CO5690549A2 - Derivados de 3-(benzoilureido)-tiofeno sustituido, metodo para su produccion y uso de los mismos - Google Patents
Derivados de 3-(benzoilureido)-tiofeno sustituido, metodo para su produccion y uso de los mismosInfo
- Publication number
- CO5690549A2 CO5690549A2 CO05080324A CO05080324A CO5690549A2 CO 5690549 A2 CO5690549 A2 CO 5690549A2 CO 05080324 A CO05080324 A CO 05080324A CO 05080324 A CO05080324 A CO 05080324A CO 5690549 A2 CO5690549 A2 CO 5690549A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- phenyl
- coo
- trophene
- benzoilureido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
1.- Compuestos de fórmula I en la queR5 es F, CI o Br;R1 es H, F, CI, Br;R2 es H, F, CI, ,Br, (C1-C6)-alquilo, CF3, OCF3,-NO2, CN, O-(C1-C6)-alquilo, CO-(C1-C6)-alquilo, COOH, COO(C1-C6)-alquilo, CONH2, CONH(C1-C6)-alquilo, CON((C1-C6)-alquilo)2, SO2-(C1-C6)-alquilo, o el radical A;R3 es H, (C1-C6)-alquilo, COO(C1-C6)-alquilo, SO2(C1-C6)-alquilo, (C1-C6)-alquil-fenilo, fenilo, SO2-fenilo, en donde el anillo fenilo puede estar, en cada caso, hasta disustituido por F, Cl, CN, OH, (C1-C6)-alquilo, O-(C1-C6)-alquilo, CF3, OCF3, COOH, COO(C1-C6)-alquilo o CONH2;R4 es H, (C1-C6)-alquilo, COO(C1-C6)-alquilo, SO2-(C1-C6)-alquilo, SO2-piperidinilo, SO2-piperazinilo, (C1-C6)-alquilfenilo, fenilo, en donde el anillo fenilo, el anillo piperidinilo y el anillo piperazinilo pueden estar hasta disustituidos por F, CI, CN, OH, (C1-C6)-alquilo, O-(C1-C6)alquilo, CF3, OCF3, COOH, COO(C1-C6)-alquilo o CONH2;A es un radical heterocíclico de la fórmula 2a, 2b, 2c o 3;X es O o NH;Y es OH o NH2;Z es OH, O(C1-C6)-alquilo, NH2, NH(C1-C6)-alquilo, N((C1-C6)-alquilo)2;y sus sales fisiológicamente toleradas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10306502A DE10306502B4 (de) | 2003-02-17 | 2003-02-17 | Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690549A2 true CO5690549A2 (es) | 2006-10-31 |
Family
ID=32841675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05080324A CO5690549A2 (es) | 2003-02-17 | 2005-08-12 | Derivados de 3-(benzoilureido)-tiofeno sustituido, metodo para su produccion y uso de los mismos |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1597247B1 (es) |
| JP (1) | JP4589301B2 (es) |
| KR (1) | KR20050105470A (es) |
| CN (1) | CN1751036A (es) |
| AR (1) | AR043179A1 (es) |
| AT (1) | ATE402160T1 (es) |
| AU (1) | AU2004212054A1 (es) |
| BR (1) | BRPI0407552A (es) |
| CA (1) | CA2516269A1 (es) |
| CO (1) | CO5690549A2 (es) |
| DE (2) | DE10306502B4 (es) |
| HR (1) | HRP20050715A2 (es) |
| MA (1) | MA27657A1 (es) |
| MX (1) | MXPA05008331A (es) |
| NO (1) | NO20054168L (es) |
| PE (1) | PE20050221A1 (es) |
| PL (1) | PL376753A1 (es) |
| RU (1) | RU2005129109A (es) |
| TW (1) | TW200505892A (es) |
| WO (1) | WO2004072060A1 (es) |
| ZA (1) | ZA200505487B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223786B2 (en) | 2004-11-15 | 2007-05-29 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
| WO2006055462A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006053274A2 (en) | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006055463A2 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006113650A1 (en) * | 2005-04-18 | 2006-10-26 | Khan Saeed R | Design and synthesis of novel tubulin polymerization inhibitors: bonzoylphenyluria (bpu) sulfur analogs |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3034004A1 (de) * | 1980-09-10 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| HUT48880A (en) * | 1987-07-20 | 1989-07-28 | Sandoz Ag | Insecticides and acaricides comprising new n-benzoyl-n'-thienyl urea derivative as active ingredient and process for producing the active ingredients |
| DE10116768A1 (de) * | 2001-04-04 | 2002-10-10 | Aventis Pharma Gmbh | Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE50102147D1 (de) * | 2000-06-09 | 2004-06-03 | Aventis Pharma Gmbh | Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| PE20021091A1 (es) * | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
| IL164249A0 (en) * | 2002-04-11 | 2005-12-18 | Aventis Pharma Gmbh | Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use |
| DE10215908B4 (de) * | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| DE10225635C1 (de) * | 2002-06-07 | 2003-12-24 | Aventis Pharma Gmbh | N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| WO2004007437A1 (de) * | 2002-07-11 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Harnstoff- und urethan-substituierte acylharnstoffe, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| NZ537603A (en) * | 2002-07-12 | 2006-09-29 | Sanofi Aventis Deutschland | Heterocyclically substituted benzoylureas, method for their production and their use as medicaments |
| DE10246434B4 (de) * | 2002-10-04 | 2005-08-04 | Aventis Pharma Deutschland Gmbh | Carboxyalkoxy-substituierte Acyl-carboxyphenyl-harnstoffderivate und ihre Verwendung als Arzneimittel |
-
2003
- 2003-02-17 DE DE10306502A patent/DE10306502B4/de not_active Expired - Fee Related
-
2004
- 2004-02-04 CA CA002516269A patent/CA2516269A1/en not_active Abandoned
- 2004-02-04 KR KR1020057015029A patent/KR20050105470A/ko not_active Application Discontinuation
- 2004-02-04 BR BRPI0407552-8A patent/BRPI0407552A/pt not_active IP Right Cessation
- 2004-02-04 CN CNA2004800044004A patent/CN1751036A/zh active Pending
- 2004-02-04 AT AT04707896T patent/ATE402160T1/de not_active IP Right Cessation
- 2004-02-04 PL PL376753A patent/PL376753A1/pl not_active Application Discontinuation
- 2004-02-04 JP JP2006501724A patent/JP4589301B2/ja not_active Expired - Fee Related
- 2004-02-04 DE DE502004007668T patent/DE502004007668D1/de not_active Expired - Lifetime
- 2004-02-04 EP EP04707896A patent/EP1597247B1/de not_active Expired - Lifetime
- 2004-02-04 AU AU2004212054A patent/AU2004212054A1/en not_active Abandoned
- 2004-02-04 MX MXPA05008331A patent/MXPA05008331A/es not_active Application Discontinuation
- 2004-02-04 RU RU2005129109/04A patent/RU2005129109A/ru not_active Application Discontinuation
- 2004-02-04 WO PCT/EP2004/000993 patent/WO2004072060A1/de active IP Right Grant
- 2004-02-13 AR ARP040100457A patent/AR043179A1/es unknown
- 2004-02-13 TW TW093103411A patent/TW200505892A/zh unknown
- 2004-02-17 PE PE2004000163A patent/PE20050221A1/es not_active Application Discontinuation
-
2005
- 2005-07-07 ZA ZA200505487A patent/ZA200505487B/en unknown
- 2005-08-12 CO CO05080324A patent/CO5690549A2/es not_active Application Discontinuation
- 2005-08-16 HR HR20050715A patent/HRP20050715A2/xx not_active Application Discontinuation
- 2005-08-16 MA MA28443A patent/MA27657A1/fr unknown
- 2005-09-07 NO NO20054168A patent/NO20054168L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2005129109A (ru) | 2006-01-27 |
| CN1751036A (zh) | 2006-03-22 |
| CA2516269A1 (en) | 2004-08-26 |
| NO20054168L (no) | 2005-11-11 |
| AR043179A1 (es) | 2005-07-20 |
| AU2004212054A1 (en) | 2004-08-26 |
| KR20050105470A (ko) | 2005-11-04 |
| NO20054168D0 (no) | 2005-09-07 |
| EP1597247A1 (de) | 2005-11-23 |
| MA27657A1 (fr) | 2005-12-01 |
| EP1597247B1 (de) | 2008-07-23 |
| BRPI0407552A (pt) | 2006-02-14 |
| JP2006517933A (ja) | 2006-08-03 |
| TW200505892A (en) | 2005-02-16 |
| PL376753A1 (pl) | 2006-01-09 |
| DE10306502B4 (de) | 2005-03-17 |
| WO2004072060A1 (de) | 2004-08-26 |
| DE502004007668D1 (de) | 2008-09-04 |
| DE10306502A1 (de) | 2004-09-09 |
| JP4589301B2 (ja) | 2010-12-01 |
| HRP20050715A2 (en) | 2006-09-30 |
| ATE402160T1 (de) | 2008-08-15 |
| PE20050221A1 (es) | 2005-04-04 |
| MXPA05008331A (es) | 2005-09-30 |
| ZA200505487B (en) | 2006-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |