CO2022016965A2 - Formas polimórficas de clorhidrato de (r)-oxibutinina - Google Patents

Formas polimórficas de clorhidrato de (r)-oxibutinina

Info

Publication number
CO2022016965A2
CO2022016965A2 CONC2022/0016965A CO2022016965A CO2022016965A2 CO 2022016965 A2 CO2022016965 A2 CO 2022016965A2 CO 2022016965 A CO2022016965 A CO 2022016965A CO 2022016965 A2 CO2022016965 A2 CO 2022016965A2
Authority
CO
Colombia
Prior art keywords
polymorphic forms
oxybutynin hydrochloride
oxybutynin
forms
hydrochloride
Prior art date
Application number
CONC2022/0016965A
Other languages
English (en)
Inventor
Dennis Molnar
Sean Johnston
Original Assignee
Apnimed Inc Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2021/030571 external-priority patent/WO2021226020A1/en
Application filed by Apnimed Inc Delaware filed Critical Apnimed Inc Delaware
Publication of CO2022016965A2 publication Critical patent/CO2022016965A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Se preparan y caracterizan formas polimórficas de HCl (R)-oxibutinina, incluidas tres formas cristalinas. También se describen los usos de las diversas formas polimórficas de HCl (R)-oxibutinina para el tratamiento de la apnea obstructiva del sueño (AOS).
CONC2022/0016965A 2020-05-05 2022-11-26 Formas polimórficas de clorhidrato de (r)-oxibutinina CO2022016965A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063020301P 2020-05-05 2020-05-05
US202163136691P 2021-01-13 2021-01-13
PCT/US2021/030571 WO2021226020A1 (en) 2020-05-05 2021-05-04 Polymorphic forms of (r)-oxybutynin hydrochloride

Publications (1)

Publication Number Publication Date
CO2022016965A2 true CO2022016965A2 (es) 2022-12-09

Family

ID=84324668

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0016965A CO2022016965A2 (es) 2020-05-05 2022-11-26 Formas polimórficas de clorhidrato de (r)-oxibutinina

Country Status (12)

Country Link
US (1) US20230286900A1 (es)
EP (1) EP4146621A1 (es)
JP (1) JP2023524783A (es)
KR (1) KR20230008120A (es)
CN (1) CN115667205A (es)
AU (1) AU2021268618A1 (es)
BR (1) BR112022022292A2 (es)
CA (1) CA3177654A1 (es)
CO (1) CO2022016965A2 (es)
CR (1) CR20220617A (es)
IL (1) IL297877A (es)
MX (1) MX2022013823A (es)

Also Published As

Publication number Publication date
KR20230008120A (ko) 2023-01-13
CA3177654A1 (en) 2021-11-11
BR112022022292A2 (pt) 2022-12-20
JP2023524783A (ja) 2023-06-13
US20230286900A1 (en) 2023-09-14
AU2021268618A1 (en) 2022-12-15
IL297877A (en) 2023-01-01
CR20220617A (es) 2023-02-09
CN115667205A (zh) 2023-01-31
EP4146621A1 (en) 2023-03-15
MX2022013823A (es) 2023-01-11

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