CS209390B1 - Agent for prevention against caries of a tooth and for medical treatment of microbial inflammation of oral cavity and paradental processes - Google Patents
Agent for prevention against caries of a tooth and for medical treatment of microbial inflammation of oral cavity and paradental processes Download PDFInfo
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- CS209390B1 CS209390B1 CS168380A CS168380A CS209390B1 CS 209390 B1 CS209390 B1 CS 209390B1 CS 168380 A CS168380 A CS 168380A CS 168380 A CS168380 A CS 168380A CS 209390 B1 CS209390 B1 CS 209390B1
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- 208000002925 dental caries Diseases 0.000 title claims description 14
- 230000004054 inflammatory process Effects 0.000 title claims description 8
- 230000000813 microbial effect Effects 0.000 title claims description 6
- 206010061218 Inflammation Diseases 0.000 title claims description 5
- 230000002265 prevention Effects 0.000 title claims description 4
- 238000000034 method Methods 0.000 title description 7
- 210000000214 mouth Anatomy 0.000 title description 4
- 230000003239 periodontal effect Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 3
- KPZGRMZPZLOPBS-UHFFFAOYSA-N 1,3-dichloro-2,2-bis(chloromethyl)propane Chemical group ClCC(CCl)(CCl)CCl KPZGRMZPZLOPBS-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 25
- 210000003298 dental enamel Anatomy 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 210000002200 mouth mucosa Anatomy 0.000 description 5
- 244000005706 microflora Species 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000001603 reducing effect Effects 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- GBVKIUSFVYOQEA-UHFFFAOYSA-N 2-[3-[bis(2-hydroxyethyl)amino]propyl-octadecylamino]ethanol;hexadecan-1-amine;dihydrofluoride Chemical compound F.F.CCCCCCCCCCCCCCCCN.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO GBVKIUSFVYOQEA-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229910021607 Silver chloride Inorganic materials 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010028116 Mucosal inflammation Diseases 0.000 description 2
- 208000005888 Periodontal Pocket Diseases 0.000 description 2
- 241000241413 Propolis Species 0.000 description 2
- -1 alcohol sugars Chemical class 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002222 fluorine compounds Chemical class 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 229940069949 propolis Drugs 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000004125 X-ray microanalysis Methods 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 150000001312 aldohexoses Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- VLQATFWRXJHWJB-UHFFFAOYSA-N azane tetrahydrochloride Chemical compound N.N.Cl.Cl.Cl.Cl VLQATFWRXJHWJB-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 230000001925 catabolic effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002574 ketohexoses Chemical group 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000005049 silicon tetrachloride Substances 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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- Cosmetics (AREA)
Description
(54) Prostriedok na prevenciu proti zubnému kazu a na liečenie mikrobiálneho zápalu tkaniva ústnej dutiny a parodontálnych chobotov(54) Means for the prevention of dental caries and for the treatment of microbial inflammation of oral tissue and periodontal trunks
Vynález sa týká prostriedku na zníženie kazivosti zubov a terapie zápalových procesov slizníc ústnej dutiny a parodontálnych chobotov v stomatologii.BACKGROUND OF THE INVENTION The present invention relates to a composition for reducing tooth decay and therapy for inflammatory processes of the oral mucosa and periodontal trunk in dentistry.
V súčasnej době převláda názor, že jeden z hlavných faktorov kariogenicity je katabolizmus a anabolizmus spósobený mikrobiálnou flórou plaku. Pri katabolickom štiepení glycidov (najma mono a oligosacharidov) dochádza k tvorbě kyslých produktov, ktoré zapríčiňujú demineralizáciu zub-, nej skloviny a tým vznik zubného kazu. Glycidovým anabolizmom dochádza k syntéze jednak intracelulámych polysacharidov a extracelulárnych polysacharidov, ktoré majú funkciu tmelovej substancie plaku. (Z. Broukal, Zubní mikrobiální povlak a jeho význam v etiologii zubního kazu a parodontopatii, Praktické zubní lékařství 20, 1977). Anaeróbna mikroflóra je silné zastúpená pri zápalovom procese slizníc ústnej dutiny a parodontálnych chobotov. V súčasnosti sa v stomatologii používá celý rad preventivných prostriedkov a metod majúcich zabránit’ vniku zubného kazu a liečiť zápal slizníc a parodontálnych chobotov, avšak nie s uspokojivým výsledkom. Zníženie kazivosti zubov možno dosiahnuť změnou režimu výživy, najma záměnou sacharózy, aldohexóz a ketohexóz alkoholickými cukrami, napr. sólfitolom, manitolom, xylitom a inými cukrami tohto druhu. ,Currently, it is believed that one of the major factors of cariogenicity is catabolism and anabolism caused by the microbial flora of plaque. Catabolic cleavage of carbohydrates (especially mono and oligosaccharides) leads to the formation of acidic products, which cause the dental enamel to demineralize and thus cause tooth decay. Glycide anabolism leads to the synthesis of both intracellular polysaccharides and extracellular polysaccharides, which have the function of a putty substance of plaque. (Z. Broukal, Dental microbial coating and its importance in the etiology of dental caries and periodontopathy, Praktické zubní lékařství 20, 1977). Anaerobic microflora is strongly involved in the inflammatory process of oral mucosa and periodontal trunks. A number of preventive measures and methods are currently used in dentistry to prevent caries and treat mucosal inflammation and periodontitis, but not with satisfactory results. Reducing tooth decay can be achieved by changing the nutritional regimen, in particular by substituting sucrose, aldohexoses, and ketohexoses with alcohol sugars, e.g. solphithol, mannitol, xylitol and other sugars of this kind. .
Na zabránenie kazivosti zubov sa používajú tiež rožne druhy lakov, tzv. pečatenie zubov (fizúr). Nevýhodou tohto spósobu je velká pracnost. Medzi najrozšírenejšie preventivné prostriedky a metody v súčasnosti používané proti vzniku zubného kazu sú rózne spósoby fluorizácie pitnej vody, kuchynskej soli, mlieka a pod. Vykonává sa to fluorom a jeho zlúčeninami, výplachom ústnej dutiny 1 %-ným roztokom fluoridu sodného, připadne nanesením róznych prípravkov obsahujúdch zlúčeniny fluóru priamo na zubnú sklovinu (Elmex — fluid, Elmex — gelée). Taktiež sa vyrába široká škála zubných pást s obsahom fluórových zlúčenín (Fluora, Elmex a i.). Na prevendu proti zubnému kazu u dětí sa podávajú tablety fluoridu sodného (Natrium fluoratum).Various types of lacquers are also used to prevent tooth decay. sealing of teeth. The disadvantage of this method is the great laboriousness. Among the most widespread preventive agents and methods currently used against tooth decay are various ways of fluorinating drinking water, table salt, milk and the like. This is done by fluorine and its compounds, rinsing the oral cavity with a 1% sodium fluoride solution, optionally by applying different preparations containing fluorine compounds directly to the enamel (Elmex fluid, Elmex gel). A wide range of toothpastes containing fluorine compounds (Fluora, Elmex, etc.) is also produced. Sodium fluoride (Natrium fluoratum) tablets are used to prevent tooth decay in children.
Súčasný stav liečenia zápalu slizníc ústnej dutiny a parodontálnych chobotov, ktorý je spósobený najma anaeróbnou mikroflórou, sa robí róznymi dezinfekčnými prostriedkami — propolisom (L. Adaměík et al., Naše výsledky léčby stómátitis aphtosa lihovým extraktem propolisu, Praktické zubní lékařství, 23,1979), preparátmi, ktoré obsahujú rastlinné trieslivá, koncentrát E-vitamínu : a pod. Převážná váčšina dezinfekčných prostriedkov má však kontanainujúce účinky na tkanivá ústnej dutiny a krátkodobý účinok.The current state of treatment of inflammation of the oral mucosa and periodontal trunks, which is mainly caused by anaerobic microflora, is done by various disinfectants - propolis (L. Adaměík et al., Our Results of Treatment of Stomatitis aphtosa with Propolis Alcohol Extract, Practical Dentistry79, 23,19) , preparations containing vegetable tanning, E-vitamin concentrate : and the like. However, the vast majority of disinfectants have contaminating effects on oral tissues and short-term effects.
Vyššie uvedené nedostatky sú odstránené pro209390 striedkom podlá vynálezu ako 10-4 až 10-2 hmot; %-ný roztok štvorboritanu diamostriebomého vo formě vodného-alebo 15 až 40 %-ného vodnoetanolického roztoku, jeho použitím na zubnú sklovinu, zapálenú sliznicu ústnej dutiny a parodontálne choboty. V uvedenom rozsahu koncentrácii nie je vodný alebo vodnoetanolický roztok štvorboritanu diamostriebomého toxický a nekontaminuje tkanivá ústnej dutiny. Štvorboritan diamostrieborný sa adsorbuje na plaka na zubnú sklovinu. Tým sa znižuje virulencia mikroorganizmov v plaku, znižuje sa ich rozmnožovanie, čím sa potenciálně znižuje tvorba kyslých kariogénnych produktov. Menovanýmprocesom je daná možnosťpreventívneho znižovania kazivosti zubov a zápalových v procesov sližníc ústnej dutiny a parodontálnych chobotov, Pri přípravě štvorboritanu diamostrieborného (3 až 5 hmot. %-ného roztoku) sa vychádza zo štvorboritanu dvojstriebomého, ktorý je biela kryštalieká látka, vo vodě slabo rozpustná, rozpustná v kyselinách (R. C. Weast, Handbook of Chemistry and Physics, Cleveland 1969).The aforementioned drawbacks are overcome for 209390 by the composition of the invention as 10 -4 to 10 -2 masses; % diammonium borohydride solution in the form of an aqueous or 15 to 40% aqueous ethanolic solution, applied to enamel, inflamed oral mucosa and periodontal trunk. Within the stated concentration range, the aqueous or aqueous ethanolic diammonium borohydride solution is not toxic and does not contaminate oral tissues. The diammonium borohydride is adsorbed to the enamel plaque. This reduces the virulence of the microorganisms in the plaque, reduces their reproduction, potentially reducing the formation of acidic cariogenic products. Said process is given the possibility to prevent tooth decay and inflammatory decay in the processes of mucous membranes of the oral cavity and periodontal pockets. The preparation of diammonium borohydride (3 to 5% by weight solution) starts from two-silicon tetrachloride, which is a white crystalline substance. Acid Soluble (RC Weast, Handbook of Chemistry and Physics, Cleveland 1969).
Příklad 1.Example 1.
407,01 g štvorboritanu dvojstriebomého Ag2[B2O5(OH)4] (1 mol) sa za stálého miešania rozpustí pri červénom svetle (o vlnovej dížke nad i 750 nm) v 560,736 g 25 %-ného roztoku NH4OH( (4 moly), pretože vzniknutá komplexně zlúčenina štvorboritanu diamostriebomého je pri svetle o vlnoVej dížke od 200 nm do 750 nm nestála a rozkládá sa. Získaný roztok štvorboritanu diamostrieborného sa zriedi 8973,7 ml destilovanej vody na koncentráciu 5 hmot. %-nú.407.01 g of two-silver Ag 2 [B 2 O 5 (OH) 4 ] quatroborate (1 mol) are dissolved under red light (wavelength above 750 nm) in 560.736 g of a 25% NH 4 OH solution under stirring. ((4 moles)), as the resulting diammonium borohydride compound is unstable and decomposes under light at 200 nm to 750 nm, and the diammonium borohydride solution obtained is diluted with 8973.7 ml of distilled water to a concentration of 5% by weight.
Analýza:analysis:
ml roztoku štvorboritanu diamostriebomého sa zriedilo 200 ml destilovanej vody a mieme okyslilo kys. dusičnou. Získaný roztok sa zahrial temer k varu a za stájeho miešania sa přidávala it 5 %-ná kys. chlorovodíková takdlho, až sa dalším přidáváním kyseliny přestane tvoriť zrazeniná AgCl. Roztok so zrazeninou sa nechal na tmavom mieste vychladnúť. Zrazenina sa odfiltrovala cez filtračný téglik a premývala destilovanou vodou slabo okyslenou kys. dusičnou, až už filtrát nerea- . guje s roztokom dusičňanu striebomého na chloridy. Nakoniec sa zrazenina chloridu striebomého v tégliku ešte premyla čistou destilovanou vodou a vysušila pri 130 °G do konštantnej váhy. Priemer z tr^ch stanovení Ag vo formě AgCl = 3,5780 g, čo prakticky odpovedá teoretickému obsahu Ag v 5ihmot. %-nom roztoku štvorboritanu diamostríébómého.ml of diammonium borohydride solution was diluted with 200 ml of distilled water and slightly acidified with acid. nitric acid. The solution was heated to almost reflux and stirred for Cattle were added thereto and t 5% strength acid. hydrochloric acid until precipitate of AgCl ceased to form by further addition of acid. The precipitate solution was allowed to cool in the dark. The precipitate was filtered through a filter crucible and washed with distilled water with slightly acidified acid. nitrate until the filtrate no longer reacted. It works with a solution of silver nitrate to chloride. Finally, the silver chloride precipitate in the crucible was still washed with pure distilled water and dried at 130 ° C to constant weight. The average of the three Ag assays in the form of AgCl = 3.5780 g, which practically corresponds to the theoretical content of Ag in 5 mass. % diammonium borohydride solution.
Fyxikálno-chemické vlastnosti:Phyxical-chemical properties:
! j hmot. %-ný roztok štvorboritanu diamostrieb^rného je bezfarebná číra kvapalina, citlivá na Světlo vlnovej dížky od 200 nm do 750 nm, pričom sarqzkladá za vzniku tmavých kovových povlakov. Dáíej sa redukuje niektorými kovmi (Cu, Zn a i.), organickými a anorganickými zlúčeninami majúcimi redukčně vlastnosti až na kovové striebro. Roztok je stály pri vylúčení světla o vlnovej dížke od 200 nm do 750 nm a teplote od 0 °C do 20 °C.! j wt. The diammonium borohydride solution is a colorless clear liquid, light sensitive to wavelengths of from 200 nm to 750 nm, and is formed to form dark metal coatings. Further, it is reduced by some metals (Cu, Zn, etc.), organic and inorganic compounds having reducing properties down to metallic silver. The solution is stable to the exclusion of light having a wavelength of from 200 nm to 750 nm and a temperature of from 0 ° C to 20 ° C.
Spósob prípravy aplikačných roztokov štvorboritanu diamostriebomého a ich použitie:Method of preparation of diammonium borohydride application solutions and their use:
Příklad 2.Example 2.
Vodný roztok štvorboritanu diamostriebomého O koncentrácii 0,01 hmot. %-nej na prevenciu proti vzniku zubného kazu sa připraví zriedením 100 ml roztoku (5 hmot. %) štvorboritanu diafhostriebomého připraveného podlá příkladu (1) 49 900 ml destilovanou vodou. Prevencia sa vykoná výplachom ústnej dutiny alebo natieraním zubnej skloviny 0,01 hmot. %-ným vodným roztokom štvorboritanu diamostriebomého po dobu 60 sekúnd.An aqueous solution of diammonium borohydride at a concentration of 0.01 wt. % to prevent tooth decay is prepared by diluting 100 ml (5% by weight) of the diaphosphite borohydride prepared according to Example (1) with 49,900 ml of distilled water. Prevention is done by rinsing the oral cavity or by brushing the dental enamel with 0.01 wt. % aqueous diammonium borohydride solution for 60 seconds.
Příklad 3.Example 3.
%-ný vodnoetanolický roztok štvorboritanu diamostriebomého o koncentrácii 0,02 hmot. % na liečenie mikrobiálneho zápalu tkaniv ústnej dutiny a parodontálnych chobotov sa připraví zriedením 200 ml 5 hmot. %-ného roztoku štvorboritanu diamostriebomého připraveného podfa příkladu (1) 49 800 ml destilovanou vodou. Terapia zápalistých procesov slizníc ústnej dutiny sa vykoná přiložením tampónov napuštěných 0,02 hmot. %-ným roztokom štvorboritanu diamostriebomého v 40 %-nom etanole na zapáleně sliznice alebo zavedením drenáží do chobotov parodontu taktiež napuštěných 0,02 hmot. %-ným roztokom štvorboritanu diamostriebomého v 40 %-nom etanole. Doba póspbenia je v oboch prípadoch 5 minút.0.02 wt.% aqueous diametrachium quinoborate borohydride solution; % for the treatment of microbial inflammation of oral tissues and periodontal trunks is prepared by diluting 200 ml of 5 wt. % of a di-ammonium borohydride solution prepared according to example (1) with 49,800 ml of distilled water. Therapy of the inflammatory processes of the oral mucous membranes is carried out by applying swabs impregnated with 0.02 masses. 0.04 wt. % diammonium borohydride solution in 40% ethanol. In both cases, the time of caution is 5 minutes.
Adsorpcia štvorboritanu diamostriebomého na plak zubov a povrch zubnej skloviny bola zistenái1 stanovením Ag RTG mikroanalýzou aspektroche-1 micky.Adsorption štvorboritanu diamostriebomého the plaque and tooth surface enamel was zistenái 1 determining Ag X-ray microanalysis aspektroche- 1 ball.
Toxicita aplikačného 10-4 až 10-2 hmot. %-ného vodného roztoku štvorboritanu diamostrieborného bola testovaná na pokusných imyšiach intravenózne a perorálne (1 ml aplikačného roztoku na 20 g živej váhy), pričom sa zistilo, že látka nepósobí toxicky.Toxicity of application 10 -4 to 10 -2 wt. % aqueous diammonium borohydride solution was tested intravenously and orally (1 ml of application solution per 20 g body weight) on the test mice, and found to be non-toxic.
Baktericídnosť aplikačného roztoku štvorboritanu diamostriebomého (10~4 až 10-2 hmot. %) vo formě 15 %-ného vodnoetanolického roztoku bola, testovaná na aeróbnu a anaeróbnu mikroflóru ústnej dutiny, ktorej kyslé produkty spósobujú kazivosť zubov, zápal slizníc a parodontálnych chobotov, pričom sa zistilo, že k zhynutiu mikroflófy dochádza za 30 sekúnd, bez toho, že by nastala kontaminácia slizníc ústnej dutiny.The bactericidal application of diammonium tetrachloride borohydride solution (10 -4 to 10 -2 wt%) in the form of a 15% aqueous ethanolic solution has been tested for aerobic and anaerobic oral microflora whose acidic products cause tooth decay, mucosal inflammation and periodontal pockets. Microflora death was found to occur in 30 seconds without contamination of the oral mucosa.
Stabilita 3 až 5 hmot. %-ného roztoku štvorboritanu diamostriebomého, z ktorého sa pripravujú aplikačně roztoky sa kontrolovala stanovením Ag gravimetricky v jednomesáíýných intervaloch po dobu 2 rokov, pričom sa jeho 3 až 5 hmot. %-ná koncentrácia prakticky nezměnila.Stability of 3 to 5 wt. % of the di-ammonium borohydride solution from which the application solutions are prepared was checked by Ag determination gravimetrically at one-month intervals for 2 years, with its 3 to 5 wt. The% concentration practically did not change.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS168380A CS209390B1 (en) | 1980-03-12 | 1980-03-12 | Agent for prevention against caries of a tooth and for medical treatment of microbial inflammation of oral cavity and paradental processes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS168380A CS209390B1 (en) | 1980-03-12 | 1980-03-12 | Agent for prevention against caries of a tooth and for medical treatment of microbial inflammation of oral cavity and paradental processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS209390B1 true CS209390B1 (en) | 1981-11-30 |
Family
ID=5351808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS168380A CS209390B1 (en) | 1980-03-12 | 1980-03-12 | Agent for prevention against caries of a tooth and for medical treatment of microbial inflammation of oral cavity and paradental processes |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS209390B1 (en) |
-
1980
- 1980-03-12 CS CS168380A patent/CS209390B1/en unknown
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