CO6341487A2 - Marcadores séricos que predicen la respuesta clínica a los anticuerpos anti tnf (alfa) en pacientes con espondilitis anquilosante - Google Patents

Marcadores séricos que predicen la respuesta clínica a los anticuerpos anti tnf (alfa) en pacientes con espondilitis anquilosante

Info

Publication number
CO6341487A2
CO6341487A2 CO11081269A CO11081269A CO6341487A2 CO 6341487 A2 CO6341487 A2 CO 6341487A2 CO 11081269 A CO11081269 A CO 11081269A CO 11081269 A CO11081269 A CO 11081269A CO 6341487 A2 CO6341487 A2 CO 6341487A2
Authority
CO
Colombia
Prior art keywords
markers
patients
therapy
anquilosing
preach
Prior art date
Application number
CO11081269A
Other languages
English (en)
Inventor
Sudha Visvanathan
Carrier Wagner
Original Assignee
Centocor Ortho Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Ortho Biotech Inc filed Critical Centocor Ortho Biotech Inc
Publication of CO6341487A2 publication Critical patent/CO6341487A2/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona herramientas para el manejo de pacientes diagnosticados con espondilitis anquilosante antes de iniciar a terapia con un agente anti-TNF alfa. Las herramientas son marcadores y algoritmos específicos para predecir la respuesta a la terapia en base a puntos finales clínicos estándar primarios y secundarios con el uso de concentraciones de marcadores séricos. En una modalidad la concentración inicial de leptina u osteocalcina se usa para predecir a respuesta en la semana 14 después de iniciar la terapia. En otra modalidad después de 4 semanas de terapia se usa el cambio en un biomarcador proteico sérico, tal como el componente 3 del complemento.
CO11081269A 2008-12-30 2011-06-29 Marcadores séricos que predicen la respuesta clínica a los anticuerpos anti tnf (alfa) en pacientes con espondilitis anquilosante CO6341487A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14142108P 2008-12-30 2008-12-30

Publications (1)

Publication Number Publication Date
CO6341487A2 true CO6341487A2 (es) 2011-11-21

Family

ID=42310120

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11081269A CO6341487A2 (es) 2008-12-30 2011-06-29 Marcadores séricos que predicen la respuesta clínica a los anticuerpos anti tnf (alfa) en pacientes con espondilitis anquilosante

Country Status (12)

Country Link
US (1) US20110251099A1 (es)
EP (1) EP2384367A4 (es)
JP (2) JP5684724B2 (es)
KR (1) KR20110110247A (es)
CN (1) CN102272326B (es)
AU (1) AU2009333489A1 (es)
BR (1) BRPI0923806A2 (es)
CA (1) CA2750155A1 (es)
CO (1) CO6341487A2 (es)
IL (1) IL213245A (es)
MX (1) MX2011007030A (es)
WO (1) WO2010077722A1 (es)

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Also Published As

Publication number Publication date
AU2009333489A1 (en) 2010-07-08
JP5684724B2 (ja) 2015-03-18
BRPI0923806A2 (pt) 2015-07-14
IL213245A (en) 2014-09-30
JP2014197013A (ja) 2014-10-16
US20110251099A1 (en) 2011-10-13
EP2384367A1 (en) 2011-11-09
JP2012514208A (ja) 2012-06-21
CN102272326A (zh) 2011-12-07
CA2750155A1 (en) 2010-07-08
CN102272326B (zh) 2014-11-12
MX2011007030A (es) 2011-07-20
IL213245A0 (en) 2011-07-31
EP2384367A4 (en) 2013-07-10
WO2010077722A1 (en) 2010-07-08
KR20110110247A (ko) 2011-10-06

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