CO2021010751A2 - Vacuna de influenza atenuada en vivo composición y proceso de preparación de los mismos - Google Patents
Vacuna de influenza atenuada en vivo composición y proceso de preparación de los mismosInfo
- Publication number
- CO2021010751A2 CO2021010751A2 CONC2021/0010751A CO2021010751A CO2021010751A2 CO 2021010751 A2 CO2021010751 A2 CO 2021010751A2 CO 2021010751 A CO2021010751 A CO 2021010751A CO 2021010751 A2 CO2021010751 A2 CO 2021010751A2
- Authority
- CO
- Colombia
- Prior art keywords
- laiv
- live attenuated
- strains
- influenza vaccine
- attenuated influenza
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente divulgación proporciona composiciones y métodos para fabricar y obtener una composición de vacuna viva atenuada contra la influenza (LAIV) que puede administrarse por vía intranasal para proporcionar protección contra la infección por el virus de la influenza. Dichas cepas LAIV se basan en fenotipos adaptados al frío, sensibles a la temperatura y atenuados de virus donantes principales (MDV) que contienen los genes de glucoproteína de superficie de las cepas de influenza pandémica o estacional de tipo salvaje. Además, dichas cepas LAIV se adaptan aún más para crecer en células MDCK (células de riñón canino Madin Darby). Se evita el uso de huevos en la fabricación de vacunas a gran escala. El proceso de purificación carece de etapas de cromatografía. Dicha composición LAIV incluye uno o más virus de vacuna contra la Influenza atenuados vivos y carece de polímeros y tensioactivos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201921006071 | 2019-02-15 | ||
PCT/IN2020/050121 WO2020165912A1 (en) | 2019-02-15 | 2020-02-07 | Live attenuated influenza vaccine composition and process for preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021010751A2 true CO2021010751A2 (es) | 2021-09-09 |
Family
ID=69740470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0010751A CO2021010751A2 (es) | 2019-02-15 | 2021-08-13 | Vacuna de influenza atenuada en vivo composición y proceso de preparación de los mismos |
Country Status (20)
Country | Link |
---|---|
US (1) | US20220211837A1 (es) |
EP (1) | EP3924052A1 (es) |
JP (1) | JP2022520443A (es) |
KR (1) | KR20210129073A (es) |
CN (1) | CN113646047A (es) |
AR (1) | AR119691A1 (es) |
AU (1) | AU2020222113A1 (es) |
BR (1) | BR112021016059A2 (es) |
CA (1) | CA3130036A1 (es) |
CL (1) | CL2021002111A1 (es) |
CO (1) | CO2021010751A2 (es) |
IL (1) | IL285526A (es) |
JO (1) | JOP20200037A1 (es) |
MA (1) | MA54942A (es) |
MX (1) | MX2021009837A (es) |
PE (1) | PE20212322A1 (es) |
SG (1) | SG11202108766RA (es) |
TW (1) | TW202045205A (es) |
UY (1) | UY38587A (es) |
WO (1) | WO2020165912A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2383105C (en) * | 1999-09-24 | 2010-01-26 | Smithkline Beecham Biologicals S.A. | Intranasal influenza virus vaccine |
CN103952376A (zh) * | 2008-09-24 | 2014-07-30 | 米迪缪尼有限公司 | 培养细胞、增殖和纯化病毒的方法 |
TWI670085B (zh) * | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
AU2018301395A1 (en) * | 2017-07-11 | 2020-02-06 | Universal Stabilization Technologies, Inc. | Method for Preserving Biological Materials |
-
2020
- 2020-02-07 KR KR1020217027060A patent/KR20210129073A/ko active Search and Examination
- 2020-02-07 AU AU2020222113A patent/AU2020222113A1/en active Pending
- 2020-02-07 EP EP20708683.6A patent/EP3924052A1/en active Pending
- 2020-02-07 BR BR112021016059-0A patent/BR112021016059A2/pt unknown
- 2020-02-07 MX MX2021009837A patent/MX2021009837A/es unknown
- 2020-02-07 PE PE2021001342A patent/PE20212322A1/es unknown
- 2020-02-07 MA MA054942A patent/MA54942A/fr unknown
- 2020-02-07 SG SG11202108766RA patent/SG11202108766RA/en unknown
- 2020-02-07 CA CA3130036A patent/CA3130036A1/en active Pending
- 2020-02-07 US US17/429,965 patent/US20220211837A1/en active Pending
- 2020-02-07 CN CN202080024926.8A patent/CN113646047A/zh active Pending
- 2020-02-07 WO PCT/IN2020/050121 patent/WO2020165912A1/en active Application Filing
- 2020-02-07 JP JP2021547436A patent/JP2022520443A/ja active Pending
- 2020-02-14 AR ARP200100405A patent/AR119691A1/es unknown
- 2020-02-14 TW TW109104708A patent/TW202045205A/zh unknown
- 2020-02-14 UY UY0001038587A patent/UY38587A/es unknown
- 2020-02-16 JO JOP/2020/0037A patent/JOP20200037A1/ar unknown
-
2021
- 2021-08-11 IL IL285526A patent/IL285526A/en unknown
- 2021-08-11 CL CL2021002111A patent/CL2021002111A1/es unknown
- 2021-08-13 CO CONC2021/0010751A patent/CO2021010751A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112021016059A2 (pt) | 2021-10-13 |
AR119691A1 (es) | 2022-01-05 |
KR20210129073A (ko) | 2021-10-27 |
CL2021002111A1 (es) | 2022-01-28 |
CA3130036A1 (en) | 2020-08-20 |
EP3924052A1 (en) | 2021-12-22 |
WO2020165912A1 (en) | 2020-08-20 |
JP2022520443A (ja) | 2022-03-30 |
UY38587A (es) | 2020-09-30 |
US20220211837A1 (en) | 2022-07-07 |
JOP20200037A1 (ar) | 2020-08-15 |
TW202045205A (zh) | 2020-12-16 |
MX2021009837A (es) | 2021-09-10 |
IL285526A (en) | 2021-09-30 |
PE20212322A1 (es) | 2021-12-14 |
SG11202108766RA (en) | 2021-09-29 |
MA54942A (fr) | 2021-12-22 |
CN113646047A (zh) | 2021-11-12 |
AU2020222113A1 (en) | 2021-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Baz et al. | H5N1 vaccines in humans | |
Wong et al. | Traditional and new influenza vaccines | |
Easterbrook et al. | Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice | |
AU2006234304B2 (en) | Process of manufacturing viral vaccines in suspension avian embryonic derived stem cell lines | |
KR102080062B1 (ko) | 인플루엔자 바이러스 돌연변이체들 및 그들의 용도들 | |
US20110171260A1 (en) | Influenza dna vaccination and methods of use thereof | |
AR069883A1 (es) | Virus de la estomatitis vesicular geneticamente modificado, composicion inmunogenica que lo comprende, metodo para producirlo, metodos para adaptar un virus para crecer en el cultivo de cedula y para proteger un mamifero contra la infeccion con un organismo patogeno | |
BR112012022939A2 (pt) | composição farmacêutica para uso em um método de imunização de um indivíduo em necessidade do mesmo contra um vírus influenza | |
KR20090007599A (ko) | 인플루엔자 바이러스 백신 | |
Looi et al. | How far have we reached in development of effective influenza vaccine? | |
Umar et al. | Emerging threat of H9N2 viruses in poultry of Pakistan and vaccination strategy | |
Wohlbold et al. | An H10N8 influenza virus vaccine strain and mouse challenge model based on the human isolate A/Jiangxi-Donghu/346/13 | |
Nishi et al. | Genetic analysis of an H5N2 highly pathogenic avian influenza virus isolated from a chicken in a live bird market in Northern Vietnam in 2012 | |
ŠANTAK | Old and new ways to combat human influenza virus | |
CO2021010751A2 (es) | Vacuna de influenza atenuada en vivo composición y proceso de preparación de los mismos | |
AR085800A1 (es) | Vacuna de rinitis equina | |
Lee et al. | Cell culture-based influenza vaccines as alternatives to egg-based vaccines | |
Wen et al. | Efficacy of a high-growth reassortant H1N1 influenza virus vaccine against the classical swine H1N1 subtype influenza virus in mice and pigs | |
Jiang et al. | Protective efficacy of H7 subtype avian influenza DNA vaccine | |
CN100467591C (zh) | 重组禽流感病毒毒株、其制备方法及由其制得的疫苗 | |
KR101426407B1 (ko) | 고생산성, 고면역원성, 및 무병원성 인플루엔자 바이러스 제작용 재조합 발현 벡터 | |
Fichera et al. | New strategies to overcome the drawbacks of currently available flu vaccines | |
US20120164175A1 (en) | Novel influenza virus | |
AR109291A1 (es) | Clon de adnc del virus del síndrome reproductivo y respiratorio porcino y usos del mismo | |
CN104711291B (zh) | 一种预防禽流感病毒感染的新型血凝素抗原的制备及应用 |