CR20210376A - COMPUESTOS Y USO PARA EL TRATAMIENTO DE LA DEFICIENCIA DE a1-ANTITRIPSINA - Google Patents
COMPUESTOS Y USO PARA EL TRATAMIENTO DE LA DEFICIENCIA DE a1-ANTITRIPSINAInfo
- Publication number
- CR20210376A CR20210376A CR20210376A CR20210376A CR20210376A CR 20210376 A CR20210376 A CR 20210376A CR 20210376 A CR20210376 A CR 20210376A CR 20210376 A CR20210376 A CR 20210376A CR 20210376 A CR20210376 A CR 20210376A
- Authority
- CR
- Costa Rica
- Prior art keywords
- treatment
- antitrypsin deficiency
- compounds
- derivatives
- a1ad
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a derivados de oxopirimidinil-metil-benzamida, por ejemplo en forma de una sal o cristal farmacéuticamente aceptable, composiciones farmacéuticas que comprenden los derivados y a su uso médico, en particular para su uso en el tratamiento de la deficiencia de α1-antitripsina (A1AD o AATD)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1820450.3A GB201820450D0 (en) | 2018-12-14 | 2018-12-14 | Compound and its use for the treatment of alpha1-antitryspin deficiency |
PCT/GB2019/053552 WO2020120992A1 (en) | 2018-12-14 | 2019-12-13 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20210376A true CR20210376A (es) | 2021-10-18 |
Family
ID=65147137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20210376A CR20210376A (es) | 2018-12-14 | 2019-12-13 | COMPUESTOS Y USO PARA EL TRATAMIENTO DE LA DEFICIENCIA DE a1-ANTITRIPSINA |
Country Status (21)
Country | Link |
---|---|
US (2) | US11312689B2 (es) |
EP (1) | EP3894393B8 (es) |
JP (1) | JP7487203B2 (es) |
KR (1) | KR20210104080A (es) |
CN (1) | CN113227057A (es) |
AU (1) | AU2019398520A1 (es) |
BR (1) | BR112021011477A2 (es) |
CA (1) | CA3122658A1 (es) |
CO (1) | CO2021009083A2 (es) |
CR (1) | CR20210376A (es) |
EA (1) | EA202191239A1 (es) |
EC (1) | ECSP21051825A (es) |
GB (1) | GB201820450D0 (es) |
IL (1) | IL283938A (es) |
MA (1) | MA54456A (es) |
MX (1) | MX2021006884A (es) |
NI (1) | NI202100047A (es) |
PE (1) | PE20211789A1 (es) |
SG (1) | SG11202105878WA (es) |
WO (1) | WO2020120992A1 (es) |
ZA (1) | ZA202103977B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201820450D0 (en) * | 2018-12-14 | 2019-01-30 | Z Factor Ltd | Compound and its use for the treatment of alpha1-antitryspin deficiency |
GB201918404D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of aplha1-antitrypsin deficiency |
GB202009074D0 (en) * | 2020-06-15 | 2020-07-29 | Z Factor Ltd | Compound |
GB202009069D0 (en) * | 2020-06-15 | 2020-07-29 | Z Factor Ltd | Process |
GB202108542D0 (en) * | 2021-06-15 | 2021-07-28 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
GB202108544D0 (en) * | 2021-06-15 | 2021-07-28 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
GB202108543D0 (en) * | 2021-06-15 | 2021-07-28 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
WO2022263829A1 (en) * | 2021-06-16 | 2022-12-22 | Z Factor Limited | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000052034A2 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
WO2001052830A2 (en) * | 2000-01-20 | 2001-07-26 | Washington University | METHODS TO TREAT α-1-ANTITRYPSIN DEFICIENCY |
US20070167621A1 (en) * | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
US7183287B2 (en) * | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
EP1735319B1 (en) * | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
EP1832586A1 (en) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
EP2114141A2 (en) | 2007-01-10 | 2009-11-11 | University of Florida | Compounds and methods for treatment of alpha-1 antitrypsin deficiency |
CN101224207A (zh) * | 2007-10-12 | 2008-07-23 | 中国科学院上海有机化学研究所 | 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法 |
SI2234985T1 (sl) * | 2007-12-20 | 2012-06-29 | Bayer Pharma AG | 4-(4-ciano-2-tioaril)dihidropirimidinoni in njihova uporaba |
CA2853833A1 (en) * | 2011-11-08 | 2013-05-16 | Arena Pharmaceuticals, Inc. | Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto |
MX2014005715A (es) * | 2011-11-11 | 2014-05-28 | Pfizer | N-metil-2-[3-((e)-2-piridin-2-il-vinil)-1h-indazol-6-ilsulfanil]- benzamida para el tratamiento de leucemia mielogenosa cronica. |
US20140221335A1 (en) * | 2013-02-06 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
JP6632532B2 (ja) * | 2014-08-29 | 2020-01-22 | 国立大学法人 東京大学 | オートタキシン阻害活性を有するピリミジノン誘導体 |
GB201820450D0 (en) | 2018-12-14 | 2019-01-30 | Z Factor Ltd | Compound and its use for the treatment of alpha1-antitryspin deficiency |
GB201918404D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of aplha1-antitrypsin deficiency |
GB201918414D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
GB201918413D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
GB202009069D0 (en) * | 2020-06-15 | 2020-07-29 | Z Factor Ltd | Process |
GB2612007A (en) * | 2021-06-15 | 2023-04-26 | Z Factor Ltd | Compounds |
WO2022263829A1 (en) * | 2021-06-16 | 2022-12-22 | Z Factor Limited | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY |
-
2018
- 2018-12-14 GB GBGB1820450.3A patent/GB201820450D0/en not_active Ceased
-
2019
- 2019-12-13 AU AU2019398520A patent/AU2019398520A1/en active Pending
- 2019-12-13 MA MA054456A patent/MA54456A/fr unknown
- 2019-12-13 SG SG11202105878WA patent/SG11202105878WA/en unknown
- 2019-12-13 CN CN201980082707.2A patent/CN113227057A/zh active Pending
- 2019-12-13 CR CR20210376A patent/CR20210376A/es unknown
- 2019-12-13 CA CA3122658A patent/CA3122658A1/en active Pending
- 2019-12-13 PE PE2021000872A patent/PE20211789A1/es unknown
- 2019-12-13 BR BR112021011477-7A patent/BR112021011477A2/pt unknown
- 2019-12-13 WO PCT/GB2019/053552 patent/WO2020120992A1/en unknown
- 2019-12-13 KR KR1020217021705A patent/KR20210104080A/ko unknown
- 2019-12-13 MX MX2021006884A patent/MX2021006884A/es unknown
- 2019-12-13 EA EA202191239A patent/EA202191239A1/ru unknown
- 2019-12-13 JP JP2021534304A patent/JP7487203B2/ja active Active
- 2019-12-13 EP EP19835312.0A patent/EP3894393B8/en active Active
-
2021
- 2021-06-09 ZA ZA2021/03977A patent/ZA202103977B/en unknown
- 2021-06-11 NI NI202100047A patent/NI202100047A/es unknown
- 2021-06-11 US US17/345,928 patent/US11312689B2/en active Active
- 2021-06-13 IL IL283938A patent/IL283938A/en unknown
- 2021-07-12 CO CONC2021/0009083A patent/CO2021009083A2/es unknown
- 2021-07-13 EC ECSENADI202151825A patent/ECSP21051825A/es unknown
-
2022
- 2022-03-21 US US17/699,408 patent/US20220274932A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20210104080A (ko) | 2021-08-24 |
US11312689B2 (en) | 2022-04-26 |
ECSP21051825A (es) | 2021-11-18 |
EP3894393B1 (en) | 2022-12-21 |
US20210332015A1 (en) | 2021-10-28 |
US20220274932A1 (en) | 2022-09-01 |
WO2020120992A1 (en) | 2020-06-18 |
EA202191239A1 (ru) | 2021-09-21 |
EP3894393B8 (en) | 2023-02-15 |
JP2022515372A (ja) | 2022-02-18 |
JP7487203B2 (ja) | 2024-05-20 |
AU2019398520A1 (en) | 2021-07-01 |
SG11202105878WA (en) | 2021-07-29 |
CN113227057A (zh) | 2021-08-06 |
PE20211789A1 (es) | 2021-09-09 |
IL283938A (en) | 2021-07-29 |
NI202100047A (es) | 2021-08-31 |
BR112021011477A2 (pt) | 2021-08-31 |
CO2021009083A2 (es) | 2021-07-30 |
MX2021006884A (es) | 2021-09-14 |
ZA202103977B (en) | 2022-10-26 |
CA3122658A1 (en) | 2020-06-18 |
EP3894393A1 (en) | 2021-10-20 |
GB201820450D0 (en) | 2019-01-30 |
MA54456A (fr) | 2022-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR20210376A (es) | COMPUESTOS Y USO PARA EL TRATAMIENTO DE LA DEFICIENCIA DE a1-ANTITRIPSINA | |
MX2021004110A (es) | Composiciones farmaceuticas que comprenden n-(3,5- dimetoxifenil)-n'-(1-metiletil)-n-[3-(1-metil-1h- pirazol-4-il)quinoxalin-6-il]etano-1,2-diamina. | |
CY1123810T1 (el) | Τριφθορομεθυλ υποκατεστημενα πυραζολια ως αναστολεις καλλικρεϊνης στο ανθρωπινο πλασμα | |
MX2021004639A (es) | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. | |
MY190835A (en) | Bicyclic heterrocyclic derivatives as bromodomain inhibitors | |
MX2021006156A (es) | Compuestos utiles en la terapia para el vih. | |
CY1124907T1 (el) | Αναστολεις καλλικρεϊνης στο ανθρωπινο πλασμα | |
PH12016502233A1 (en) | (s)-pirlindole or its pharmaceutically acceptable salts for use in medicine | |
MX2021015770A (es) | Inhibidores macrociclicos de mcl-1. | |
CY1119522T1 (el) | (r)- πιρλινδολη και τα φαρμακευτικως αποδεκτα αλατα αυτης για χρηση στην ιατρικη | |
PH12017501668A1 (en) | Bace1 inhibitors | |
MX2022001261A (es) | Derivados de dihidropirimidina y usos de los mismos en el tratamiento de infeccion por vhb o de enfermedades inducidas por vhb. | |
PL424452A1 (pl) | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu | |
MX2022006180A (es) | Derivados macrociclicos de sulfonilo como inhibidores de mcl-1. | |
MX2022006179A (es) | Derivados macrociclicos de indol como inhibidores de mcl-1. | |
MX2022001266A (es) | Derivados de dihidropirimidina y usos de estos en el tratamiento de la infeccion por vhb o de enfermedades inducidas por vhb. | |
MX2021012146A (es) | Formulacion de tableta vaginal. | |
MX2022001271A (es) | Derivados de dihidropirimidina y usos de estos en el tratamiento de la infeccion por vhb o de enfermedades inducidas por vhb. | |
TW202428584A (zh) | 用於hiv治療之化合物 | |
MX2019014773A (es) | Inhibidores de ccl2. | |
EA201791798A1 (ru) | Фармацевтические композиции, включающие n-(3,5-диметоксифенил)-n'-(1-метилэтил)-n-[3-(1-метил-1h-пиразол-4-ил)хиноксалин-6-ил]этан-1,2-диамин |