MA28662B1 - 1-BETA-HYDROXY STEROID DEHYDROGENASE INHIBITORS OF TYPE 1 - Google Patents
1-BETA-HYDROXY STEROID DEHYDROGENASE INHIBITORS OF TYPE 1Info
- Publication number
- MA28662B1 MA28662B1 MA29529A MA29529A MA28662B1 MA 28662 B1 MA28662 B1 MA 28662B1 MA 29529 A MA29529 A MA 29529A MA 29529 A MA29529 A MA 29529A MA 28662 B1 MA28662 B1 MA 28662B1
- Authority
- MA
- Morocco
- Prior art keywords
- beta
- type
- dehydrogenase inhibitors
- steroid dehydrogenase
- hydroxy steroid
- Prior art date
Links
- 101710088194 Dehydrogenase Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention se rapporte à des composés de la formule (I), (II), (III) ou (IV) : où R1, R2, R3, R4, R5, R6, R7, X et Z sont tel que définis dans les présentes, comme elle se rapporte également aux compositions pharmaceutiques comportant les composés, aussi bien que les méthodes d'utilisation des composés pour le traitement des troubles associés à l'enzyme de déshydrogénase humaine 11-(beta)-hydroxysteroïde de type 1 et pour la préparation d'un médicament qui agit sur l'enzyme de déshydrogénase humaine 11-(beta)-hydroxysteroïde de type 1.The present invention relates to compounds of the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined in herein, as well as the pharmaceutical compositions comprising the compounds, as well as the methods of using the compounds for the treatment of disorders associated with the human 1-(beta) -hydroxysteroid dehydrogenase enzyme type 1 and for the preparation of a drug which acts on the human dehydrogenase enzyme 11- (beta) -hydroxysteroid type 1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0401324A SE0401324D0 (en) | 2004-05-24 | 2004-05-24 | New compounds |
SE0402509A SE0402509D0 (en) | 2004-10-15 | 2004-10-15 | New compounds |
US65077705P | 2005-01-31 | 2005-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28662B1 true MA28662B1 (en) | 2007-06-01 |
Family
ID=41717469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29529A MA28662B1 (en) | 2004-05-24 | 2006-12-14 | 1-BETA-HYDROXY STEROID DEHYDROGENASE INHIBITORS OF TYPE 1 |
Country Status (10)
Country | Link |
---|---|
KR (1) | KR101296408B1 (en) |
CR (2) | CR8771A (en) |
EC (1) | ECSP067108A (en) |
HK (1) | HK1096095A1 (en) |
HR (1) | HRP20060456A2 (en) |
IL (1) | IL179167A (en) |
MA (1) | MA28662B1 (en) |
MX (1) | MXPA06013657A (en) |
NO (1) | NO20065781L (en) |
NZ (1) | NZ552284A (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU228111B1 (en) | 1998-07-08 | 2012-11-28 | Sanofi Aventis Deutschland | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
-
2005
- 2005-05-24 NZ NZ552284A patent/NZ552284A/en not_active IP Right Cessation
- 2005-05-24 MX MXPA06013657A patent/MXPA06013657A/en active IP Right Grant
- 2005-05-24 KR KR1020067026575A patent/KR101296408B1/en not_active IP Right Cessation
-
2006
- 2006-11-09 IL IL179167A patent/IL179167A/en not_active IP Right Cessation
- 2006-11-24 CR CR8771A patent/CR8771A/en unknown
- 2006-12-13 NO NO20065781A patent/NO20065781L/en not_active Application Discontinuation
- 2006-12-14 MA MA29529A patent/MA28662B1/en unknown
- 2006-12-21 HR HR20060456A patent/HRP20060456A2/en not_active Application Discontinuation
- 2006-12-21 EC EC2006007108A patent/ECSP067108A/en unknown
-
2007
- 2007-03-26 HK HK07103229.0A patent/HK1096095A1/en not_active IP Right Cessation
-
2012
- 2012-08-10 CR CR20120420A patent/CR20120420A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20060456A2 (en) | 2007-03-31 |
IL179167A0 (en) | 2007-03-08 |
HK1096095A1 (en) | 2007-05-25 |
CR20120420A (en) | 2012-09-14 |
CR8771A (en) | 2007-07-24 |
KR20070058382A (en) | 2007-06-08 |
IL179167A (en) | 2012-01-31 |
MXPA06013657A (en) | 2007-11-07 |
NZ552284A (en) | 2010-01-29 |
ECSP067108A (en) | 2007-05-30 |
NO20065781L (en) | 2007-02-08 |
KR101296408B1 (en) | 2013-08-13 |
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