CO5611144A2 - USE OF 3-PHENYL-5-ALCOXI-1,3,4-OXADIAZOL-2-SUBSTITUTED WAVES TO PRODUCE MEDICINES WITH AN INHIBITING EFFECT ON PANCREATIC LIPASE - Google Patents
USE OF 3-PHENYL-5-ALCOXI-1,3,4-OXADIAZOL-2-SUBSTITUTED WAVES TO PRODUCE MEDICINES WITH AN INHIBITING EFFECT ON PANCREATIC LIPASEInfo
- Publication number
- CO5611144A2 CO5611144A2 CO04083781A CO04083781A CO5611144A2 CO 5611144 A2 CO5611144 A2 CO 5611144A2 CO 04083781 A CO04083781 A CO 04083781A CO 04083781 A CO04083781 A CO 04083781A CO 5611144 A2 CO5611144 A2 CO 5611144A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- groups
- substituted
- alkyloxy
- aryl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- El uso de 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas sustituidas de fórmula 1 en la que los significados son:R1 los grupos alquilo de C1-C6, cicloalquilo de C3-C9, siendo posible que ambos grupos estén sustituidos una o más veces con los grupos fenilo, alquiloxi de C1-C4, S-alquilo de C1-C4, N(alquilo de C1-C4)2, y el grupo fenilo es posible que a su vez esté sustituido una o más veces con los grupos halógeno, alquilo de C1-C4, alquiloxi de C1-C4, nitro, CF3, y R2, R3, R4 y R5 son, independientemente uno de otro, hidrógeno o los grupos halógeno, nitro, alquilo de C1-C4, alquiloxi de C1-C9, que está sustituido con los grupos flúor, arilo de C6-C10, amino o alquilo de C1-C4-amino, los grupos arilo de C6-C10-alquiloxi de C1-C4, ariloxi de C6-C10, arilo de C6-C10, ariloxi de C6-C10-alquilo de C1-C4, cicloalquilo de C3-C8 u O-cicloalquilo de C3-C8, cada uno de los cuales puede estar sustituido una, dos o tres veces con los grupos halógeno, CF3, alquiloxi de C1-C4 o alquilo de C1-C4 los grupos SO2-NH-alquilo de C1-C6, opcionalmente sustituidos con un grupo N(alquilo de C1-C6)2, o SO2-NH(2,2,6,6-tetrametilpiperidin-4-il), SO2-NH-cicloalquilo de C3-C8, opcionalmente sustituido una o más veces con un grupo alquilo de C1-C4, o SO2-N (alquilo de C1-C6)2 o COX, 2-oxo-pirrolidin-1-ilo, 2,5-dimetilpirrol-1-ilo o NR6-A-R7, con la condición de que R2, R3, R4 y R5 no sean simultáneamente hidrógeno, con X los grupos O-alquilo de C1-C6, NH-alquilo de C1-C6, NH-cicloalquilo de C3-C8 o N (alquilo de C1-C6)2 y el grupoN(alquilo de C1-C6)2 también puede ser los grupos pirrolidino, piperidino, morfolino, tiomorfolino o piperazino, cada uno de los cuales puede estar opcionalmente sustituido con los grupos alquilo de C1-C4, bencilo, arilo de C6-C10, CO-alquilo de C1-C4, CO-arilo de C6-C10, CO-O-alquilo de C1-C4, SO2-alquilo de C1-C4, o SO2arilo de C6-C10;R6 hidrógeno, o los grupos alquilo de C1-C4 o arilo de C6-C10-alquilo de C1-C4, en el que el grupo arilo puede estar sustituido con los grupos halógeno, CF3, alquiloxi de C1-C8 o alquilo de C1-C4;A un enlace simple, COn, SOn o CONH; ...1.- The use of substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones of formula 1 in which the meanings are: R1 C1-C6 alkyl groups, C3-C9 cycloalkyl , it being possible that both groups are substituted one or more times with the phenyl, C1-C4 alkyloxy, S-C1-C4 alkyl, N (C1-C4 alkyl) 2 groups, and the phenyl group is possible that at its once it is substituted one or more times with the halogen groups, C1-C4 alkyl, C1-C4 alkyloxy, nitro, CF3, and R2, R3, R4 and R5 are, independently of each other, hydrogen or the halogen groups, nitro , C1-C4 alkyl, C1-C9 alkyloxy, which is substituted with the fluorine groups, C6-C10 aryl, amino or C1-C4-amino alkyl, the C6-C10-C1-C4 alkyloxy groups , C6-C10 aryloxy, C6-C10 aryl, C6-C10 aryloxy-C1-C4 alkyl, C3-C8 cycloalkyl or C3-C8 O-cycloalkyl, each of which may be substituted one, two or three times with the halogen, CF3, C1-C4 alkyloxy or C1 alkyl groups -C4 the groups SO2-NH-C1-C6 alkyl, optionally substituted with a group N (C1-C6 alkyl) 2, or SO2-NH (2,2,6,6-tetramethylpiperidin-4-yl), SO2 -NH-C3-C8 cycloalkyl, optionally substituted one or more times with a C1-C4 alkyl group, or SO2-N (C1-C6 alkyl) 2 or COX, 2-oxo-pyrrolidin-1-yl, 2 , 5-dimethylpyrrol-1-yl or NR6-A-R7, with the proviso that R2, R3, R4 and R5 are not simultaneously hydrogen, with X the C1-C6 O-alkyl, NH-C1- alkyl groups C6, C3-C8 or N-cycloalkyl or N (C1-C6 alkyl) 2 and the N (C1-C6 alkyl) 2 group may also be the pyrrolidino, piperidino, morpholino, thiomorpholino or piperazino groups, each of which it may be optionally substituted with the C1-C4 alkyl, benzyl, C6-C10 aryl, CO-C1-C4 alkyl, CO-C6-C10 aryl, CO-O-C1-C4 alkyl, SO2-alkyl groups of C1-C4, or SO2aryl of C6-C10; R6 hydrogen, or C1-C4 alkyl or aryl groups of C6-C10-C1-C4 alkyl, in which the aryl group may be substituted with the halogen, CF3, C1-C8 alkyloxy or C1-C4 alkyl groups, to a single bond, COn, SOn or CONH; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10208986A DE10208986A1 (en) | 2002-02-28 | 2002-02-28 | Use of substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one for the production of medicaments with an inhibitory effect on the pancreatic lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5611144A2 true CO5611144A2 (en) | 2006-02-28 |
Family
ID=27740557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04083781A CO5611144A2 (en) | 2002-02-28 | 2004-08-26 | USE OF 3-PHENYL-5-ALCOXI-1,3,4-OXADIAZOL-2-SUBSTITUTED WAVES TO PRODUCE MEDICINES WITH AN INHIBITING EFFECT ON PANCREATIC LIPASE |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1482929A1 (en) |
| JP (1) | JP2005519079A (en) |
| KR (1) | KR20040101250A (en) |
| CN (1) | CN1638766A (en) |
| AR (1) | AR038702A1 (en) |
| AU (1) | AU2003210292A1 (en) |
| BR (1) | BR0308045A (en) |
| CA (1) | CA2477005A1 (en) |
| CO (1) | CO5611144A2 (en) |
| DE (1) | DE10208986A1 (en) |
| HR (1) | HRP20040783A2 (en) |
| HU (1) | HUP0500093A2 (en) |
| IL (1) | IL163719A0 (en) |
| MA (1) | MA27173A1 (en) |
| MX (1) | MXPA04007480A (en) |
| NO (1) | NO20044091L (en) |
| PL (1) | PL371310A1 (en) |
| RU (1) | RU2004128932A (en) |
| TW (1) | TW200400026A (en) |
| WO (1) | WO2003072098A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2410384C2 (en) | 2004-06-17 | 2011-01-27 | Цитокинетикс, Инк. | Compounds, compositions and methods of their application |
| WO2006045799A2 (en) | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions |
| EP1959960B1 (en) | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| KR101613610B1 (en) * | 2007-12-25 | 2016-04-19 | 깃세이 야쿠힌 고교 가부시키가이샤 | Novel catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition |
| TW201028406A (en) | 2008-12-23 | 2010-08-01 | Bial Portela & Ca Sa | 5-O-substituted 3-N-aryl-1,3,4-oxadiazolones for medical use |
| CN103086859B (en) * | 2011-11-08 | 2015-11-11 | 清华大学 | 2,4-dihydroxyl-5,6-replaces-1-halogeno-benzene derivative, its synthetic method and application thereof |
| EP3676243A4 (en) * | 2017-09-01 | 2021-05-26 | Curtin University | Synthetic derivatives of oleoyl-lysophosphatidylinositol (oleolyl-lpi) and uses thereof |
| CN109879839B (en) * | 2019-03-12 | 2023-04-25 | 沈阳大学 | 6-piperazinemethyl-7-hydroxy benzofuran compound and medical application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19942354A1 (en) * | 1999-09-04 | 2001-03-08 | Aventis Pharma Gmbh | Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, their manufacture and use in medicinal products |
| EE04877B1 (en) * | 2000-03-07 | 2007-08-15 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-1-5 -alkoxy-1,3,4-oxadiazol-2-one, its preparation and its use in a hormone-sensitive lipase suppressant and a sugar-containing drug containing it |
-
2002
- 2002-02-28 DE DE10208986A patent/DE10208986A1/en not_active Withdrawn
-
2003
- 2003-02-17 IL IL16371903A patent/IL163719A0/en unknown
- 2003-02-17 MX MXPA04007480A patent/MXPA04007480A/en unknown
- 2003-02-17 EP EP03742942A patent/EP1482929A1/en not_active Withdrawn
- 2003-02-17 RU RU2004128932/15A patent/RU2004128932A/en not_active Application Discontinuation
- 2003-02-17 CA CA002477005A patent/CA2477005A1/en not_active Abandoned
- 2003-02-17 PL PL03371310A patent/PL371310A1/en not_active Application Discontinuation
- 2003-02-17 WO PCT/EP2003/001560 patent/WO2003072098A1/en not_active Application Discontinuation
- 2003-02-17 HU HU0500093A patent/HUP0500093A2/en unknown
- 2003-02-17 BR BR0308045-5A patent/BR0308045A/en not_active Application Discontinuation
- 2003-02-17 AU AU2003210292A patent/AU2003210292A1/en not_active Abandoned
- 2003-02-17 CN CNA038047675A patent/CN1638766A/en active Pending
- 2003-02-17 JP JP2003570844A patent/JP2005519079A/en not_active Withdrawn
- 2003-02-17 KR KR10-2004-7013470A patent/KR20040101250A/en not_active Application Discontinuation
- 2003-02-26 TW TW092103972A patent/TW200400026A/en unknown
- 2003-02-26 AR ARP030100625A patent/AR038702A1/en unknown
-
2004
- 2004-07-27 MA MA27804A patent/MA27173A1/en unknown
- 2004-08-26 CO CO04083781A patent/CO5611144A2/en not_active Application Discontinuation
- 2004-08-27 HR HR20040783A patent/HRP20040783A2/en not_active Application Discontinuation
- 2004-09-27 NO NO20044091A patent/NO20044091L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04007480A (en) | 2004-11-10 |
| JP2005519079A (en) | 2005-06-30 |
| HUP0500093A2 (en) | 2005-04-28 |
| RU2004128932A (en) | 2005-04-10 |
| EP1482929A1 (en) | 2004-12-08 |
| AR038702A1 (en) | 2005-01-26 |
| CA2477005A1 (en) | 2003-09-04 |
| CN1638766A (en) | 2005-07-13 |
| TW200400026A (en) | 2004-01-01 |
| DE10208986A1 (en) | 2003-09-11 |
| IL163719A0 (en) | 2005-12-18 |
| HRP20040783A2 (en) | 2005-04-30 |
| WO2003072098A1 (en) | 2003-09-04 |
| NO20044091L (en) | 2004-09-27 |
| PL371310A1 (en) | 2005-06-13 |
| MA27173A1 (en) | 2005-01-03 |
| AU2003210292A1 (en) | 2003-09-09 |
| BR0308045A (en) | 2004-12-21 |
| KR20040101250A (en) | 2004-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |