CO2024009411A2 - Procesos para la preparación de degradadores selectivos del receptor de estrógeno - Google Patents
Procesos para la preparación de degradadores selectivos del receptor de estrógenoInfo
- Publication number
- CO2024009411A2 CO2024009411A2 CONC2024/0009411A CO2024009411A CO2024009411A2 CO 2024009411 A2 CO2024009411 A2 CO 2024009411A2 CO 2024009411 A CO2024009411 A CO 2024009411A CO 2024009411 A2 CO2024009411 A2 CO 2024009411A2
- Authority
- CO
- Colombia
- Prior art keywords
- estrogen receptor
- selective estrogen
- processes
- preparation
- receptor degraders
- Prior art date
Links
- 229940125641 estrogen receptor degrader Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263305520P | 2022-02-01 | 2022-02-01 | |
| US202263409060P | 2022-09-22 | 2022-09-22 | |
| PCT/US2023/011671 WO2023150056A1 (en) | 2022-02-01 | 2023-01-27 | Processes for the preparation of selective estrogen receptor degraders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2024009411A2 true CO2024009411A2 (es) | 2024-07-29 |
Family
ID=85382684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2024/0009411A CO2024009411A2 (es) | 2022-02-01 | 2024-07-16 | Procesos para la preparación de degradadores selectivos del receptor de estrógeno |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11926634B2 (https=) |
| EP (1) | EP4472982A1 (https=) |
| JP (3) | JP7387926B2 (https=) |
| KR (2) | KR20250006312A (https=) |
| AU (2) | AU2023216654B2 (https=) |
| CA (1) | CA3243621A1 (https=) |
| CO (1) | CO2024009411A2 (https=) |
| CR (1) | CR20240283A (https=) |
| DO (1) | DOP2024000150A (https=) |
| IL (1) | IL313886A (https=) |
| JO (1) | JOP20240169A1 (https=) |
| MX (1) | MX2024009453A (https=) |
| PE (1) | PE20241731A1 (https=) |
| TW (2) | TWI863110B (https=) |
| WO (1) | WO2023150056A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020137965A (ja) * | 2019-03-01 | 2020-09-03 | 株式会社三洋物産 | 遊技機 |
| US20240199629A1 (en) * | 2022-02-01 | 2024-06-20 | Eli Lilly And Company | Processes for the preparation of selective estrogen receptor degraders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1709021B1 (en) | 2004-01-22 | 2010-08-04 | Eli Lilly And Company | Selective estrogen receptor modulators for the treatment of vasomotor symptoms |
| US20080221163A1 (en) | 2005-01-18 | 2008-09-11 | Jeffrey Alan Dodge | Selective Estrogen Receptor Modulators |
| EP2343287A1 (en) * | 2009-12-10 | 2011-07-13 | Almirall, S.A. | New 2-aminothiadiazole derivatives |
| CN103582637B (zh) * | 2011-05-17 | 2015-08-12 | 弗·哈夫曼-拉罗切有限公司 | 酪氨酸激酶抑制剂 |
| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| CN107406424B (zh) | 2014-12-18 | 2020-08-25 | 豪夫迈·罗氏有限公司 | 雌激素受体调节剂及其用途 |
| MD3820874T2 (ro) | 2018-07-12 | 2023-05-31 | Lilly Co Eli | Degradanți selectivi ai receptorului estrogen |
| TWI702219B (zh) | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| US11014915B2 (en) * | 2019-07-22 | 2021-05-25 | Sun Pharma Advanced Research Company Limited | Selective estrogen receptor degrader |
| CN115175679A (zh) | 2020-03-06 | 2022-10-11 | 奥列马制药公司 | 治疗雌激素受体相关疾病的方法 |
| CN115867282B (zh) * | 2020-03-26 | 2025-05-27 | 奈克斯拉制药英国有限公司 | 用于抗癌的5-氨基-8-(4-吡啶基)-[1,2,4]三唑并[4,3-c]嘧啶-3-酮化合物 |
| AR123185A1 (es) * | 2020-08-10 | 2022-11-09 | Novartis Ag | Compuestos y composiciones para inhibir ezh2 |
| TWI837605B (zh) | 2021-03-09 | 2024-04-01 | 美商美國禮來大藥廠 | 使用serd組合給藥方案治療癌症之方法 |
| TWI894443B (zh) | 2021-03-16 | 2025-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
-
2023
- 2023-01-27 EP EP23707540.3A patent/EP4472982A1/en active Pending
- 2023-01-27 PE PE2024001567A patent/PE20241731A1/es unknown
- 2023-01-27 WO PCT/US2023/011671 patent/WO2023150056A1/en not_active Ceased
- 2023-01-27 AU AU2023216654A patent/AU2023216654B2/en active Active
- 2023-01-27 CA CA3243621A patent/CA3243621A1/en active Pending
- 2023-01-27 MX MX2024009453A patent/MX2024009453A/es unknown
- 2023-01-27 CR CR20240283A patent/CR20240283A/es unknown
- 2023-01-27 KR KR1020247041076A patent/KR20250006312A/ko active Pending
- 2023-01-27 KR KR1020247028876A patent/KR102743629B1/ko active Active
- 2023-01-27 US US18/160,457 patent/US11926634B2/en active Active
- 2023-01-27 IL IL313886A patent/IL313886A/en unknown
- 2023-02-01 TW TW112103450A patent/TWI863110B/zh active
- 2023-02-01 TW TW113140271A patent/TW202523669A/zh unknown
- 2023-02-01 JP JP2023013779A patent/JP7387926B2/ja active Active
- 2023-08-28 JP JP2023138310A patent/JP7805336B2/ja active Active
-
2024
- 2024-07-16 CO CONC2024/0009411A patent/CO2024009411A2/es unknown
- 2024-07-30 JO JOJO/P/2024/0169A patent/JOP20240169A1/ar unknown
- 2024-07-31 DO DO2024000150A patent/DOP2024000150A/es unknown
-
2025
- 2025-09-04 JP JP2025146941A patent/JP2025183283A/ja active Pending
- 2025-09-16 AU AU2025234145A patent/AU2025234145A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7387926B2 (ja) | 2023-11-28 |
| MX2024009453A (es) | 2024-08-09 |
| CA3243621A1 (en) | 2023-08-10 |
| EP4472982A1 (en) | 2024-12-11 |
| US11926634B2 (en) | 2024-03-12 |
| JP2023112696A (ja) | 2023-08-14 |
| KR102743629B1 (ko) | 2024-12-17 |
| AU2025234145A1 (en) | 2025-10-02 |
| KR20250006312A (ko) | 2025-01-10 |
| US20230242545A1 (en) | 2023-08-03 |
| DOP2024000150A (es) | 2024-08-30 |
| AU2023216654B2 (en) | 2025-09-25 |
| TWI863110B (zh) | 2024-11-21 |
| JOP20240169A1 (ar) | 2024-07-30 |
| TW202523669A (zh) | 2025-06-16 |
| KR20240135862A (ko) | 2024-09-12 |
| JP2023162334A (ja) | 2023-11-08 |
| IL313886A (en) | 2024-08-01 |
| CR20240283A (es) | 2024-09-03 |
| WO2023150056A1 (en) | 2023-08-10 |
| JP7805336B2 (ja) | 2026-01-23 |
| TW202346300A (zh) | 2023-12-01 |
| PE20241731A1 (es) | 2024-08-19 |
| AU2023216654A1 (en) | 2024-07-11 |
| JP2025183283A (ja) | 2025-12-16 |
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