CO2017010662A2 - Dispositivo médico para ablacionar células de tejido en una región determinada de tratamiento - Google Patents

Dispositivo médico para ablacionar células de tejido en una región determinada de tratamiento

Info

Publication number
CO2017010662A2
CO2017010662A2 CONC2017/0010662A CO2017010662A CO2017010662A2 CO 2017010662 A2 CO2017010662 A2 CO 2017010662A2 CO 2017010662 A CO2017010662 A CO 2017010662A CO 2017010662 A2 CO2017010662 A2 CO 2017010662A2
Authority
CO
Colombia
Prior art keywords
medical device
treatment region
tissue cells
given treatment
ablate tissue
Prior art date
Application number
CONC2017/0010662A
Other languages
English (en)
Inventor
Robert Neal
S Nahum Goldberg
Gordon Single
Original Assignee
Angiodynamics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiodynamics Inc filed Critical Angiodynamics Inc
Publication of CO2017010662A2 publication Critical patent/CO2017010662A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1477Needle-like probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00022Sensing or detecting at the treatment site
    • A61B2017/00084Temperature
    • A61B2017/00092Temperature using thermocouples
    • A61B2017/00097Temperature using thermocouples one of the thermometric elements being an electrode or the heating element
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613Irreversible electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00696Controlled or regulated parameters
    • A61B2018/00744Fluid flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00791Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00827Current

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)
  • Laser Surgery Devices (AREA)

Abstract

Un dispositivo y método de tratamiento para administrar pulsos eléctricos capaces de crear electroporación irreversible. El sistema puede incluir una sonda bipolar con perfusión abierta o cerrada con el propósito de controlar el aumento de conductividad eléctrica para eliminar la formación de un arco eléctrico, sin alterar significativamente la distribución de campo eléctrico y la zona de tratamiento. Esta invención puede incluir perfusión junto con la administración de parámetros de pulsos específicos o personalizados para obtener tamaños de ablación clínicamente aceptables usando una sonda bipolar, reduciendo al mismo tiempo el riesgo total de la formación de arco eléctrico o la falla del sistema.
CONC2017/0010662A 2015-04-10 2017-10-19 Dispositivo médico para ablacionar células de tejido en una región determinada de tratamiento CO2017010662A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562145581P 2015-04-10 2015-04-10
US201562151513P 2015-04-23 2015-04-23
US201562173538P 2015-06-10 2015-06-10
PCT/US2016/026998 WO2016164930A1 (en) 2015-04-10 2016-04-11 System and method for irreversible electroporation with thermally controlled electrodes

Publications (1)

Publication Number Publication Date
CO2017010662A2 true CO2017010662A2 (es) 2018-03-09

Family

ID=57072343

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0010662A CO2017010662A2 (es) 2015-04-10 2017-10-19 Dispositivo médico para ablacionar células de tejido en una región determinada de tratamiento

Country Status (7)

Country Link
US (1) US20180071014A1 (es)
EP (1) EP3282953A4 (es)
CN (1) CN108024803B (es)
AU (1) AU2016246146B2 (es)
CO (1) CO2017010662A2 (es)
HK (1) HK1254629A1 (es)
WO (1) WO2016164930A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702337B2 (en) 2016-06-27 2020-07-07 Galary, Inc. Methods, apparatuses, and systems for the treatment of pulmonary disorders

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CN108135653B (zh) 2015-10-07 2022-02-11 梅约医学教育与研究基金会 用于肥胖症或糖尿病治疗的电穿孔
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
EP3500199B1 (en) * 2016-11-29 2021-07-28 St. Jude Medical, Cardiology Division, Inc. Electroporation systems and catheters for electroporation systems
US10569081B2 (en) * 2017-03-03 2020-02-25 Medtronic, Inc. Stacked potential electroporation
CN110891644A (zh) * 2017-07-17 2020-03-17 波士顿科学国际有限公司 具有不透辐射的标记物的多孔球囊
CN108186108A (zh) * 2017-10-12 2018-06-22 天津市鹰泰利安康医疗科技有限责任公司 多极双向高压陡脉冲放电系统及放电方法
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
WO2019133608A1 (en) 2017-12-26 2019-07-04 Gala Therapeutics, Inc. Optimization of energy delivery for various applications
US20200405387A1 (en) * 2018-03-06 2020-12-31 St. Jude Medical, Cardiology Division, Inc. Systems and methods for limiting arcing in electroporation systems
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) * 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
EP3801340A4 (en) * 2018-05-31 2022-03-09 North Carolina State University ELECTROTHERMAL THERAPY FOR THE TREATMENT OF DISEASE OR UNWANTED TISSUE
WO2019237107A1 (en) * 2018-06-08 2019-12-12 Mayo Foundation For Medical Education And Research Dermatological electroporation devices and methods
US20200046414A1 (en) * 2018-08-10 2020-02-13 Covidien Lp Systems, methods, and computer-readable media for controlling ablation energy delivery
CN109157280A (zh) * 2018-08-10 2019-01-08 重庆大学 不可逆电穿孔组织消融效果动态实时评估设备
CN108742834A (zh) * 2018-08-21 2018-11-06 重庆半岛医疗科技有限公司 一种射频治疗装置
EP3892219B1 (en) 2018-08-23 2022-06-01 Novocure GmbH Using alternating electric fields to increase permeability of the blood brain barrier
EP3852868A4 (en) 2018-09-18 2022-06-15 Virginia Tech Intellectual Properties, Inc. TREATMENT PLANNING SYSTEM FOR IMMUNOTHERAPY USING NON-THERMAL ABLATION
CN112969425A (zh) * 2018-11-07 2021-06-15 美敦力公司 在组织能量递送期间识别并消除电弧和电弧诱发的等离子体的方法
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
CN118203401A (zh) * 2019-04-18 2024-06-18 盖能适治疗股份有限公司 用于治疗异常组织的装置、系统和方法
EP3975896A4 (en) * 2019-05-31 2023-06-28 North Carolina State University Methods and apparatus for modifying or killing cells by manipulating the cell membrane charging time
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
CN110755148B (zh) * 2019-09-20 2020-09-08 姚陈果 脉冲电场肿瘤消融参数优化系统
CN113365566A (zh) * 2019-12-03 2021-09-07 圣犹达医疗用品心脏病学部门有限公司 电穿孔系统和方法
CN110946642A (zh) * 2019-12-13 2020-04-03 天津市鹰泰利安康医疗科技有限责任公司 一种高频双极性不可恢复电穿孔系统
US20220031386A1 (en) * 2020-07-28 2022-02-03 Biosense Webster (Israel) Ltd. Controlling irreversible electroporation ablation using a focal catheter having contact-force and temperature sensors
EP4319673A1 (en) 2021-04-07 2024-02-14 BTL Medical Development A.S. Pulsed field ablation device and method
CN113229928B (zh) * 2021-06-18 2023-12-15 杭州维纳安可医疗科技有限责任公司 电极针、消融设备及消融方法、装置、存储介质
CN113229929A (zh) * 2021-06-18 2021-08-10 杭州维纳安可医疗科技有限责任公司 电极针、消融设备及消融方法、装置、存储介质
CN113229930B (zh) * 2021-06-18 2023-09-22 杭州维纳安可医疗科技有限责任公司 电极针、消融设备及消融方法、装置、存储介质
IL309432A (en) 2021-07-06 2024-02-01 Btl Medical Dev A S Apparatus and method for ablation (burning) by electric pulse field
CN113520585B (zh) * 2021-07-16 2022-06-17 河南科技大学第一附属医院 一种隔离灌注件、消融电极头以及肿瘤射频消融治疗装置
US20230048486A1 (en) 2021-08-16 2023-02-16 Biosense Webster (Israel) Ltd. Language for generating ablation protocols and system configurations
WO2023049954A1 (en) * 2021-10-01 2023-04-06 Microfield Global Pty Ltd Method, systems, apparatuses and devices for cardiac tissue characterization and ablation using reversible electroporation and electrolysis
WO2023076767A1 (en) * 2021-10-26 2023-05-04 Pulse Biosciences, Inc. Percutaneous treatment device and method
CN114271931B (zh) * 2021-12-23 2023-09-12 心航路医学科技(广州)有限公司 一种脉冲消融系统
CN114366280B (zh) * 2022-03-22 2022-11-08 上海睿刀医疗科技有限公司 脉冲处理装置、脉冲处理方法、电子设备和存储介质
US20230329769A1 (en) * 2022-04-19 2023-10-19 St. Jude Medical, Cardiology Division, Inc. Systems and methods for electroporation using arbitrary electrode addressing
CN117653324A (zh) * 2022-08-31 2024-03-08 杭州诺沁医疗器械有限公司 消融针、消融装置及消融系统
CN117653322A (zh) * 2022-08-31 2024-03-08 杭州诺沁医疗器械有限公司 用于实现稳定出针的引导组件、消融装置及消融系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856081A (en) * 1991-07-08 1999-01-05 The American National Red Cross Computer controlled cryoprotectant perfusion apparatus
US5462521A (en) * 1993-12-21 1995-10-31 Angeion Corporation Fluid cooled and perfused tip for a catheter
US6328735B1 (en) * 1998-10-30 2001-12-11 E.P., Limited Thermal ablation system
US6994706B2 (en) * 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
EP2474281B1 (en) * 2003-12-24 2019-03-27 The Regents of The University of California Tissue ablation with irreversible electroporation
US9867652B2 (en) * 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US8992517B2 (en) * 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US9233241B2 (en) * 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
WO2012142291A1 (en) * 2011-04-12 2012-10-18 Thermedical, Inc. Devices and methods for shaping therapy in fluid enhanced ablation
US9414881B2 (en) * 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN103315808A (zh) * 2012-03-23 2013-09-25 心诺普医疗技术(北京)有限公司 一种消融电极及采用该电极的灌注型电极导管
EP3154463B1 (en) * 2014-06-12 2019-03-27 Farapulse, Inc. Apparatus for rapid and selective transurethral tissue ablation
US10531914B2 (en) * 2015-08-06 2020-01-14 Medtronic, Inc. Cardiac pulsed field ablation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702337B2 (en) 2016-06-27 2020-07-07 Galary, Inc. Methods, apparatuses, and systems for the treatment of pulmonary disorders
US10939958B2 (en) 2016-06-27 2021-03-09 Galary, Inc. Methods, apparatuses, and systems for the treatment of pulmonary disorders
US11369433B2 (en) 2016-06-27 2022-06-28 Galvanize Therapeutics, Inc. Methods, apparatuses, and systems for the treatment of pulmonary disorders

Also Published As

Publication number Publication date
US20180071014A1 (en) 2018-03-15
AU2016246146A1 (en) 2017-10-26
EP3282953A4 (en) 2019-04-17
EP3282953A1 (en) 2018-02-21
HK1254629A1 (zh) 2019-07-26
AU2016246146B2 (en) 2021-03-11
WO2016164930A1 (en) 2016-10-13
CN108024803B (zh) 2021-10-19
CN108024803A (zh) 2018-05-11

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