CO2021006290A2 - Dosificación subcutánea y administración de anticuerpos anti-c5 para el tratamiento de la hemoglobinuria paroxistica nocturna (pnh) - Google Patents
Dosificación subcutánea y administración de anticuerpos anti-c5 para el tratamiento de la hemoglobinuria paroxistica nocturna (pnh)Info
- Publication number
- CO2021006290A2 CO2021006290A2 CONC2021/0006290A CO2021006290A CO2021006290A2 CO 2021006290 A2 CO2021006290 A2 CO 2021006290A2 CO 2021006290 A CO2021006290 A CO 2021006290A CO 2021006290 A2 CO2021006290 A2 CO 2021006290A2
- Authority
- CO
- Colombia
- Prior art keywords
- pnh
- administration
- treatment
- paroxysmal nocturnal
- nocturnal hemoglobinuria
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
RESUMEN Se proporcionan métodos para el tratamiento clínico de la hemoglobinuria paroxística nocturna (PNH) que comprenden administrar al paciente un anticuerpo anti-C5, o un fragmento de unión al antígeno de este, donde el anticuerpo anti-C5, o fragmento de unión al antígeno de este, se administra (o es para administración) subcutáneamente de acuerdo con un régimen de dosificación clínico particular (es decir, en una cantidad de dosis particular y de acuerdo con un programa de dosificación específico). En una realización, el paciente ha sido tratado previamente con eculizumab (Soliris®).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862752563P | 2018-10-30 | 2018-10-30 | |
PCT/US2019/058846 WO2020092549A1 (en) | 2018-10-30 | 2019-10-30 | Subcutaneous dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021006290A2 true CO2021006290A2 (es) | 2021-06-10 |
Family
ID=68621358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0006290A CO2021006290A2 (es) | 2018-10-30 | 2021-05-13 | Dosificación subcutánea y administración de anticuerpos anti-c5 para el tratamiento de la hemoglobinuria paroxistica nocturna (pnh) |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210395352A1 (es) |
EP (2) | EP3873602B1 (es) |
JP (2) | JP2022512632A (es) |
KR (1) | KR20210084533A (es) |
CN (1) | CN112996561A (es) |
AU (1) | AU2019370295A1 (es) |
BR (1) | BR112021008063A2 (es) |
CA (1) | CA3118282A1 (es) |
CO (1) | CO2021006290A2 (es) |
EA (1) | EA202191189A1 (es) |
IL (1) | IL281990A (es) |
MX (1) | MX2021004994A (es) |
WO (1) | WO2020092549A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116194478A (zh) * | 2020-06-24 | 2023-05-30 | 阿雷克森制药公司 | 皮下(sc)施用抗c5抗体治疗补体相关病症 |
EP4281472A1 (en) * | 2021-01-22 | 2023-11-29 | Alexion Pharmaceuticals, Inc. | Methods of treating complement mediated thrombotic microangiopathy using an anti-c5 antibody |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
JP5815403B2 (ja) | 2008-08-05 | 2015-11-17 | ノバルティス アーゲー | 補体タンパク質c5を標的とする抗体に関する組成物および方法 |
US8883979B2 (en) * | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
WO2014099546A1 (en) | 2012-12-19 | 2014-06-26 | Promerus, Llc | Process for the preparation of high purity norbornene alkanols and derivatives thereof |
NZ711451A (en) * | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
KR102515796B1 (ko) | 2014-12-19 | 2023-03-30 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 그의 사용 방법 |
US20190135903A1 (en) * | 2015-03-31 | 2019-05-09 | Alexion Pharmaceuticals, Inc. | Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients |
JP6650042B2 (ja) * | 2015-12-27 | 2020-02-19 | アッヴィ・インコーポレイテッド | 装着型自動注射装置ならびに関連する組立方法および使用方法 |
US20190023775A1 (en) * | 2016-01-11 | 2019-01-24 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment |
AU2017283470B2 (en) | 2016-06-14 | 2024-03-21 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibodies and uses thereof |
SI3658184T1 (sl) * | 2017-07-27 | 2024-01-31 | Alexion Pharmaceuticals, Inc., | Formulacije z visoko koncentracijo protiteles proti-C5 |
KR20200070355A (ko) * | 2017-10-26 | 2020-06-17 | 알렉시온 파마슈티칼스, 인코포레이티드 | 발작성 야간 혈색소뇨 (pnh) 및 비정형 용혈성 요독 증후군 (ahus)의 치료를 위한 항-c5 항체의 투여량 및 투여 |
EP3802593A1 (en) * | 2018-05-31 | 2021-04-14 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
-
2019
- 2019-10-30 AU AU2019370295A patent/AU2019370295A1/en active Pending
- 2019-10-30 CA CA3118282A patent/CA3118282A1/en active Pending
- 2019-10-30 EA EA202191189A patent/EA202191189A1/ru unknown
- 2019-10-30 EP EP19806353.9A patent/EP3873602B1/en active Active
- 2019-10-30 JP JP2021519110A patent/JP2022512632A/ja active Pending
- 2019-10-30 MX MX2021004994A patent/MX2021004994A/es unknown
- 2019-10-30 EP EP23200753.4A patent/EP4306128A3/en active Pending
- 2019-10-30 WO PCT/US2019/058846 patent/WO2020092549A1/en unknown
- 2019-10-30 US US17/289,178 patent/US20210395352A1/en active Pending
- 2019-10-30 KR KR1020217015554A patent/KR20210084533A/ko unknown
- 2019-10-30 BR BR112021008063-5A patent/BR112021008063A2/pt unknown
- 2019-10-30 CN CN201980070341.7A patent/CN112996561A/zh active Pending
-
2021
- 2021-04-02 IL IL281990A patent/IL281990A/en unknown
- 2021-05-13 CO CONC2021/0006290A patent/CO2021006290A2/es unknown
-
2023
- 2023-11-24 JP JP2023199206A patent/JP2024015045A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3118282A1 (en) | 2020-05-07 |
CN112996561A (zh) | 2021-06-18 |
EA202191189A1 (ru) | 2021-08-06 |
WO2020092549A1 (en) | 2020-05-07 |
EP3873602A1 (en) | 2021-09-08 |
AU2019370295A1 (en) | 2021-06-03 |
KR20210084533A (ko) | 2021-07-07 |
IL281990A (en) | 2021-05-31 |
BR112021008063A2 (pt) | 2021-08-10 |
JP2022512632A (ja) | 2022-02-07 |
JP2024015045A (ja) | 2024-02-01 |
MX2021004994A (es) | 2021-06-15 |
EP4306128A3 (en) | 2024-03-27 |
EP3873602B1 (en) | 2023-12-06 |
EP4306128A2 (en) | 2024-01-17 |
US20210395352A1 (en) | 2021-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2021006290A2 (es) | Dosificación subcutánea y administración de anticuerpos anti-c5 para el tratamiento de la hemoglobinuria paroxistica nocturna (pnh) | |
CO2020004838A2 (es) | Dosis y administración de anticuerpos anti-c5 para el tratamiento de la hemoglobinuria paroxística nocturna (hpn) y el síndrome hemolítico urémico atípico (shua) | |
AR099078A2 (es) | Un medicamento que comprende acetato de glatiramer | |
MD3883606T2 (ro) | Metodă sigură și eficientă de tratament al colitei ulcerative cu anticorpi anti-IL12/IL23 | |
EA201791199A1 (ru) | Способ лечения болезни альцгеймера | |
MX2020006650A (es) | Esketamina para el tratamiento de la depresión. | |
CO2020004831A2 (es) | Dosis y administración de anticuerpos antic-c5 para el tratamiento de pacientes con glomerulonefritis membranoproliferativa | |
EA201890182A1 (ru) | Терапевтическое средство для лечения синдрома гунтера и способ его лечения | |
AR104771A1 (es) | Inhalador de polvo seco | |
AR120055A1 (es) | Métodos para tratar la enfermedad de fabry en pacientes que tienen insuficiencia renal | |
EA202090242A1 (ru) | Лечение болезни фабри у фзт-наивных и фзт-леченных пациентов | |
NI201700024A (es) | Tratamientos médicos a base de anamorelina | |
CO2021014370A2 (es) | Regímenes de dosificación para anticuerpos anti-vrs y composiciones que los incluyen | |
MX2022001153A (es) | Regimen de dosificacion y administracion para el tratamiento o prevencion de enfermedades relacionadas con c5 mediante el uso del anticuerpo anti-c5 crovalimab. | |
CO2020001314A2 (es) | Tratamiento de pacientes con enfermedad de von willebrand grave que se someten a cirugía electiva mediante administración de vwf recombinante | |
CL2019001867A1 (es) | Régimen terapéutico para el tratamiento de fabry usando alfa-galactosidasa estabilizada. | |
AR111491A1 (es) | Métodos para tratar enfermedades pediátricas | |
CR20220041A (es) | Régimen de dosificación y administración para el tratamiento o prevención de enfermedades relacionadas con c5 mediante el uso del anticuerpo anti-c5 crovalimab | |
AR117784A1 (es) | Tratamiento del sobreuso de medicación para el dolor de cabeza utilizando anticuerpos anti-cgrp o anti-cgrp-r | |
Kinoshita | Linezolid/warfarin interaction | |
RU2018147275A (ru) | Способ лечения сахарного диабета 2 типа у больных со стеатогепатитом | |
EA202091036A1 (ru) | ДОЗИРОВАНИЕ И ВВЕДЕНИЕ АНТИТЕЛ ПРОТИВ C5 ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ С ПАРОКСИЗМАЛЬНОЙ НОЧНОЙ ГЕМОГЛОБИНУРИЕЙ (PNH) И АТИПИЧНЫМ ГЕМОЛИТИКО-УРЕМИЧЕСКИМ СИНДРОМОМ (aHUS) | |
UA115063U (xx) | Спосіб лікування собак із больовим синдромом при панкреатиті | |
Kato | Drug hypersensitivity: case report | |
EA202090894A1 (ru) | Дозирование и введение антител против c5 для лечения пациентов с мембранопролиферативным гломерулонефритом |