 57 (l979\7> kde sa zistila 5 až 10%-ná relativná nízká afinita testovaných lignínov pre cholovú kyse*linu.Based on the knowledge to date, the interaction of bile acids and fiber components is likely to be physical adsorption, and lignin is considered to be one of the most potent polymeric fiber components in terms of its adsorption capacity to bile acids. by Kaya and Wayman / iKKay, S.Wayman: Dietary Pibers, Academic Press, 57 (1979), where a 5-10% relative low affinity of the tested lignins for choline acid was found.
Uvedené nevýhody v podstatnej miere odstraňuje sposob přípravy ad s orb en ta žlčových kyselin podl’a vynálezu, ktorého podstata spočívá v tom, že sa dřevný materiál alebo sulfátový výluh hydrolyzuje s 10 až 70%-nou kyselinou sírovou pri teplote 100°C po dobu 4 až 6 h a výsledný lignínový preparát sa izoluje filtráciou.The above-mentioned disadvantages are substantially eliminated by the process according to the invention for the preparation of the bile acid orbic acid according to the invention, characterized in that the wood material or the sulfate liquor is hydrolysed with 10 to 70% sulfuric acid at 100 ° C for a period of time. 4-6 h, the resulting lignin preparation is isolated by filtration.
Výhodou navrhovaného sposobu přípravy adsorbentov je zvýšená účinnost, Dáva^ možnost využit lahko dostupné odpadne produkty v celulózo-papierenskom priemysle. Technologické pi*evedenie kondenzácie je nenáročné na chemikálie a zariadenie.The advantage of the proposed process for the preparation of adsorbents is the increased efficiency. Technological condensation is low on chemicals and equipment.
Příklad 1Example 1
224 974224 974
Smrekové piliny /100g/ predextrahované zmesou benzenetylalkohol /2:1/ /9^> sušiny/ s obsahom ligninu 29^ /Tappi T-13m - 54/ sa hydrolyzujú 60%-nou kyselinou sírovou /400^1/ po dobu 2 h pri laboratorněj teplote a po zriedení na 10%-nú koncentráciu po dobu 5 h pri 1003C. Nerozpustný podiel sa odfiltroval a premyl 0,01%-ným roztokom hydroxidu sodného. Adsorpčná kapacita stanovená spektrofotometricky modifikovanou metodou podlá Mosbacha /l.Mosbach, K.Smid: Arch. Biochem. Biophys. 51, 402 (1954)7 takto připraveného lignínového preparátu bola 9^% pri pH 5,4 a 87l% pri pH 8.Spruce sawdust (100g) pre-extracted with a 2: 1 mixture of benzene ethyl alcohol (9% dry matter) containing 29% lignin (Tappi T-13m-54) is hydrolyzed with 60% sulfuric acid (400%) for 2 hours at room temperature and diluted to a 10% concentration for 5 h at 100 3 C. the insoluble material is filtered and washed with 0.01% sodium hydroxide solution. Adsorption capacity determined by spectrophotometric modified method according to Mosbach / I.Mosbach, K.Smid: Arch. Biochem. Biophys. 51, 402 (1954) 7 of the lignin preparation thus prepared was 9% at pH 5.4 and 87% at pH 8.
Příklad 2 ml sulfátového výluhu o sušině 60^ s obsahom ligninuExample 2 ml of lignin-containing sulphate liquor with a dry content of 60%
FF
22,čj% /T-l3m - 54/ sa zriedilo 50 ml vody a za stálého miešania sa přidávala po kvapkách koncentrovaná kyselina sírová v takom množstve, aby sa dosiahla 10%-ná výsledná koncentrácia kyseliny Po 5 h hydrolýze reakčnej zmesi pri lOoj°C výzrážaný lignin /výťažok 4Cjí% na sušinu výluhu/ sa odfiltroval, premyl 0,01%-ným roztokom hydroxidu sodného /výťažok 3C^% na sušinu výluhu/. Adsorpčná kapacita: 59% pri pH 5,4 a 95Í% pri pH 8.22% (T-13m-54) was diluted with 50 ml of water and concentrated sulfuric acid was added dropwise with stirring to achieve a 10% final acid concentration. After 5 hours hydrolysis of the reaction mixture at 10 ° C. The precipitated lignin (4% yield on dry extract) was filtered off, washed with 0.01% sodium hydroxide solution (3% yield on dry extract yield). Adsorption capacity: 59% at pH 5.4 and 95% at pH 8.
Vynález bude mať uplatnenie pri výrobě adsorbentov židových kyselin na báze ligninu v medicíně pri liečbe hypercholesterolémie.The invention will have application in the manufacture of lignin-based Jewish acid adsorbents in the treatment of hypercholesterolemia.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS825566A CS224974B1 (en) | 1982-07-21 | 1982-07-21 | The production of adsorbents of gall acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS825566A CS224974B1 (en) | 1982-07-21 | 1982-07-21 | The production of adsorbents of gall acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS224974B1 true CS224974B1 (en) | 1984-02-13 |
Family
ID=5400804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS825566A CS224974B1 (en) | 1982-07-21 | 1982-07-21 | The production of adsorbents of gall acids |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS224974B1 (en) |
-
1982
- 1982-07-21 CS CS825566A patent/CS224974B1/en unknown
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