CO4810374A1 - NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITY - Google Patents
NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITYInfo
- Publication number
- CO4810374A1 CO4810374A1 CO98060225A CO98060225A CO4810374A1 CO 4810374 A1 CO4810374 A1 CO 4810374A1 CO 98060225 A CO98060225 A CO 98060225A CO 98060225 A CO98060225 A CO 98060225A CO 4810374 A1 CO4810374 A1 CO 4810374A1
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- mammal
- independently
- compound
- case
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
Abstract
Un método de tratamiento de prurito en un mamífero que necesitade ello, que comprende administrar a dicho mamífero una cantidad eficaz de un compuesto de un inhibidor de PDE4 , distinto de CP 80633. El método según la reivindicación 1, en el que el inhibidor de PDE4 es un compuesto de la fórmula: en la que: R1 y R2 , independientemente en cada caso, representan alquilo o -(CH2 )m -A; m representa cero o el número entero 1, 2 ó 3; A representa un radical hidrocarbonado cíclico no sustituido o sustituido; R3 representa un átomo de halógeno, un grupo nitro o un grupo -NR4 R5 ; R4 y R5 , independientemente en cada caso, representan hidrógeno, alquilo o alquilcarbonilo, o R4 y R5 junto con el nitrógeno al que están unidos forman un anillo heterocíclico opcionalmente sustituido; y sus sales farmacéuticamente aceptables.A method of treating pruritus in a mammal in need thereof, comprising administering to said mammal an effective amount of a compound of a PDE4 inhibitor, other than CP 80633. The method according to claim 1, wherein the PDE4 inhibitor it is a compound of the formula: wherein: R1 and R2, independently in each case, represent alkyl or - (CH2) m -A; m represents zero or the integer 1, 2 or 3; A represents an unsubstituted or substituted cyclic hydrocarbon radical; R3 represents a halogen atom, a nitro group or a -NR4 R5 group; R4 and R5, independently in each case, represent hydrogen, alkyl or alkylcarbonyl, or R4 and R5 together with the nitrogen to which they are attached form an optionally substituted heterocyclic ring; and its pharmaceutically acceptable salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6374697P | 1997-10-17 | 1997-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4810374A1 true CO4810374A1 (en) | 1999-06-30 |
Family
ID=22051225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98060225A CO4810374A1 (en) | 1997-10-17 | 1998-10-16 | NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITY |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1030666A4 (en) |
JP (1) | JP2001520196A (en) |
KR (1) | KR20010031149A (en) |
CN (1) | CN1306426A (en) |
AR (1) | AR015966A1 (en) |
AU (1) | AU740875B2 (en) |
BR (1) | BR9814080A (en) |
CA (1) | CA2306985A1 (en) |
CO (1) | CO4810374A1 (en) |
CZ (1) | CZ20001376A3 (en) |
HU (1) | HUP0003792A3 (en) |
IL (1) | IL135581A0 (en) |
NO (1) | NO20001847L (en) |
NZ (1) | NZ503551A (en) |
PL (1) | PL341062A1 (en) |
TR (1) | TR200001040T2 (en) |
WO (1) | WO1999020280A1 (en) |
ZA (1) | ZA989450B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL365443A1 (en) | 2001-01-31 | 2005-01-10 | Pfizer Products Inc. | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
CA2436535A1 (en) | 2001-01-31 | 2002-08-08 | Prizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
WO2002060896A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
US20030175314A1 (en) * | 2001-11-19 | 2003-09-18 | Didriksen Erik Johannes | Pharmaceutical composition for dermal application |
EP1647274A4 (en) * | 2003-07-17 | 2008-12-10 | Ono Pharmaceutical Co | Remedy for pruritus comprising piperidine derivative as the active ingredient |
JP2005187458A (en) * | 2003-12-04 | 2005-07-14 | Santen Pharmaceut Co Ltd | Itchiness-treating agent consisting of cilomilast or its salt as active ingredient |
WO2005053672A1 (en) * | 2003-12-04 | 2005-06-16 | Santen Pharmaceutical Co., Ltd. | Remedy for pruritus comprising cilomilast or salt thereof as the active ingredient |
KR101100601B1 (en) * | 2004-02-14 | 2011-12-29 | 글락소스미스클라인 엘엘씨 | Novel compounds |
JP2008137892A (en) * | 2005-03-04 | 2008-06-19 | Eisai Co Ltd | Antipruritic agent |
JP2009504592A (en) | 2005-08-10 | 2009-02-05 | スミスクライン・ビーチャム・コーポレイション | Xanthine derivatives as selective HM74A agonists |
TWI404709B (en) * | 2006-02-21 | 2013-08-11 | Eisai R&D Man Co Ltd | 4-(3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives |
MX2008010774A (en) | 2006-02-21 | 2008-09-01 | Eisai R&D Man Co Ltd | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative. |
EP2123641A4 (en) | 2007-02-16 | 2011-06-22 | Eisai R&D Man Co Ltd | Crystal, amorphous form and salt of methyl n-ý3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl¨terephthalamic acid |
JP5060561B2 (en) | 2007-08-17 | 2012-10-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | New topical preparation |
JP5043945B2 (en) | 2007-08-17 | 2012-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Method for producing quinazoline derivative |
EP2727594B1 (en) * | 2011-06-28 | 2017-12-20 | Mitsubishi Tanabe Pharma Corporation | Naphtalene compounds to treat itch |
SG10201907026RA (en) | 2015-01-30 | 2019-09-27 | Shanton Pharma Co Ltd | Prevention or Treatment of Uratic or Gouty Diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992011260A1 (en) * | 1990-12-21 | 1992-07-09 | Beecham Group Plc | Xanthine derivatives |
JP4141501B2 (en) * | 1996-03-26 | 2008-08-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Novel 6-substituted phenanthridine |
AU2892397A (en) * | 1996-05-15 | 1997-12-05 | Byk Gulden | Novel imidazopyridines |
PT968211E (en) * | 1997-03-07 | 2004-01-30 | Altana Pharma Ag | TETRAZOLE DERIVATIVES |
PL336464A1 (en) * | 1997-03-18 | 2000-06-19 | Basf Ag | Method of and compositions for modulating reactivity in respect to corticosteroids i |
JP2002502403A (en) * | 1997-06-03 | 2002-01-22 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Benzonaphthyridine |
-
1998
- 1998-10-15 AR ARP980105131A patent/AR015966A1/en not_active Application Discontinuation
- 1998-10-16 CZ CZ20001376A patent/CZ20001376A3/en unknown
- 1998-10-16 CN CN98810066A patent/CN1306426A/en active Pending
- 1998-10-16 EP EP98953608A patent/EP1030666A4/en not_active Withdrawn
- 1998-10-16 CO CO98060225A patent/CO4810374A1/en unknown
- 1998-10-16 TR TR2000/01040T patent/TR200001040T2/en unknown
- 1998-10-16 WO PCT/US1998/021886 patent/WO1999020280A1/en not_active Application Discontinuation
- 1998-10-16 NZ NZ503551A patent/NZ503551A/en unknown
- 1998-10-16 KR KR1020007004053A patent/KR20010031149A/en not_active Application Discontinuation
- 1998-10-16 BR BR9814080-9A patent/BR9814080A/en not_active IP Right Cessation
- 1998-10-16 AU AU10938/99A patent/AU740875B2/en not_active Ceased
- 1998-10-16 ZA ZA989450A patent/ZA989450B/en unknown
- 1998-10-16 HU HU0003792A patent/HUP0003792A3/en unknown
- 1998-10-16 IL IL13558198A patent/IL135581A0/en unknown
- 1998-10-16 CA CA002306985A patent/CA2306985A1/en not_active Abandoned
- 1998-10-16 JP JP2000516677A patent/JP2001520196A/en not_active Withdrawn
- 1998-10-16 PL PL98341062A patent/PL341062A1/en unknown
-
2000
- 2000-04-10 NO NO20001847A patent/NO20001847L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR9814080A (en) | 2000-09-26 |
NO20001847D0 (en) | 2000-04-10 |
CZ20001376A3 (en) | 2002-06-12 |
AU1093899A (en) | 1999-05-10 |
NZ503551A (en) | 2002-05-31 |
EP1030666A1 (en) | 2000-08-30 |
JP2001520196A (en) | 2001-10-30 |
CN1306426A (en) | 2001-08-01 |
NO20001847L (en) | 2000-04-10 |
WO1999020280A1 (en) | 1999-04-29 |
ZA989450B (en) | 1999-04-19 |
CA2306985A1 (en) | 1999-04-29 |
IL135581A0 (en) | 2001-05-20 |
TR200001040T2 (en) | 2001-01-22 |
PL341062A1 (en) | 2001-03-26 |
AR015966A1 (en) | 2001-05-30 |
AU740875B2 (en) | 2001-11-15 |
HUP0003792A3 (en) | 2001-12-28 |
KR20010031149A (en) | 2001-04-16 |
HUP0003792A2 (en) | 2001-10-28 |
EP1030666A4 (en) | 2002-10-16 |
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