PE72299A1 - Arylsulphonamides and analogues - Google Patents

Arylsulphonamides and analogues

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Publication number
PE72299A1
PE72299A1 PE1998000123A PE00012398A PE72299A1 PE 72299 A1 PE72299 A1 PE 72299A1 PE 1998000123 A PE1998000123 A PE 1998000123A PE 00012398 A PE00012398 A PE 00012398A PE 72299 A1 PE72299 A1 PE 72299A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
acil
formula
group
Prior art date
Application number
PE1998000123A
Other languages
Spanish (es)
Inventor
Friedel Arno
Vohringer Verena
Mauler Frank
De Vry Jean-Marie-Viktor
Mittendorf Joachim
Schuhmacher Joachim
Keldenich Jorg
Dressel Jurgen
Franz Jurgen
Mohrs Klaus-Helmut
Matzke Michael
Rock Michael-Harold
Spreyer Peter
Jork Reinhard
Raddatz Siegfried
Horvath Ervin
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE72299A1 publication Critical patent/PE72299A1/en

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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C311/35—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

SE REFIERE A UN COMPUESTO UTIL EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS COMO APOPLEJIA CEREBRAL Y TRAUMATISMO CRANEO-ENCEFALICO, FORMULA I R1-A-D-E-G-L-R2, DE DONDE R1 PUEDE SER UN GRUPO DE ARILO C6-C10, QUINOLILO, ISOQUINOLILO o UN RESTO DE FORMULA: 1, 2, 3, 4, 5, 6, o 7, DONDE a ES 1 o 2, R3 PUEDE SER H, ALQUENILO C2-C6, ALQUILO o ACILO C1-C6, ESTOS SISTEMAS ANULARES Y RESTOS PUEDEN ESTAR SUSTITUIDOS POR: HALOGENO, CARBOXILO, HIDROXILO, FENILO, ALCOXI o ALCOXICARBONILO C1-C6, ALQUILO C1-C8, ALQUILSULFONILOXI C1-C6, AZIDO, AMINO, MONO o DI ALQUILAMINO C1-C6, UN GRUPO DE FORMULA -(CO)b-NR4R5, DONDE b PUEDE SER 0 o 1, R4 Y R5 PUEDEN SER H, FENILO, ACILO C1-C6, CICLOACILO C4-C7, BENZOILO O ALQUILO C1-C6 SUSTITUIDO POR AMINO, MONO o DI ALQUILAMINO C1-C6, UN GRUPO DE FORMULA -NR6-SO2-R7, DONDE R6 PUEDE SER: H, FENILO, ALQUILO o ACILO C1-C6, R7 PUEDE SER: FENILO o ALQUILO C1-C6; A Y E PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAN UN ENLACE o UN ALQUILENO C1-C4; D PUEDE SER OXIGENO o RESTO DE FORMULA -S(O)c- o -N(R9)-, DONDE c PUEDE SER 0, 1 o 2, R9 PUEDE SER: H, ALQUILO o ACILO C1-C6; G ES UN GRUPO ARILO C1-C6 SUSTITUIDO; L PUEDE SER -O-, -NH-, O COMPUESTOS SULFONAMIDAS; R2 PUEDE SER FENILO, NAFTILO, PIRIDILO, FURILO, TIENILO o PIRIMIDILOREFERS TO A COMPOUND USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS BRAIN APOPLEJIA AND CRANIAL-ENCEPHALIC INJURY, FORMULA I R1-ADEGL-R2, WHERE R1 MAY BE A RESIDENT OF ARILO C6-C10, QUINO : 1, 2, 3, 4, 5, 6, or 7, WHERE IS 1 or 2, R3 MAY BE H, C2-C6 ALKYLENE, C1-C6 ALKYL OR RING, THESE RING AND REMAINING SYSTEMS MAY BE REPLACED BY: HALOGEN, CARBOXYL, HYDROXYL, PHENYL, ALCOXY or ALCOXYCARBONYL C1-C6, ALKYL C1-C8, ALKYL SULFONYLOXI C1-C6, AZIDO, AMINO, MONO or DI ALKYLAMINE C1-C6, ONE GROUP OF-BULD - COUL b MAY BE 0 or 1, R4 AND R5 MAY BE H, PHENYL, ACIL C1-C6, CYCLOACE C4-C7, BENZOIL OR C1-C6 ALKYL SUBSTITUTED BY AMINO, MONKEY OR DI C1-C6 ALKYLAMINE, A GROUP OF FORMULA -NR6 -SO2-R7, WHERE R6 MAY BE: H, PHENYL, ALKYL or C1-C6 ACIL, R7 MAY BE: PHENYL or C1-C6 ALKYL; A AND E MAY BE THE SAME OR DIFFERENT AND REPRESENT A LINK or C1-C4 ALKYLENE; D MAY BE OXYGEN or REST OF FORMULA -S (O) c- or -N (R9) -, WHERE c MAY BE 0, 1 or 2, R9 MAY BE: H, ALKYL or ACIL C1-C6; G IS A SUBSTITUTED ARYL GROUP C1-C6; L MAY BE -O-, -NH-, OR SULPHONAMID COMPOUNDS; R2 MAY BE PHENYL, NAPHTHYL, PIRIDYL, FURYL, TENYL or PYRIMIDYL

PE1998000123A 1997-02-21 1998-02-20 Arylsulphonamides and analogues PE72299A1 (en)

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US8877794B2 (en) * 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
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