CO2018010430A1 - Lipopeptidos cortos con actividad antimicrobiana contra bacterias gram negativas y gram positivas - Google Patents
Lipopeptidos cortos con actividad antimicrobiana contra bacterias gram negativas y gram positivasInfo
- Publication number
- CO2018010430A1 CO2018010430A1 CONC2018/0010430A CO2018010430A CO2018010430A1 CO 2018010430 A1 CO2018010430 A1 CO 2018010430A1 CO 2018010430 A CO2018010430 A CO 2018010430A CO 2018010430 A1 CO2018010430 A1 CO 2018010430A1
- Authority
- CO
- Colombia
- Prior art keywords
- stivarius
- staphylocaccus
- minimum
- present
- activity against
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente inVenCión se refiere a lipOpáplidos sintéticos de formula Cnal-X2-X3-NH2 en donde: Cn es un ácido graso seleccionado del grupo que consiste de 012 a C18; X1 es al menos una molécula de glicina; X2 es al menos dos aminoácidos naturales con carga neta Reabra y/a no proteinogénicos; y. X3 puede estar presente o ausente y cuando está presente es al menos un aminoácido alitatico. Los lipopéptidos presentan actividad antibacteriana contra bacterias patógenas (Step hylococcus aureus, Enterocaocus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella p eumoniae, Acinetobacter baurnannit Serraba marcescens. Staphylocaccus saprophyticus, StaPhylococcus haemolyticus y Streptocaccus salivarius) a concentraciones mínimas inhibitorias (CM') entre 8 a 50 utd, Adicionalmente, n presentaron toxicidad en eritrocitos humanos ni en larvas de mosquito en concentraciones entre 3,13 y 50,0 pM a na concentración evaluada de 100 pM,
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CONC2018/0010430A CO2018010430A1 (es) | 2018-09-28 | 2018-09-28 | Lipopeptidos cortos con actividad antimicrobiana contra bacterias gram negativas y gram positivas |
| PCT/IB2019/058204 WO2020065595A1 (es) | 2018-09-28 | 2019-09-27 | Lipopeptidos cortos con actividad antimicrobiana contra bacterias gram negativas y gram positivas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CONC2018/0010430A CO2018010430A1 (es) | 2018-09-28 | 2018-09-28 | Lipopeptidos cortos con actividad antimicrobiana contra bacterias gram negativas y gram positivas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018010430A1 true CO2018010430A1 (es) | 2020-04-01 |
Family
ID=69951850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0010430A CO2018010430A1 (es) | 2018-09-28 | 2018-09-28 | Lipopeptidos cortos con actividad antimicrobiana contra bacterias gram negativas y gram positivas |
Country Status (2)
| Country | Link |
|---|---|
| CO (1) | CO2018010430A1 (es) |
| WO (1) | WO2020065595A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1633380A4 (en) * | 2003-06-19 | 2010-08-11 | Yeda Res & Dev | ANTIMICROBIAL AND ANTICANCER LIPOPEPTIDES |
| EP3323827A1 (en) * | 2016-11-21 | 2018-05-23 | Christian-Albrechts-Universität zu Kiel | Cationic intrinsically disordered antimicrobial peptides |
-
2018
- 2018-09-28 CO CONC2018/0010430A patent/CO2018010430A1/es unknown
-
2019
- 2019-09-27 WO PCT/IB2019/058204 patent/WO2020065595A1/es active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020065595A1 (es) | 2020-04-02 |
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