CN2444230Y - Immunohistochemistry apparatus - Google Patents
Immunohistochemistry apparatus Download PDFInfo
- Publication number
- CN2444230Y CN2444230Y CN 00234677 CN00234677U CN2444230Y CN 2444230 Y CN2444230 Y CN 2444230Y CN 00234677 CN00234677 CN 00234677 CN 00234677 U CN00234677 U CN 00234677U CN 2444230 Y CN2444230 Y CN 2444230Y
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- reaction plate
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- temperature control
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Abstract
The utility model relates to an immunohistochemistry apparatus, which is composed of a reagent box, an electromagnetic valve, a peristaltic pump, a reaction plate, a temperature control box and a waste liquid box. The reagent box is in a funnel shape. The reaction plate is arranged in the temperature control box. The control of a liquid inlet amount, a liquid inlet speed, a liquid inlet temperature, etc. realize the automatic sample feed and temperature control of a full progress without the influence of an outer temperature to make experimental conditions kept consistence, eliminate the defect that former immunohistochemistry is difficultly standardized, and replace the histo slice dyeing process of traditional pureness manual operation. The utility model reaches the purposes of time saving and labour saving and makes the dyeing process standardized and normalized. The utility model is favorable to accurate diagnosis and mutual comparison.
Description
The utility model belongs to the immunohistochemistry instrument, is mainly used in the immunohistochemical staining of histotomy, is applicable to the various occasions that need carry out immunohistochemical staining.
At present, immunohistochemical section statining process is finished by manual operations, because each operating process time is different in size, step is many, and is dry as dust, time-consuming taking a lot of work, and because manual operations, randomness is strong, is difficult to standardization.Often cause under the similarity condition, same people's operation, different dyeing qualities appears in two sections of same tissue, causes end product difference, causes difficult diagnosis.
The purpose of this utility model provides a kind of immunohistochemistry instrument, by control, reach automatic operation dyeing course, thereby replace traditional pure manual tissue section strain process, reach and both save labour and time, make dyeing course standardization, standardization again, help accurately diagnosis and relatively mutual.
The utility model is achieved through the following technical solutions: the design feature of this immunohistochemistry instrument is, in housing, be provided with kit, solenoid valve, peristaltic pump, reaction plate, temperature control box, the waste liquid box, kit is funnel-form, its lower end links to each other with an end of feed tube, the other end of feed tube links to each other with solenoid valve, the overall channel of feed tube is connected with an end of peristaltic pump, the other end of peristaltic pump links to each other with reaction plate, the other end of reaction plate is connected with the waste liquid box, reaction plate is positioned at temperature control box, and in the middle of reaction plate, have a circular pan, coincide, have a symmetrical passage in the pan with histotomy position on the microslide.
But reaction plate multilayer of the present utility model stacks.
The utlity model has following characteristics: 1, reasonable in design, easy to operate, the result is accurate; 2, the whole operation process can adopt computer program control, and is desirable for traditional pure manual tissue section strain process, reaches and both saves labour and time; 3, use the utility model work, can make dyeing course standardization, standardization, help accurately diagnosis and relatively mutual.
Description of drawings of the present utility model is as follows:
Fig. 1 is the utility model structural representation.
Fig. 2 is the reaction plate structural representation.
The utility model will be further described in conjunction with the accompanying drawings.
Referring to Fig. 1, Fig. 2, the immunohistochemistry instrument mainly is provided with kit 1 in housing 11, solenoid valve 2, peristaltic pump 3, reaction plate 4, temperature control box 5, waste liquid box 6, kit 1 is funnel-form, its lower end links to each other with an end of feed tube 7, the other end of feed tube 7 links to each other with solenoid valve 2, the overall channel 12 of feed tube 7 is connected with an end of peristaltic pump 3, the other end of peristaltic pump 3 links to each other with reaction plate 4, the other end of reaction plate 4 is connected with waste liquid box 6, reaction plate 4 is positioned at temperature control box 5, and in the middle of reaction plate 4, have a circular pan 8, coincide with histotomy position on the microslide 10, have a symmetrical passage 9 in the pan 8, but reaction plate 4 multilayers stack, the two ends of each reaction plate 4 passage 9 are connected to form fluid path from beginning to end by tubule, make liquid flow to waste liquid box 6.
Workflow of the present utility model is: the reagent of the usefulness that will dye in order earlier adds in the kit 1 of numbering in advance, the microslide 10 that will be loaded with histotomy is then put into reaction plate 4, make histotomy just in time embed circular pan 8, again reaction plate 4 is placed temperature control box 5, temperature control box 5 regulating and controlling temperatures are between 0 ℃～100 ℃, precision ± 0.1 ℃, design temperature as required, after reaching predetermined temperature, open the solenoid valve 2 of a kit 1 correspondence, control feed liquor amount and feed liquor speed, simultaneously according to reagent requirement, set the speed of peristaltic pump 3, rotating speed is from 0.1～100 rev/min, thereby reach control reagent flows into peristaltic pump 3 from solenoid valve 2 time, reagent flows into the reaction plate 4 that is arranged in temperature control box 5 by an end of peristaltic pump 3, the histotomy of flowing through on the microslide 10 by the passage on the reaction plate 49 carries out tissue staining, if polylith reaction plate 4 stacks, the fluid path that is connected to form by passage 9 two ends of reagent then by each deblocking reaction plate 4, each reaction plate 4 of flowing through, flow into waste liquid box 6 at last, finish dyeing course.When second kind of reagent of needs dyes, after finishing in the reagent feed liquor amount of a kit 1 and feed liquor time, close corresponding solenoid valve 2, open the solenoid valve 2 of b kit 1 correspondence, press reagent requirement and regulate reagent in the speed input b kit 1 of peristaltic pump 3, and the like, promptly finished whole dyeing course.
Claims (2)
1. immunohistochemistry instrument, it is characterized in that: in housing (11), be provided with kit (1), solenoid valve (2), peristaltic pump (3), reaction plate (4), temperature control box (5), waste liquid box (6), kit (1) is funnel-form, its lower end links to each other with an end of feed tube (7), the other end of feed tube (7) links to each other with solenoid valve (2), the overall channel (12) of feed tube (7) is connected with an end of peristaltic pump (3), the other end of peristaltic pump (3) links to each other with reaction plate (4), the other end of reaction plate (4) is connected with waste liquid box (6), reaction plate (4) is positioned at temperature control box (5), and in the middle of reaction plate (4), have a circular pan (8), go up the histotomy position with microslide (10) and coincide, have a symmetrical passage (9) in the pan (8).
2. immunohistochemistry instrument as claimed in claim 1 is characterized in that: reaction plate (4) but multilayer stack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00234677 CN2444230Y (en) | 2000-05-16 | 2000-05-16 | Immunohistochemistry apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00234677 CN2444230Y (en) | 2000-05-16 | 2000-05-16 | Immunohistochemistry apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2444230Y true CN2444230Y (en) | 2001-08-22 |
Family
ID=33596709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00234677 Expired - Fee Related CN2444230Y (en) | 2000-05-16 | 2000-05-16 | Immunohistochemistry apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2444230Y (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103513024A (en) * | 2012-06-20 | 2014-01-15 | 上海市东方医院 | Full-automatic immunochemical instrument and use method thereof |
| CN106526161A (en) * | 2016-12-29 | 2017-03-22 | 广州江元医疗科技有限公司 | Full-automatic cell immunolabeling instrument |
| CN107907396A (en) * | 2017-11-07 | 2018-04-13 | 山西大学 | A kind of biological tissue's active immunity histochemical staining system |
| CN107949790A (en) * | 2015-08-06 | 2018-04-20 | 激光基因公司 | Marked using light cleavable and carry out antigen detection |
| CN109283032A (en) * | 2018-11-19 | 2019-01-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | A kind of frozen section immunohistochemistry automation dyeing instrument |
| WO2021121148A1 (en) * | 2019-12-19 | 2021-06-24 | 石家庄禾柏生物技术股份有限公司 | Air path system |
-
2000
- 2000-05-16 CN CN 00234677 patent/CN2444230Y/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103513024A (en) * | 2012-06-20 | 2014-01-15 | 上海市东方医院 | Full-automatic immunochemical instrument and use method thereof |
| CN103513024B (en) * | 2012-06-20 | 2015-08-26 | 上海市东方医院 | Full-automatic immunochemical instrument and using method thereof |
| CN107949790A (en) * | 2015-08-06 | 2018-04-20 | 激光基因公司 | Marked using light cleavable and carry out antigen detection |
| US10942176B2 (en) | 2015-08-06 | 2021-03-09 | Agilent Technologies, Inc. | Antigen detection using photocleavable labels |
| CN106526161A (en) * | 2016-12-29 | 2017-03-22 | 广州江元医疗科技有限公司 | Full-automatic cell immunolabeling instrument |
| CN107907396A (en) * | 2017-11-07 | 2018-04-13 | 山西大学 | A kind of biological tissue's active immunity histochemical staining system |
| CN109283032A (en) * | 2018-11-19 | 2019-01-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | A kind of frozen section immunohistochemistry automation dyeing instrument |
| WO2021121148A1 (en) * | 2019-12-19 | 2021-06-24 | 石家庄禾柏生物技术股份有限公司 | Air path system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Hangli Document name: Notification of Termination of Patent Right |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |