CS212431B1 - Means for prevention the tooth damage and for healing the microbial inflammation of the mouth cavity and parodental trunks - Google Patents

Description

The present invention relates to a composition for reducing tooth decay and therapy for inflammatory processes of oral mucosa and periodontal trunks in dentistry.

Currently, it is believed that one of the major factors of cariogenicity is catabolism and anabolism due to plaque microbial flora. Catabolic cleavage of carbohydrates (especially mono- and oligosaccharides) leads to the formation of acidic products which cause dental enamel demineralization and thus tooth decay.

Glycide anabolism leads to the synthesis of both intracellular polysaccharides and extracellular polysaccharides, which act as putty plaque substance (Z. Broukal, Dental microbial coating and its importance in dental caries etiology and paradontopathy. Practical dentistry δ, 20, December 1977). Anaerobic microflora is strongly represented in the inflammatory process of oral mucous membranes and periodontal pockets. A number of preventive means and methods are currently used in dentistry to prevent caries and treat periodontal pockets inflammation, but not with a satisfactorily expected result.

Reducing tooth decay can be achieved by altering the nutritional regimen, in particular by substituting sucrose, eldohexoses, and ketohexoses with alcohol sugars, e.g. solfitol, mannitol, xylito and other sugars of this kind.

Various types of lacquers are also used to prevent tooth decay. sealing of teeth. The disadvantage of this method is the great laboriousness. Among the most widespread preventive agents and methods currently used against tooth decay are various ways of fluoridation of drinking water, table salt, milk β under.

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This is done by fluorine and its compounds, by rinsing the oral cavity with a 1% sodium fluoride solution, optionally by applying different preparations containing fluorine compounds directly to the enamel (Elmex-fluid, Elmex-gel). A wide range of toothpastes containing fluorine compounds (Fluore, Elmex, etc.) is also produced.

Sodium fluoride (Natrium fluoratum) tablets are used to prevent tooth decay in children.

The current state of treatment of inflammation of the oral mucosa and periodontal trunks, which is caused mainly by anaerobic microflora, is done by cutting disinfectants - propolis (L. Adamčík et al. Our results of treatment of stomatitis aphtosa with propolis alcohol extract, Practical Dentistry, No. 23, 1977 ), preparations containing vegetable tanning, E-vitamin concentrate and the like. However, the vast majority of disinfectants have contaminating effects on oral tissues and short-term effects.

The above-mentioned drawbacks are eliminated according to the invention by using a solution of tri-silver tri-borate of 10 ^-4 to 10 ^-2 % in the form of an aqueous or up to 40% aqueous ethanol solution for dental enamel, inflamed oral mucosa and paradoxical trunk.

At the indicated concentration, the ethanolic solution of tridiammonium borohydride is not toxic and does not contaminate oral tissues. Tri-silver tri-borate is adsorbed to the protein components of the plaque, reducing the virulence of the microorganisms in the plaque, reducing their reproduction, potentially reducing the formation of acid products of a cariogenic nature. Said process is given the possibility of preventive reduction of tooth decay and inflammatory processes of oral mucosa and periodontal trunks.

An example of the production of a solution of tri-tri-boron trifluoride, its physico-chemical properties and its application in the therapy of inflammatory processes of oral tissues, trunks of the paradontium and in the prevention of dental caries:

Example 1 (Stable solution)

To 1 liter of a 0.3 molar disodium borohydride solution of Na ₂ B 3 O 3 (OH) 2 is added 1 liter of a 0.6 molar sodium hydroxide solution. The resulting trisodium borohydride solution (Na 2 B ₂ O 3. 12H ₂ O) was separated from the excess alkali by filtration and washing with acetone and then dissolved in 1 liter of distilled water.

To this solution was added 1.2 moles of silver nitrate (AgNO3) dissolved in 1 liter of distilled water. The precipitate of tri-silver boronate precipitated is decanted with distilled water, filtered off and dissolved in 2,399 mol of 20% ammonium hydroxide on the filter.

The resulting tri-ammonium trisammonium borohydride solution was diluted with 10.455 L of distilled water to give a 5% solution that was stable. Since the complex compound of tri-boron tri-borate is sensitive to light with a wavelength from 200 nm to 750 nm, and is reduced, it is necessary to work! in red light.

Analysis of the ml solution was diluted to 200 ml with distilled water, the obtained solution was precipitated with 5% hydrochloric acid, the silver chloride precipitate was washed with distilled water, filtered and weighed after drying. The average of three AgCl determinations = 0.0792 g, which corresponds to the theoretical silver content in a 5% tridiammonium silver borate solution.

Physico-chemical properties

A 5% tri-ammonium silver borate tri-boron solution, a brownish brown liquid, with a wavelength of from 200 nm to 750 nm, decomposes to form metal-enamel coatings. Treatment with the reducing compounds results in the elimination of AggO.

Method of production of tridiammonium silverborate application solutions:

Example 2 (Aqueous Solution Concentration 0.01% To Prevent Tooth Decay)

Dilute 100 ml of the solution prepared according to Example 1 with 4,900 ml of distilled water.

Example 3 (40% aqueous ethanolic solution concentration of 0.02%, for the treatment of microbial inflammations of oral tissues and periodontal trunks)

200 ml of the solution prepared according to Example 1 are diluted with 4800 ml of 40% aqueous ethanol.

Example 4 (Prevention of dental caries is performed by rinsing the oral cavity, or by brushing the enamel with a 0.01% solution of aqueous tridiammonium borate for 60 seconds.)

Example 5 (Therapy of inflammatory processes of oral mucous membranes and periodontal trunks.)

This is done by applying a swab impregnated with a 0.02% tridiammonium trisborate solution, prepared by diluting 200 ml of a 4,800 ml solution with 40% aqueous ethanol, to the ignited mucous membranes, or by introducing drainage into the periodontal trunks impregnated with a 0.02% solution. The exposure time is 5 minutes in both cases.

The adsorption of tri-silver tri-borate to the plaque of the teeth and the enamel surface was altered by determining the silver content by X-ray microanalysis and spectrochemically. Increased silver contents in dental enamel were also found after washing the dental enamel in a stream of running water for 30 minutes without contaminating the oral cavity tissues.

Toxic safety was tested by administering 1 ml of a 1% aqueous solution of trisammonium borohydride in aqueous solution to 1 mouse of 20 g average weight, intravenously in 10 test mice, none of which died, and orally in 15 test mice, and no one died. .

The bactericidal effect has been demonstrated on a wide range of anaerobic and aerobic plaque bacteria by the application of a 10 to 10 ^-2 % tridiammonium trisborate solution in the form of an aqueous or 40% aqueous ethanol solution. The death of the bacteria occurred in 30 to 60 seconds without contamination of the oral tissues.

The stability of the 5% tridiammonium borohydride, from which the application solutions are prepared, was checked at one-month intervals for 2 years, and its concentration remained virtually unchanged.

Claims (1)

SUBJECT INVENTION A composition for preventing oral cavity and periodontal caries in a form comprising, as an active ingredient, and for the treatment of microbial tissue inflammation of an aqueous or aqueous ethanolic solution, a tri-borate tri-ammonium silver of the formula H-IM-Ag-C-H t / \ S ₃ at 10 '^ 10 to ² wt. %. Severografia. n. p., plant 7, Most