AR063096A1 - Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina - Google Patents
Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinaInfo
- Publication number
- AR063096A1 AR063096A1 ARP070104358A ARP070104358A AR063096A1 AR 063096 A1 AR063096 A1 AR 063096A1 AR P070104358 A ARP070104358 A AR P070104358A AR P070104358 A ARP070104358 A AR P070104358A AR 063096 A1 AR063096 A1 AR 063096A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pirazolopirimidinas
- cycline
- inhibitors
- dependent kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Composiciones farmacéuticas que contienen uno o más de dichos compuestos, métodos para preparar formulaciones farmacéuticas que comprenden uno o más de dichos compuestos, y métodos de tratamiento, prevencion, inhibicion o mejoramiento de una o más enfermedades proliferativas asociadas con las CDKs usando dichos compuestos o composiciones farmacéuticas. Reivindicacion 1: Un compuesto seleccionado del grupo que consiste en los compuestos del grupo de formulas (1) o una sal, solvato, éster o profármaco farmacéuticamente aceptable de éstos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/542,920 US7605155B2 (en) | 2002-09-04 | 2006-10-04 | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063096A1 true AR063096A1 (es) | 2008-12-30 |
Family
ID=39111854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104358A AR063096A1 (es) | 2006-10-04 | 2007-10-02 | Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina |
Country Status (10)
Country | Link |
---|---|
US (1) | US7605155B2 (es) |
EP (1) | EP2069349B1 (es) |
JP (1) | JP2010505839A (es) |
CN (1) | CN101573363B (es) |
AR (1) | AR063096A1 (es) |
CA (1) | CA2665127A1 (es) |
CL (1) | CL2007002856A1 (es) |
PE (1) | PE20080974A1 (es) |
TW (1) | TW200821313A (es) |
WO (1) | WO2008045267A2 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101360499B (zh) * | 2005-10-06 | 2015-10-07 | 默沙东公司 | 吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途 |
JP2009538304A (ja) * | 2006-05-22 | 2009-11-05 | シェーリング コーポレイション | CDK阻害剤としてのピラゾロ[1,5−a]ピリミジン |
WO2009155551A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
BRPI0909945A2 (pt) * | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
WO2011028638A1 (en) | 2009-09-04 | 2011-03-10 | Schering Corporation | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
KR102012398B1 (ko) | 2009-11-05 | 2019-08-20 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 벤조피란 키나제 조절제 |
WO2011090935A1 (en) * | 2010-01-19 | 2011-07-28 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
US8680271B2 (en) * | 2010-03-26 | 2014-03-25 | Merck Sharp & Dohme Corp. | Process for synthesizing 6-bromo-3-1-(1-methyl-1H-pyrazol-4-yl)-5-(3(R)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine |
US8703784B2 (en) | 2010-08-23 | 2014-04-22 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrido[3.2-e]pyrimidin-6-one inhibitors of mammalian target of rapamycin |
EP2608669B1 (en) * | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
MX365160B (es) | 2011-05-04 | 2019-05-24 | Rhizen Pharmaceuticals Sa | Compuestos novedosos como moduladores de proteína cinasas. |
DK3260455T3 (da) | 2012-07-04 | 2019-06-11 | Rhizen Pharmaceuticals S A | Selektive pi3k delta-hæmmere |
US9573954B2 (en) | 2012-11-16 | 2017-02-21 | University Health Network | Pyrazolopyrimidine compounds |
HUE057061T2 (hu) * | 2013-08-14 | 2022-04-28 | Novartis Ag | Kombinációs terápia rák kezelésére |
US9505767B2 (en) | 2013-09-05 | 2016-11-29 | Genentech, Inc. | Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors |
CN106727474A (zh) * | 2017-01-04 | 2017-05-31 | 仪修南 | 苯氧乙酸类除草剂作为化学治疗剂治疗疾病的应用 |
CN108653282B (zh) * | 2018-06-28 | 2020-08-14 | 中国科学院昆明植物研究所 | 苯并噻唑类及苯并吡咯类化合物在制备抗肿瘤药物中的应用 |
JP2022502515A (ja) * | 2018-10-15 | 2022-01-11 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
MA54092A (fr) | 2018-10-30 | 2021-09-08 | Kronos Bio Inc | Composés, compositions et procédés de modulation de l'activité de cdk9 |
CN111393447B (zh) * | 2020-05-14 | 2021-01-15 | 苏州信诺维医药科技有限公司 | 一种嘧啶并吡唑类化合物、其制备方法及应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0302991A3 (en) | 2000-09-15 | 2009-10-28 | Vertex Pharma | Isoxazoles and their use as inhibitors of erk and pharmaceutical compositions containing the compounds |
ATE364608T1 (de) * | 2002-09-04 | 2007-07-15 | Schering Corp | Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen |
US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
BRPI0314001B8 (pt) * | 2002-09-04 | 2021-05-25 | Merck Sharp & Dohme | pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas |
CN1880317B (zh) * | 2002-09-04 | 2012-10-10 | 先灵公司 | 作为细胞周期蛋白依赖性激酶抑制剂的吡唑并嘧啶 |
US20070179161A1 (en) * | 2003-03-31 | 2007-08-02 | Vernalis (Cambridge) Limited. | Pyrazolopyrimidine compounds and their use in medicine |
PE20051089A1 (es) * | 2004-01-22 | 2006-01-25 | Novartis Ag | Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina |
CN101360499B (zh) * | 2005-10-06 | 2015-10-07 | 默沙东公司 | 吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途 |
-
2006
- 2006-10-04 US US11/542,920 patent/US7605155B2/en not_active Expired - Lifetime
-
2007
- 2007-10-02 WO PCT/US2007/021274 patent/WO2008045267A2/en active Application Filing
- 2007-10-02 AR ARP070104358A patent/AR063096A1/es not_active Application Discontinuation
- 2007-10-02 CN CN2007800446523A patent/CN101573363B/zh not_active Expired - Fee Related
- 2007-10-02 JP JP2009531445A patent/JP2010505839A/ja not_active Ceased
- 2007-10-02 EP EP07839218.0A patent/EP2069349B1/en active Active
- 2007-10-02 CA CA002665127A patent/CA2665127A1/en not_active Abandoned
- 2007-10-02 PE PE2007001331A patent/PE20080974A1/es not_active Application Discontinuation
- 2007-10-03 CL CL2007002856A patent/CL2007002856A1/es unknown
- 2007-10-03 TW TW096137089A patent/TW200821313A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008045267A2 (en) | 2008-04-17 |
JP2010505839A (ja) | 2010-02-25 |
US7605155B2 (en) | 2009-10-20 |
EP2069349A2 (en) | 2009-06-17 |
CA2665127A1 (en) | 2008-04-17 |
CN101573363B (zh) | 2013-03-06 |
PE20080974A1 (es) | 2008-07-19 |
EP2069349B1 (en) | 2016-06-15 |
CL2007002856A1 (es) | 2008-01-18 |
WO2008045267A3 (en) | 2008-07-31 |
TW200821313A (en) | 2008-05-16 |
US20070072881A1 (en) | 2007-03-29 |
CN101573363A (zh) | 2009-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |