CO4940492A1 - Inhibidor de proteasa de vih - Google Patents
Inhibidor de proteasa de vihInfo
- Publication number
- CO4940492A1 CO4940492A1 CO98029716A CO98029716A CO4940492A1 CO 4940492 A1 CO4940492 A1 CO 4940492A1 CO 98029716 A CO98029716 A CO 98029716A CO 98029716 A CO98029716 A CO 98029716A CO 4940492 A1 CO4940492 A1 CO 4940492A1
- Authority
- CO
- Colombia
- Prior art keywords
- crystalline compound
- compound
- solution
- formula
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto cristalino de fórmula:en donde el compuesto cristalino es caracterizado por (i) una curva de barrido diferencial de calorimetría (DSC), a una tasa de calentamiento de 10 °C/minuto en una taza abierta, bajo flujo de nitrógeno, que exhibe una endoterma con una temperatura extrapolada de inicio de 190°C, una temperatura pico de 193°C y un calor asociado de 120 J/gm y (ii) un patrón de difracción del polvo a los rayos X con espaciamientos-d de 11,72 Å (11,72* 10-8 cm), 5,56 Å (5,56* 10-8 cm), 5,20 Å (5,20* 10-8 cm), 5,00 Å (5,00*10-8 cm), 4,60 Å (4,60*10-8 cm), 4,50 Å (4,50*10-8 cm), 4,40 Å (4,40*10-8 cm), 4,26 Å (4,26*10-8 cm), 4,17 Å (4,17*10-8 cm), 4,08 Å (4,08*10-8 cm), 3,90 Å (3,90*10-8 cm), 3,81 Å (3,81*10-8 cm), 3,69 Å (3,69*10-8 cm), 3,24 Å (3,24*10-8 cm) y 3,33 Å (3,33*10-8 cm).1Un procedimiento para preparar el compuesto cristalino de la reivindicación 1, que comprende: (a) disolver el compuesto de base libre del compuesto de fórmula: en un solvente para formar una solución; y (b) tratar la solución del paso (a) con ácido sulfúrico para formar el compuesto cristalino.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4795097P | 1997-05-29 | 1997-05-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4940492A1 true CO4940492A1 (es) | 2000-07-24 |
Family
ID=21951924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98029716A CO4940492A1 (es) | 1997-05-29 | 1998-05-27 | Inhibidor de proteasa de vih |
Country Status (3)
Country | Link |
---|---|
US (1) | US6071916A (es) |
CO (1) | CO4940492A1 (es) |
ZA (1) | ZA984514B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100336699B1 (ko) | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
US6482827B1 (en) * | 1997-07-10 | 2002-11-19 | Pharmacia & Upjohn S.P.A. | Matrix metalloproteinase inhibitors |
US7122376B2 (en) * | 2001-11-01 | 2006-10-17 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
US7049146B2 (en) | 2000-11-14 | 2006-05-23 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
NZ536497A (en) * | 2002-05-16 | 2006-08-31 | Tibotec Pharm Ltd | Pseudopolymorphic forms of a HIV protease inhibitor and their use as a medicament |
US20040131504A1 (en) * | 2002-09-17 | 2004-07-08 | Landers James P. | Remote temperature sensing of small volume and related apparatus thereof |
CA2531116A1 (en) * | 2003-07-01 | 2005-01-20 | Michael Hawley | Diffusion layer modulated solids |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4629786A (en) * | 1983-02-28 | 1986-12-16 | Eli Lilly And Company | C-20- and C-23 modified macrolide derivatives |
US4631286A (en) * | 1984-10-25 | 1986-12-23 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
US5717097A (en) * | 1991-11-08 | 1998-02-10 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
AU692509B2 (en) * | 1993-12-15 | 1998-06-11 | Merck & Co., Inc. | HIV protease inhibitors |
-
1998
- 1998-05-27 ZA ZA984514A patent/ZA984514B/xx unknown
- 1998-05-27 CO CO98029716A patent/CO4940492A1/es unknown
- 1998-05-28 US US09/086,021 patent/US6071916A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ZA984514B (en) | 1998-11-30 |
US6071916A (en) | 2000-06-06 |
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