CO4930275A1 - ARISULFONAMIDES AND ANALOGS - Google Patents

ARISULFONAMIDES AND ANALOGS

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Publication number
CO4930275A1
CO4930275A1 CO98008408A CO98008408A CO4930275A1 CO 4930275 A1 CO4930275 A1 CO 4930275A1 CO 98008408 A CO98008408 A CO 98008408A CO 98008408 A CO98008408 A CO 98008408A CO 4930275 A1 CO4930275 A1 CO 4930275A1
Authority
CO
Colombia
Prior art keywords
different
alkyl
formula
group
same
Prior art date
Application number
CO98008408A
Other languages
Spanish (es)
Inventor
Joachim Mittendorf
Jurgen Dressel
Michael Matzke
Jorg Keldenich
Siegfried Raddatz
Original Assignee
Bayer Ag
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Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CO4930275A1 publication Critical patent/CO4930275A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/35—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Compuestos de fórmula general (I)R1 - A - D - E - G - L - R2 (I)en la cualR1 representa (C6 -C10 )arilo, quinolilo, isoquinolilo o un resto de fórmuladondea significa un número 1 ó 2,R3 significa hidrógeno (C2 -C6 ) alquenilo, (C1 -C6 ) alquilo o (C1 -C6 ) acilo,y donde todos los sistemas anulares y restos indicados más arriba están sustituidos, dado el caso, por uno o varios sustituyentes iguales o distintos, dado el caso geminados, elegidos del grupo que está compuesto por : halógeno, carboxilo, hidroxilo, fenilo, (C1 -C6 )alcoxi, (C1 -C6 ) alcoxicarbonilo, (C1 -C8 )alquilo que, por su parte, puede estar sustituido por halógeno, (C1 -C6 ) alquilsulfoniloxi, azido, amino, mono (C1 -C6 ) alquilamino, di(C1 -C6 ) alquilamino o hidroxilo,un grupo de fórmula -(CO)b -NR4 R5 ,dondeb significa un número 0 ó 1,R4 y R5 son iguales o distintos y significan,independientemente uno de otro, hidrógeno, fenilo,(C1 -C6 )acilo, ciclo (C4 -C7 ) acilo, benzoilo o (C1 -C6 )alquilo que, dado el caso, está sustituido por amino, mono (C1 -C6 )alquilamino.o R4 y R5 forman, junto con el átomo de nitrógeno, unheterociclo saturado de 5 ó 6 eslabones que, dado elcaso, puede contener uno o varios heteroátomo (s)adicional (es) del grupo S, O y/o uno o variosresto(s) de fórmula -NR8 - 2 -dondeR8 significa hidrógeno, (C1 AND#8209;C6 )alquilo o (C1 AND#8209;C6 )acilo,yun grupo de fórmula AND#8209;NR6 AND#8209;SO2 AND#8209;R7 dondeR6 significa hidrógeno, fenilo, (C1 AND#8209;C6 )alquilo o(C1 AND#8209;C6 )acilo,R7 significa fenilo o (C1 AND#8209;C6 )alquilo,A y E son iguales o distintos y representan un enlace o (C1 AND#8209;C4 ) alquileno,D representa un átomo de oxígeno o un resto de fórmula S(O)c AND#8209; oAND#8209;N(R9 )AND#8209;,dondec significa un número 0, 1 ó 2,R9 significa hidrógeno, (C1 AND#8209;C6 )alquilo o (C1 AND#8209;C6 )acilo,G representa (C6 AND#8209;C10 )arilo unido por dos sitios o unheterociclo aromático de 5 a 7 eslabones unido por dos sitios con hasta 3 heteroátomos del grupo S, N y/u o que, dado el caso, están sustituidos por uno o varios sustituyentes iguales o distintos elegidos del qrupo compuesto por : hidroxilo, triflúormetilo, carboxilo, halógeno, (C1 -C6 )alquilo, hidroxi(C1 AND#8209;C6 )alquilo, (C1 AND#8209;C6 )alcoxi, (C1 -C6 )alcoxicarbonilo,así como grupos de fórmulasAND#8209;COAND#8209;OAND#8209;(CH2 )d AND#8209;NR10 R11 , AND#8209;NR12 AND#8209;SOR13 ,(CH2 )e -(CO)f AND#8209;NR14 R15 y AND#8209;OR16 , donded significa un número 1, 2, 3 ó 4,e y f son iguales o distintos y significan un número O ó 1,R10 y R11 tienen el significado indicado más arribapara R4 y R5 y son iguales o distintos a éstos,R12 tiene el significado indicado más arriba para R6 y es igual o distinto a éste,R13 tiene el significado indicado más arriba para R7 y es igual o distinto a éste,R14 y R15 tienen el significado indicado más arribapara R4 y R5 y son iguales o distintos a éstos,o independientemente uno de otro constituyen unresto de fórmula AND#8209;(CH2 )g -NR17 R18 ,dondeg significa un número 1, 2, 3 ó 4,yR17 y R18 tienen el significado indicado más arribapara R4 y R5 y son iguales o distintos a éstos,R16 significa (C6 AND#8209;C10 )arilo,L representa un resto de fórmulaefectuándose se la unión de los restos a G por la izquierda, y donde R19 , R20 , R21 , R22 , R23 , R24 , R25 , R26 y R27 son iguales o distintos y significan hidrógeno o (C1 AND#8209;C4 )alquilo, oR19 significa un resto de fórmula AND#8209;SO2 R2 ,R2 representa (C6 AND#8209;C10 )arilo o un heterociclo de 5 a 7 eslabones saturado o aromático con hasta 3 heteroátomos del grupo S, N y/u o que, dado el caso, están sustituidos por uno o varios sustituyentes iguales o distintos elegidos del grupo compuestopor : halógeno, triflúormetilo, nitro, amino y (C1 AND#8209;C6 )alquilo,orepresenta el resto de fórmularepresenta (C3 AND#8209;C8 )cicloalquilo, orepresenta (C1 AND#8209;C12 )alquilo, (C2 AND#8209;C12 )alquenilo, o (C2 AND#8209;C12 )alquinilo que, dado el caso, están sustituidos por uno o varios sustituyentes iguales o distintos elegidos del grupo compuesto porhalógeno, triflúormetilo, hidroxilo, ciano, azido, (C1 AND#8209;C6 )alcoxi, (C1 AND#8209;C6 )perflúoralcoxi, (C1 AND#8209;C6 )alcoxi parcialmente fluorado, unresto de fórmuladonde R28 y R29 tienen el significado indicado más arriba para R4 y R5 y son iguales o distintos a éstos, fenilo, dado el caso sustituido por uno o varios sustituyentes iguales o distintos elegidos del grupo compuesto porhalógeno, nitro, hidroxilo, (C1 AND#8209;C6 )alquilo, (C1 AND#8209;C6 )alcoxi y un grupo de fórmula AND#8209;NR30 R31 , onde R30 y R31 son iguales o distintos y significan hidrógeno o (C1 AND#8209;C6 )alquilo o (C1 AND#8209;C6 )acilo, y un heterociclo aromático de 5 a 6 eslabones con hasta tres heteroátomos del grupo S, N y/u O, dado el caso sustituido por uno o varios sustituyentes iguales o distintos elegidos del grupo compuesto por:halógeno, nitro, hidroxilo, (C1 AND#8209;C6 )alquilo, (C1 AND#8209;C6 )alcoxi y un grupo de fórmula AND#8209;NR30 R31 ,donde R30 y R31 se definen como más arriba,L Y R2 representan juntos un resto de fórmulay sus sales.Compounds of general formula (I) R1 - A - D - E - G - L - R2 (I) in which R1 represents (C6 -C10) aryl, quinolyl, isoquinolyl or a residue of the formula where 1 or 2 denotes a number, R3 means hydrogen (C2-C6) alkenyl, (C1-C6) alkyl or (C1-C6) acyl, and where all the ring systems and residues indicated above are substituted, if appropriate, by one or more same or different substituents, optionally geminates, chosen from the group consisting of: halogen, carboxyl, hydroxyl, phenyl, (C1-C6) alkoxy, (C1-C6) alkoxycarbonyl, (C1-C8) alkyl, which in turn can be substituted by halogen, (C1-C6) alkylsulfonyloxy, azido, amino, mono (C1-C6) alkylamino, di (C1-C6) alkylamino or hydroxyl, a group of formula - (CO) b -NR4 R5, where b is a number 0 or 1, R4 and R5 are the same or different and mean, independently of each other, hydrogen, phenyl, (C1-C6) acyl, cyclo (C4 -C7) acyl, benzoyl or (C1-C6) alkyl which, given the case is substituted by amino, mono (C1-C6) alkylamino.o R4 and R5 form, together with the nitrogen atom, a saturated heterocycle of 5 or 6 links that, if necessary, can contain one or more heteroatom (s) additional group (s) S, O and / or one or more other residue (s) of the formula -NR8 - 2 - where R8 means hydrogen, (C1 AND # 8209; C6) alkyl or (C1 AND # 8209; C6) acyl, and a group of formula AND # 8209; NR6 AND # 8209; SO2 AND # 8209; R7 where R6 means hydrogen, phenyl, (C1 AND # 8209; C6) alkyl or (C1 AND # 8209; C6) acyl, R7 means phenyl or (C1 AND # 8209; C6) alkyl, A and E are the same or different and represent a bond or (C1 AND # 8209; C4) alkylene, D represents an oxygen atom or a residue of formula S (O) c AND # 8209; oAND # 8209; N (R9) AND # 8209;, where c means a number 0, 1 or 2, R9 means hydrogen, (C1 AND # 8209; C6) alkyl or (C1 AND # 8209; C6) acyl, G represents ( C6 AND # 8209; C10) aryl linked by two sites or an aromatic heterocycle of 5 to 7 links linked by two sites with up to 3 heteroatoms of the group S, N and / or which, if appropriate, are replaced by one or more equal substituents or different ones chosen from the group consisting of: hydroxyl, trifluoromethyl, carboxyl, halogen, (C1-C6) alkyl, hydroxy (C1 AND # 8209; C6) alkyl, (C1 AND # 8209; C6) alkoxy, (C1-C6) alkoxycarbonyl , as well as groups of formulasAND # 8209; COAND # 8209; OAND # 8209; (CH2) d AND # 8209; NR10 R11, AND # 8209; NR12 AND # 8209; SOR13, (CH2) e - (CO) f AND # 8209; NR14 R15 and AND # 8209; OR16, donded means a number 1, 2, 3 or 4, e and f are the same or different and mean a number O or 1, R10 and R11 have the meaning indicated above for R4 and R5 and are equal to or different from these, R12 has the indicated meaning above a for R6 and is the same or different from this, R13 has the meaning indicated above for R7 and is the same or different from this, R14 and R15 have the meaning indicated above for R4 and R5 and are the same or different from these, or independently they constitute a remainder of the formula AND # 8209; (CH2) g -NR17 R18, where g means a number 1, 2, 3 or 4, and R17 and R18 have the meaning indicated above for R4 and R5 and are the same or different from these , R16 means (C6 AND # 8209; C10) aryl, L represents a residue of the formula with the residues joining G to the left, and where R19, R20, R21, R22, R23, R24, R25, R26 and R27 are the same or different and signify hydrogen or (C1 AND # 8209; C4) alkyl, or R19 means a residue of formula AND # 8209; SO2 R2, R2 represents (C6 AND # 8209; C10) aryl or a 5- to 7-membered heterocycle saturated or aromatic with up to 3 S, N and / or group heteroatoms which are optionally substituted by one or more equal substituents or different chosen from the group consisting of: halogen, trifluoromethyl, nitro, amino and (C1 AND # 8209; C6) alkyl, represents the rest of the formula represents (C3 AND # 8209; C8) cycloalkyl, represents (C1 AND # 8209; C12) alkyl , (C2 AND # 8209; C12) alkenyl, or (C2 AND # 8209; C12) alkynyl which are optionally substituted by one or more same or different substituents chosen from the group consisting of halogen, trifluoromethyl, hydroxyl, cyano, azido , (C1 AND # 8209; C6) alkoxy, (C1 AND # 8209; C6) perfluoroalkoxy, (C1 AND # 8209; C6) partially fluorinated alkoxy, a remainder of the formula where R28 and R29 have the meaning indicated above for R4 and R5 and are the same or different from these, phenyl, optionally substituted by one or more same or different substituents chosen from the group consisting of halogen, nitro, hydroxyl, (C1 AND # 8209; C6) alkyl, (C1 AND # 8209; C6) alkoxy and a group of the formula AND # 8209; NR30 R31, where R30 and R31 are the same or different and signify hydrogen or (C1 AND # 8209; C6) alkyl or (C1 AND # 8209; C6) acyl, and a 5- to 6-membered aromatic heterocycle with up to three S, N and / or O group heteroatoms, optionally substituted by one or more substituents the same or different chosen from the group consisting of: halogen, nitro, hydroxyl, (C1 AND # 8209; C6) alkyl, (C1 AND # 8209; C6) alkoxy and a group of formula AND # 8209; NR30 R31, where R30 and R31 defined as above, LY R2 together represent a moiety of formula and its salts.

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