CO6241136A2 - Formulaciones orales de liberacion controlada de compuestos moduladores de canal ionico y metodos relacionados para la prevencion de arritmias - Google Patents
Formulaciones orales de liberacion controlada de compuestos moduladores de canal ionico y metodos relacionados para la prevencion de arritmiasInfo
- Publication number
- CO6241136A2 CO6241136A2 CO09137710A CO09137710A CO6241136A2 CO 6241136 A2 CO6241136 A2 CO 6241136A2 CO 09137710 A CO09137710 A CO 09137710A CO 09137710 A CO09137710 A CO 09137710A CO 6241136 A2 CO6241136 A2 CO 6241136A2
- Authority
- CO
- Colombia
- Prior art keywords
- mammal
- cyp
- cytochrome
- metabolizer
- prevention
- Prior art date
Links
- 108090000862 Ion Channels Proteins 0.000 title abstract 5
- 102000004310 Ion Channels Human genes 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 230000002265 prevention Effects 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 abstract 8
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 abstract 8
- 241000124008 Mammalia Species 0.000 abstract 6
- 206010003119 arrhythmia Diseases 0.000 abstract 2
- 230000006793 arrhythmia Effects 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91612907P | 2007-05-04 | 2007-05-04 | |
| US6615607P | 2007-08-01 | 2007-08-01 | |
| US3411908P | 2008-03-05 | 2008-03-05 | |
| US3719808P | 2008-03-17 | 2008-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6241136A2 true CO6241136A2 (es) | 2011-01-20 |
Family
ID=39691347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09137710A CO6241136A2 (es) | 2007-05-04 | 2009-12-02 | Formulaciones orales de liberacion controlada de compuestos moduladores de canal ionico y metodos relacionados para la prevencion de arritmias |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20080312309A1 (enExample) |
| EP (3) | EP2462933A1 (enExample) |
| JP (1) | JP2010526102A (enExample) |
| KR (1) | KR20100017648A (enExample) |
| CN (1) | CN101711174A (enExample) |
| AU (1) | AU2008247508B2 (enExample) |
| BR (1) | BRPI0810697A2 (enExample) |
| CA (1) | CA2686396A1 (enExample) |
| CO (1) | CO6241136A2 (enExample) |
| CR (1) | CR11117A (enExample) |
| EA (1) | EA200971025A1 (enExample) |
| EC (1) | ECSP099777A (enExample) |
| IL (1) | IL201934A0 (enExample) |
| MA (1) | MA31664B1 (enExample) |
| MX (1) | MX2009011929A (enExample) |
| NI (1) | NI200900196A (enExample) |
| NZ (1) | NZ581351A (enExample) |
| TN (1) | TN2009000461A1 (enExample) |
| WO (1) | WO2008137778A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| WO2011103398A1 (en) * | 2010-02-18 | 2011-08-25 | Aegis Sciences Corporation | Detection and quantitation of pain medications in oral fluid specimens |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69126064T2 (de) | 1990-06-22 | 1997-08-28 | Hoffmann La Roche | Nachweis von schwachen Metabolisierungsreagentien von Drogen |
| US5891696A (en) * | 1996-08-02 | 1999-04-06 | Panvera Corporation | Compositions for cytochrome P450 biotransformation reactions |
| JP3176342B2 (ja) | 1997-08-13 | 2001-06-18 | ファイザー製薬株式会社 | 薬剤代謝の評価方法及び前記方法用の試薬組成物 |
| CZ302147B6 (cs) * | 1998-04-01 | 2010-11-18 | Nortran Pharmaceuticals Inc. | Aminocyklohexyletherová sloucenina, použití této slouceniny pri výrobe léciva, farmaceutická kompozice tuto slouceninu obsahující a tato sloucenina a kompozice pro použití pri lécení |
| US7507545B2 (en) * | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| EP1281755A3 (en) | 2001-07-31 | 2003-06-18 | Pfizer Products Inc. | Variants of the human cyp2d6 gene |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| US20080063707A1 (en) * | 2003-05-02 | 2008-03-13 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| BR122018009866B8 (pt) * | 2003-05-02 | 2021-07-27 | Cardiome Pharma Corp | métodos para preparar compostos de éter aminocicloexílico e compostos intermediários |
| CA2524034A1 (en) * | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7674820B2 (en) * | 2003-08-07 | 2010-03-09 | Cardiome Pharma Corp. | Ion channel modulating activity I |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| MX2007005496A (es) * | 2004-11-08 | 2007-07-09 | Cardiome Pharma Corp | Nuevo regimen de dosificacion para compuestos moduladores de canal de iones, para el tratamiento de fibrilacion auricular aguda en un humano. |
| BRPI0612138B8 (pt) * | 2005-06-15 | 2021-05-25 | Cardiome Pharma Corp | compostos éter aminocicloexílicos e método para fazer os mesmos |
| WO2009018547A1 (en) * | 2007-08-01 | 2009-02-05 | Cardiome Pharma Corp. | Extended release formulations containing an ion-channel-modulating compound for the prevention of arrhythmias |
-
2008
- 2008-05-02 WO PCT/US2008/062551 patent/WO2008137778A2/en not_active Ceased
- 2008-05-02 KR KR1020097025421A patent/KR20100017648A/ko not_active Withdrawn
- 2008-05-02 EP EP12001273A patent/EP2462933A1/en not_active Withdrawn
- 2008-05-02 EA EA200971025A patent/EA200971025A1/ru unknown
- 2008-05-02 MX MX2009011929A patent/MX2009011929A/es not_active Application Discontinuation
- 2008-05-02 AU AU2008247508A patent/AU2008247508B2/en not_active Ceased
- 2008-05-02 CN CN200880021022A patent/CN101711174A/zh active Pending
- 2008-05-02 NZ NZ581351A patent/NZ581351A/en not_active IP Right Cessation
- 2008-05-02 EP EP12001278A patent/EP2468278A1/en not_active Withdrawn
- 2008-05-02 US US12/114,652 patent/US20080312309A1/en not_active Abandoned
- 2008-05-02 EP EP08755034A patent/EP2155334A2/en not_active Withdrawn
- 2008-05-02 JP JP2010506692A patent/JP2010526102A/ja active Pending
- 2008-05-02 BR BRPI0810697A patent/BRPI0810697A2/pt not_active IP Right Cessation
- 2008-05-02 CA CA002686396A patent/CA2686396A1/en not_active Abandoned
-
2009
- 2009-11-04 IL IL201934A patent/IL201934A0/en unknown
- 2009-11-04 TN TNP2009000461A patent/TN2009000461A1/fr unknown
- 2009-11-04 NI NI200900196A patent/NI200900196A/es unknown
- 2009-11-18 CR CR11117A patent/CR11117A/es unknown
- 2009-11-26 MA MA32379A patent/MA31664B1/fr unknown
- 2009-12-02 EC EC2009009777A patent/ECSP099777A/es unknown
- 2009-12-02 CO CO09137710A patent/CO6241136A2/es not_active Application Discontinuation
-
2014
- 2014-06-17 US US14/306,915 patent/US20150099788A1/en not_active Abandoned
-
2015
- 2015-12-02 US US14/957,109 patent/US20160089361A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MA31664B1 (fr) | 2010-09-01 |
| ECSP099777A (es) | 2010-02-26 |
| MX2009011929A (es) | 2010-03-08 |
| CA2686396A1 (en) | 2008-11-13 |
| AU2008247508B2 (en) | 2014-07-10 |
| IL201934A0 (en) | 2010-06-16 |
| EP2468278A1 (en) | 2012-06-27 |
| NZ581351A (en) | 2012-07-27 |
| CR11117A (es) | 2010-02-19 |
| BRPI0810697A2 (pt) | 2019-08-27 |
| KR20100017648A (ko) | 2010-02-16 |
| US20160089361A1 (en) | 2016-03-31 |
| WO2008137778A2 (en) | 2008-11-13 |
| JP2010526102A (ja) | 2010-07-29 |
| EA200971025A1 (ru) | 2010-04-30 |
| WO2008137778A3 (en) | 2009-03-12 |
| AU2008247508A1 (en) | 2008-11-13 |
| CN101711174A (zh) | 2010-05-19 |
| EP2462933A1 (en) | 2012-06-13 |
| US20080312309A1 (en) | 2008-12-18 |
| TN2009000461A1 (en) | 2011-03-31 |
| NI200900196A (es) | 2010-03-11 |
| EP2155334A2 (en) | 2010-02-24 |
| US20150099788A1 (en) | 2015-04-09 |
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