CO2022010606A2 - Composiciones y métodos para la regulación ajustable de la transcripción - Google Patents

Composiciones y métodos para la regulación ajustable de la transcripción

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Publication number
CO2022010606A2
CO2022010606A2 CONC2022/0010606A CO2022010606A CO2022010606A2 CO 2022010606 A2 CO2022010606 A2 CO 2022010606A2 CO 2022010606 A CO2022010606 A CO 2022010606A CO 2022010606 A2 CO2022010606 A2 CO 2022010606A2
Authority
CO
Colombia
Prior art keywords
compositions
methods
transcription
tunable
tunable regulation
Prior art date
Application number
CONC2022/0010606A
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English (en)
Inventor
Vipin Suri
Mara Christine Inniss
Samantha Fleury
Original Assignee
Obsidian Therapeutics Inc
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Publication date
Application filed by Obsidian Therapeutics Inc filed Critical Obsidian Therapeutics Inc
Publication of CO2022010606A2 publication Critical patent/CO2022010606A2/es

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    • C07K14/4702—Regulators; Modulating activity
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
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Abstract

La presente descripción proporciona composiciones y métodos relacionados con los sistemas de factores de transcripción. Dichos sistemas proporcionan una expresión de proteínas modular y ajustable impulsada por una actividad transcripcional regulada.
CONC2022/0010606A 2020-01-08 2022-07-28 Composiciones y métodos para la regulación ajustable de la transcripción CO2022010606A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062958693P 2020-01-08 2020-01-08
US202062959859P 2020-01-10 2020-01-10
PCT/US2021/012845 WO2021142376A1 (en) 2020-01-08 2021-01-08 Compositions and methods for tunable regulation of transcription

Publications (1)

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CO2022010606A2 true CO2022010606A2 (es) 2022-08-19

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US (1) US20230056856A1 (es)
EP (1) EP4087861A1 (es)
JP (1) JP2023509770A (es)
KR (1) KR20220139319A (es)
CN (1) CN115210250A (es)
AU (1) AU2021205416A1 (es)
BR (1) BR112022013355A2 (es)
CA (1) CA3163838A1 (es)
CO (1) CO2022010606A2 (es)
MX (1) MX2022008415A (es)
WO (1) WO2021142376A1 (es)

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WO2023200745A1 (en) * 2022-04-11 2023-10-19 The Regents Of The University Of Michigan Chemogenetic regulation of peptide function

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