HRP20050715A2 - Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof - Google Patents

Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof

Info

Publication number
HRP20050715A2
HRP20050715A2 HR20050715A HRP20050715A HRP20050715A2 HR P20050715 A2 HRP20050715 A2 HR P20050715A2 HR 20050715 A HR20050715 A HR 20050715A HR P20050715 A HRP20050715 A HR P20050715A HR P20050715 A2 HRP20050715 A2 HR P20050715A2
Authority
HR
Croatia
Prior art keywords
benzoylureido
substituted
production
thiophene derivatives
compounds
Prior art date
Application number
HR20050715A
Other languages
Croatian (hr)
Inventor
Schoenafinger Karl
Defossa Elisabeth
Von Roedern Erich
Kadereit Dieter
Herling Andreas
Burger Hans-Joerg
Klabunde Thomas
Wendt Karl-Ulrich
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of HRP20050715A2 publication Critical patent/HRP20050715A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Izum se odnosi na spojeve formule (I)u kojoj radikali imaju navedena značenja, kao i njihove fiziološki podnošljive soli. Ovi spojevi se mogu upotrijebiti npr. kao lijekovi za prevenciju i za liječenje tipa 2 dijabetesa.The invention relates to compounds of formula (I) in which the radicals have the meanings given, as well as their physiologically tolerable salts. These compounds can be used, for example, as medicaments for the prevention and treatment of type 2 diabetes.

HR20050715A 2003-02-17 2005-08-16 Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof HRP20050715A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10306502A DE10306502B4 (en) 2003-02-17 2003-02-17 Substituted 3- (benzoylureido) thiophene derivatives and medicaments containing them
PCT/EP2004/000993 WO2004072060A1 (en) 2003-02-17 2004-02-04 Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof

Publications (1)

Publication Number Publication Date
HRP20050715A2 true HRP20050715A2 (en) 2006-09-30

Family

ID=32841675

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050715A HRP20050715A2 (en) 2003-02-17 2005-08-16 Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof

Country Status (21)

Country Link
EP (1) EP1597247B1 (en)
JP (1) JP4589301B2 (en)
KR (1) KR20050105470A (en)
CN (1) CN1751036A (en)
AR (1) AR043179A1 (en)
AT (1) ATE402160T1 (en)
AU (1) AU2004212054A1 (en)
BR (1) BRPI0407552A (en)
CA (1) CA2516269A1 (en)
CO (1) CO5690549A2 (en)
DE (2) DE10306502B4 (en)
HR (1) HRP20050715A2 (en)
MA (1) MA27657A1 (en)
MX (1) MXPA05008331A (en)
NO (1) NO20054168L (en)
PE (1) PE20050221A1 (en)
PL (1) PL376753A1 (en)
RU (1) RU2005129109A (en)
TW (1) TW200505892A (en)
WO (1) WO2004072060A1 (en)
ZA (1) ZA200505487B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214704B2 (en) 2004-11-15 2007-05-08 Bristol-Myers Squibb Company 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006055462A1 (en) 2004-11-15 2006-05-26 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
CA2606174A1 (en) * 2005-04-18 2006-10-26 Saeed R. Khan Design and synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs
PE20080251A1 (en) 2006-05-04 2008-04-25 Boehringer Ingelheim Int USES OF DPP IV INHIBITORS
CA3144848C (en) 2019-06-28 2023-11-21 Pfizer Inc. 5-(thiophen-2-yl)-1h-tetrazole derivatives as bckdk inhibitors useful for treating various diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034004A1 (en) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt SULFONYL UREAS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
HUT48880A (en) * 1987-07-20 1989-07-28 Sandoz Ag Insecticides and acaricides comprising new n-benzoyl-n'-thienyl urea derivative as active ingredient and process for producing the active ingredients
DE10116768A1 (en) * 2001-04-04 2002-10-10 Aventis Pharma Gmbh Hypoglycemic medicaments useful for treating type II diabetes contain new or known N-aroyl-N'-phenyl-urea derivatives which are glycogen phosphorylase a inhibitors
EE200200634A (en) * 2000-06-09 2004-04-15 Aventis Pharma Deutschland Gmbh Acylphenylurea derivatives, their preparation and their use in the preparation of a blood glucose lowering drug and a medicament containing them
PE20021091A1 (en) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh DERIVATIVES OF PHENYLUREA SUBSTITUTED WITH CARBONAMIDE AND PROCEDURE FOR THEIR PREPARATION
DE10215908B4 (en) * 2002-04-11 2005-08-18 Aventis Pharma Deutschland Gmbh Acyl-3-carboxyphenyl-urea derivatives and their use as medicaments
DE10215907A1 (en) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-urea derivatives, processes for their preparation and their use
DE10225635C1 (en) * 2002-06-07 2003-12-24 Aventis Pharma Gmbh N-benzoylureido-cinnamic acid derivatives, process for their preparation and their use
WO2004007437A1 (en) * 2002-07-11 2004-01-22 Aventis Pharma Deutschland Gmbh Urea-substituted and urethane-substituted acylureas, methods for the production thereof and their use as medicaments
EP1523475B1 (en) * 2002-07-12 2009-12-23 Sanofi-Aventis Deutschland GmbH Heterocyclically substituted benzoylureas, method for their production and their use as medicaments
DE10246434B4 (en) * 2002-10-04 2005-08-04 Aventis Pharma Deutschland Gmbh Carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives and their use as pharmaceuticals

Also Published As

Publication number Publication date
AU2004212054A1 (en) 2004-08-26
AR043179A1 (en) 2005-07-20
RU2005129109A (en) 2006-01-27
MA27657A1 (en) 2005-12-01
BRPI0407552A (en) 2006-02-14
ATE402160T1 (en) 2008-08-15
EP1597247B1 (en) 2008-07-23
PL376753A1 (en) 2006-01-09
PE20050221A1 (en) 2005-04-04
KR20050105470A (en) 2005-11-04
MXPA05008331A (en) 2005-09-30
EP1597247A1 (en) 2005-11-23
NO20054168L (en) 2005-11-11
DE10306502A1 (en) 2004-09-09
NO20054168D0 (en) 2005-09-07
DE10306502B4 (en) 2005-03-17
ZA200505487B (en) 2006-08-30
DE502004007668D1 (en) 2008-09-04
TW200505892A (en) 2005-02-16
CO5690549A2 (en) 2006-10-31
WO2004072060A1 (en) 2004-08-26
JP4589301B2 (en) 2010-12-01
JP2006517933A (en) 2006-08-03
CN1751036A (en) 2006-03-22
CA2516269A1 (en) 2004-08-26

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