HUE050419T2 - Humán PDE1 inhibitorként alkalmas triazolopirazinon származék - Google Patents

Humán PDE1 inhibitorként alkalmas triazolopirazinon származék

Info

Publication number
HUE050419T2
HUE050419T2 HUE17761381A HUE17761381A HUE050419T2 HU E050419 T2 HUE050419 T2 HU E050419T2 HU E17761381 A HUE17761381 A HU E17761381A HU E17761381 A HUE17761381 A HU E17761381A HU E050419 T2 HUE050419 T2 HU E050419T2
Authority
HU
Hungary
Prior art keywords
derivative useful
pde1 inhibitor
triazolopyrazinone
human pde1
human
Prior art date
Application number
HUE17761381A
Other languages
English (en)
Inventor
Mark David Rekhter
Qing Shi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HUE050419T2 publication Critical patent/HUE050419T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HUE17761381A 2016-08-25 2017-08-18 Humán PDE1 inhibitorként alkalmas triazolopirazinon származék HUE050419T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662379372P 2016-08-25 2016-08-25

Publications (1)

Publication Number Publication Date
HUE050419T2 true HUE050419T2 (hu) 2020-12-28

Family

ID=59762063

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17761381A HUE050419T2 (hu) 2016-08-25 2017-08-18 Humán PDE1 inhibitorként alkalmas triazolopirazinon származék

Country Status (37)

Country Link
US (1) US10138244B2 (hu)
EP (1) EP3504208B1 (hu)
JP (1) JP6633246B2 (hu)
KR (1) KR20190028544A (hu)
CN (1) CN109641902B (hu)
AR (1) AR109328A1 (hu)
AU (1) AU2017317111A1 (hu)
BR (1) BR112019000988A2 (hu)
CA (1) CA3034828A1 (hu)
CL (1) CL2019000487A1 (hu)
CO (1) CO2019001644A2 (hu)
CR (1) CR20190078A (hu)
CY (1) CY1123406T1 (hu)
DK (1) DK3504208T3 (hu)
DO (1) DOP2019000021A (hu)
EA (1) EA201990313A1 (hu)
EC (1) ECSP19013196A (hu)
ES (1) ES2800433T3 (hu)
HR (1) HRP20201187T1 (hu)
HU (1) HUE050419T2 (hu)
JO (1) JOP20170164A1 (hu)
LT (1) LT3504208T (hu)
MA (1) MA46039B1 (hu)
MD (1) MD3504208T2 (hu)
ME (1) ME03791B (hu)
MX (1) MX2019002065A (hu)
PE (1) PE20190452A1 (hu)
PH (1) PH12019500370A1 (hu)
PL (1) PL3504208T3 (hu)
PT (1) PT3504208T (hu)
RS (1) RS60442B1 (hu)
SG (1) SG11201901311WA (hu)
SI (1) SI3504208T1 (hu)
SV (1) SV2019005838A (hu)
TN (1) TN2019000038A1 (hu)
TW (1) TWI651323B (hu)
WO (1) WO2018039051A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112457A1 (es) * 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
AR112346A1 (es) 2017-08-10 2019-10-16 Lilly Co Eli Derivados de [1,2,4]triazolo
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
EP2103613B1 (en) * 2006-12-13 2016-02-17 ASKA Pharmaceutical Co., Ltd. Quinoxaline derivative
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
CN103097393B (zh) 2010-09-07 2015-09-16 安斯泰来制药株式会社 喹喔啉化合物
BR112014031730B1 (pt) * 2012-06-18 2023-05-16 Dart Neuroscience (Cayman) Ltd Compostos ou sais farmaceuticamente aceitáveis dos mesmos e seu uso
US9938284B2 (en) * 2014-08-07 2018-04-10 Intra-Cellular Therapies, Inc. Organic compounds
US20160083400A1 (en) * 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) * 2014-10-10 2016-08-16 H 朗德貝克公司 作爲pde1抑制劑之三唑並吡酮
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑

Also Published As

Publication number Publication date
HRP20201187T1 (hr) 2020-11-13
AU2017317111A1 (en) 2019-01-31
EP3504208B1 (en) 2020-06-10
TN2019000038A1 (en) 2020-07-15
ME03791B (me) 2021-04-20
ES2800433T3 (es) 2020-12-30
DK3504208T3 (da) 2020-07-27
CR20190078A (es) 2019-04-05
CN109641902A (zh) 2019-04-16
RS60442B1 (sr) 2020-07-31
MD3504208T2 (ro) 2020-08-31
US10138244B2 (en) 2018-11-27
ECSP19013196A (es) 2019-03-29
SG11201901311WA (en) 2019-03-28
AR109328A1 (es) 2018-11-21
CL2019000487A1 (es) 2019-07-12
PE20190452A1 (es) 2019-03-29
PH12019500370A1 (en) 2019-10-21
WO2018039051A1 (en) 2018-03-01
CN109641902B (zh) 2021-06-08
DOP2019000021A (es) 2019-02-28
MA46039B1 (fr) 2020-09-30
CA3034828A1 (en) 2018-03-01
PL3504208T3 (pl) 2020-11-16
JP2019526567A (ja) 2019-09-19
EA201990313A1 (ru) 2019-07-31
BR112019000988A2 (pt) 2019-05-14
KR20190028544A (ko) 2019-03-18
EP3504208A1 (en) 2019-07-03
CY1123406T1 (el) 2021-12-31
JP6633246B2 (ja) 2020-01-22
US20180057494A1 (en) 2018-03-01
SV2019005838A (es) 2019-04-04
LT3504208T (lt) 2020-08-10
TW201819379A (zh) 2018-06-01
TWI651323B (zh) 2019-02-21
MX2019002065A (es) 2019-06-03
CO2019001644A2 (es) 2019-05-21
PT3504208T (pt) 2020-08-31
JOP20170164A1 (ar) 2019-01-30
SI3504208T1 (sl) 2020-08-31

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