CR8771A - INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1 - Google Patents

INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1

Info

Publication number
CR8771A
CR8771A CR8771A CR8771A CR8771A CR 8771 A CR8771 A CR 8771A CR 8771 A CR8771 A CR 8771A CR 8771 A CR8771 A CR 8771A CR 8771 A CR8771 A CR 8771A
Authority
CR
Costa Rica
Prior art keywords
hydroxi
beta
inhibitor
dehydrogenase type
steroid dehydrogenase
Prior art date
Application number
CR8771A
Other languages
Spanish (es)
Inventor
Henriksson Martin
Homan Evert
Johansson Lars
Vallgarda Jerk
Williams Meredith
Bercot Eric
H Fotsch Christopher
Li Aiwen
Cai Guolin
Hungate Randal
Chenguang Yuan Chester
Tegley Christopher
St Jean David
Han Nianhe
Huang Qi
Liu Qingyian
D Bartberger Michael
A Moniz George
J Frizzle Matthew
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0401324A external-priority patent/SE0401324D0/en
Priority claimed from SE0402509A external-priority patent/SE0402509D0/en
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CR8771A publication Critical patent/CR8771A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a compuestos con la formula (I), ( II ), ( III ) o ( IV), en los cuales R1,R2,R3,R4,R5,R6,R7, X y Z son como se define aqui y ademas a composiciones farmaceuticas que comprenden los compuestos, como tambien metodos de uso de los compuestos para el tratamiento de transtornos asociados con la enzima deshidrogenasa 11-B- hidroxiesteroide tipo 1 y para la preparacion de un medicamento que actua sobre la enzima deshidrogenasa 11-b- hidroxiesteroide tipo 1 humana.The present invention relates to compounds with the formula (I), (II), (III) or (IV), in which R1, R2, R3, R4, R5, R6, R7, X and Z are as defined here and in addition to pharmaceutical compositions comprising the compounds, as well as methods of using the compounds for the treatment of disorders associated with the enzyme dehydrogenase 11-B-hydroxysteroid type 1 and for the preparation of a medicament acting on the enzyme dehydrogenase 11 -b- human type 1 hydroxysteroid.

CR8771A 2004-05-24 2006-11-24 INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1 CR8771A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0401324A SE0401324D0 (en) 2004-05-24 2004-05-24 New compounds
SE0402509A SE0402509D0 (en) 2004-10-15 2004-10-15 New compounds
US65077705P 2005-01-31 2005-01-31

Publications (1)

Publication Number Publication Date
CR8771A true CR8771A (en) 2007-07-24

Family

ID=41717469

Family Applications (2)

Application Number Title Priority Date Filing Date
CR8771A CR8771A (en) 2004-05-24 2006-11-24 INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1
CR20120420A CR20120420A (en) 2004-05-24 2012-08-10 INHIBITOR OF 11-BETA-HYDROXI EXTEROID DEHYDROGENASE TYPE 1

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20120420A CR20120420A (en) 2004-05-24 2012-08-10 INHIBITOR OF 11-BETA-HYDROXI EXTEROID DEHYDROGENASE TYPE 1

Country Status (10)

Country Link
KR (1) KR101296408B1 (en)
CR (2) CR8771A (en)
EC (1) ECSP067108A (en)
HK (1) HK1096095A1 (en)
HR (1) HRP20060456A2 (en)
IL (1) IL179167A (en)
MA (1) MA28662B1 (en)
MX (1) MXPA06013657A (en)
NO (1) NO20065781L (en)
NZ (1) NZ552284A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100720844B1 (en) 1998-07-08 2007-05-25 사노피-아벤티스 도이칠란트 게엠베하 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, and pharmaceutical preparations comprising them

Also Published As

Publication number Publication date
MA28662B1 (en) 2007-06-01
MXPA06013657A (en) 2007-11-07
IL179167A (en) 2012-01-31
NO20065781L (en) 2007-02-08
IL179167A0 (en) 2007-03-08
CR20120420A (en) 2012-09-14
KR101296408B1 (en) 2013-08-13
KR20070058382A (en) 2007-06-08
HK1096095A1 (en) 2007-05-25
NZ552284A (en) 2010-01-29
HRP20060456A2 (en) 2007-03-31
ECSP067108A (en) 2007-05-30

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