CO2022017502A2 - Metil (r)–2–(fluorometil)–5–oxo–4–fenil–4,5,6,7–tetrahidro–1h–ciclopenta[b]piridin–3–carboxilato y metil (r)–2–(fluorometil)–5–oxo–4–fenil–1,4,5,7–tetrahidrofuro[3,4–b]piridin–3–carboxilato como activadores de cav1.2 - Google Patents

Metil (r)–2–(fluorometil)–5–oxo–4–fenil–4,5,6,7–tetrahidro–1h–ciclopenta[b]piridin–3–carboxilato y metil (r)–2–(fluorometil)–5–oxo–4–fenil–1,4,5,7–tetrahidrofuro[3,4–b]piridin–3–carboxilato como activadores de cav1.2

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Publication number
CO2022017502A2
CO2022017502A2 CONC2022/0017502A CO2022017502A CO2022017502A2 CO 2022017502 A2 CO2022017502 A2 CO 2022017502A2 CO 2022017502 A CO2022017502 A CO 2022017502A CO 2022017502 A2 CO2022017502 A2 CO 2022017502A2
Authority
CO
Colombia
Prior art keywords
fluoromethyl
carboxylate
oxo
pyridine
phenyl
Prior art date
Application number
CONC2022/0017502A
Other languages
English (en)
Inventor
James Neef
Sung David C Kim
Zaixing Li
Chui Lu
Danuta Lubicka
Hye-Yeon Park
Tejaskumar Pankajbhai Pathak
Amir Masoud Sadaghiani
Xilin Zhou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO2022017502A2 publication Critical patent/CO2022017502A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente divulgación proporciona un compuesto de acuerdo con la fórmula (I) (I) o una sal farmacéuticamente aceptable de este como activadores de CaV1.22 para el tratamiento de esquizofrenia, trastorno bipolar, trastorno depresivo mayor, trastorno debido al uso de sustancias, TDAH, síndrome de Phelan–McDermid, trastornos del espectro autista, esclerosis múltiple, demencia frontotemporal, enfermedad de Alzheimer, síndrome de Brugada, síndrome de QT corto, o síndrome de repolarización precoz.
CONC2022/0017502A 2020-06-15 2022-12-05 Metil (r)–2–(fluorometil)–5–oxo–4–fenil–4,5,6,7–tetrahidro–1h–ciclopenta[b]piridin–3–carboxilato y metil (r)–2–(fluorometil)–5–oxo–4–fenil–1,4,5,7–tetrahidrofuro[3,4–b]piridin–3–carboxilato como activadores de cav1.2 CO2022017502A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2020/096177 WO2021253180A1 (en) 2020-06-15 2020-06-15 Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators
PCT/IB2021/055183 WO2021255607A1 (en) 2020-06-15 2021-06-11 Methyl 2-(fluoromethyl)-5-oxo-4-phenyl-4,5,6,7-tetrahydro-1h-cyclopenta[b]pyridine-3-carboxylates and methyl 2-(fluoromethyl)-5-oxo-4-phenyl-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylates as cav1.2 activators

Publications (1)

Publication Number Publication Date
CO2022017502A2 true CO2022017502A2 (es) 2022-12-20

Family

ID=76523252

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0017502A CO2022017502A2 (es) 2020-06-15 2022-12-05 Metil (r)–2–(fluorometil)–5–oxo–4–fenil–4,5,6,7–tetrahidro–1h–ciclopenta[b]piridin–3–carboxilato y metil (r)–2–(fluorometil)–5–oxo–4–fenil–1,4,5,7–tetrahidrofuro[3,4–b]piridin–3–carboxilato como activadores de cav1.2

Country Status (20)

Country Link
US (1) US11919911B2 (es)
EP (1) EP4165047A1 (es)
JP (1) JP2023530917A (es)
KR (1) KR20230022982A (es)
CN (1) CN115836076A (es)
AR (1) AR122615A1 (es)
AU (1) AU2021293976B2 (es)
BR (1) BR112022025212A2 (es)
CA (1) CA3182354A1 (es)
CL (1) CL2022003525A1 (es)
CO (1) CO2022017502A2 (es)
CR (1) CR20230008A (es)
DO (1) DOP2022000276A (es)
EC (1) ECSP23001748A (es)
IL (1) IL298448A (es)
MX (1) MX2022015866A (es)
PE (1) PE20231079A1 (es)
TW (1) TW202214651A (es)
UY (1) UY39265A (es)
WO (2) WO2021253180A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
CN118510782A (zh) * 2021-12-13 2024-08-16 诺华股份有限公司 作为CaV1.2激活剂的吡啶-3-甲酸酯化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
EP0111455A3 (de) 1982-12-10 1984-07-25 Ciba-Geigy Ag Ungesättigte Lactone
DE3410645A1 (de) 1984-03-23 1985-09-26 Bayer Ag, 5090 Leverkusen L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4567268A (en) 1984-04-03 1986-01-28 Merck & Co., Inc. Process for preparation of certain tetrahydrofuro[3,4-b]pyridines
US6518279B2 (en) * 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
WO2010015037A1 (en) 2008-08-08 2010-02-11 Howard Florey Institute Therapeutic methods and compositions

Also Published As

Publication number Publication date
KR20230022982A (ko) 2023-02-16
DOP2022000276A (es) 2023-01-15
IL298448A (en) 2023-01-01
CL2022003525A1 (es) 2023-08-11
ECSP23001748A (es) 2023-03-31
MX2022015866A (es) 2023-01-24
JP2023530917A (ja) 2023-07-20
CR20230008A (es) 2023-01-25
UY39265A (es) 2022-01-31
AR122615A1 (es) 2022-09-21
PE20231079A1 (es) 2023-07-17
US11919911B2 (en) 2024-03-05
TW202214651A (zh) 2022-04-16
US20210395261A1 (en) 2021-12-23
WO2021253180A1 (en) 2021-12-23
CN115836076A (zh) 2023-03-21
AU2021293976A1 (en) 2022-11-24
BR112022025212A2 (pt) 2023-01-03
EP4165047A1 (en) 2023-04-19
CA3182354A1 (en) 2021-12-23
WO2021255607A1 (en) 2021-12-23
AU2021293976B2 (en) 2023-12-14

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