CN203191234U - Fast-slow type double-purpose automatic biological tissue dehydrator of single-specimen processing cylinder - Google Patents
Fast-slow type double-purpose automatic biological tissue dehydrator of single-specimen processing cylinder Download PDFInfo
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- CN203191234U CN203191234U CN 201320022580 CN201320022580U CN203191234U CN 203191234 U CN203191234 U CN 203191234U CN 201320022580 CN201320022580 CN 201320022580 CN 201320022580 U CN201320022580 U CN 201320022580U CN 203191234 U CN203191234 U CN 203191234U
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Abstract
The utility model relates to a fast-slow type double-purpose automatic biological tissue dehydrator of a single-specimen processing cylinder which is used for carrying out processing steps of fixing, dehydrating, hyalinizing and performing wax dipping on tissue specimens at rapid and slow speed and is applied to manufacturing of hospital pathological tissue specimen paraffin sections. Three technologies such as an ultrasonic molecular movement mechanics principle, mixing of reagents in a stirring mode and vacuum wax dipping are combined, a liquid path solenoid valve and an air path solenoid valve are sequentially controlled by using a computer intelligence system to start the dehydrator, and alternating programming operation steps of temperature in the specimen processing cylinder, negative pressure vacuum degree and healthy atmosphere pressure are carried out. Different patient sources on the day and pathological inspection specimens of different patients who have a requirement on time urgency can be processed at the fast and slow speeds in a different way, and manufacturing of paraffin section is finished, so that the improvement on medical service quality in China is facilitated and the medical treatment level is increased.
Description
Technical field
The utility model relates to the equipment that a kind of biological tissue specimens paraffin section is made.Specifically be exactly that the fast and slow two kinds of speed of a kind of usefulness carry out that tissue specimen is fixed, the novel single sample disposal cylinder automated biological tissue processor of dehydration, transparent and waxdip, be applied to hospital's pathological tissue sample paraffin section and make.
Background technology
Tissue specimen processing procedure biological and that pathological tissue sample paraffin section is made generally has four steps: fix, dehydration, transparent and waxdip.The present employed reagent of automated biological tissue processor normally uses 10% formalin-fixed tissue, after grade concentration dehydration of alcohol and dimethylbenzene are transparent, carry out the sample waxdip again.The required reagent of entire process process is too many, the time is tediously long and flow process is complicated, lacks the function of fast automatic processing tissue specimen simultaneously.Can not preserve the integrality of tissue or the big molecule of intracellular biology such as nucleic acid and protein etc. rapidly; Pathology department be can not satisfy again and quick paraffin wax flaking and the requirement of finishing rapid pathological diagnosis on the same day in 1 to 3 hour realized.Handling tissue specimen generally needs 10 to 15 reagent tanks, handles the tissue specimen time and need spend the night to the tissue specimen treatment facility of second day (needing 12 to 24 hours approximately) and be called routine (at a slow speed) automated biological tissue processor or claim traditional automated biological tissue processor.The tissue specimen treatment facility that the time of processing tissue specimen was shorter than within 5 hours is commonly referred to fast automatic biological tissue dehydrator.
Modern pathology demand of laboratory should be advanced technology and protection environment, and possess multiple functional characteristics simultaneously: (1) makes great efforts to shorten the manufacturing cycle time of sample, strives for making in the shortest time (same day) the pathological diagnosis report.(2) strengthening molecular biology uses; Molecular biological research will play an important role in the diagnostic analysis in future, and the preservation of DNA and RNA is crucial in the paraffin-embedded tissue.(3) set up the Pathology Lab of environment-friendly type, the working environment that avirulence gas fills the air is accomplished to do the transparency of organization agent without the formaldehyde fixed tissue without dimethylbenzene.(4) in the censorship sample of pathology department, what have derives from outpatient's biopsy specimen, the excision sample that derives from the inpatient that also has.The outpatient expects to obtain fast the pathological diagnosis report, in order to obtain effective diagnosis and treatment immediately, can reduce anxiety and the spending of saving journey that patient waits for simultaneously again.At present, the task of China's hospital pathology department is tired heavy, can not in a few days finish the diagnosis report of all patient specimens; Therefore, inventing a kind of while can come differentiating and processing different patients source on the same day and the time sense of urgency be required different patient's pathology inspect the new type auto biological tissue dehydrator of samples by ready samples with slow two kinds of speed with fast, very necessary to improving China's medical service quality and improving medical level.
Summary of the invention
The present invention is directed to that tediously long, the employed reagent of the organized processing program time that overcomes present dewaterer is too many, flow process is complicated and can not quick complete preservation protein and shortcoming such as the big molecule of biological nucleic acid, ultrasound wave molecular motion mechanics principle, alr mode mixing reagent and three kinds of technical methods of vacuum waxdip are combined, use the order unlatching of Computerized intelligent system control liquid road and electromagnetic valve of gas circuit and the programming operations step that temperature, negative-pressure vacuum degree and healthy tendency pressure in the sample disposal cylinder replace, to solve the shortcomings and deficiencies in the above-mentioned background technology.
The technical matters that the utility model solves realizes by the following technical solutions: a kind of speed dual-purpose type list sample disposal cylinder automated biological tissue processor has box body, sample disposal cabinet, reagent cabinet, computerized control system and display screen; (list) sample disposal cylinder and two deposit wax cylinders are installed in the sample disposal cabinet, sample disposal cashier's office in a shop face be sample disposal cylinder cap and the deposit wax cylinder cap that O-ring seal is housed; Four reagent kettles, two clean-out system kettles, two waste liquids discharge taps, pressure vacuum pump, ultrasonic generator and computerized control systems are installed in the reagent cabinet, the pressure vacuum pump is below the clean-out system kettle, and ultrasonic generator and computerized control system are at reagent kettle rear.
Described sample disposal cylinder comprises sample disposal cylinder cap, well heater, liquid level sensor, temperature sensor, ultrasonic transducer, stirrer, gateway, sample disposal cylinder reagent solution road, gateway, sample disposal cylinder reagent solution road filter screen, sample disposal cylinder gas circuit gateway, Sample basket and the reagent liquid level that O-ring seal is housed.
Described each reagent kettle and clean-out system kettle link by solenoid valve and reagent pipeline and gateway, sample disposal cylinder reagent solution road.
Described each deposit wax cylinder links by solenoid valve and reagent pipeline and gateway, sample disposal cylinder reagent solution road.
Described pressure vacuum pump is connected malleation gas cylinder and negative pressure gas cylinder and sample disposal cylinder gas circuit gateway by solenoid valve, pressure transducer and gas piping and links.
Beneficial effect: the utility model combines ultrasound wave molecular motion mechanics principle, alr mode mixing reagent and three kinds of technology of vacuum waxdip, uses the order unlatching of Computerized intelligent system control liquid road and electromagnetic valve of gas circuit and the programming operations that temperature, negative-pressure vacuum degree and healthy tendency pressure in the sample disposal cylinder replace.Can come differentiating and processing different patients source on the same day and the time sense of urgency be required different patient's pathology censorship samples with slow two kinds of speed with fast, and finish paraffin section and make, help improve China's medical service quality and raising medical level.
Description of drawings
Fig. 1 is the front contour structures synoptic diagram of the utility model dewaterer.
Fig. 2 is the back side contour structures synoptic diagram of the utility model dewaterer.
Fig. 3 is that the structure of the utility model dewaterer is formed and each parts connection diagram.
Fig. 4 is the structural representation of the utility model dewaterer list sample disposal cylinder.
Among the above-mentioned figure: 1. box body, 2. sample disposal cabinet, 3. sample disposal cylinder, 4. the sample disposal cylinder cap of O-ring seal is housed, 5. computerized control system, 6. display screen, 7. deposit wax cylinder is 8. laid in wax cylinder cap, 9. reagent cabinet, 10. reagent kettle, 11. clean-out system kettles, 12. pressure vacuum pumps, 13. waste liquid is discharged tap, 14. malleation gas cylinders, 15. negative pressure gas cylinders, 16. the reagent pipeline, 17. solenoid valves, 18. well heaters, 19. liquid level sensor, 20. pressure transducers, 21. ultrasonic generators, 22. ultrasonic transducer, 23. stirrer, 24. temperature sensors, gateway, 25. sample disposal cylinder reagent solution road, 26. sample disposal cylinder reagent gateway filter screen, 27. sample disposal cylinder gas circuit gateway, 28. Sample baskets, 29. reagent liquid levels, 30. gas piping, 31. reagent storage cabinets.
Embodiment
In order to understand concrete structure of the present utility model and content more meticulously, for example the utility model embodiment is described further below in conjunction with accompanying drawing.
Principle of the present utility model and architectural feature are in conjunction with Fig. 1, Fig. 2, Fig. 3 and Fig. 4 explanation, single sample disposal cylinder 3 is as carrying out all tissue specimen treatment steps that comprise fixing, dehydration, transparent and waxdip, Sample basket 28 is as the carrier of the sample embedded box in the tissue specimen processing procedure, Computerized intelligent control system 5 sees through touch display screen 6 editor and storage operation programs, and Computerized intelligent control system 5 is come complete whole tissue specimen processing procedure according to selected storage operation program.Ultrasonic generator 21 is delivered to reagent in the sample disposal cylinder 3 to strengthen reagent to the processing power of tissue specimen by ultrasonic transducer 22 with hyperacoustic molecular motion mechanics effect, shorten the processing time of sample, reagent in the stirrer 23 continuous stirring sample disposal cylinders 3 are in order to make tissue specimen thermally equivalent in the Sample basket 28, when Sample basket and sample wherein immerse in the dewaxing, vacuum pump is started working, keep vacuum tightness 50-80 kPa, when waxdip disposes, vacuum pump quits work.
Below in conjunction with accompanying drawing work of the present utility model and operational process are elaborated: at first, add reagent, clean-out system and paraffin branch and be clipped to reagent kettle 10, clean-out system kettle 11 and deposit wax cylinder 7, Sample basket 28 is put into sample disposal cylinder 3 and covered close cylinder cap 4.Then, open the machine power switch, pressure vacuum pump 12 starts → gives negative pressure bottle 15 and add negative pressure → solenoid valve 17 and open → when the 1st reagent kettle adds reagent → reagent in the sample disposal cylinder 3 and is added to the reagent liquid level 28 of capacity → sample disposal cylinder 3 in liquid level sensors 19 carry out control and stop to be heated in liquid feeding → cylinder when requiring Wen Ding and pressure → startups ultrasonic generator 21 and/or stirrer 23 → at this moment, the fixing of tissue specimen, dehydration, after the processing time that the transparent and waxdip process program that picks up counting → reach requires → program start automatically close negative pressure solenoid valve → pressure vacuum pump 12 start → give malleation bottle 14 and add malleation → positive pressure electromagnetic valve and open → send reagent in the sample disposal cylinder 3 back to first reagent kettle.Repeat the aforesaid operations process in proper order by reagent kettle the 1st kettle to the 4 kettles and deposit wax cylinder the 1st cylinder to the 2 cylinders in succession.After whole sample disposal process was finished, taking-up Sample basket 28 and sample carried out embedding, section and dyeing from sample disposal cylinder 3.After each tissue specimen processing procedure circulation is finished, all to repeat the aforesaid operations process in proper order by clean-out system kettle the 1st kettle to the 2 kettles, carry out sample disposal cylinder cleaning function.
When machine was carried out quick tissue specimen processing capacity, sample processing speed in the sample disposal cylinder 3 was accelerated in ultrasonic generator 21, stirrer 23 and vacuum waxdip function unlatching work; Carry out routine at a slow speed during the tissue specimen processing capacity when machine, ultrasonic generator 21, stirrer 23 and vacuum waxdip function are in off-position automatically, and reagent is in molecule proper motion state, the gradual processing procedure of finishing tissue specimen in the sample disposal cylinder.Following table one and table two are that 60 minutes quick tissue specimens are handled and conventional spend the night tissue specimen handling procedure and the embodiment of time at a slow speed.
60 minutes quick tissue specimen handling procedures of table one and time.
Table two routine is spent the night tissue specimen handling procedure and time at a slow speed.
More than show and described ultimate principle of the present utility model, principal character and advantage.The technician of the industry should understand; the utility model is not restricted to the described embodiments; that describes in above-described embodiment and the instructions just illustrates principle of the present utility model; under the prerequisite that does not break away from the utility model spirit and scope; the utility model also has various changes and modifications, and these changes and improvements all fall in claimed the utility model scope.The claimed scope of the utility model is defined by appending claims and equivalent thereof.
Claims (5)
1. speed dual-purpose type list sample disposal cylinder automated biological tissue processor, by box body (1), sample disposal cabinet (2), reagent cabinet (9), computerized control system (5) and display screen (6) are formed, it is characterized in that: a sample disposal cylinder (3) and two deposit wax cylinders (7) are installed in sample disposal cabinet (2), be sample disposal cylinder cap (4) and the deposit wax cylinder cap (8) that O-ring seal is housed on sample disposal cabinet (2), four reagent kettles (10) are installed in reagent cabinet (9), two clean-out system kettles (11), two waste liquids are discharged tap (13), pressure vacuum pump (12), ultrasonic generator (21) and computerized control system (5), pressure vacuum pump (12) is in clean-out system kettle (11) below, and ultrasonic generator (21) and computerized control system (5) are at reagent kettle (10) rear.
2. a kind of speed dual-purpose type list sample disposal cylinder automated biological according to claim 1 tissue processor, it is characterized in that: described sample disposal cylinder (3) comprises cylinder cap (4), well heater (18), liquid level sensor (19), ultrasonic transducer (22), stirrer (23), temperature sensor (24), gateway, sample disposal cylinder reagent solution road (25), sample disposal cylinder reagent solution road gateway filter screen (26), sample disposal cylinder gas circuit gateway (27), Sample basket (28) and the reagent liquid level (29) that O-ring seal is housed.
3. a kind of speed dual-purpose type list sample disposal cylinder automated biological according to claim 1 tissue processor, it is characterized in that: described each reagent kettle (10) and clean-out system kettle (11) link with gateway, sample disposal cylinder reagent solution road (25) by solenoid valve (17) and reagent pipeline (16).
4. a kind of speed dual-purpose type list sample disposal cylinder automated biological according to claim 1 tissue processor is characterized in that: described each deposit wax cylinder (7) links by solenoid valve (17) and reagent pipeline (16) and gateway, sample disposal cylinder reagent solution road (25).
5. a kind of speed dual-purpose type list sample disposal cylinder automated biological according to claim 1 tissue processor, it is characterized in that: described pressure vacuum pump (12) is connected malleation gas cylinder (14) by solenoid valve (17), pressure transducer (20) and gas piping (30) and negative pressure gas cylinder (15) links with sample disposal cylinder gas circuit gateway (27).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320022580 CN203191234U (en) | 2013-01-16 | 2013-01-16 | Fast-slow type double-purpose automatic biological tissue dehydrator of single-specimen processing cylinder |
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| CN 201320022580 CN203191234U (en) | 2013-01-16 | 2013-01-16 | Fast-slow type double-purpose automatic biological tissue dehydrator of single-specimen processing cylinder |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105606437A (en) * | 2016-03-01 | 2016-05-25 | 青岛锴锦医疗器械有限公司 | Rapid pathological tissue dehydrating machine |
| CN106018040A (en) * | 2016-07-19 | 2016-10-12 | 关慧娟 | Pathological tissue dehydration device |
| CN106353164A (en) * | 2016-07-21 | 2017-01-25 | 深圳市美雅洁技术股份有限公司 | Ultrasonic rapid wax dipping system for pathological tissues and usage method |
| CN106373475A (en) * | 2016-11-30 | 2017-02-01 | 李懿 | Manufacturing method of biological plasticized specimen capable of being assembled |
| CN106644635A (en) * | 2016-12-07 | 2017-05-10 | 贵州大学 | Automatic medicine changing device and method for paraffin sections |
| CN106680058A (en) * | 2017-01-13 | 2017-05-17 | 无锡启盛实验设备有限公司 | Dual-cylinder dual-system full-automatic closed tissue dehydrating machine |
| CN104330289B (en) * | 2014-09-26 | 2017-08-08 | 湖北阳光神琦医用科技有限公司 | A kind of twin-tub vacuumizes biological tissue dehydrator and its dewatering |
| CN108415489A (en) * | 2018-01-29 | 2018-08-17 | 东莞市鸥翼实业有限公司 | A kind of control method and control system of pathological section rapid treatment instrument |
| CN108760447A (en) * | 2018-05-23 | 2018-11-06 | 深圳大学 | Semi-automatic dyeing apparatus |
| CN110031279A (en) * | 2019-03-30 | 2019-07-19 | 吴淑华 | Sample fixed station |
| CN110595853A (en) * | 2019-09-20 | 2019-12-20 | 湖北泰康医疗设备有限公司 | Safe and rapid automatic processing equipment for biological samples |
| CN112945657A (en) * | 2021-01-22 | 2021-06-11 | 中国科学院东北地理与农业生态研究所 | Pretreatment device and method for preparing plant material paraffin section |
| CN113776909A (en) * | 2021-09-13 | 2021-12-10 | 青岛锴锦医疗器械有限公司 | Integrated normal-treatment and rapid-treatment dual-purpose pathological tissue dehydrator |
| CN114264537A (en) * | 2021-12-21 | 2022-04-01 | 达科为（深圳）医疗设备有限公司 | Dehydrator, control method and system thereof, electronic device, and readable storage medium |
| CN117850281A (en) * | 2024-03-08 | 2024-04-09 | 金华市益迪医疗设备有限公司 | Intelligent control system and full-automatic tissue dehydrator |
-
2013
- 2013-01-16 CN CN 201320022580 patent/CN203191234U/en not_active Expired - Fee Related
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104330289B (en) * | 2014-09-26 | 2017-08-08 | 湖北阳光神琦医用科技有限公司 | A kind of twin-tub vacuumizes biological tissue dehydrator and its dewatering |
| CN105606437A (en) * | 2016-03-01 | 2016-05-25 | 青岛锴锦医疗器械有限公司 | Rapid pathological tissue dehydrating machine |
| CN105606437B (en) * | 2016-03-01 | 2018-06-19 | 青岛锴锦医疗器械有限公司 | A kind of rapid pathology tissue processor |
| CN106018040A (en) * | 2016-07-19 | 2016-10-12 | 关慧娟 | Pathological tissue dehydration device |
| CN106018040B (en) * | 2016-07-19 | 2019-07-26 | 杨静 | Pathological tissue dehydrating device |
| CN106353164A (en) * | 2016-07-21 | 2017-01-25 | 深圳市美雅洁技术股份有限公司 | Ultrasonic rapid wax dipping system for pathological tissues and usage method |
| CN106373475B (en) * | 2016-11-30 | 2019-01-08 | 李懿 | It is a kind of can assembled biological plasticized sample production method |
| CN106373475A (en) * | 2016-11-30 | 2017-02-01 | 李懿 | Manufacturing method of biological plasticized specimen capable of being assembled |
| CN106644635A (en) * | 2016-12-07 | 2017-05-10 | 贵州大学 | Automatic medicine changing device and method for paraffin sections |
| CN106680058A (en) * | 2017-01-13 | 2017-05-17 | 无锡启盛实验设备有限公司 | Dual-cylinder dual-system full-automatic closed tissue dehydrating machine |
| CN108415489A (en) * | 2018-01-29 | 2018-08-17 | 东莞市鸥翼实业有限公司 | A kind of control method and control system of pathological section rapid treatment instrument |
| CN108760447A (en) * | 2018-05-23 | 2018-11-06 | 深圳大学 | Semi-automatic dyeing apparatus |
| CN110031279A (en) * | 2019-03-30 | 2019-07-19 | 吴淑华 | Sample fixed station |
| CN110595853A (en) * | 2019-09-20 | 2019-12-20 | 湖北泰康医疗设备有限公司 | Safe and rapid automatic processing equipment for biological samples |
| CN110595853B (en) * | 2019-09-20 | 2024-03-29 | 湖北泰康医疗设备有限公司 | Biological sample safe and quick automatic processing equipment |
| CN112945657A (en) * | 2021-01-22 | 2021-06-11 | 中国科学院东北地理与农业生态研究所 | Pretreatment device and method for preparing plant material paraffin section |
| CN112945657B (en) * | 2021-01-22 | 2023-08-25 | 中国科学院东北地理与农业生态研究所 | Pretreatment device and method for preparing plant material paraffin section |
| CN113776909A (en) * | 2021-09-13 | 2021-12-10 | 青岛锴锦医疗器械有限公司 | Integrated normal-treatment and rapid-treatment dual-purpose pathological tissue dehydrator |
| CN114264537A (en) * | 2021-12-21 | 2022-04-01 | 达科为（深圳）医疗设备有限公司 | Dehydrator, control method and system thereof, electronic device, and readable storage medium |
| CN117850281A (en) * | 2024-03-08 | 2024-04-09 | 金华市益迪医疗设备有限公司 | Intelligent control system and full-automatic tissue dehydrator |
| CN117850281B (en) * | 2024-03-08 | 2024-05-07 | 金华市益迪医疗设备有限公司 | Intelligent control system and full-automatic tissue dehydrator |
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