HUP0500093A2 - Use of substituted 3-phenyl-5-alkoxy-1,3,4-oxdiazole-2-one for producing medicaments that inhibit pancreatic lipase - Google Patents
Use of substituted 3-phenyl-5-alkoxy-1,3,4-oxdiazole-2-one for producing medicaments that inhibit pancreatic lipaseInfo
- Publication number
- HUP0500093A2 HUP0500093A2 HU0500093A HUP0500093A HUP0500093A2 HU P0500093 A2 HUP0500093 A2 HU P0500093A2 HU 0500093 A HU0500093 A HU 0500093A HU P0500093 A HUP0500093 A HU P0500093A HU P0500093 A2 HUP0500093 A2 HU P0500093A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkoxy
- substituted
- alkyl
- group
- phenyl
- Prior art date
Links
- 102000019280 Pancreatic lipases Human genes 0.000 title abstract 2
- 108050006759 Pancreatic lipases Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940116369 pancreatic lipase Drugs 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 phenyl- Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgya az (1) általános képletű (szubsztituált 3-fenil-5-alkoxi-1,3,4-oxadiazol-2-onok, valamint farmakológiailag elfogadhatósói és savaddíciós sói alkalmazása gyógyszer előállítására, amelyekhasnyálmirigy lipázt gátolnak. Az (1) általános képletben R1 jelentése1-6 szénatomos alkil-, 3-9 szénatomos cikloalkilcsoport, ahol mindkétcsoport egyszer vagy többször szubsztituálva lehet fenil-, 1-4szénatomos alkoxi-, S-(1-4 szénatomos alkil)-, N(1-4 szénatomosalkil)2-csoporttal, és a fenilcsoport még szubsztituálva lehet egyvagy több halogénatommal, 1-4 szénatomos alkil-, 1-4 szénatomosalkoxi-, nitro-, trifluor-metil-csoporttal; és R2, R3, R4 és R5jelentése egymástól függetlenül hidrogén- vagy halogénatom, nitro-, 1-4 szénatomos alkil-, 1-9 szénatomos alkoxicsoport, amelyszubsztituálva van fluoratommal, 6-10 szénatomos aril-, amino- vagy 1-4 szénatomos alkil-amino-csoporttal; (6-10 szénatomos aril)-(1-4szénatomos alkoxi)-, 6-10 szénatomos aril-oxi-, 6-10 szénatomos aril-,(6-10 szénatomos aril-oxi)-(1-4 szénatomos alkil)-, 3-8 szénatomoscikloalkil- vagy O-(3-8 szénatomos cikloalkil)-csoport, azzal amegkötéssel, hogy R2, R3, R4 és R5 nem lehet egyidejűleg hidrogénatom. ÓThe subject of the invention is the use of substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones of general formula (1) and their pharmacologically acceptable salts and acid addition salts for the production of drugs that inhibit pancreatic lipase. in the formula, R1 is a C1-6 alkyl group, a C3-9 cycloalkyl group, where both groups can be substituted once or more by phenyl-, C1-4 alkoxy-, S-(1-4 C alkyl)-, N(1-4 C alkyl)2 - group, and the phenyl group may be substituted with one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy, nitro, trifluoromethyl groups; and R2, R3, R4 and R5 are independently hydrogen or halogen atoms, nitro, C1-C4 alkyl, C1-C9 alkoxy group substituted with fluorine, C6-10 aryl, amino or C1-4 alkylamino; (C6-10 aryl)-(1 -C4 oxy)-, C6-C10 aryloxy-, C6-C10 aryl-, (C6-C10 aryloxy)-(C1-C4 alkyl)-, C3-8 cycloalkyl- or O-( 3-8 cycloalkyl) group, with the stipulation that R2, R3, R4 and R5 cannot be hydrogen atoms at the same time. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10208986A DE10208986A1 (en) | 2002-02-28 | 2002-02-28 | Use of substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one for the production of medicaments with an inhibitory effect on the pancreatic lipase |
| PCT/EP2003/001560 WO2003072098A1 (en) | 2002-02-28 | 2003-02-17 | Use of substituted 3-phenyl-5-alkoxy-1,3,4-oxdiazole-2-one for producing medicaments that inhibit pancreatic lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0500093A2 true HUP0500093A2 (en) | 2005-04-28 |
Family
ID=27740557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500093A HUP0500093A2 (en) | 2002-02-28 | 2003-02-17 | Use of substituted 3-phenyl-5-alkoxy-1,3,4-oxdiazole-2-one for producing medicaments that inhibit pancreatic lipase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1482929A1 (en) |
| JP (1) | JP2005519079A (en) |
| KR (1) | KR20040101250A (en) |
| CN (1) | CN1638766A (en) |
| AR (1) | AR038702A1 (en) |
| AU (1) | AU2003210292A1 (en) |
| BR (1) | BR0308045A (en) |
| CA (1) | CA2477005A1 (en) |
| CO (1) | CO5611144A2 (en) |
| DE (1) | DE10208986A1 (en) |
| HR (1) | HRP20040783A2 (en) |
| HU (1) | HUP0500093A2 (en) |
| IL (1) | IL163719A0 (en) |
| MA (1) | MA27173A1 (en) |
| MX (1) | MXPA04007480A (en) |
| NO (1) | NO20044091L (en) |
| PL (1) | PL371310A1 (en) |
| RU (1) | RU2004128932A (en) |
| TW (1) | TW200400026A (en) |
| WO (1) | WO2003072098A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2410384C2 (en) | 2004-06-17 | 2011-01-27 | Цитокинетикс, Инк. | Compounds, compositions and methods of their application |
| WO2006045799A2 (en) | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions |
| EP1959960B1 (en) | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| KR101613610B1 (en) * | 2007-12-25 | 2016-04-19 | 깃세이 야쿠힌 고교 가부시키가이샤 | Novel catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition |
| TW201028406A (en) | 2008-12-23 | 2010-08-01 | Bial Portela & Ca Sa | 5-O-substituted 3-N-aryl-1,3,4-oxadiazolones for medical use |
| CN103086859B (en) * | 2011-11-08 | 2015-11-11 | 清华大学 | 2,4-dihydroxyl-5,6-replaces-1-halogeno-benzene derivative, its synthetic method and application thereof |
| EP3676243A4 (en) * | 2017-09-01 | 2021-05-26 | Curtin University | Synthetic derivatives of oleoyl-lysophosphatidylinositol (oleolyl-lpi) and uses thereof |
| CN109879839B (en) * | 2019-03-12 | 2023-04-25 | 沈阳大学 | 6-piperazinemethyl-7-hydroxy benzofuran compound and medical application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19942354A1 (en) * | 1999-09-04 | 2001-03-08 | Aventis Pharma Gmbh | Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, their manufacture and use in medicinal products |
| EE04877B1 (en) * | 2000-03-07 | 2007-08-15 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-1-5 -alkoxy-1,3,4-oxadiazol-2-one, its preparation and its use in a hormone-sensitive lipase suppressant and a sugar-containing drug containing it |
-
2002
- 2002-02-28 DE DE10208986A patent/DE10208986A1/en not_active Withdrawn
-
2003
- 2003-02-17 IL IL16371903A patent/IL163719A0/en unknown
- 2003-02-17 MX MXPA04007480A patent/MXPA04007480A/en unknown
- 2003-02-17 EP EP03742942A patent/EP1482929A1/en not_active Withdrawn
- 2003-02-17 RU RU2004128932/15A patent/RU2004128932A/en not_active Application Discontinuation
- 2003-02-17 CA CA002477005A patent/CA2477005A1/en not_active Abandoned
- 2003-02-17 PL PL03371310A patent/PL371310A1/en not_active Application Discontinuation
- 2003-02-17 WO PCT/EP2003/001560 patent/WO2003072098A1/en not_active Application Discontinuation
- 2003-02-17 HU HU0500093A patent/HUP0500093A2/en unknown
- 2003-02-17 BR BR0308045-5A patent/BR0308045A/en not_active Application Discontinuation
- 2003-02-17 AU AU2003210292A patent/AU2003210292A1/en not_active Abandoned
- 2003-02-17 CN CNA038047675A patent/CN1638766A/en active Pending
- 2003-02-17 JP JP2003570844A patent/JP2005519079A/en not_active Withdrawn
- 2003-02-17 KR KR10-2004-7013470A patent/KR20040101250A/en not_active Application Discontinuation
- 2003-02-26 TW TW092103972A patent/TW200400026A/en unknown
- 2003-02-26 AR ARP030100625A patent/AR038702A1/en unknown
-
2004
- 2004-07-27 MA MA27804A patent/MA27173A1/en unknown
- 2004-08-26 CO CO04083781A patent/CO5611144A2/en not_active Application Discontinuation
- 2004-08-27 HR HR20040783A patent/HRP20040783A2/en not_active Application Discontinuation
- 2004-09-27 NO NO20044091A patent/NO20044091L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04007480A (en) | 2004-11-10 |
| JP2005519079A (en) | 2005-06-30 |
| RU2004128932A (en) | 2005-04-10 |
| EP1482929A1 (en) | 2004-12-08 |
| AR038702A1 (en) | 2005-01-26 |
| CA2477005A1 (en) | 2003-09-04 |
| CO5611144A2 (en) | 2006-02-28 |
| CN1638766A (en) | 2005-07-13 |
| TW200400026A (en) | 2004-01-01 |
| DE10208986A1 (en) | 2003-09-11 |
| IL163719A0 (en) | 2005-12-18 |
| HRP20040783A2 (en) | 2005-04-30 |
| WO2003072098A1 (en) | 2003-09-04 |
| NO20044091L (en) | 2004-09-27 |
| PL371310A1 (en) | 2005-06-13 |
| MA27173A1 (en) | 2005-01-03 |
| AU2003210292A1 (en) | 2003-09-09 |
| BR0308045A (en) | 2004-12-21 |
| KR20040101250A (en) | 2004-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |