CN2713992Y - Comprehensive target therapy platform for human body tumor treatment - Google Patents
Comprehensive target therapy platform for human body tumor treatment Download PDFInfo
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- CN2713992Y CN2713992Y CN 200420081186 CN200420081186U CN2713992Y CN 2713992 Y CN2713992 Y CN 2713992Y CN 200420081186 CN200420081186 CN 200420081186 CN 200420081186 U CN200420081186 U CN 200420081186U CN 2713992 Y CN2713992 Y CN 2713992Y
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Abstract
The utility model refers to a comprehensive target therapy platform for human body tumor treatment, comprising a control host a supervisory keyboard and a display which are connected with the control host, an analog input module, an analog output module, a digital input module, a digital output module, a video input module and a communication module. The respectively modules are connected with the control host via a data bus. A radio frequency current-generator is connecting arranged between the analog input module and the analog output module. An ultra imager is connected between the video input module and the communication module via data-wires, while further, a pressing sensor is connected on the digital input module. A pressing alarm lamp, an electromagnetic valve and a relay are connected on the digital output module. The analog input module is connected with a radio-frequency electrode temperature sensor. The radio frequency current-generator is connected with a skin electrode, and further, an electrode needle is connected on the relay. The comprehensive therapy platform of the utility model simultaneously integrative using various known methods of treatment can get a better therapeutic effect.
Description
Technical field
The relevant a kind of human of this utility model is in the treatment platform of human tumor, and especially relevant a kind of comprehensive targeting that is used for human tumor is treated platform.
Background technology
Along with the continuous intensification to tumor understanding, Comprehensive Treatment has more and more accounted for consequence in treatment, and reasonable and planned Comprehensive Treatment replaces traditional single therapy to become common recognition.Surgical resection is the prefered method of oncotherapy, but for not tolerating surgical operation or having lost the patient that surgical engine is understood, the then important effect of play more and more of Minimally Invasive Surgery or Wicresoft's interventional therapy.With hepatocarcinoma is example, and primary hepatocarcinoma is common alimentary system malignant tumour, if do not treat, mean survival time (MST) only is 1-3 month.Hepatocarcinoma is because the pathological characteristic of itself is often asymptomatic in early days, and once discovery, how to middle and advanced stage, the excision person that can perform the operation only is 10%-15%, and interventional therapy just becomes unique selection.Compare with traditional surgery, interventional therapy has its unique distinction, is the process that a kind of accurate targeting destroys, and can not cause a large amount of normal structures cut, and wound is little, go out insufficiency of blood, patient recovers fast.In the interventional therapy of tumor, the important effect of local cold and hot treatment play more and more.
The cold therapy of tumor is that several the cryoprobes that thermocouple is installed that can control separately insert tumor locus, imposes low temperature at the cryoprobe head then tumor is killed.The ultimate principle of cold therapy tumor is the mechanical injuries of ice crystal formation and ice crystal in the cell, cell dehydration and shrinkage, the concentrated and pH value change of cell electrolyte toxicity, cell membrane lipid protein ingredient degeneration etc.In addition, refrigerated effect also may be relevant with immunity.Be applied to cold therapy at present and mainly contain two kinds of systems: liquid nitrogen system and argon system.Liquid nitrogen system is that the principle that need absorb a large amount of heats when utilizing material to become gas by liquid reduces tissue temperature rapidly.In the operation liquid nitrogen is fed in the cryoprobe, absorb a large amount of heats during liquid nitrogen vaporization, the cryoprobe temperature reduces, and makes and organizes fast cooling, freezes, and then use electrical heating or pass to room temperature nitrogen, makes and organizes rewarming, through freeze-thaw cycle repeatedly tumor is killed.See also shown in Figure 1ly, low temperature liquid nitrogen is introduced from Dewar container for liquefied nitrogen bottle 30, liquid nitrogen is passed to effective cold section of liquid nitrogen cryosurgical system 37,38 ends by feed tube, after the heat absorption evaporation, and the temperature reduction, pathological tissues is freezing, and gas nitrogen enters in the air.Effectively the part more than cold section adopts vacuum insulation.Also be provided with relief valve 31 on the transfer pipeline, when loine pressure is higher than setting value, discharge unnecessary pressure, air bleeding valve 32, finish treatment circulation after, exclude unnecessary gas in the pipeline, by control electromagnetic valve 33,34, control respectively and whenever cryoprobe is begun and end feed liquor.Above-mentioned liquid nitrogen cryosurgical system 37,38 links to each other with feed tube by fast interface 35,36.Liquid nitrogen system can reach lower cryogenic temperature (subzero 196 spend subzero 209 degree), but the process of its cooling and rewarming is all longer.
Another kind of Therapeutic Method is to use the argon cutter.Different with liquid nitrogen system is that the argon cutter has response speed faster, can finish cooling and rewarming process in the shorter time.The argon cutter is to utilize the adiabatic throttling effect of gas to finish the therapeutic process of cooling and rewarming, when the higher gas of pressure is flowed through the aperture adiabatic throttling, along with the decline temperature of pressure tends to change, some gas temperature descends, and some gas temperature rises, the adiabatic throttling effect is also referred to as joule thomson effect.When cryoprobe internal recycle argon, argon is in the point of a knife rapid expansion, and freezing in a short period of time pathological tissues is at subzero 140 degree, and recycling helium or electrically heated method make and organize rewarming then.Freezing and rewarming alternate cycles is killed tumor.See also shown in Figure 2, argon as the refrigeration matchmaker.During cooling, argon filters out microgranule, moisture, oil from argon bottle 1 through filter 2, and after gas arrived cryoprobe 17,18,19 by the road, argon was in the point of a knife rapid expansion, and temperature descends rapidly after the throttling, and pathological tissues is freezing.Also be provided with pressure-regulating valve 5 on the pipeline, adjustments of gas pressure in OK range, relief valve 6, when gas pressure is higher than setting value, discharge unnecessary pressure, air bleeding valve 7, finish treatment circulation after, exclude unnecessary gas in the pipeline, by control electromagnetic valve 8,9,10, control respectively and whenever cryoprobe is begun and end air inlet, before gas enters cryoprobe, through filter 11,12,13, further filter redundant moisture.Also be provided with pressure-regulating valve 24 on the pipeline, adjustments of gas pressure is in OK range, and relief valve 25 when gas pressure is higher than when setting value, discharges unnecessary pressure, electromagnetic valve 26, and control begins and ends air inlet.Cryoprobe links to each other with body by the snap joint on the cabinet 14,15,16.Treatment needs usually through repeatedly cooling and rewarming circulation, and the time of cooling and rewarming is controlled.
Radiofrequency therapy is a kind of emerging technology of oncotherapy, the electrode emission high-frequency radio frequency ripple that utilization is inserted into tumor locus produces heat energy, make and produce the above high temperature of 50 degree in the tumor, cause the degeneration of tumor cell internal protein, the double-deck dissolving of cell membrane lipid, produce cell thermocoagulation necrosis, the kill tumor cell reaches the purpose for the treatment of tumor fast.See also shown in Figure 3ly, the radio-frequency (RF) therapy system mainly is made up of radio-frequency current generator 39, electrode needle 40, skin electrode 41, relay 42, Control Computer 43 and power supply 44.This system forms a closed circuit, and the patient links to each other electrode needle 40 with skin electrode 41.Conduct to the ion of organizing around the alternating current vibrations electrode needle 40 of tumor tissues, cause frictional heat, and conduct to adjacent tissue, around electrode needle, produce a spherical district of damaging.
Liquid nitrogen cryotherapy, argon cold therapy, radio-frequency (RF) thermotherapeutic respectively have its certain limitation.The problem of radio frequency is possible cause the blood flow vibration, takes away a large amount of heats, and the heating-up temperature field is difficult to effective control simultaneously, comprises the protection to normal cell and tissue.
How radio-frequency (RF) thermotherapeutic, liquid nitrogen cryotherapy, argon cold therapy being combined, form a kind of combined therapy of tumour platform, is the current problem to be solved of industry with the purpose that reaches thorough kill tumor.
The utility model content
The purpose of this utility model is to provide a kind of comprehensive targeting treatment platform that is used for human tumor, and it can be applicable to various Therapeutic Method, reaches the purpose of thorough kill tumor.
The purpose of this utility model is achieved in that a kind of comprehensive targeting treatment platform that is used for human tumor, comprise a main frame, supervisory keyboard that links to each other with main frame and display, analog input module, the numeral output module, video input module and communication module, more than each module link to each other with main frame by data/address bus, between above-mentioned analog input module and analog output module, be connected with the radio-frequency current generator, data wire connects ultra imager by video input module, and further be connected with pressure transducer on the digital input module, be connected with temperature sensor on the analog input module, be connected with the pressure alarm lamp on the digital output module, low-temperature solenoid valve and relay.
Compared with prior art, the beneficial effects of the utility model are: radio-frequency (RF) thermotherapeutic, liquid nitrogen cryotherapy, argon cold therapy are combined, form a kind of combined therapy of tumour platform, to reach the purpose of thorough kill tumor.
Description of drawings
Fig. 1 is the structural representation of liquid nitrogen therapy system in the prior art.
Fig. 2 is the structural representation of argon therapy system in the prior art.
Fig. 3 is the structural representation of radio-frequency (RF) therapy system in the prior art.
Fig. 4 is the structural representation that a kind of comprehensive targeting that is used for human tumor of this utility model is treated an embodiment of platform.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is further described.
See also shown in Figure 4, it is an a kind of embodiment who is used for the comprehensive targeting treatment platform of human tumor of the present utility model, comprise a main control system 43, the supervisory keyboard 45 that links to each other with main frame 43 and display 67, supervisory keyboard 45 is in order to controller 43 transmission commands, and display 67 then can be with the data show in the therapeutic process for treatment personnel reference; Analog input module 48, analog output module 49, digital input module 47, digital output module 46, video input module 50 and communication module 51 all are connected by data/address bus 53 with above-mentioned controller 43, in order to the transmission signal; Between above-mentioned analog input module 48 and analog output module 49, be connected with radio-frequency current generator 39, be connected with a ultra imager 52 by data wire between video input module 50 and the communication module 51, in order in therapeutic process, to carry out localization by ultrasonic, further be connected with joystick 66 on the communication module 51; And further be connected with a plurality of pressure transducers on the digital input module 47, comprise argon pressure pick off 55, liquid nitrogen pressure transducer 59, also be connected with control pin pedal 65 on the digital input module 47, correspondence is connected with a plurality of pressure alarm lamps on the numeral output module 46, comprise argon pressure alarm lamp 54, liquid nitrogen pressure alarm lamp 58 and a plurality of electromagnetic valve 8,10,33,34 and relay 42, also has alarm buzzer 64, analog input module 48 links to each other with a plurality of temperature sensors, comprise radio-frequency electrode temperature sensor 63, be connected in the argon cryoprobe temperature sensor 60 of argon pipeline, be connected in liquid nitrogen cryosurgical system temperature sensor 61 and independent thermometric temperature sensor 62 in the liquid nitrogen pipe, radio-frequency current generator 39 is connected with skin electrode (figure does not show), further is connected with electrode needle (figure does not show) on the relay 42.An enterprising step of above-mentioned pipeline is connected with various low-temperature solenoid valves, pop off valve and dries and micronic filter.Above-mentioned main control system 43 is a Control Computer in this utility model, and described temperature sensor is temperature thermocouple in this utility model.
Before the operation, the doctor is before the operating board that Control Computer 43, display 67 and supervisory keyboard 45 are formed, select one or more treatment modules according to patient's concrete condition, and under the assistance of computer assisted surgery planning system, determine respectively to treat treatment order, treatment time and the cycle-index of module, determine to select for use the safe approach and the emplacement depth of cryoprobe or electrode needle.
In the operation, the doctor at first uses ultra imager 52, under the ultrasonoscopy guiding that display 67 shows, with cryoprobe or electrode needle by art before in plan or the art approach of actual needs accurately be inserted into tumor locus, also can increase or reduce the quantity of cryoprobe or electrode needle according to practical situation.Simultaneously, in the critical tissue of position, tumor edge or vicinity, insert some independent temperature thermocouples 62, so that monitor the temperature at these positions.The ultrasonoscopy that display 67 shows be ultra imager 52 by video input module 50 as calculated machine bus 53 deliver to Control Computer 43 and show.The doctor also can be switched between the automatic or manual control model by supervisory keyboard 45 or joystick 66 by supervisory keyboard 45, joystick 66 or control pin pedal 65 starting device begin treatments.Supervisory keyboard 45 directly links to each other with Control Computer 43, and machine bus 53 is continuous with Control Computer 43 as calculated by communication module 51 for joystick 66, and machine bus 53 is continuous with Control Computer 43 as calculated by digital input module 47 for the control pin pedal.
In the equipment work process, being positioned at the vertical temperature thermocouple 60 of argon cryoprobe is voltage signal input analog input module 48 with the vertical temperature transition of argon cryoprobe, analog input module 48 is converted to digital signal after computer bus 53 passes to Control Computer 43 with this voltage signal, Control Computer 43 goes out the vertical temperature of argon cryoprobe according to this calculated signals and with reference to default cryogenic temperature value and low temperature retention time, controls the vertical temperature of argon cryoprobe by the digital output module 46 switch low-temperature solenoid valves 8 that link to each other with computer bus 53 and whether continues the speed that descends and descend.If according to requiring needs rewarming argon cryoprobe in the result of pre-operative surgical plan or the art, Control Computer 43 will be closed low-temperature solenoid valve 8 and be stopped to provide argon.Being positioned at the vertical temperature thermocouple 61 of liquid nitrogen cryosurgical system is voltage signal input analog input module 48 with the vertical temperature transition of liquid nitrogen cryosurgical system, analog input module 48 is converted to digital signal after computer bus 53 passes to Control Computer 43 with this voltage signal, Control Computer 43 goes out the vertical temperature of liquid nitrogen cryosurgical system according to this calculated signals and with reference to default cryogenic temperature value and low temperature retention time, controls the vertical temperature of liquid nitrogen cryosurgical system by digital output module 46 switch electromagnetic valves 33 that link to each other with computer bus 53 and whether continues the speed that descends and descend.If stop the liquid nitrogen cryosurgical system cooling according to the result of pre-operative surgical plan or the needs that require in the art, Control Computer 43 will be closed electromagnetic valve 33 and be stopped to supply with liquid nitrogen.Being positioned at the vertical temperature thermocouple 63 of electrode needle is voltage signal input analog input module 48 with the vertical temperature transition of electrode needle, analog input module 48 is converted to digital signal after computer bus 53 passes to Control Computer 43 with this voltage signal, vertical temperature of electrode needle and default thermotherapy temperature value and retention time of reference that Control Computer 43 goes out according to this calculated signals, come the radio frequency of control electrode pin whether to export by digital output module 46 switch relays 42 that link to each other with computer bus 53, simultaneously radio-frequency signal generator 39 with the impedance variation between electrode needle 40 and the skin electrode 41 by analog input module 48 as calculated machine bus 53 feed back to Control Computer 43, Control Computer 43 is regulated the output of radio-frequency signal generator 39 according to the impedance variation situation of feedback by default rule by the analog output module 49 that links to each other with computer bus 53.The voltage that independent temperature thermocouple 62 generates will by analog input module 48 be converted to digital signal as calculated machine bus 53 pass in the Control Computer 43, if the temperature that independent temperature thermocouple 62 detects has exceeded range of set temperature, Control Computer 43 will stop or reducing the output of equipment according to default step and lead to the digital output module 46 connection alarm buzzers 64 that link to each other in computer bus 53.When argon pressure sensing 55, liquid nitrogen pressure transducer 59 exceed set point in the force value that monitors separately, will be respectively by digital input module 47 as calculated machine bus 53 submit to Control Computer 43 alarm signals, Control Computer 43 will be carried out sound and light alarm by the digital output module that links to each other with computer bus 53 46 control argon pressure alarm lamps 54, liquid nitrogen pressure alarm lamp 58 and alarm buzzer 64, simultaneously with the associated components work of arrestment to guarantee safety.Display 67 will show the temperature value of each cryoprobe that is using, electrode needle and independent temperature thermocouple, the on off state of corresponding electromagnetic valve of cryoprobe and the corresponding relay of electrode needle, real-time parameter values such as the output of electrode needle and impedance.
In the therapeutic process, the doctor at any time can start and stop any one treatment module, and can between automatic and manual control model, switch at any time.All ultrasonoscopys and the various data that collect can be saved in the Control Computer 43 or backup on other computer-readable storage medium, carry out analysis of cases and tracking for doctor's postoperative.
In sum, this utility model has been finished designer's purpose, in the process of treatment tumor, can select one or more therapeutic modality as required quickly and easily for use, to kill tumor up hill and dale, reaches preferable therapeutic effect.
Claims (10)
1. a comprehensive targeting that is used for human tumor is treated platform, it is characterized in that: comprise a main frame, supervisory keyboard that links to each other with main frame and display, analog input module, the numeral output module, video input module and communication module, more than each module link to each other with main frame by data/address bus, between above-mentioned analog input module and analog output module, be connected with the radio-frequency current generator, data wire connects ultra imager by video input module, and further be connected with pressure transducer on the digital input module, be connected with temperature sensor on the analog input module, be connected with the pressure alarm lamp on the digital output module, low-temperature solenoid valve and relay.
2. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1 is characterized in that: be connected with the temperature sensor of argon cryoprobe on the analog input module.
3. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1 is characterized in that: be connected with the liquid nitrogen cryosurgical system temperature sensor on the analog input module.
4. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1: be connected with the radio-frequency electrode temperature sensor on the analog input module.
5. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1, it is characterized in that: temperature sensor is installed on the liquid nitrogen pipeline, and is connected with low-temperature solenoid valve on the above-mentioned pipeline.
6. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1, it is characterized in that: temperature sensor is installed on the argon pipeline, and is connected with low-temperature solenoid valve on the above-mentioned pipeline.
7. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1, it is characterized in that: the radio-frequency current generator is connected with the radio-frequency electrode pin by relay.
8. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1, it is characterized in that: temperature sensor is installed on the liquid nitrogen pipeline, and is connected with pop off valve on the above-mentioned pipeline, dries and micronic filter.
9. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1 is characterized in that: connect in the temperature sensor and be installed on the argon pipeline, and be connected with pop off valve on the above-mentioned pipeline, dry and micronic filter.
10. the comprehensive targeting treatment platform that is used for human tumor as claimed in claim 1 is characterized in that: be connected with skin electrode on the radio-frequency current generator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420081186 CN2713992Y (en) | 2004-07-28 | 2004-07-28 | Comprehensive target therapy platform for human body tumor treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420081186 CN2713992Y (en) | 2004-07-28 | 2004-07-28 | Comprehensive target therapy platform for human body tumor treatment |
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| Publication Number | Publication Date |
|---|---|
| CN2713992Y true CN2713992Y (en) | 2005-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200420081186 Expired - Lifetime CN2713992Y (en) | 2004-07-28 | 2004-07-28 | Comprehensive target therapy platform for human body tumor treatment |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755190A (en) * | 2011-04-26 | 2012-10-31 | 中国科学院理化技术研究所 | All-functional wide warm area low-temperature treatment equipment |
| CN103006315A (en) * | 2013-01-09 | 2013-04-03 | 中国科学技术大学 | Freezing-heating tool |
| CN103006316A (en) * | 2013-01-09 | 2013-04-03 | 中国科学技术大学 | Freezing-heating tool |
| CN104783890A (en) * | 2015-04-14 | 2015-07-22 | 上海交通大学 | Melanoma cold and hot therapy device |
-
2004
- 2004-07-28 CN CN 200420081186 patent/CN2713992Y/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755190A (en) * | 2011-04-26 | 2012-10-31 | 中国科学院理化技术研究所 | All-functional wide warm area low-temperature treatment equipment |
| CN102755190B (en) * | 2011-04-26 | 2014-12-31 | 中国科学院理化技术研究所 | All-functional wide warm area low-temperature treatment equipment |
| CN103006315A (en) * | 2013-01-09 | 2013-04-03 | 中国科学技术大学 | Freezing-heating tool |
| CN103006316A (en) * | 2013-01-09 | 2013-04-03 | 中国科学技术大学 | Freezing-heating tool |
| CN103006315B (en) * | 2013-01-09 | 2015-05-27 | 中国科学技术大学 | Freezing-heating tool |
| CN103006316B (en) * | 2013-01-09 | 2015-11-25 | 中国科学技术大学 | A kind of cold and hot cutter |
| CN104783890A (en) * | 2015-04-14 | 2015-07-22 | 上海交通大学 | Melanoma cold and hot therapy device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: SHANGHAI DAOXIANG TREATMENT SYSTEM CO., LTD. Free format text: FORMER NAME OR ADDRESS: SHANGHAI TARGET MEDIAPHARAMA SYSTEMS CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Patentee after: Shanghai Daoxiang Medical System Co., Ltd. Patentee before: Shanghai Target Mediapharama Systems Co., Ltd. |
|
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20140728 Granted publication date: 20050803 |