CO2023013976A2 - Composición farmacéutica y uso del agonista dual del receptor de gip y glp-1 - Google Patents
Composición farmacéutica y uso del agonista dual del receptor de gip y glp-1Info
- Publication number
- CO2023013976A2 CO2023013976A2 CONC2023/0013976A CO2023013976A CO2023013976A2 CO 2023013976 A2 CO2023013976 A2 CO 2023013976A2 CO 2023013976 A CO2023013976 A CO 2023013976A CO 2023013976 A2 CO2023013976 A2 CO 2023013976A2
- Authority
- CO
- Colombia
- Prior art keywords
- glp
- gip
- pharmaceutical composition
- agonist
- compound
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 title abstract 2
- 229940125542 dual agonist Drugs 0.000 title abstract 2
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 102100039997 Gastric inhibitory polypeptide receptor Human genes 0.000 abstract 1
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 abstract 1
- 101000886866 Homo sapiens Gastric inhibitory polypeptide receptor Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 abstract 1
- GNZCSGYHILBXLL-UHFFFAOYSA-N n-tert-butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine Chemical compound ClC1=C(Cl)C=C2N=C(S(C)(=O)=O)C(NC(C)(C)C)=NC2=C1 GNZCSGYHILBXLL-UHFFFAOYSA-N 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un agonista dual del receptor de GIP y GLP-1, una composición farmacéutica y el uso. En particular, la presente solicitud se relaciona con un compuesto representado por la fórmula I, una composición farmacéutica que involucra el compuesto y el uso del compuesto como un agonista dual del receptor de GIP y GLP-1 en el campo de la medicina. El compuesto representado por la fórmula I muestra excelente actividad agonista del GIPR y GLP-1R, así como excelente actividad farmacéutica en la reducción del azúcar en sangre y el control del peso corporal. Es un fármaco terapéutico con una perspectiva de aplicación clínica y puede ser usado para prevenir y tratar enfermedades como la diabetes, complicaciones de la diabetes, obesidad o complicaciones de la obesidad.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110321851 | 2021-03-25 | ||
| CN202110553745 | 2021-05-20 | ||
| PCT/CN2022/082552 WO2022199629A1 (zh) | 2021-03-25 | 2022-03-23 | Gip和glp-1的双受体激动剂、药物组合物及用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2023013976A2 true CO2023013976A2 (es) | 2023-11-20 |
Family
ID=83376697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2023/0013976A CO2023013976A2 (es) | 2021-03-25 | 2023-10-20 | Composición farmacéutica y uso del agonista dual del receptor de gip y glp-1 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4317179A1 (es) |
| JP (1) | JP2024511107A (es) |
| KR (1) | KR20230160369A (es) |
| CN (2) | CN115124602B (es) |
| AU (1) | AU2022245736A1 (es) |
| BR (1) | BR112023019389A2 (es) |
| CA (1) | CA3213261A1 (es) |
| CL (1) | CL2023002639A1 (es) |
| CO (1) | CO2023013976A2 (es) |
| WO (1) | WO2022199629A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024061310A1 (zh) * | 2022-09-23 | 2024-03-28 | 博瑞生物医药（苏州）股份有限公司 | 一种glp-1和gip双受体激动剂药物组合物及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| EP2718317B1 (en) * | 2011-06-10 | 2018-11-14 | Beijing Hanmi Pharmaceutical Co., Ltd. | Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof |
| JP2016503771A (ja) * | 2012-12-21 | 2016-02-08 | サノフイ | エキセンジン−４誘導体 |
| CN104945499B (zh) * | 2014-03-31 | 2019-12-10 | 博瑞生物医药（苏州）股份有限公司 | 结构修饰的glp-1类似物及其制备方法 |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| CN106554404B (zh) * | 2015-09-25 | 2020-11-20 | 博瑞生物医药（苏州）股份有限公司 | 艾塞那肽修饰物及其用途 |
| CN106554403B (zh) * | 2015-09-25 | 2021-08-31 | 博瑞生物医药（苏州）股份有限公司 | 艾塞那肽修饰物及其用途 |
| EP3954701A4 (en) * | 2019-04-11 | 2023-09-06 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | DUAL AGONIST COMPOUNDS OF GLP-1 AND GIP RECEPTOR AND USE THEREOF |
| CN110642935A (zh) * | 2019-09-25 | 2020-01-03 | 成都奥达生物科技有限公司 | 一种替瑞帕肽类似物 |
-
2022
- 2022-03-23 CN CN202210294984.3A patent/CN115124602B/zh active Active
- 2022-03-23 BR BR112023019389A patent/BR112023019389A2/pt unknown
- 2022-03-23 CA CA3213261A patent/CA3213261A1/en active Pending
- 2022-03-23 AU AU2022245736A patent/AU2022245736A1/en active Pending
- 2022-03-23 KR KR1020237036350A patent/KR20230160369A/ko unknown
- 2022-03-23 EP EP22774284.8A patent/EP4317179A1/en active Pending
- 2022-03-23 JP JP2023558333A patent/JP2024511107A/ja active Pending
- 2022-03-23 CN CN202280032045.XA patent/CN117222661A/zh active Pending
- 2022-03-23 WO PCT/CN2022/082552 patent/WO2022199629A1/zh active Application Filing
-
2023
- 2023-09-05 CL CL2023002639A patent/CL2023002639A1/es unknown
- 2023-10-20 CO CONC2023/0013976A patent/CO2023013976A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN115124602B (zh) | 2024-01-26 |
| CL2023002639A1 (es) | 2024-04-26 |
| JP2024511107A (ja) | 2024-03-12 |
| BR112023019389A2 (pt) | 2023-11-28 |
| AU2022245736A1 (en) | 2023-10-12 |
| CA3213261A1 (en) | 2022-09-29 |
| KR20230160369A (ko) | 2023-11-23 |
| CN117222661A (zh) | 2023-12-12 |
| EP4317179A1 (en) | 2024-02-07 |
| CN115124602A (zh) | 2022-09-30 |
| WO2022199629A1 (zh) | 2022-09-29 |
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