CO2021009297A2 - Variantes de alfa-galactosidasa humana - Google Patents
Variantes de alfa-galactosidasa humanaInfo
- Publication number
- CO2021009297A2 CO2021009297A2 CONC2021/0009297A CO2021009297A CO2021009297A2 CO 2021009297 A2 CO2021009297 A2 CO 2021009297A2 CO 2021009297 A CO2021009297 A CO 2021009297A CO 2021009297 A2 CO2021009297 A2 CO 2021009297A2
- Authority
- CO
- Colombia
- Prior art keywords
- human alpha
- galactosidase
- modified human
- improve
- compositions
- Prior art date
Links
- 102000005840 alpha-Galactosidase Human genes 0.000 title abstract 4
- 108010030291 alpha-Galactosidase Proteins 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862782553P | 2018-12-20 | 2018-12-20 | |
| PCT/US2019/067493 WO2020132252A2 (en) | 2018-12-20 | 2019-12-19 | Human alpha-galactosidase variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2021009297A2 true CO2021009297A2 (es) | 2021-07-30 |
Family
ID=71099305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2021/0009297A CO2021009297A2 (es) | 2018-12-20 | 2021-07-15 | Variantes de alfa-galactosidasa humana |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11427813B2 (https=) |
| EP (1) | EP3898960A4 (https=) |
| JP (2) | JP2022515742A (https=) |
| KR (1) | KR102898199B1 (https=) |
| CN (1) | CN113544268A (https=) |
| AU (1) | AU2019403323B2 (https=) |
| BR (1) | BR112021011750A2 (https=) |
| CA (1) | CA3123598A1 (https=) |
| CO (1) | CO2021009297A2 (https=) |
| EA (1) | EA202191735A1 (https=) |
| IL (1) | IL284133A (https=) |
| MX (1) | MX2021007552A (https=) |
| MY (1) | MY207075A (https=) |
| PH (1) | PH12021551372A1 (https=) |
| SG (1) | SG11202106348QA (https=) |
| WO (1) | WO2020132252A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3237621T (lt) | 2014-12-22 | 2023-09-25 | Codexis, Inc. | Žmogaus alfa-galaktozidazės variantai |
| AU2019403323B2 (en) | 2018-12-20 | 2026-02-26 | Codexis, Inc. | Human alpha-galactosidase variants |
| AR124981A1 (es) * | 2021-02-26 | 2023-05-24 | Takeda Pharmaceuticals Co | Composición y métodos para el tratamiento de la enfermedad de fabry |
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| AU2019403323B2 (en) | 2018-12-20 | 2026-02-26 | Codexis, Inc. | Human alpha-galactosidase variants |
| KR20220044560A (ko) * | 2019-08-07 | 2022-04-08 | 아미쿠스 세라퓨틱스, 인코포레이티드 | Gla 유전자에 돌연변이를 갖는 환자에서 파브리 질병을 치료하는 방법 |
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-
2019
- 2019-12-19 AU AU2019403323A patent/AU2019403323B2/en active Active
- 2019-12-19 SG SG11202106348QA patent/SG11202106348QA/en unknown
- 2019-12-19 EA EA202191735A patent/EA202191735A1/ru unknown
- 2019-12-19 CN CN201980092718.9A patent/CN113544268A/zh active Pending
- 2019-12-19 MY MYPI2021003380A patent/MY207075A/en unknown
- 2019-12-19 WO PCT/US2019/067493 patent/WO2020132252A2/en not_active Ceased
- 2019-12-19 BR BR112021011750-4A patent/BR112021011750A2/pt unknown
- 2019-12-19 JP JP2021535658A patent/JP2022515742A/ja active Pending
- 2019-12-19 MX MX2021007552A patent/MX2021007552A/es unknown
- 2019-12-19 CA CA3123598A patent/CA3123598A1/en active Pending
- 2019-12-19 US US16/721,102 patent/US11427813B2/en active Active
- 2019-12-19 KR KR1020217023026A patent/KR102898199B1/ko active Active
- 2019-12-19 EP EP19897710.0A patent/EP3898960A4/en active Pending
-
2021
- 2021-06-10 PH PH12021551372A patent/PH12021551372A1/en unknown
- 2021-06-17 IL IL284133A patent/IL284133A/en unknown
- 2021-07-15 CO CONC2021/0009297A patent/CO2021009297A2/es unknown
-
2022
- 2022-07-22 US US17/814,371 patent/US12286655B2/en active Active
-
2024
- 2024-04-23 JP JP2024070026A patent/JP2024087015A/ja active Pending
-
2025
- 2025-03-14 US US19/080,087 patent/US20250207118A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20250207118A1 (en) | 2025-06-26 |
| US20220356458A1 (en) | 2022-11-10 |
| IL284133A (en) | 2021-08-31 |
| EA202191735A1 (ru) | 2021-11-24 |
| CN113544268A (zh) | 2021-10-22 |
| KR20210106537A (ko) | 2021-08-30 |
| MY207075A (en) | 2025-01-28 |
| WO2020132252A3 (en) | 2020-07-23 |
| KR102898199B1 (ko) | 2025-12-09 |
| EP3898960A4 (en) | 2022-11-30 |
| US20200199563A1 (en) | 2020-06-25 |
| AU2019403323B2 (en) | 2026-02-26 |
| AU2019403323A1 (en) | 2021-07-01 |
| US11427813B2 (en) | 2022-08-30 |
| JP2022515742A (ja) | 2022-02-22 |
| JP2024087015A (ja) | 2024-06-28 |
| MX2021007552A (es) | 2021-08-11 |
| CA3123598A1 (en) | 2020-06-25 |
| WO2020132252A2 (en) | 2020-06-25 |
| SG11202106348QA (en) | 2021-07-29 |
| BR112021011750A2 (pt) | 2021-08-31 |
| PH12021551372A1 (en) | 2021-11-29 |
| EP3898960A2 (en) | 2021-10-27 |
| US12286655B2 (en) | 2025-04-29 |
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