CO5640088A2 - Sales de 2-metoximetil-3-(3,4-diclorofenil)-8-azabiciclo[3.2.1]octan tartrato - Google Patents

Sales de 2-metoximetil-3-(3,4-diclorofenil)-8-azabiciclo[3.2.1]octan tartrato

Info

Publication number
CO5640088A2
CO5640088A2 CO06001282A CO06001282A CO5640088A2 CO 5640088 A2 CO5640088 A2 CO 5640088A2 CO 06001282 A CO06001282 A CO 06001282A CO 06001282 A CO06001282 A CO 06001282A CO 5640088 A2 CO5640088 A2 CO 5640088A2
Authority
CO
Colombia
Prior art keywords
azabicyclo
dichlorophenyl
methoxymethyl
octane
salt
Prior art date
Application number
CO06001282A
Other languages
English (en)
Inventor
Brian Frostrup
Frank Watjen
Klaus Snej Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of CO5640088A2 publication Critical patent/CO5640088A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Una sal seleccionada de las formas anhídrida e hidratada de tartrato de (1R, 2R, 3S, 5S)-2-metoximetil-3-(3,4-diclorofenil)-8-azabiciclo [3.2.1] octano.2.- La sal de la reivindicación 1 seleccionada de las formas anhídrida e hidratada de L-tartrato de (1R, 2R, 3S, 5S)-2-metoximetil-3-(4,3-diclorofenil)-8-azabiciclo[3.2.1] octano.3.- La sal de la reivindicación 1, que es monohidrato de L-tartrato de (1R, 2R, 3S, 5S)-2-metoximetil-3-(4,3-diclorofenil)-8-azabiciclo[3.2.1] octano.4.- La sal de la reivindicación 1, que es una forma anhídrida de L-tartrato de (1R, 2R, 3S, 5S)-2-metoximetil-3-(4,3-diclorofenil)-8-azabiciclo[3.2.1] octano.5.- La sal de la reivindicación 4, que es una forma polimórfica (forma II) de anhídrido de L-tartrato de (1R, 2R, 3S, 5S)-2-metoximetil-3-(4,3-diclorofenil)-8-azabiciclo[3.2.1] octano caracterizada por los siguientes picos principales en el patrón de difracción de rayos X del polvo:6.- La sal de la reivindicación 4, que es una forma polimórfica (forma III) del anhídrido del L-tartrato de (1R, 2R, 3S, 5S)-2-metoximetil-3-(4,3-diclorofenil)-8-azabiciclo[3.2.1] octano caracterizada por los siguientes picos en el patrón de difracción de rayos X del polvo:
CO06001282A 2003-07-31 2006-01-06 Sales de 2-metoximetil-3-(3,4-diclorofenil)-8-azabiciclo[3.2.1]octan tartrato CO5640088A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301117 2003-07-31
US49409003P 2003-08-12 2003-08-12

Publications (1)

Publication Number Publication Date
CO5640088A2 true CO5640088A2 (es) 2006-05-31

Family

ID=34117517

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06001282A CO5640088A2 (es) 2003-07-31 2006-01-06 Sales de 2-metoximetil-3-(3,4-diclorofenil)-8-azabiciclo[3.2.1]octan tartrato

Country Status (9)

Country Link
KR (1) KR20060054386A (es)
CO (1) CO5640088A2 (es)
CY (1) CY1107639T1 (es)
HK (1) HK1089968A1 (es)
HR (1) HRP20070197T3 (es)
IL (1) IL172576A0 (es)
IS (1) IS2588B (es)
MX (1) MXPA06001050A (es)
NO (1) NO20060934L (es)

Also Published As

Publication number Publication date
CY1107639T1 (el) 2013-04-18
IS2588B (is) 2010-02-15
HK1089968A1 (en) 2006-12-15
IS8330A (is) 2006-02-27
IL172576A0 (en) 2006-04-10
MXPA06001050A (es) 2006-04-24
HRP20070197T3 (en) 2007-06-30
KR20060054386A (ko) 2006-05-22
NO20060934L (no) 2006-04-28

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