CR20190078A - Derivado de triazolopirazinona útil como un inhibidor de pde1 humano - Google Patents

Derivado de triazolopirazinona útil como un inhibidor de pde1 humano

Info

Publication number
CR20190078A
CR20190078A CR20190078A CR20190078A CR20190078A CR 20190078 A CR20190078 A CR 20190078A CR 20190078 A CR20190078 A CR 20190078A CR 20190078 A CR20190078 A CR 20190078A CR 20190078 A CR20190078 A CR 20190078A
Authority
CR
Costa Rica
Prior art keywords
pde1 inhibitor
derivative useful
human pde1
triazolopyrazinone
human
Prior art date
Application number
CR20190078A
Other languages
English (en)
Inventor
Mark David Rekhter
Qing Shi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR20190078A publication Critical patent/CR20190078A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto de Fórmula I o una sal del mismo farmacéuticamente aceptable, para uso como un inhibidor de PDE1 humana
CR20190078A 2016-08-25 2017-08-18 Derivado de triazolopirazinona útil como un inhibidor de pde1 humano CR20190078A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662379372P 2016-08-25 2016-08-25
PCT/US2017/047479 WO2018039051A1 (en) 2016-08-25 2017-08-18 Triazolopyrazinone derivative useful as a human pde1 inhibitor

Publications (1)

Publication Number Publication Date
CR20190078A true CR20190078A (es) 2019-04-05

Family

ID=59762063

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190078A CR20190078A (es) 2016-08-25 2017-08-18 Derivado de triazolopirazinona útil como un inhibidor de pde1 humano

Country Status (37)

Country Link
US (1) US10138244B2 (es)
EP (1) EP3504208B1 (es)
JP (1) JP6633246B2 (es)
KR (1) KR20190028544A (es)
CN (1) CN109641902B (es)
AR (1) AR109328A1 (es)
AU (1) AU2017317111A1 (es)
BR (1) BR112019000988A2 (es)
CA (1) CA3034828A1 (es)
CL (1) CL2019000487A1 (es)
CO (1) CO2019001644A2 (es)
CR (1) CR20190078A (es)
CY (1) CY1123406T1 (es)
DK (1) DK3504208T3 (es)
DO (1) DOP2019000021A (es)
EA (1) EA201990313A1 (es)
EC (1) ECSP19013196A (es)
ES (1) ES2800433T3 (es)
HR (1) HRP20201187T1 (es)
HU (1) HUE050419T2 (es)
JO (1) JOP20170164A1 (es)
LT (1) LT3504208T (es)
MA (1) MA46039B1 (es)
MD (1) MD3504208T2 (es)
ME (1) ME03791B (es)
MX (1) MX2019002065A (es)
PE (1) PE20190452A1 (es)
PH (1) PH12019500370A1 (es)
PL (1) PL3504208T3 (es)
PT (1) PT3504208T (es)
RS (1) RS60442B1 (es)
SG (1) SG11201901311WA (es)
SI (1) SI3504208T1 (es)
SV (1) SV2019005838A (es)
TN (1) TN2019000038A1 (es)
TW (1) TWI651323B (es)
WO (1) WO2018039051A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112457A1 (es) 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
AR112346A1 (es) 2017-08-10 2019-10-16 Lilly Co Eli Derivados de [1,2,4]triazolo
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
CA2671980C (en) * 2006-12-13 2015-05-05 Aska Pharmaceutical Co., Ltd. Quinoxaline derivatives
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
CN103097393B (zh) 2010-09-07 2015-09-16 安斯泰来制药株式会社 喹喔啉化合物
RU2659779C2 (ru) 2012-06-18 2018-07-04 Дарт Нейросайенс (Кайман) Лтд Замещенные соединения тиофен- и фуран-конденсированного азолопиримидин-5-(6н)-она
US9938284B2 (en) * 2014-08-07 2018-04-10 Intra-Cellular Therapies, Inc. Organic compounds
US20160083400A1 (en) * 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) * 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑

Also Published As

Publication number Publication date
CA3034828A1 (en) 2018-03-01
MX2019002065A (es) 2019-06-03
PH12019500370A1 (en) 2019-10-21
MD3504208T2 (ro) 2020-08-31
PT3504208T (pt) 2020-08-31
SV2019005838A (es) 2019-04-04
TW201819379A (zh) 2018-06-01
EA201990313A1 (ru) 2019-07-31
EP3504208B1 (en) 2020-06-10
JP2019526567A (ja) 2019-09-19
KR20190028544A (ko) 2019-03-18
TN2019000038A1 (en) 2020-07-15
AR109328A1 (es) 2018-11-21
US10138244B2 (en) 2018-11-27
ES2800433T3 (es) 2020-12-30
AU2017317111A1 (en) 2019-01-31
HRP20201187T1 (hr) 2020-11-13
EP3504208A1 (en) 2019-07-03
CN109641902A (zh) 2019-04-16
SI3504208T1 (sl) 2020-08-31
RS60442B1 (sr) 2020-07-31
MA46039B1 (fr) 2020-09-30
ME03791B (me) 2021-04-20
PE20190452A1 (es) 2019-03-29
CO2019001644A2 (es) 2019-05-21
JOP20170164A1 (ar) 2019-01-30
CN109641902B (zh) 2021-06-08
CL2019000487A1 (es) 2019-07-12
PL3504208T3 (pl) 2020-11-16
US20180057494A1 (en) 2018-03-01
CY1123406T1 (el) 2021-12-31
BR112019000988A2 (pt) 2019-05-14
ECSP19013196A (es) 2019-03-29
SG11201901311WA (en) 2019-03-28
DK3504208T3 (da) 2020-07-27
LT3504208T (lt) 2020-08-10
WO2018039051A1 (en) 2018-03-01
TWI651323B (zh) 2019-02-21
DOP2019000021A (es) 2019-02-28
HUE050419T2 (hu) 2020-12-28
JP6633246B2 (ja) 2020-01-22

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