CO2021008997A2 - Constructos de arni para inhibir la expresión de pnpla3 y métodos de uso de estos - Google Patents

Constructos de arni para inhibir la expresión de pnpla3 y métodos de uso de estos

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Publication number
CO2021008997A2
CO2021008997A2 CONC2021/0008997A CO2021008997A CO2021008997A2 CO 2021008997 A2 CO2021008997 A2 CO 2021008997A2 CO 2021008997 A CO2021008997 A CO 2021008997A CO 2021008997 A2 CO2021008997 A2 CO 2021008997A2
Authority
CO
Colombia
Prior art keywords
methods
constructs
arni
pnpla3 expression
inhibit
Prior art date
Application number
CONC2021/0008997A
Other languages
English (en)
Spanish (es)
Inventor
Ingrid Rulifson
Justin K Murray
Michael Ollmann
Oliver Homann
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CO2021008997A2 publication Critical patent/CO2021008997A2/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CONC2021/0008997A 2018-12-10 2021-07-08 Constructos de arni para inhibir la expresión de pnpla3 y métodos de uso de estos CO2021008997A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862777714P 2018-12-10 2018-12-10
PCT/US2019/065481 WO2020123508A2 (en) 2018-12-10 2019-12-10 Rnai constructs for inhibiting pnpla3 expression and methods of use thereof

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CO2021008997A2 true CO2021008997A2 (es) 2021-07-30

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US (2) US12674166B2 (enExample)
EP (1) EP3894555A2 (enExample)
JP (2) JP2022511550A (enExample)
KR (1) KR20210102932A (enExample)
CN (2) CN121320339A (enExample)
AR (1) AR117297A1 (enExample)
AU (1) AU2019396419B2 (enExample)
BR (1) BR112021011061A2 (enExample)
CA (1) CA3121510A1 (enExample)
CL (1) CL2021001489A1 (enExample)
CO (1) CO2021008997A2 (enExample)
CR (1) CR20210371A (enExample)
EA (1) EA202191629A1 (enExample)
IL (1) IL283473A (enExample)
JO (1) JOP20210142A1 (enExample)
MX (2) MX2021006784A (enExample)
PE (1) PE20211225A1 (enExample)
PH (1) PH12021551326A1 (enExample)
SG (1) SG11202105711SA (enExample)
TW (1) TW202039843A (enExample)
UY (1) UY38503A (enExample)
WO (1) WO2020123508A2 (enExample)

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CA3121510A1 (en) 2018-12-10 2020-06-18 Amgen Inc. Rnai constructs for inhibiting pnpla3 expression and methods of use thereof
WO2021154791A1 (en) 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR20230171431A (ko) * 2021-04-14 2023-12-20 다이서나 파마수이티컬, 인크. Pnpla3 발현을 조절하기 위한 조성물 및 방법
WO2022256395A1 (en) * 2021-06-02 2022-12-08 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
US20250243491A1 (en) * 2021-09-01 2025-07-31 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
WO2024023256A1 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds
JP2025542119A (ja) * 2022-12-07 2025-12-25 シャンハイ アルゴ バイオファーマシューティカル カンパニー，リミテッド パタチン様ホスホリパーゼドメイン含有３（ｐｎｐｌａ３）の発現を阻害するための組成物及び方法
CN121294438A (zh) * 2022-12-19 2026-01-09 昂拓生物医药有限公司 高级rna靶向(arnatar)
CN121152879A (zh) * 2023-02-14 2025-12-16 基愈治疗公司 经修饰的双链rna药剂
WO2024182446A2 (en) * 2023-02-28 2024-09-06 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
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