CS209766B1 - Dietetic preparation - Google Patents

Abstract

The invention relates to a phosphatide dietetic an agent for the prevention and treatment of arteriosclerosis, by direct oral administration, with other overall reinforcing effects, on based on natural soy lecithin and the ingredient vegetable oil. The composition of the invention contains natural soy lecithin in high concentration a the unsaponifiable fraction of vegetable oils, preferably corn germ oils. Their the mixture is prepared on a carrier from the group prepared cereals, preferably oatmeal flakes, modified soy proteins as a dried concentrate or isolate milk, either alone or in a mixture. To increase the boosting effect it can the composition comprising fortifying agents. It may also contain food flavorings or natural or synthetic aromas origin for improving organoleptic Properties. Use of the Invention is assumed in the health sector.

Description

The invention relates to a dietary composition for the prevention and treatment of arteriosclerosis, by direct oral administration with further overall enhancing effects, based on natural soy lecithin and a component of the unsaponifiable fraction of vegetable oil.

A number of so-called risk factors are known from the literature, which are substantially involved in the development and development of arteriosclerosis. One of the most important remains an excessive supply of cholesterol or a disorder of its degradation in the body. Therefore, new and new substances are being sought which would reduce the cholesterol level of the organism or prevent its deposition in the blood vessels. In recent years, so-called essential phosphatides have been used with considerable success for the prevention and treatment of arteriosclerosis, where the active ingredient is phosphatidylcholine with a high content of unsaturated fatty acids, especially linoleic acid. The mechanism of beneficial anti-sclerotic action is not fully understood, but most likely phosphatidylcholine acts as an unsaturated fatty acid donor in cholesterol esterification. Cholesterol esters with unsaturated fatty acids have no sclerosing effect because they are not deposited in the vessel walls.

Attempts are also made to utilize a mixture of a phosphatide fraction of a vegetable oil, preferably soybean, with a lecithin content of 40 to 80% by weight, a free fatty acid of 5 to 10% by weight and a component of the unsaponifiable fraction of vegetable oil, preferably corn, 10 to 100: 1, optionally with an addition of vitamins B and E of the vitamin in trace amounts, as a means for the prevention and treatment of arteriosclerosis.

This composition has been successfully tested in experimental animals for the efficacy of the components for inhibiting the formation of oholesterol arteriosclerosis. However, it has been found that the dosage form used is unacceptable for clinical work, both in the oral and in the injectable form. The reason is the physical and organoleptic properties of soya lecithin, whose characteristic flavor is furthermore negatively highlighted by the presence of unsaponifiable fraction of vegetable oil. The composition is a pasty consistency, strongly tacky that adheres when used in the oral cavity. The oily flavor causes aversion to prolonged oral administration associated with stomach and intestinal problems. For oral administration, it is therefore necessary to adapt it to a suitable ingestible form without compromising the therapeutic value of the composition.

It has now been found that these deficiencies are completely eliminated and the phosphatide composition according to the invention comprising: 30 to 60% by weight, by direct oral administration, enables the prevention and treatment of arteriosclerosis. parts of soya lecithin with a content of 60 to 70 wt. plant phosphatides, 0.6 to 3.0 wt. parts by weight of an unsaponifiable fraction of vegetable oil, preferably corn germ oil, 8 to 25 wt. parts by weight of sugars selected from the group consisting of sorbitol, glucose, sucrose, fructose, lactose, maltose, polysaeharides and mixtures thereof; parts of the carrier selected from the group consisting of treated cereals, preferably oatmeal, soy protein concentrate, soy protein isolate, milk powder and mixtures thereof, and 1.0 to 11 wt. parts of water.

In order to increase the overall therapeutic effect, the composition according to the invention may contain fortifying agents, for example 0.1 to 0.15 wt. % of pantothenate calcium and / or 0.06 to 0.15 wt. % of alpha-tocopherol and / or 0.03 to 0.06 wt. Part vitamins selected from the group consisting of B vitamins ;, _B2, Bg, B ₁₂ and mixtures thereof, and / or 0.06 to 0.15 wt. % of nicotinic acid amide. Improved organoleptic properties have a composition according to the invention comprising 0.3 to 3 wt. parts of food flavorings and / or flavorings of natural or synthetic origin.

The composition according to the invention comprises a high concentration of natural soy lecithin and an unsaponifiable fraction of vegetable oils, preferably maize germ oil, the mixture of which is prepared on a carrier from the group of treated cereals, preferably oatmeal, treated soy protein in concentrate or isolate, milk powder , either alone or in admixture. Oatmeal has a protective effect on the mucosa of the gastrointestinal tract, is well digestible, assimilatable and represents a benefit of substances with provitamin substances. Modified soy proteins are a donor of highly digestible proteins in native form with a high content of essential amino acids. Both treated cereals, especially oatmeal in the form of musilaga, and treated soy protein, whether in the form of an isolate or concentrate, and milk powder, have a high absorbency to the soy lecithin-unsaponifiable mixture of vegetable oils and form a homogeneous mass therewith. The preparation of a mixture of soy lecithin with unsaponifiable fraction of vegetable oils on said carriers or mixtures thereof, removes their oily character including tackiness, and the obtained composition has excellent organoleptic properties, exhibits perfect mouthfulness, without any indication of gummyness, stickiness or tackiness. Modified soy protein, processed cereal and milk powder, which form the carrier for the preparation of soy lecithin in the new medicament, are not merely an inert filler that removes and corrects the physical and organoleptic properties of the active ingredients of soy lecithin and unsaponifiable proportions of vegetable oil. complementing its composition with the high biological effectiveness of the new medicament.

Compared to the prior art compositions containing essential phosphatides, purified phosphatidyloholine or soya lecithin, whose antisclerotic activity is particularly apparent in the field of lowering cholesterol in the heart vessels, reducing lipoid infiltration in the kidneys and liver parenchyma, the anti-sclerotic activity in these organs and moreover, it is also applied in the aorta, where previous similar means have not demonstrated anti-sclerotic efficacy. The composition according to the invention contains protective agents against irritation of the mucosa of the digestive tract, which lacks similar preparations so far produced. When using sugars from the sorbitol family, it has special applications for diabetics. The presence of vitamin B and vitamin E contributes to increasing the overall resistance of the organism. The composition of the invention may be flavored with food flavorings and flavoring agents and formulated as tablets and granules.

Example

At 70 ° C, 40 wt. parts of natural soya lecithin containing 65% phosphatides to which 3.5 wt. % of the unsaponifiable fraction of vegetable oil. The resulting mixture was hydrated by the addition of 6.0 wt. parts of syrup containing 3.5 wt. % glucose and -2.5 wt. water. After the mixture of lecithin and the unsaponifiable portion of the vegetable oil with the syrup has been hydrated, a mixture containing 16.5 wt. % glucose and 34.0 wt. parts of crushed oatmeal. After complete homogenization, the resulting mixture was cooled to 20 ° C. Subsequent grinding and granulation brought the composition to its final form.

Example 2

In a tempered homogenizer, 45 wt. parts of natural soy lecithin containing 70% phosphatides to which 4.5 wt. % of the unsaponifiable fraction of vegetable oil. The resulting mixture was hydrated by the addition of 8.0 wt. parts of syrup containing 5.5 wt. % sucrose and 2.5 wt. water. After hydrating the mixture of lecithin and the unsaponifiable portion of vegetable oil with syrup, 0.1 wt. % of alpha-tocopherol, 0.15 wt. % of pantothenate calcium and 0.05 wt. While stirring, a mixture containing 13.0 wt.% of the Bp, Bg, Bg, Bg. parts of glucose and 29.2 wt. of crushed oatmeal. After complete homogenization, the resulting mixture was cooled to 20 ° C. Subsequent grinding and tabletting brought the composition to its final form.

Example 3

35.0 wt.% Were dissolved in the tempered homogenizer at 70 ° C. parts of natural soy lecithin containing 68% phosphatides to which 0.4 wt. % of the unsaponifiable fraction of vegetable oil. The resulting mixture was hydrated by adding 7.0 wt.

parts of syrup containing 5.0 wt. parts of maltose and 2.0 wt. parts of water. After the hydrate mixture of lecithin and the unsaponifiable portion of vegetable oil with syrup, 2.0 wt. parts of ground anise and 0.2 wt. part of the coconut aroma. While stirring, a mixture of 10.0 wt. parts by weight of glucose, 5.0 wt. parts of lactose and 40.4 wt. of crushed oat flakes. After complete homogenization, the resulting mixture was cooled to 20 ° C. After subsequent grinding and tabletting, the formulation was coated with a protective coating to the final mold.

Example 4

Following the procedure of Examples 2 and 3, a composition was prepared which contained

300.0 g of soya lecithin, containing 65 wt. plant phosphatides,

30,0 g of unsaponifiable fraction of maize germ oil,

229.9 g of glucose and sucrose in a weight ratio of 1: 1,

0,6 g alpha-tocopherol,

0.3 g of vitamins B ₁ , Bg, B _g , B ₁₂ ,

1,2 g calcium panthothenate,

5.0 g of synthetic coconut aroma,

220.0 g oatmeal with an average content of 12% by weight water,

200.0 g soya protein concentrate with an average content of 12% by weight water and 13.0 g of additional water

The composition was biologically active, with therapeutic effects against arteriosclerosis, fortified with vitamins, enriched with essential amino acids. It is characterized by a high nutritional value compared to the prior art. It can be used for all ages.

Example5

Following the procedure of Examples 2 and 3, a composition was prepared which contained

400.0 g soya lecithin containing 60% by weight plant phosphatides,

20,0 g of unsaponifiable fraction of maize germ oil,

193.0 g glucose,

1.0 g alpha-tocopherol

0.4 g vitamin B _1, BG, B _G, B ^, ·

1,2 g calcium panthothenate,

0,1 g of synthetic menthol aroma,

7.0 g ground coconut,

330.0 g oatmeal with an average content of 12% by weight water and

43.7 g of additional water.

The composition was biologically active, with therapeutic effects against arteriosclerosis, fortified with vitamins, with a natural flavoring. It is characterized by a high protective effect against irritation of the mucosa of the digestive tract over the prior art.

Example 6

Following the procedure of Examples 2 and 3, the composition was prepared

500.0 g of soya lecithin containing 70 wt. plant phosphatides,

15,0 g of unsaponifiable fraction of maize germ oil,

80,0 g sorbitol,

1.1 g alpha-tocopherol,

0.5 g vitamin Bg Bp, B _G, B ^,

1,4 g nicotinic acid amide,

20976b

10.0 g of synthetic coffee aroma,

375.0 g of soy protein isolate with an average content of 12 wt. water and 17.0 g of additional water.

The composition was highly biologically effective, with preventive therapeutic effects against arteriosclerosis, fortified with a high dose of vitamins, flavored, enriched with essential amino acids. It is characterized by high nutritional value and increased assimilatability compared to the existing means. It is especially suitable for diabetics.

Example 7

Following the procedure of Examples 2 and 3, a composition was prepared which contained

550.0 g of soya lecithin containing 65 wt. plant phosphatides,

6.0 g of unsaponifiable fraction of maize germ oil,

140.0 g of glucose and maltose in a weight ratio of 1: 1,

1.4 g alpha-tocopherol,

0.6 g of vitamins B ₁ , Bg, Bg, B, g,

1.5 g calcium panthothenate,

20,0 g of cocoa powder,

144.0 g of soy protein concentrate with an average content of 12 wt. water,

100.0 g of milk powder with an average content of 12% by weight water and

36.5 g of additional water.

The preparation was highly biologically active, with preventive therapeutic effects against arteriosclerosis, fortified with a high dose of vitamins, with a natural flavoring and the presence of essential amino acids. It significantly supports metabolism in the body with regard to the high content of necessary amino acids in comparison with previous preparations. It is suitable for all ages.

Example 8

Following the procedure of Examples 2 and 3, a composition was prepared which contained

400.0 g of soya lecithin with a content of 65 wt. grew, phosphatides,

16.0 g saponification of soya oil,

200.0 g lactose,

1.4 g alpha-tocopherol,

0.6 g of vitamins Bp Bg, Bg, B ₁₂ ,

1.5 g of calcium panthothenate,

15,0 g natural ground anise,

134.0 g oatmeal with an average content of 12 wt. water and

31.5 g of additional water.

The composition was highly biologically active, with preventive effects against arteriosclerosis, fortified with a high dose of vitamins, flavored. It is characterized by high efficiency against irritation of the mucosa of the digestive tract.

Example 9

Following the procedure of Example 1, a composition was prepared which contained

400.0 g of soya lecithin with a content of 65 wt. plant phosphatides,

12,0 g of unsaponifiable fraction of maize germ oil,

215,0 g sucrose,

348.0 g oatmeal with an average content of 12% by weight water and 25.0 g of additional water.

The composition was biologically active, with preventive therapeutic effects against arteriosclerosis, without vitamins and without aromatization. It is characterized by high assimilation. Its composition is mainly intended for dietetic purposes. It is suitable for all ages.

Example 10

Following the procedure of Example 2, a composition was prepared which contained

450.0 g soya lecithin containing 65% by weight plant phosphatides,

9.0 g of unsaponifiable fraction of maize germ oil,

205.0 g of lactose and maltose in a weight ratio of 1: 1,

1.0 g alpha-tocopherol

0.5 g of vitamins B, Bg, Bg, B ₁₂ ,

1,5 g nicotinic acid amide,

308.0 g oatmeal with an average content of 12% by weight water and 25.0 g of additional water.

The composition was biologically active, with preventive therapeutic effects against arteriosclerosis, fortified with vitamins, without aromatization. It has a high protective effect against irritation of the intestinal tract mucosa. It is suitable for all ages.

Example 11

Following the procedure of Example 3, a composition was prepared which contained

350.0 g soya lecithin containing 65% by weight plant phosphatides,

20,0 g of unsaponifiable fraction of maize germ oil,

200.0 g glucose,

2.0 g of synthetic vanillin aroma,

20,0 g of cocoa powder,

208.0 g oatmeal with an average content of 12% by weight water,

180.0 g of milk powder with an average content of 12% by weight water and 20.0 g of additional water.

The preparation was biologically active, with therapeutic effects against arteriosclerosis, without vitamins, flavored. It is characterized by significantly improved organoleptic properties and high biological and nutritional value.

Claims (3)

SUBJECT OF THE INVENTION Dietary composition based on natural soya lecithin and a component of the unsaponifiable fraction of vegetable oil, characterized in that it comprises: 30 to 60 wt. parts sol 0.6 to 3.0 wt. parts 8.0 to 25 wt. parts 15 Dec to 45 wt. parts 1.0 to 11 wt. parts The composition is selected from the group consisting of sorbitol, glucose, sucrose, fructose, lactose, maltose, polysaccharides, and mixtures thereof, a carrier selected from the group consisting of sorbitol, glucose, sucrose, fructose, lactose, maltose, polysaccharides and mixtures thereof. a group consisting of treated cereals, preferably oatmeal, soy protein concentrate, soy protein isolate, milk powder and mixtures thereof and water. 2. The dietetic composition of claim 1, wherein said diet contains fortification fliers 0.1 % to 0.15 wt. part 0.06 % to 0.15 wt. part 0.03 to 0.06 wt. part 0.06 % to 0.15 wt. part calcium panthothenate and / or alpha-tocopherol and / or vitamins selected from the group consisting of vitamins B1, Bg, Bg, B. | g and mixtures thereof and / or nicotinic amide. 3. Dietary composition according to claim 1 or 2, characterized in that it contains 0.3 to 3 wt. parts of food flavorings and / or flavorings of natural or synthetic origin.